Nelfb (negative elongation factor complex member B) - Rat Genome Database

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Gene: Nelfb (negative elongation factor complex member B) Heterocephalus glaber
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Symbol: Nelfb
Name: negative elongation factor complex member B
RGD ID: 18907705
Description: ENCODES a protein that exhibits translation elongation factor activity (inferred); INVOLVED IN cell population proliferation (ortholog); negative regulation of stem cell differentiation (ortholog); stem cell differentiation (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: negative elongation factor B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760692,735 - 705,328 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760692,735 - 703,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
NELF complex  (IEA)
nucleoplasm  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nelfb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760692,735 - 705,328 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760692,735 - 703,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NELFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,255,327 - 137,273,542 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,255,327 - 137,273,542 (+)EnsemblGRCh38hg38GRCh38
GRCh379140,149,779 - 140,167,994 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,269,768 - 139,287,815 (+)NCBINCBI36Build 36hg18NCBI36
Celera9110,665,618 - 110,683,794 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,609,072 - 109,627,292 (+)NCBIHuRef
CHM1_19140,298,493 - 140,316,577 (+)NCBICHM1_1
T2T-CHM13v2.09149,492,996 - 149,511,192 (+)NCBIT2T-CHM13v2.0
Nelfb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,089,724 - 25,101,501 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,089,724 - 25,101,501 (-)EnsemblGRCm39 Ensembl
GRCm38225,199,712 - 25,211,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,199,712 - 25,211,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv37225,055,232 - 25,067,009 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,021,726 - 25,033,390 (-)NCBIMGSCv36mm8
Celera224,927,483 - 24,939,264 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.06NCBI
Nelfb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,409,045 - 28,425,564 (-)NCBIGRCr8
mRatBN7.238,010,883 - 8,027,403 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,010,888 - 8,027,403 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,115,610 - 11,132,086 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,701,839 - 19,718,315 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,891,682 - 17,908,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,414,448 - 2,431,148 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,414,451 - 2,431,148 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,395,734 - 2,412,431 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,360,222 - 3,376,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,360,218 - 3,376,563 (-)NCBI
Celera32,837,727 - 2,854,117 (-)NCBICelera
Cytogenetic Map3p13NCBI
Nelfb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,248,190 - 5,262,044 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,248,190 - 5,261,018 (+)NCBIChiLan1.0ChiLan1.0
NELFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,126,248 - 2,144,680 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,128,581 - 2,147,028 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,314,535 - 108,333,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,283,264 - 137,301,751 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,278,964 - 137,301,751 (+)Ensemblpanpan1.1panPan2
NELFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,411,725 - 48,425,044 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,408,005 - 48,423,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,598,208 - 47,608,900 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,273,065 - 49,283,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,206,548 - 49,287,069 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,049,494 - 48,060,162 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,348,232 - 48,358,986 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,395,161 - 48,405,870 (-)NCBIUU_Cfam_GSD_1.0
Nelfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,636,347 - 202,648,327 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669726,658 - 738,848 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669726,731 - 738,714 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21314,117,252 - 314,125,940 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112914,384 - 933,921 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660584,373,307 - 4,392,656 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004848743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01040404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000022344   ⟹   ENSHGLP00000022133
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624760692,735 - 705,328 (-)Ensembl
RefSeq Acc Id: XM_004848743   ⟹   XP_004848800
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624760692,735 - 703,571 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004848800 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022133
RefSeq Acc Id: XP_004848800   ⟸   XM_004848743
- UniProtKB: G5BFZ3 (UniProtKB/TrEMBL),   A0AAX6PCZ5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000022133   ⟸   ENSHGLT00000022344


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015793 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000022344 ENTREZGENE
InterPro COBRA1 UniProtKB/TrEMBL
NCBI Gene Nelfb ENTREZGENE
PANTHER NEGATIVE ELONGATION FACTOR B UniProtKB/TrEMBL
  NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B UniProtKB/TrEMBL
Pfam COBRA1 UniProtKB/TrEMBL
UniProt A0AAX6PCZ5 ENTREZGENE, UniProtKB/TrEMBL
  G5BFZ3 ENTREZGENE, UniProtKB/TrEMBL