Calca (calcitonin related polypeptide alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Calca (calcitonin related polypeptide alpha) Heterocephalus glaber
Analyze
Symbol: Calca
Name: calcitonin related polypeptide alpha
RGD ID: 18917697
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN activation of adenylate cyclase activity (ortholog); activation of protein kinase activity (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); amyotrophic lateral sclerosis (ortholog); Animal Disease Models (ortholog); FOUND IN axon (ortholog); extracellular space (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CALCB; Calcitonin; calcitonin gene-related peptide 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,766,185 - 6,768,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247666,764,388 - 6,771,396 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (ISO)
activation of protein kinase activity  (ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
amylin receptor 1 signaling pathway  (ISO)
amylin receptor 2 signaling pathway  (IEA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure  (IEA,ISO)
calcitonin family receptor signaling pathway  (IEA)
calcitonin gene-related peptide receptor signaling pathway  (ISO)
cell adhesion  (ISO)
cellular response to nerve growth factor stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (IEA,ISO)
embryo implantation  (IEA)
endothelial cell migration  (ISO)
endothelial cell proliferation  (ISO)
feeding behavior  (IEA,ISO)
G protein-coupled receptor internalization  (ISO)
inflammatory response  (IEA,ISO)
innate immune response  (ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
leukocyte cell-cell adhesion  (ISO)
monocyte chemotaxis  (IEA)
negative regulation of blood pressure  (IEA,ISO)
negative regulation of bone resorption  (IEA)
negative regulation of calcium ion transport into cytosol  (ISO)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of ossification  (IEA,ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of smooth muscle contraction  (IEA,ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (ISO)
neuropeptide signaling pathway  (IEA,ISO)
ossification  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA)
positive regulation of interleukin-1 alpha production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of macrophage differentiation  (ISO)
protein phosphorylation  (ISO)
receptor internalization  (ISO)
regulation of cytosolic calcium ion concentration  (IEA)
response to heat  (IEA,ISO)
response to pain  (IEA,ISO)
signal transduction  (IEA)
smooth muscle contraction  (IEA,ISO)
vasculature development  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Calca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247666,766,185 - 6,768,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247666,764,388 - 6,771,396 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CALCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381114,966,668 - 14,972,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1114,966,622 - 14,972,354 (-)EnsemblGRCh38hg38GRCh38
GRCh371114,988,214 - 14,993,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361114,944,792 - 14,950,408 (-)NCBINCBI36Build 36hg18NCBI36
Build 341114,946,625 - 14,950,427NCBI
Celera1115,115,335 - 15,120,952 (-)NCBICelera
Cytogenetic Map11p15.2NCBI
HuRef1114,671,857 - 14,677,473 (-)NCBIHuRef
CHM1_11114,987,226 - 14,992,843 (-)NCBICHM1_1
T2T-CHM13v2.01115,063,025 - 15,068,708 (-)NCBIT2T-CHM13v2.0
Calca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397114,225,223 - 114,236,145 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7114,230,713 - 114,235,592 (-)EnsemblGRCm39 Ensembl
GRCm387114,625,981 - 114,636,910 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7114,631,478 - 114,636,357 (-)EnsemblGRCm38mm10GRCm38
MGSCv377121,774,992 - 121,779,871 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367114,422,640 - 114,427,439 (-)NCBIMGSCv36mm8
Celera7114,584,937 - 114,589,792 (-)NCBICelera
Cytogenetic Map7F1NCBI
cM Map759.99NCBI
Calca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,312,636 - 178,317,588 (-)NCBIGRCr8
mRatBN7.21168,878,212 - 168,883,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,878,214 - 168,883,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,192,440 - 177,197,339 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,378,496 - 184,383,399 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01177,090,892 - 177,095,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,184,018 - 184,188,922 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,184,020 - 184,188,911 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,158,061 - 191,162,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41172,686,168 - 172,691,061 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11172,824,299 - 172,827,127 (-)NCBI
Celera1166,711,610 - 166,716,491 (-)NCBICelera
RH 3.4 Map11317.6RGD
RH 2.0 Map1757.3RGD
Cytogenetic Map1q34NCBI
CALCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2917,335,385 - 17,340,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11117,296,273 - 17,300,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01115,055,897 - 15,061,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11114,745,588 - 14,751,267 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1114,745,588 - 14,751,267 (-)Ensemblpanpan1.1panPan2
CRSP-3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12137,676,841 - 37,680,643 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2137,676,841 - 37,680,645 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2137,176,307 - 37,180,108 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02138,770,713 - 38,774,520 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2138,770,713 - 38,774,522 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.02137,993,320 - 37,997,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02138,281,026 - 38,284,825 (+)NCBIUU_Cfam_GSD_1.0
Calca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494747,766,690 - 47,772,207 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365283,800,577 - 3,805,004 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365283,800,801 - 3,806,000 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CALCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1244,043,135 - 44,048,651 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2247,248,414 - 47,253,904 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103239768
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1149,946,574 - 49,956,010 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl149,951,694 - 49,954,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038147,447,203 - 147,453,110 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000010388   ⟹   ENSHGLP00000010274
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247666,766,185 - 6,768,173 (-)Ensembl
RefSeq Acc Id: XM_004851472   ⟹   XP_004851529
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247666,765,956 - 6,769,608 (-)NCBI
RefSeq Acc Id: XM_004851473   ⟹   XP_004851530
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247666,764,388 - 6,771,396 (-)NCBI
RefSeq Acc Id: XM_021263836   ⟹   XP_021119495
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247666,765,956 - 6,771,396 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004851529 (Get FASTA)   NCBI Sequence Viewer  
  XP_004851530 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119495 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB12900 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000010274
GenBank Protein JAO00851 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004851530   ⟸   XM_004851473
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JHW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119495   ⟸   XM_021263836
- Peptide Label: isoform X1
- UniProtKB: G5BUD9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004851529   ⟸   XM_004851472
- Peptide Label: isoform X1
- UniProtKB: G5BUD9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000010274   ⟸   ENSHGLT00000010388


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007371 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000010388 ENTREZGENE
Gene3D-CATH 6.10.250.2190 UniProtKB/TrEMBL
InterPro Calcitonin UniProtKB/TrEMBL
  Calcitonin-like UniProtKB/TrEMBL
  Calcitonin/adrenomedullin UniProtKB/TrEMBL
  Calcitonin_CS UniProtKB/TrEMBL
  Calcitonin_gene-rel_peptide UniProtKB/TrEMBL
  Calcitonin_peptide-like UniProtKB/TrEMBL
KEGG Report hgl:101725159 UniProtKB/TrEMBL
NCBI Gene Calca ENTREZGENE
PANTHER CALCITONIN UniProtKB/TrEMBL
  CALCITONIN GENE-RELATED PEPTIDE 2 UniProtKB/TrEMBL
  PTHR10505 UniProtKB/TrEMBL
Pfam Calc_CGRP_IAPP UniProtKB/TrEMBL
PRINTS CALCITONINA UniProtKB/TrEMBL
  CALCITONINB UniProtKB/TrEMBL
PROSITE CALCITONIN UniProtKB/TrEMBL
SMART CALCITONIN UniProtKB/TrEMBL
UniProt A0A0P6JHW7 ENTREZGENE, UniProtKB/TrEMBL
  G5BUD9 ENTREZGENE, UniProtKB/TrEMBL