Alk (ALK receptor tyrosine kinase) - Rat Genome Database

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Gene: Alk (ALK receptor tyrosine kinase) Heterocephalus glaber
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Symbol: Alk
Name: ALK receptor tyrosine kinase
RGD ID: 18907189
Description: ENCODES a protein that exhibits heparin binding (ortholog); identical protein binding (ortholog); receptor signaling protein tyrosine kinase activator activity (ortholog); INVOLVED IN adult behavior (ortholog); brain development (ortholog); energy homeostasis (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); anaplastic large cell lymphoma (ortholog); Brain Neoplasms (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ALK tyrosine kinase receptor; anaplastic lymphoma receptor tyrosine kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473811,095,134 - 11,288,891 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473811,094,699 - 12,010,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Alk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473811,095,134 - 11,288,891 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473811,094,699 - 12,010,349 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ALK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38229,192,774 - 29,921,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl229,192,774 - 29,921,586 (-)EnsemblGRCh38hg38GRCh38
GRCh37229,415,640 - 30,144,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36229,269,144 - 29,997,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 34229,327,292 - 30,056,083NCBI
Celera229,260,042 - 29,988,141 (-)NCBICelera
Cytogenetic Map2p23.2-p23.1NCBI
HuRef229,156,646 - 29,883,927 (-)NCBIHuRef
CHM1_1229,345,879 - 30,074,503 (-)NCBICHM1_1
T2T-CHM13v2.0229,236,229 - 29,965,553 (-)NCBIT2T-CHM13v2.0
Alk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391772,174,206 - 72,911,719 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1772,175,967 - 72,911,622 (-)EnsemblGRCm39 Ensembl
GRCm381771,868,988 - 72,604,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1771,868,972 - 72,604,627 (-)EnsemblGRCm38mm10GRCm38
MGSCv371772,218,328 - 72,953,647 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361771,009,971 - 71,745,160 (-)NCBIMGSCv36mm8
MGSCv361771,773,845 - 72,508,684 (-)NCBIMGSCv36mm8
Celera1776,136,594 - 76,877,724 (-)NCBICelera
Cytogenetic Map17E1.3NCBI
cM Map1743.77NCBI
Alk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8628,631,431 - 29,351,321 (+)NCBIGRCr8
mRatBN7.2622,879,653 - 23,599,636 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl622,880,625 - 23,598,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx623,211,130 - 23,929,220 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0623,526,957 - 24,245,096 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0623,008,575 - 23,732,971 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,696,415 - 23,203,791 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,696,397 - 23,203,775 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,690,337 - 33,703,521 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0632,580,744 - 33,082,977 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4623,009,061 - 23,730,939 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1623,700,711 - 23,727,905 (+)NCBI
Celera622,414,691 - 23,129,629 (+)NCBICelera
Cytogenetic Map6q14NCBI
Alk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546911,047,048 - 11,548,233 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546911,049,373 - 11,751,235 (-)NCBIChiLan1.0ChiLan1.0
ALK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21296,583,820 - 97,316,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A96,587,794 - 97,320,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A29,196,195 - 29,930,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A29,276,041 - 30,007,687 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A29,276,041 - 30,006,735 (-)Ensemblpanpan1.1panPan2
ALK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11723,010,308 - 23,688,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1723,010,308 - 23,688,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,797,195 - 23,482,846 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01723,570,633 - 24,250,513 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,572,834 - 24,250,519 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,869,939 - 23,549,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,932,402 - 23,612,861 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01723,038,591 - 23,719,569 (-)NCBIUU_Cfam_GSD_1.0
Alk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629267,167,996 - 67,810,992 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364933,028,608 - 3,671,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364933,624,288 - 3,671,567 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.13109,411,146 - 110,105,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23116,847,214 - 116,923,998 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11477,632,809 - 78,408,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604533,719,552 - 34,471,342 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004839247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021253678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021253679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021253680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01015673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01015691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000013480   ⟹   ENSHGLP00000013340
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473811,095,134 - 11,288,891 (-)Ensembl
RefSeq Acc Id: XM_004839247   ⟹   XP_004839304
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473811,094,699 - 11,800,188 (-)NCBI
RefSeq Acc Id: XM_021253678   ⟹   XP_021109337
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473811,094,699 - 11,800,192 (-)NCBI
RefSeq Acc Id: XM_021253679   ⟹   XP_021109338
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473811,094,699 - 12,009,169 (-)NCBI
RefSeq Acc Id: XM_021253680   ⟹   XP_021109339
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473811,094,699 - 12,010,349 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004839304 (Get FASTA)   NCBI Sequence Viewer  
  XP_021109337 (Get FASTA)   NCBI Sequence Viewer  
  XP_021109338 (Get FASTA)   NCBI Sequence Viewer  
  XP_021109339 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021109339   ⟸   XM_021253680
- Peptide Label: isoform X3
- UniProtKB: A0AAX6SKE3 (UniProtKB/TrEMBL),   G5C2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109338   ⟸   XM_021253679
- Peptide Label: isoform X3
- UniProtKB: A0AAX6SKE3 (UniProtKB/TrEMBL),   G5C2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109337   ⟸   XM_021253678
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SKI0 (UniProtKB/TrEMBL),   G5C2X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839304   ⟸   XM_004839247
- Peptide Label: isoform X2
- UniProtKB: A0AAX6NXV7 (UniProtKB/TrEMBL),   G5C2X6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000013340   ⟸   ENSHGLT00000013480


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009536 Ensembl
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Low-density Lipoprotein Receptor UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ALK/LTK-like_GRD UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/TrEMBL
NCBI Gene Alk ENTREZGENE
PANTHER ALK TYROSINE KINASE RECEPTOR UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Gly_rich UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE MAM_2 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/TrEMBL
SMART LDLa UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Concanavalin A-like lectins/glucanases UniProtKB/TrEMBL
  LDL receptor-like module UniProtKB/TrEMBL
  Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt A0AAX6NXV7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SKE3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SKI0 ENTREZGENE, UniProtKB/TrEMBL
  G5C2X6 ENTREZGENE, UniProtKB/TrEMBL