Iqgap2 (IQ motif containing GTPase activating protein 2) - Rat Genome Database

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Gene: Iqgap2 (IQ motif containing GTPase activating protein 2) Heterocephalus glaber
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Symbol: Iqgap2
Name: IQ motif containing GTPase activating protein 2
RGD ID: 18917810
Description: ENCODES a protein that exhibits Arp2/3 complex binding (ortholog); phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); small GTPase binding (ortholog); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); regulation of actin cytoskeleton organization (ortholog); thrombin-activated receptor signaling pathway (ortholog); ASSOCIATED WITH Brain Neoplasms (ortholog); hepatocellular carcinoma (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); filopodium (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ras GTPase-activating-like protein IQGAP2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624869889,091 - 1,171,983 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624869888,868 - 1,172,747 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Iqgap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624869889,091 - 1,171,983 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624869888,868 - 1,172,747 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IQGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,403,285 - 76,708,132 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,403,285 - 76,708,132 (+)EnsemblGRCh38hg38GRCh38
GRCh37575,699,110 - 76,003,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36575,734,905 - 76,039,713 (+)NCBINCBI36Build 36hg18NCBI36
Build 34575,734,904 - 76,039,711NCBI
Celera571,592,826 - 71,897,903 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef570,906,692 - 71,211,466 (+)NCBIHuRef
CHM1_1575,131,847 - 75,437,149 (+)NCBICHM1_1
T2T-CHM13v2.0576,885,042 - 77,189,993 (+)NCBIT2T-CHM13v2.0
Iqgap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,763,685 - 96,028,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,763,682 - 96,028,991 (-)EnsemblGRCm39 Ensembl
GRCm381395,627,177 - 95,892,280 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,627,174 - 95,892,483 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,397,132 - 96,661,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,397,132 - 96,661,877 (-)NCBIMGSCv36mm8
Celera1399,243,963 - 99,510,431 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.26NCBI
Iqgap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,629,558 - 28,904,649 (-)NCBIGRCr8
mRatBN7.2226,894,836 - 27,170,270 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,894,825 - 27,170,279 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0226,161,628 - 26,439,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,167,199 - 26,438,790 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,295,534 - 45,569,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,039,689 - 26,147,538 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera222,958,327 - 23,102,329 (-)NCBICelera
Cytogenetic Map2q12NCBI
Iqgap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542524,167,104 - 24,385,146 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542524,167,985 - 24,384,912 (-)NCBIChiLan1.0ChiLan1.0
IQGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,597,137 - 38,902,374 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,750,767 - 37,056,000 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,593,574 - 38,900,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1539,137,539 - 39,516,894 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,138,359 - 39,516,596 (-)Ensemblpanpan1.1panPan2
IQGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,894,192 - 30,134,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,894,870 - 30,174,259 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,132,907 - 31,420,147 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,818,056 - 30,105,892 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,818,467 - 30,106,093 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,749,579 - 30,036,702 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,730,444 - 30,016,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,099,810 - 30,387,253 (-)NCBIUU_Cfam_GSD_1.0
Iqgap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,317,091 - 190,603,571 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549255,303 - 541,917 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936549256,097 - 541,860 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,294,530 - 85,633,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,294,423 - 85,633,645 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2286,916,946 - 87,086,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IQGAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,672,171 - 70,979,766 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl470,672,553 - 70,979,763 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,502,207 - 19,811,126 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000001605   ⟹   ENSHGLP00000001561
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624869889,091 - 1,171,983 (+)Ensembl
RefSeq Acc Id: XM_004870168   ⟹   XP_004870225
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624869888,868 - 1,172,747 (+)NCBI
RefSeq Acc Id: XM_021248555   ⟹   XP_021104214
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624869889,523 - 1,172,747 (+)NCBI
RefSeq Acc Id: XM_021248556   ⟹   XP_021104215
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624869889,411 - 1,172,747 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004870225 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104214 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104215 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001561
  ENSHGLP00000052174
GenBank Protein JAN97198 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004870225   ⟸   XM_004870168
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JTU5 (UniProtKB/TrEMBL),   G5ATK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104215   ⟸   XM_021248556
- Peptide Label: isoform X3
- UniProtKB: G5ATK8 (UniProtKB/TrEMBL),   A0AAX6S941 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104214   ⟸   XM_021248555
- Peptide Label: isoform X1
- UniProtKB: G5ATK8 (UniProtKB/TrEMBL),   A0AAX6S6B2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000001561   ⟸   ENSHGLT00000001605


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001189 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000001605 ENTREZGENE
  ENSHGLT00000089597 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  GTPase Activation - p120gap, domain 1 UniProtKB/TrEMBL
InterPro CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  ZW10_C UniProtKB/TrEMBL
NCBI Gene Iqgap2 ENTREZGENE
PANTHER RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF UniProtKB/TrEMBL
  RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2 UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
  ZW10_C UniProtKB/TrEMBL
PROSITE PS50021 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART RasGAP UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
Superfamily-SCOP RGC domain-like UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
UniProt A0A0P6JTU5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S6B2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S941 ENTREZGENE, UniProtKB/TrEMBL
  G5ATK8 ENTREZGENE, UniProtKB/TrEMBL