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Gene: Dbh (dopamine beta-hydroxylase) Heterocephalus glaber

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Symbol:

Dbh

Name:

dopamine beta-hydroxylase

RGD ID:

18904204

Description:

ENCODES a protein that exhibits copper ion binding (ortholog); dopamine beta-monooxygenase activity (ortholog); INVOLVED IN associative learning (ortholog); behavioral response to ethanol (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN alkaptonuria pathway; aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Anorexia (ortholog); attention deficit hyperactivity disorder (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); centriolar satellite (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DBH (dopamine beta-hydroxylase)	NCBI	Ortholog
Mus musculus (house mouse):	Dbh (dopamine beta hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Dbh (dopamine beta-hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dbh (dopamine beta-hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DBH (dopamine beta-hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DBH (dopamine beta-hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dbh (dopamine beta-hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DBH (dopamine beta-hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DBH (dopamine beta-hydroxylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	2,015,474 - 2,029,939 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	2,016,066 - 2,030,240 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

Anorexia (ISO)

attention deficit hyperactivity disorder (ISO)

brain ischemia (ISO)

Contusions (ISO)

depressive disorder (ISO)

developmental and epileptic encephalopathy 14 (ISO)

dopamine beta-hydroxylase deficiency (ISO)

Ehlers-Danlos syndrome classic type 1 (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hypertension (ISO)

Hypotension (ISO)

intellectual disability (ISO)

Kleefstra syndrome 1 (ISO)

Leigh disease (ISO)

migraine with aura (ISO)

neuroblastoma (ISO)

Paranoid Disorders (ISO)

Parkinson's disease (ISO)

pheochromocytoma (ISO)

portal hypertension (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

sensorineural hearing loss (ISO)

tuberous sclerosis 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

associative learning (ISO)

behavioral response to ethanol (ISO)

blood vessel remodeling (ISO)

bone development (ISO)

catecholamine biosynthetic process (IEA)

cellular response to manganese ion (ISO)

cellular response to nicotine (ISO)

dopamine catabolic process (IEA,ISO)

fear response (ISO)

glucose homeostasis (ISO)

homoiothermy (ISO)

leukocyte mediated immunity (ISO)

leukocyte migration (ISO)

locomotory behavior (ISO)

maternal behavior (ISO)

memory (ISO)

norepinephrine biosynthetic process (IEA,ISO)

octopamine biosynthetic process (IEA)

octopamine metabolic process (ISO)

positive regulation of cold-induced thermogenesis (ISO)

positive regulation of vasoconstriction (ISO)

regulation of extrinsic apoptotic signaling pathway (ISO)

regulation of vascular associated smooth muscle cell proliferation (ISO)

regulation of vascular endothelial cell proliferation (ISO)

response to amphetamine (ISO)

response to copper ion (ISO)

response to estradiol (ISO)

response to ethanol (ISO)

response to immobilization stress (ISO)

response to iron ion (ISO)

response to isolation stress (ISO)

response to ozone (ISO)

response to pain (ISO)

response to peptide hormone (ISO)

response to xenobiotic stimulus (ISO)

social behavior (ISO)

vasoconstriction (ISO)

visual learning (ISO)

Cellular Component

apical part of cell (ISO)

axon (ISO)

centriolar satellite (ISO)

chromaffin granule lumen (IEA)

chromaffin granule membrane (IEA)

cytoplasmic vesicle (IEA)

dendrite (ISO)

endoplasmic reticulum (ISO)

extracellular space (IEA)

intracellular membrane-bounded organelle (ISO)

membrane (IEA)

neuronal cell body (ISO)

secretory granule lumen (ISO)

secretory granule membrane (IEA)

terminal bouton (ISO)

varicosity (ISO)

Molecular Function

copper ion binding (IEA,ISO)

dopamine beta-monooxygenase activity (IEA,ISO)

L-ascorbic acid binding (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alkaptonuria pathway (ISO)

aromatic L-amino acid decarboxylase deficiency pathway (ISO)

catecholamine biosynthetic pathway (ISO)

disulfiram pharmacodynamics pathway (ISO)

dopamine beta-hydroxylase deficiency pathway (ISO)

epinephrine biosynthetic pathway (ISO)

hawkinsinuria pathway (ISO)

norepinephrine biosynthetic pathway (ISO)

tyrosine metabolic pathway (ISO)

tyrosinemia type I pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dbh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	2,015,474 - 2,029,939 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	2,016,066 - 2,030,240 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

DBH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	133,636,363 - 133,659,329 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	133,636,363 - 133,659,329 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	136,501,485 - 136,524,451 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	135,491,306 - 135,514,287 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	133,531,038 - 133,554,020	NCBI
Celera	9	107,048,360 - 107,071,346 (+)	NCBI		Celera
Cytogenetic Map	9	q34.2	NCBI
HuRef	9	106,002,148 - 106,025,141 (+)	NCBI		HuRef
CHM1_1	9	136,651,448 - 136,674,425 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	145,852,365 - 145,875,347 (+)	NCBI		T2T-CHM13v2.0

