Sppl2a (signal peptide peptidase like 2A) - Rat Genome Database

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Gene: Sppl2a (signal peptide peptidase like 2A) Heterocephalus glaber
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Symbol: Sppl2a
Name: signal peptide peptidase like 2A
RGD ID: 18918548
Description: ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN membrane protein ectodomain proteolysis (ortholog); membrane protein intracellular domain proteolysis (ortholog); regulation of immune response (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); hereditary spastic paraplegia 51 (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); late endosome (ortholog); late endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Signal peptide peptidase-like 2A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,430,790 - 9,473,839 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,430,702 - 9,469,961 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sppl2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247319,430,790 - 9,473,839 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247319,430,702 - 9,469,961 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPPL2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381550,702,266 - 50,765,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1550,702,266 - 50,765,948 (-)EnsemblGRCh38hg38GRCh38
GRCh371550,994,463 - 51,057,903 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361548,787,022 - 48,845,202 (-)NCBINCBI36Build 36hg18NCBI36
Celera1527,892,656 - 27,950,835 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1527,830,092 - 27,887,195 (-)NCBIHuRef
CHM1_11551,117,735 - 51,175,916 (-)NCBICHM1_1
T2T-CHM13v2.01548,509,322 - 48,573,674 (-)NCBIT2T-CHM13v2.0
Sppl2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392126,732,311 - 126,775,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2126,732,311 - 126,775,155 (-)EnsemblGRCm39 Ensembl
GRCm382126,890,391 - 126,933,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2126,890,391 - 126,933,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv372126,716,127 - 126,758,971 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362126,585,573 - 126,624,676 (-)NCBIMGSCv36mm8
Celera2128,131,294 - 128,174,122 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.76NCBI
Sppl2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83134,602,684 - 134,646,752 (-)NCBIGRCr8
mRatBN7.23114,149,337 - 114,193,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,151,069 - 114,193,264 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,038,543 - 118,079,820 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03126,634,069 - 126,675,351 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,294,450 - 124,335,732 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,361,651 - 119,405,453 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,361,655 - 119,405,453 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03125,885,610 - 125,930,156 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,428,234 - 114,469,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3112,992,568 - 113,033,419 (-)NCBICelera
Cytogenetic Map3q36NCBI
Sppl2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554093,645,555 - 3,670,551 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554093,642,113 - 3,670,779 (+)NCBIChiLan1.0ChiLan1.0
SPPL2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21639,955,464 - 40,013,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11544,135,883 - 44,194,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01529,660,190 - 29,718,477 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11547,997,304 - 48,055,334 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1547,997,304 - 48,055,239 (-)Ensemblpanpan1.1panPan2
SPPL2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13016,593,834 - 16,638,435 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3016,596,967 - 16,745,608 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3016,521,419 - 16,576,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03016,739,659 - 16,794,816 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3016,737,324 - 16,794,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13016,662,066 - 16,717,186 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03016,780,177 - 16,835,314 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03016,886,809 - 16,941,959 (-)NCBIUU_Cfam_GSD_1.0
Sppl2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864094,850,035 - 94,882,446 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647112,701,014 - 12,729,995 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647112,700,777 - 12,730,509 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPPL2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1121,067,454 - 121,134,888 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11121,067,638 - 121,134,896 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21134,517,344 - 134,571,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPPL2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12632,574,585 - 32,633,473 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2632,574,612 - 32,634,034 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048108,522,070 - 108,582,241 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000013779   ⟹   ENSHGLP00000013638
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247319,430,790 - 9,473,839 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000013780   ⟹   ENSHGLP00000013639
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247319,430,790 - 9,473,839 (+)Ensembl
RefSeq Acc Id: XM_004835417   ⟹   XP_004835474
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247319,430,702 - 9,469,961 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004835474 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB17939 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000013639
GenBank Protein JAO02880 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004835474   ⟸   XM_004835417
- UniProtKB: A0A0P6JHW9 (UniProtKB/TrEMBL),   G5C8S8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000013638   ⟸   ENSHGLT00000013779
Ensembl Acc Id: ENSHGLP00000013639   ⟸   ENSHGLT00000013780


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009752 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000013780 ENTREZGENE
Gene3D-CATH 3.50.30.30 UniProtKB/TrEMBL
InterPro PA_dom_sf UniProtKB/TrEMBL
  PA_domain UniProtKB/TrEMBL
  Peptidase_A22B_SPP UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/TrEMBL
NCBI Gene Sppl2a ENTREZGENE
PANTHER PTHR12174 UniProtKB/TrEMBL
  SIGNAL PEPTIDE PEPTIDASE-LIKE 2A UniProtKB/TrEMBL
Pfam Peptidase_A22B UniProtKB/TrEMBL
  PF02225 UniProtKB/TrEMBL
SMART PSN UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/TrEMBL
UniProt A0A0P6JHW9 ENTREZGENE, UniProtKB/TrEMBL
  G5C8S8 ENTREZGENE, UniProtKB/TrEMBL