Sppl2b (signal peptide peptidase like 2B) - Rat Genome Database

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Gene: Sppl2b (signal peptide peptidase like 2B) Heterocephalus glaber
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Symbol: Sppl2b
Name: signal peptide peptidase like 2B
RGD ID: 18909863
Description: ENCODES a protein that exhibits aspartic endopeptidase activity, intramembrane cleaving (ortholog); protein homodimerization activity (ortholog); INVOLVED IN membrane protein ectodomain proteolysis (ortholog); membrane protein intracellular domain proteolysis (ortholog); regulation of immune response (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); progressive myoclonus epilepsy 9 (ortholog); FOUND IN actin cytoskeleton (ortholog); centrosome (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal peptide peptidase-like 2B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,562,426 - 6,576,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sppl2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,562,426 - 6,576,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SPPL2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,328,684 - 2,355,095 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,328,615 - 2,355,095 (+)EnsemblGRCh38hg38GRCh38
GRCh37192,328,683 - 2,355,093 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,279,629 - 2,306,100 (+)NCBINCBI36Build 36hg18NCBI36
Celera192,262,722 - 2,289,416 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,099,320 - 2,126,087 (+)NCBIHuRef
CHM1_1192,328,242 - 2,354,745 (+)NCBICHM1_1
T2T-CHM13v2.0192,302,357 - 2,328,755 (+)NCBIT2T-CHM13v2.0
Sppl2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,691,067 - 80,704,542 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,691,109 - 80,704,542 (+)EnsemblGRCm39 Ensembl
GRCm381080,855,242 - 80,868,708 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,855,275 - 80,868,708 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,318,020 - 80,331,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,258,386 - 80,271,834 (+)NCBIMGSCv36mm8
Celera1081,874,073 - 81,887,506 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Sppl2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,494,593 - 9,507,317 (-)NCBIGRCr8
mRatBN7.278,843,918 - 8,856,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,843,918 - 8,856,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,727,769 - 11,740,555 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,603,273 - 13,616,059 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,469,804 - 11,482,591 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,712,187 - 11,724,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,712,188 - 11,724,843 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,879,707 - 11,892,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,354,554 - 10,367,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,354,554 - 10,367,210 (-)NCBI
Celera77,028,038 - 7,040,694 (-)NCBICelera
Cytogenetic Map7q11NCBI
Sppl2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,818,337 - 5,829,889 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,816,979 - 5,829,938 (-)NCBIChiLan1.0ChiLan1.0
SPPL2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,711,728 - 6,736,722 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,941,082 - 5,968,189 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,337,570 - 1,355,755 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,309,360 - 2,331,951 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,309,360 - 2,331,951 (+)Ensemblpanpan1.1panPan2
SPPL2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,714,306 - 56,730,388 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,712,390 - 56,757,938 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,509,908 - 56,525,995 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,447,711 - 57,463,802 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,447,720 - 57,463,752 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,499,796 - 56,515,881 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,985,051 - 57,001,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,185,354 - 57,201,441 (-)NCBIUU_Cfam_GSD_1.0
Sppl2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,426,113 - 216,435,356 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,399,085 - 1,408,783 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,399,125 - 1,408,676 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPPL2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,230,061 - 76,247,051 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,230,060 - 76,247,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,781,961 - 76,798,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPPL2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,121,568 - 2,142,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,121,634 - 2,144,682 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,566,507 - 6,588,105 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000012603   ⟹   ENSHGLP00000012467
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248286,562,426 - 6,576,609 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000012604   ⟹   ENSHGLP00000012468
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248286,562,426 - 6,571,910 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000012605   ⟹   ENSHGLP00000012469
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248286,564,719 - 6,572,525 (-)Ensembl
RefSeq Acc Id: XM_004865875   ⟹   XP_004865932
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBI
RefSeq Acc Id: XM_004865876   ⟹   XP_004865933
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBI
RefSeq Acc Id: XM_021244909   ⟹   XP_021100568
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248286,564,127 - 6,576,663 (-)NCBI
RefSeq Acc Id: XM_021244910   ⟹   XP_021100569
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248286,564,844 - 6,576,663 (-)NCBI
RefSeq Acc Id: XM_021244911   ⟹   XP_021100570
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248286,564,844 - 6,576,663 (-)NCBI
RefSeq Acc Id: XP_004865932   ⟸   XM_004865875
- Peptide Label: isoform X2
- UniProtKB: A0A0P6K4U2 (UniProtKB/TrEMBL),   G5BBD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100568   ⟸   XM_021244909
- Peptide Label: isoform X3
- UniProtKB: G5BBD0 (UniProtKB/TrEMBL),   A0AAX6RW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865933   ⟸   XM_004865876
- Peptide Label: isoform X1
- UniProtKB: G5BBD0 (UniProtKB/TrEMBL),   A0AAX6Q594 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100569   ⟸   XM_021244910
- Peptide Label: isoform X4
- UniProtKB: A0AAX6RVS2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021100570   ⟸   XM_021244911
- Peptide Label: isoform X4
- UniProtKB: A0AAX6RVS2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000012468   ⟸   ENSHGLT00000012604
Ensembl Acc Id: ENSHGLP00000012469   ⟸   ENSHGLT00000012605
Ensembl Acc Id: ENSHGLP00000012467   ⟸   ENSHGLT00000012603


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008911 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000012603 ENTREZGENE
  ENSHGLT00000012605 ENTREZGENE
Gene3D-CATH 3.50.30.30 UniProtKB/TrEMBL
InterPro PA_dom_sf UniProtKB/TrEMBL
  PA_domain UniProtKB/TrEMBL
  Peptidase_A22B_SPP UniProtKB/TrEMBL
  Preselin/SPP UniProtKB/TrEMBL
KEGG Report hgl:101708060 UniProtKB/TrEMBL
NCBI Gene Sppl2b ENTREZGENE
PANTHER PTHR12174 UniProtKB/TrEMBL
  PTHR12174:SF39 UniProtKB/TrEMBL
Pfam Peptidase_A22B UniProtKB/TrEMBL
  PF02225 UniProtKB/TrEMBL
SMART PSN UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/TrEMBL
UniProt A0A0P6K4U2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6Q594 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RVS2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RW88 ENTREZGENE, UniProtKB/TrEMBL
  G5BBD0 ENTREZGENE, UniProtKB/TrEMBL