Dbh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	27,055,519 - 27,073,216 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	27,055,245 - 27,073,212 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	27,165,507 - 27,183,204 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	27,165,233 - 27,183,200 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	27,021,027 - 27,038,724 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	26,987,242 - 27,004,928 (+)	NCBI		MGSCv36	mm8
Celera	2	26,868,411 - 26,886,118 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	19.29	NCBI

Dbh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	30,886,313 - 30,903,313 (+)	NCBI		GRCr8
mRatBN7.2	3	10,488,260 - 10,505,245 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	10,488,260 - 10,505,248 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	13,554,214 - 13,571,202 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	22,139,613 - 22,156,601 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	20,394,908 - 20,411,896 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	5,709,236 - 5,731,895 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	5,709,236 - 5,731,898 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	11,073,477 - 11,095,363 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	6,052,706 - 6,069,826 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	6,053,005 - 6,070,129 (+)	NCBI
Celera	3	5,285,082 - 5,302,054 (+)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

Dbh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	2,918,286 - 2,932,247 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	2,918,085 - 2,932,481 (+)	NCBI	ChiLan1.0	ChiLan1.0

DBH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	5,692,146 - 5,715,877 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	5,694,480 - 5,717,385 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	104,761,504 - 104,784,445 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	133,371,818 - 133,394,581 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	133,371,821 - 133,393,697 (+)	Ensembl	panpan1.1		panPan2

DBH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	50,004,806 - 50,024,130 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	50,004,806 - 50,024,130 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	49,285,838 - 49,305,131 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	50,879,184 - 50,898,677 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	50,879,184 - 50,898,677 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	49,640,508 - 49,659,973 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	49,982,444 - 50,001,971 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	50,060,855 - 50,080,372 (+)	NCBI		UU_Cfam_GSD_1.0

Dbh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	200,048,835 - 200,073,044 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	3,301,802 - 3,320,643 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	3,302,014 - 3,326,233 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DBH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	273,204,175 - 273,225,552 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	273,204,407 - 273,225,562 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	307,178,237 - 307,199,384 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	1	q2.13	NCBI

DBH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	4,474,041 - 4,498,942 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	4,474,958 - 4,498,910 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	490,145 - 515,071 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004849590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01040412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000017175 ⟹ ENSHGLP00000017004

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624760	2,015,474 - 2,029,939 (+)	Ensembl

RefSeq Acc Id:

XM_004849590 ⟹ XP_004849647

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624760	2,016,066 - 2,030,240 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004849647	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000017004

RefSeq Acc Id:	XP_004849647 ⟸ XM_004849590
- UniProtKB:	A0AAX6PDP8 (UniProtKB/TrEMBL), G5B8I2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000017004 ⟸ ENSHGLT00000017175

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000012166	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000017175	ENTREZGENE
Gene3D-CATH	2.60.120.230	UniProtKB/TrEMBL
	Copper type II, ascorbate-dependent monooxygenase, N-terminal domain	UniProtKB/TrEMBL
InterPro	Cu2_ascorb_mOase-like_C	UniProtKB/TrEMBL
	Cu2_ascorb_mOase_CS-1	UniProtKB/TrEMBL
	Cu2_ascorb_mOase_CS-2	UniProtKB/TrEMBL
	Cu2_ascorb_mOase_N	UniProtKB/TrEMBL
	Cu2_ascorb_mOase_N_sf	UniProtKB/TrEMBL
	Cu2_monoox_C	UniProtKB/TrEMBL
	DBH-like	UniProtKB/TrEMBL
	DOH_DOMON	UniProtKB/TrEMBL
	DOMON_domain	UniProtKB/TrEMBL
	PHM/PNGase_F_dom_sf	UniProtKB/TrEMBL
	Tbh/DBH	UniProtKB/TrEMBL
NCBI Gene	Dbh	ENTREZGENE
PANTHER	DOPAMINE BETA HYDROXYLASE RELATED	UniProtKB/TrEMBL
	DOPAMINE BETA-HYDROXYLASE	UniProtKB/TrEMBL
Pfam	Cu2_monoox_C	UniProtKB/TrEMBL
	Cu2_monooxygen	UniProtKB/TrEMBL
	DOMON	UniProtKB/TrEMBL
PRINTS	DBMONOXGNASE	UniProtKB/TrEMBL
PROSITE	CU2_MONOOXYGENASE_1	UniProtKB/TrEMBL
	CU2_MONOOXYGENASE_2	UniProtKB/TrEMBL
	DOMON	UniProtKB/TrEMBL
SMART	DoH	UniProtKB/TrEMBL
Superfamily-SCOP	PHM/PNGase F	UniProtKB/TrEMBL
UniProt	A0AAX6PDP8	ENTREZGENE, UniProtKB/TrEMBL
	G5B8I2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB