Alad (aminolevulinate dehydratase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Alad (aminolevulinate dehydratase) Heterocephalus glaber
Analyze
Symbol: Alad
Name: aminolevulinate dehydratase
RGD ID: 18914442
Description: ENCODES a protein that exhibits porphobilinogen synthase activity (ortholog); proteasome core complex binding (ortholog); INVOLVED IN cellular response to lead ion (ortholog); heme biosynthetic process (ortholog); response to activity (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH acute kidney failure (ortholog); adult respiratory distress syndrome (ortholog); ALAD-Deficiency Porphyria (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: delta-aminolevulinic acid dehydratase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,698,587 - 21,711,822 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476021,698,689 - 21,709,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Alad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,698,587 - 21,711,822 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476021,698,689 - 21,709,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ALAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,386,312 - 113,401,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9113,386,312 - 113,401,290 (-)EnsemblGRCh38hg38GRCh38
GRCh379116,148,592 - 116,163,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,188,413 - 115,203,391 (-)NCBINCBI36Build 36hg18NCBI36
Build 349113,228,146 - 113,243,124NCBI
Celera986,796,194 - 86,811,219 (-)NCBICelera
Cytogenetic Map9q32NCBI
HuRef985,755,612 - 85,770,551 (-)NCBIHuRef
CHM1_19116,295,230 - 116,310,254 (-)NCBICHM1_1
T2T-CHM13v2.09125,585,129 - 125,600,114 (-)NCBIT2T-CHM13v2.0
Alad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,422,762 - 62,438,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl462,427,406 - 62,438,155 (-)EnsemblGRCm39 Ensembl
GRCm38462,505,984 - 62,520,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,509,169 - 62,519,918 (-)EnsemblGRCm38mm10GRCm38
MGSCv37462,170,204 - 62,181,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36461,995,531 - 62,006,424 (-)NCBIMGSCv36mm8
Celera461,179,310 - 61,187,276 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.17NCBI
Alad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,977,562 - 80,987,901 (-)NCBIGRCr8
mRatBN7.2575,961,993 - 75,972,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,961,993 - 75,972,474 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx578,361,344 - 78,371,685 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,178,441 - 80,188,782 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,153,956 - 80,164,297 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,368,867 - 78,379,206 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,368,867 - 78,379,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0582,488,238 - 82,498,577 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4579,505,645 - 79,515,983 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1579,510,757 - 79,521,096 (-)NCBI
Celera574,903,347 - 74,913,685 (-)NCBICelera
Cytogenetic Map5q24NCBI
Alad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541914,093,010 - 14,104,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541914,093,010 - 14,104,376 (+)NCBIChiLan1.0ChiLan1.0
ALAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,972,297 - 25,987,310 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,974,656 - 25,991,945 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0984,488,339 - 84,503,360 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19112,859,171 - 112,873,784 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,859,171 - 112,873,784 (-)Ensemblpanpan1.1panPan2
ALAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,736,643 - 67,752,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,741,390 - 67,752,321 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1166,141,416 - 66,157,086 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01168,860,894 - 68,876,553 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1168,861,709 - 68,876,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,378,968 - 67,394,637 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01167,409,910 - 67,425,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,146,847 - 68,162,517 (-)NCBIUU_Cfam_GSD_1.0
Alad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,026,318 - 183,040,122 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936559226,424 - 241,684 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936559226,481 - 237,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,011,833 - 254,027,537 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11254,015,426 - 254,027,584 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,173,063 - 26,185,456 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1226,173,096 - 26,189,845 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603516,615,859 - 16,628,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004849532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01040942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000019551   ⟹   ENSHGLP00000019360
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476021,698,587 - 21,711,822 (+)Ensembl
RefSeq Acc Id: XM_004849532   ⟹   XP_004849589
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476021,698,689 - 21,709,907 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004849589 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000019360
RefSeq Acc Id: XP_004849589   ⟸   XM_004849532
- UniProtKB: A0A0P6JXB6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000019360   ⟸   ENSHGLT00000019551


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013865 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000019551 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro ALAD UniProtKB/TrEMBL
  ALAD_AS UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/TrEMBL
KEGG Report hgl:101701839 UniProtKB/TrEMBL
NCBI Gene Alad ENTREZGENE
PANTHER DELTA-AMINOLEVULINIC ACID DEHYDRATASE UniProtKB/TrEMBL
  PTHR11458 UniProtKB/TrEMBL
Pfam ALAD UniProtKB/TrEMBL
PIRSF Porphbilin_synth UniProtKB/TrEMBL
PRINTS DALDHYDRTASE UniProtKB/TrEMBL
PROSITE D_ALA_DEHYDRATASE UniProtKB/TrEMBL
SMART ALAD UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/TrEMBL
UniProt A0A0P6JXB6 ENTREZGENE, UniProtKB/TrEMBL