Nelfa (negative elongation factor complex member A) - Rat Genome Database

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Gene: Nelfa (negative elongation factor complex member A) Heterocephalus glaber
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Symbol: Nelfa
Name: negative elongation factor complex member A
RGD ID: 18918177
Description: ENCODES a protein that exhibits chromatin binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN negative regulation of transcription elongation by RNA polymerase II (ortholog); positive regulation of protein modification process (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH cherubism (ortholog); FOUND IN cytosol (ortholog); nuclear body (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: negative elongation factor A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,498,431 - 25,508,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,498,336 - 25,508,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
cherubism  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
NELF complex  (IEA)
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Nelfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475525,498,431 - 25,508,753 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475525,498,336 - 25,508,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NELFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3841,982,723 - 2,008,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl41,982,717 - 2,041,903 (-)EnsemblGRCh38hg38GRCh38
GRCh3741,984,450 - 2,010,701 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,954,248 - 1,980,547 (-)NCBINCBI36Build 36hg18NCBI36
Build 3441,951,683 - 1,977,980NCBI
Celera41,896,671 - 1,923,194 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef41,925,800 - 1,952,332 (-)NCBIHuRef
CHM1_141,983,104 - 2,009,627 (-)NCBICHM1_1
T2T-CHM13v2.041,981,232 - 2,007,492 (-)NCBIT2T-CHM13v2.0
Nelfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39534,055,263 - 34,093,615 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl534,055,260 - 34,093,757 (-)EnsemblGRCm39 Ensembl
GRCm38533,897,916 - 33,936,301 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl533,897,916 - 33,936,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv37534,240,828 - 34,278,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36534,215,036 - 34,253,115 (-)NCBIMGSCv36mm8
Celera531,375,430 - 31,405,361 (-)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.83NCBI
Nelfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81481,033,470 - 81,057,546 (+)NCBIGRCr8
mRatBN7.21476,808,920 - 76,832,998 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1476,808,870 - 76,832,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1481,260,792 - 81,284,853 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01482,501,435 - 82,525,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01478,946,688 - 78,970,749 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01482,093,837 - 82,117,913 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1482,093,837 - 82,117,906 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01482,778,077 - 82,802,153 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41482,502,840 - 82,526,916 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11482,505,230 - 82,529,304 (+)NCBI
Celera1475,732,469 - 75,756,545 (+)NCBICelera
Cytogenetic Map14q21NCBI
Nelfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555141,162,993 - 1,173,278 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555141,162,993 - 1,173,278 (-)NCBIChiLan1.0ChiLan1.0
NELFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v232,310,013 - 2,374,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan142,247,052 - 2,311,265 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v042,119,699 - 2,147,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.142,027,939 - 2,054,669 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl42,027,939 - 2,054,669 (-)Ensemblpanpan1.1panPan2
NELFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,147,948 - 62,164,039 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,147,948 - 62,164,112 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha364,665,674 - 64,682,273 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,623,281 - 62,639,884 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,623,336 - 62,639,877 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,115,860 - 62,133,779 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,319,512 - 62,337,145 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,679,577 - 62,696,178 (+)NCBIUU_Cfam_GSD_1.0
Nelfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528567,740,863 - 67,758,307 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647721,442,380 - 21,464,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647721,442,493 - 21,459,999 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,018,453 - 1,039,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,018,443 - 1,039,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28515,274 - 626,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12746,759,742 - 46,786,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2746,760,707 - 46,787,090 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660513,131,850 - 3,158,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000006404   ⟹   ENSHGLP00000006323
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475525,498,431 - 25,508,753 (+)Ensembl
RefSeq Acc Id: XM_004847399   ⟹   XP_004847456
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475525,498,605 - 25,508,753 (+)NCBI
RefSeq Acc Id: XM_004847400   ⟹   XP_004847457
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475525,498,336 - 25,508,753 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004847456 (Get FASTA)   NCBI Sequence Viewer  
  XP_004847457 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000006323
RefSeq Acc Id: XP_004847457   ⟸   XM_004847400
- Peptide Label: isoform X2
- UniProtKB: G5BCI3 (UniProtKB/TrEMBL),   A0AAX6PBH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004847456   ⟸   XM_004847399
- Peptide Label: isoform X1
- UniProtKB: G5BCI3 (UniProtKB/TrEMBL),   A0AAX6PAL7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000006323   ⟸   ENSHGLT00000006404


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000004622 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000006404 ENTREZGENE
InterPro HDAG_dom UniProtKB/TrEMBL
  NELF-A_domain UniProtKB/TrEMBL
NCBI Gene Nelfa ENTREZGENE
PANTHER NEGATIVE ELONGATION FACTOR A UniProtKB/TrEMBL
  NEGATIVE ELONGATION FACTOR A NELF-A UniProtKB/TrEMBL
PROSITE HDAG UniProtKB/TrEMBL
UniProt A0AAX6PAL7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6PBH3 ENTREZGENE, UniProtKB/TrEMBL
  G5BCI3 ENTREZGENE, UniProtKB/TrEMBL