Afp (alpha fetoprotein) - Rat Genome Database

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Gene: Afp (alpha fetoprotein) Heterocephalus glaber
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Symbol: Afp
Name: alpha fetoprotein
RGD ID: 18904537
Description: ENCODES a protein that exhibits metal ion binding (inferred); small molecule binding (inferred); INVOLVED IN animal organ regeneration (ortholog); apoptotic process (ortholog); cellular response to retinoic acid (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH Alpha-Fetoprotein Deficiency (ortholog); Alpha-Fetoprotein, Hereditary Persistence of (ortholog); Breast Neoplasms (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-fetoprotein
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473534,072,192 - 34,092,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473534,072,257 - 34,092,540 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Afp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473534,072,192 - 34,092,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473534,072,257 - 34,092,540 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
AFP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,436,221 - 73,456,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,431,138 - 73,456,174 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,301,938 - 74,321,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,520,797 - 74,540,356 (+)NCBINCBI36Build 36hg18NCBI36
Build 34474,666,967 - 74,686,527NCBI
Celera471,661,745 - 71,681,240 (+)NCBICelera
Cytogenetic Map4q13.3ENTREZGENE
HuRef470,113,467 - 70,132,962 (+)NCBIHuRef
CHM1_1474,338,122 - 74,357,615 (+)NCBICHM1_1
T2T-CHM13v2.0476,779,943 - 76,799,830 (+)NCBIT2T-CHM13v2.0
Afp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,638,573 - 90,656,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,638,596 - 90,656,766 (+)EnsemblGRCm39 Ensembl
GRCm38590,490,714 - 90,508,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,490,737 - 90,508,907 (+)EnsemblGRCm38mm10GRCm38
MGSCv37590,919,740 - 90,937,933 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,565,937 - 91,584,106 (+)NCBIMGSCv36mm8
Celera588,652,007 - 88,670,199 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.77NCBI
Afp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,857,584 - 17,875,645 (-)NCBIGRCr8
mRatBN7.21417,573,412 - 17,591,476 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,573,412 - 17,591,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,559,718 - 17,577,743 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,878,645 - 18,896,663 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,577,705 - 17,595,633 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01419,141,755 - 19,159,919 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1419,141,755 - 19,159,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01419,049,096 - 19,067,260 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41419,092,563 - 19,110,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11419,092,562 - 19,110,728 (-)NCBI
Celera1416,939,827 - 16,957,879 (-)NCBICelera
RH 3.4 Map14214.49RGD
Cytogenetic Map14p22NCBI
AFP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,607,582 - 56,626,380 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,796,622 - 56,815,436 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,739,197 - 50,758,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,571,519 - 56,590,391 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,571,519 - 56,590,391 (-)Ensemblpanpan1.1panPan2
AFP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,182,876 - 62,203,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,053,814 - 62,294,709 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1361,852,491 - 61,873,033 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01362,992,405 - 63,012,932 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1362,992,405 - 63,012,932 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,603,973 - 62,624,508 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,097,020 - 62,117,581 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,232,901 - 63,253,687 (+)NCBIUU_Cfam_GSD_1.0
Afp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,606,058 - 13,625,722 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365982,058,117 - 2,077,728 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365982,058,474 - 2,077,711 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,677,690 - 69,698,864 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,677,690 - 69,698,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2873,777,748 - 73,798,926 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1721,904,225 - 21,924,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl721,905,154 - 21,924,092 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084873,280 - 892,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000015890   ⟹   ENSHGLP00000015725
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473534,072,192 - 34,092,604 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000015891   ⟹   ENSHGLP00000015726
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473534,072,192 - 34,092,604 (-)Ensembl
RefSeq Acc Id: XM_004838012   ⟹   XP_004838069
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473534,072,257 - 34,092,540 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004838069 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB04602 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000015726
GenBank Protein JAN96230 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004838069   ⟸   XM_004838012
- UniProtKB: A0A0P6IWC1 (UniProtKB/TrEMBL),   G5B5P1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000015726   ⟸   ENSHGLT00000015891
Ensembl Acc Id: ENSHGLP00000015725   ⟸   ENSHGLT00000015890


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011251 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000015891 ENTREZGENE
Gene3D-CATH 1.10.246.10 UniProtKB/TrEMBL
InterPro ALB/AFP/VDB UniProtKB/TrEMBL
  Serum_albumin-like UniProtKB/TrEMBL
  Serum_albumin/AFP/Afamin UniProtKB/TrEMBL
  Serum_albumin_CS UniProtKB/TrEMBL
  Serum_albumin_N UniProtKB/TrEMBL
KEGG Report hgl:101725205 UniProtKB/TrEMBL
NCBI Gene Afp ENTREZGENE
PANTHER ALPHA-FETOPROTEIN UniProtKB/TrEMBL
  PTHR11385 UniProtKB/TrEMBL
Pfam Serum_albumin UniProtKB/TrEMBL
PIRSF Serum_albumin_subgroup UniProtKB/TrEMBL
PRINTS AFETOPROTEIN UniProtKB/TrEMBL
  SERUMALBUMIN UniProtKB/TrEMBL
PROSITE ALBUMIN_1 UniProtKB/TrEMBL
  ALBUMIN_2 UniProtKB/TrEMBL
SMART ALBUMIN UniProtKB/TrEMBL
Superfamily-SCOP SSF48552 UniProtKB/TrEMBL
UniProt A0A0P6IWC1 ENTREZGENE, UniProtKB/TrEMBL
  G5B5P1 ENTREZGENE, UniProtKB/TrEMBL