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Gene: Atp6ap2 (ATPase H+ transporting accessory protein 2) Heterocephalus glaber

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Symbol:

Atp6ap2

Name:

ATPase H+ transporting accessory protein 2

RGD ID:

18914025

Description:

ENCODES a protein that exhibits signaling receptor activity (inferred); INVOLVED IN angiotensin maturation (inferred); central nervous system maturation (inferred); eye pigmentation (inferred); PARTICIPATES IN renin-angiotensin cascade pathway; ASSOCIATED WITH autistic disorder (ortholog); congenital disorder of glycosylation type IIr (ortholog); Craniofacial Abnormalities (ortholog); FOUND IN apical plasma membrane (ortholog); cell body (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

renin receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	14,952,002 - 14,975,900 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624762	14,952,313 - 14,975,678 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

congenital disorder of glycosylation type IIr (ISO)

Craniofacial Abnormalities (ISO)

Fibrosis (ISO)

genetic disease (ISO)

hypertension (ISO)

Neurodevelopmental Disorders (ISO)

ornithine carbamoyltransferase deficiency (ISO)

Prenatal Exposure Delayed Effects (ISO)

syndromic microphthalmia 2 (ISO)

syndromic X-linked intellectual disability Hedera type (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

syndromic X-linked intellectual disability Najm type (ISO)

X-linked parkinsonism-spasticity syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiotensin maturation (IEA)

central nervous system maturation (IEA)

eye pigmentation (IEA)

head morphogenesis (IEA)

lysosomal lumen acidification (IEA)

positive regulation of canonical Wnt signaling pathway (IEA)

positive regulation of transforming growth factor beta1 production (IEA)

positive regulation of Wnt signaling pathway (IEA)

regulation of MAPK cascade (IEA)

rostrocaudal neural tube patterning (IEA)

synaptic vesicle lumen acidification (IEA)

Cellular Component

apical plasma membrane (ISO)

autophagosome membrane (IEA)

bounding membrane of organelle (IEA)

cell body (ISO)

clathrin-coated vesicle membrane (IEA)

cytoplasm (IEA)

dendritic spine membrane (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

endosome membrane (IEA)

external side of plasma membrane (IEA)

extracellular space (ISO)

lysosomal membrane (IEA)

lysosome (IEA)

membrane (IEA)

plasma membrane (IEA)

synaptic vesicle membrane (IEA,ISO)

vacuolar proton-transporting V-type ATPase complex (IEA)

Molecular Function

protein binding (ISO)

signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

renin-angiotensin cascade pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Atp6ap2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	14,952,002 - 14,975,900 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624762	14,952,313 - 14,975,678 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

ATP6AP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	40,580,970 - 40,606,848 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	40,579,372 - 40,606,848 (+)	Ensembl			hg38	GRCh38
GRCh37	X	40,440,222 - 40,466,100 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	40,325,160 - 40,350,833 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	40,196,446 - 40,222,125	NCBI
Celera	X	44,580,390 - 44,606,072 (+)	NCBI		Celera
Cytogenetic Map	X	p11.4	NCBI
HuRef	X	38,171,318 - 38,196,989 (+)	NCBI		HuRef
CHM1_1	X	40,472,702 - 40,498,380 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	39,982,532 - 40,008,405 (+)	NCBI		T2T-CHM13v2.0

Atp6ap2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	12,453,998 - 12,483,290 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	12,454,040 - 12,483,288 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	12,587,759 - 12,617,051 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	12,587,801 - 12,617,049 (+)	Ensembl			mm10	GRCm38
MGSCv37	X	12,164,885 - 12,194,177 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	11,736,552 - 11,773,924 (+)	NCBI		MGSCv36	mm8
Celera	X	10,281,818 - 10,311,001 (+)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	7.42	NCBI

Atp6ap2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	12,856,708 - 12,883,670 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	12,855,859 - 12,905,875 (-)	Ensembl				GRCr8
mRatBN7.2	X	10,183,983 - 10,210,948 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	10,183,068 - 10,210,918 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	10,365,151 - 10,392,104 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	13,862,316 - 13,889,268 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	10,131,474 - 10,158,431 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	11,137,889 - 11,164,854 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	11,136,939 - 11,164,915 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	11,936,459 - 11,963,424 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	22,264,078 - 22,291,988 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	10,708,369 - 10,735,267 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

Atp6ap2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955565	2,002,408 - 2,030,491 (-)	Ensembl
ChiLan1.0	NW_004955565	2,006,154 - 2,029,921 (-)	NCBI	ChiLan1.0	ChiLan1.0

ATP6AP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	42,225,026 - 42,250,788 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	42,228,419 - 42,254,164 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	33,026,525 - 33,052,252 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	40,730,677 - 40,756,209 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	40,730,677 - 40,756,209 (+)	Ensembl			panPan2	panpan1.1

ATP6AP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	35,050,588 - 35,073,633 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	35,050,606 - 35,073,067 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	22,398,893 - 22,421,901 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	35,099,002 - 35,122,024 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	35,099,006 - 35,122,017 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	35,178,090 - 35,201,096 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	35,150,804 - 35,173,213 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	35,193,579 - 35,216,589 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Atp6ap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	27,365,515 - 27,392,087 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	7,206,172 - 7,233,912 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	7,206,226 - 7,232,798 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP6AP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	36,271,223 - 36,300,240 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	36,271,154 - 36,300,240 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	40,369,340 - 40,398,417 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP6AP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	37,742,550 - 37,769,022 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	37,742,545 - 37,769,062 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666076	2,940,061 - 2,966,802 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004850019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01043200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01000124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000013208 ⟹ ENSHGLP00000013071

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624762	14,952,002 - 14,975,900 (-)	Ensembl

RefSeq Acc Id:

XM_004850019 ⟹ XP_004850076

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624762	14,952,313 - 14,975,678 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004850076	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000013071
GenBank Protein	JAO03509	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_004850076 ⟸ XM_004850019
- UniProtKB:	A0A0P6JG22 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000013071 ⟸ ENSHGLT00000013208

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000009344	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000013208	ENTREZGENE
InterPro	Renin_r_C	UniProtKB/TrEMBL
	Renin_rcpt	UniProtKB/TrEMBL
KEGG Report	hgl:101703484	UniProtKB/TrEMBL
NCBI Gene	Atp6ap2	ENTREZGENE
PANTHER	PTHR13351	UniProtKB/TrEMBL
	RENIN RECEPTOR	UniProtKB/TrEMBL
Pfam	Renin_r	UniProtKB/TrEMBL
	RENR_N	UniProtKB/TrEMBL
UniProt	A0A0P6JG22	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations