Hspa8 (heat shock protein family A (Hsp70) member 8) - Rat Genome Database

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Gene: Hspa8 (heat shock protein family A (Hsp70) member 8) Heterocephalus glaber
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Symbol: Hspa8
Name: heat shock protein family A (Hsp70) member 8
RGD ID: 18912787
Description: ENCODES a protein that exhibits A1 adenosine receptor binding (ortholog); ADP binding (ortholog); ATP binding (ortholog); INVOLVED IN ATP metabolic process (ortholog); axo-dendritic transport (ortholog); cellular response to cadmium ion (ortholog); PARTICIPATES IN androgen signaling pathway; chaperone mediated autophagy pathway; clathrin-dependent synaptic vesicle endocytosis; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN asymmetric synapse (ortholog); autophagosome (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heat shock cognate 71 kDa protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248802,070,523 - 2,079,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248802,070,410 - 2,075,069 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
axo-dendritic transport  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to heat  (ISO)
cellular response to hydrogen peroxide  (ISO)
cerebellum development  (ISO)
chaperone cofactor-dependent protein refolding  (IEA)
chaperone-mediated autophagy  (ISO)
chaperone-mediated autophagy translocation complex disassembly  (ISO)
chaperone-mediated protein folding  (IEA,ISO)
clathrin coat disassembly  (IEA,ISO)
estrous cycle  (ISO)
forebrain development  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
kidney development  (ISO)
late endosomal microautophagy  (IEA)
maintenance of postsynaptic specialization structure  (ISO)
modulation by host of viral process  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of NLRP3 inflammasome complex assembly  (ISO)
negative regulation of supramolecular fiber organization  (ISO)
positive regulation by host of viral genome replication  (IEA)
positive regulation of catalytic activity  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of lysosomal membrane permeability  (ISO)
positive regulation of mRNA splicing, via spliceosome  (IEA)
positive regulation of phagocytosis  (ISO)
positive regulation of protein refolding  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
protein autophosphorylation  (ISO)
protein folding  (IEA)
protein import into nucleus  (ISO)
protein refolding  (ISO)
protein targeting to lysosome involved in chaperone-mediated autophagy  (ISO)
protein transmembrane import into intracellular organelle  (ISO)
protein-containing complex disassembly  (ISO)
regulation of cell cycle  (IEA)
regulation of postsynapse organization  (IEA)
regulation of protein complex stability  (ISO)
regulation of protein stability  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to nickel cation  (ISO)
response to odorant  (ISO)
response to progesterone  (ISO)
response to starvation  (ISO)
response to xenobiotic stimulus  (ISO)
skeletal muscle tissue development  (ISO)
slow axonal transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hspa8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248802,070,523 - 2,079,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248802,070,410 - 2,075,069 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HSPA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811123,057,489 - 123,062,462 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11123,057,489 - 123,063,230 (-)EnsemblGRCh38hg38GRCh38
GRCh3711122,928,197 - 122,932,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,433,410 - 122,438,054 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411122,433,410 - 122,438,054NCBI
Celera11120,087,529 - 120,092,173 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11118,870,278 - 118,875,122 (-)NCBIHuRef
CHM1_111122,814,192 - 122,819,035 (-)NCBICHM1_1
T2T-CHM13v2.011123,086,071 - 123,093,285 (-)NCBIT2T-CHM13v2.0
Hspa8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,712,572 - 40,716,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl940,712,280 - 40,721,383 (+)EnsemblGRCm39 Ensembl
GRCm38940,801,276 - 40,805,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,800,984 - 40,810,087 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,609,356 - 40,613,282 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,102,053 - 8,104,168 (+)NCBIMGSCv36mm8
MGSCv36940,552,355 - 40,556,269 (+)NCBIMGSCv36mm8
Celera938,034,609 - 38,038,251 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.55NCBI
Hspa8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8850,080,514 - 50,084,376 (+)NCBIGRCr8
mRatBN7.2841,183,397 - 41,187,260 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,183,264 - 41,187,259 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx846,682,619 - 46,686,480 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0844,961,220 - 44,965,081 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0842,828,805 - 42,832,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0844,989,401 - 44,993,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl844,990,014 - 44,993,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0846,005,304 - 46,006,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0843,478,238 - 43,480,456 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,784,035 - 43,787,760 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1843,792,829 - 43,796,525 (+)NCBI
Celera840,782,916 - 40,786,778 (+)NCBICelera
Cytogenetic Map8q22NCBI
Hspa8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,862,590 - 23,867,984 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541223,863,513 - 23,867,984 (-)NCBIChiLan1.0ChiLan1.0
HSPA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29123,758,689 - 123,764,231 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111124,863,401 - 124,868,370 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011117,890,545 - 117,895,262 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111121,809,800 - 121,814,628 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,809,800 - 121,815,773 (-)Ensemblpanpan1.1panPan2
HSPA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1511,292,219 - 11,296,851 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl511,292,262 - 11,296,797 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha511,348,073 - 11,352,702 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0511,243,037 - 11,247,671 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl511,242,826 - 11,307,583 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1511,346,458 - 11,351,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0511,279,270 - 11,283,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0511,323,539 - 11,328,166 (+)NCBIUU_Cfam_GSD_1.0
Hspa8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947104,655,786 - 104,660,238 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365427,577,149 - 7,581,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365427,577,192 - 7,581,598 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,982,284 - 49,990,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,982,278 - 49,986,760 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,405,395 - 55,409,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HSPA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,447,348 - 114,452,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,446,544 - 114,451,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604311,677,166 - 11,681,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000002552   ⟹   ENSHGLP00000002500
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248802,070,523 - 2,079,421 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000002553   ⟹   ENSHGLP00000002501
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248802,071,335 - 2,074,881 (+)Ensembl
RefSeq Acc Id: XM_004870899   ⟹   XP_004870956
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248802,070,410 - 2,075,069 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004870956 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000002500
GenBank Protein JAN96864 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004870956   ⟸   XM_004870899
- UniProtKB: A0A0P6J944 (UniProtKB/TrEMBL),   G5BS02 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000002500   ⟸   ENSHGLT00000002552
Ensembl Acc Id: ENSHGLP00000002501   ⟸   ENSHGLT00000002553


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000001884 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000002552 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/TrEMBL
  3.30.30.30 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/TrEMBL
  Actin, Chain A, domain 4 UniProtKB/TrEMBL
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/TrEMBL
KEGG Report hgl:101708313 UniProtKB/TrEMBL
NCBI Gene Hspa8 ENTREZGENE
PANTHER PTHR19375 UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/TrEMBL
PRINTS HEATSHOCK70 UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/TrEMBL
  HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/TrEMBL
  SSF100934 UniProtKB/TrEMBL
  SSF53067 UniProtKB/TrEMBL
UniProt A0A0P6J944 ENTREZGENE, UniProtKB/TrEMBL
  G5BS02 ENTREZGENE, UniProtKB/TrEMBL