Dab2 (DAB adaptor protein 2) - Rat Genome Database

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Gene: Dab2 (DAB adaptor protein 2) Heterocephalus glaber
Analyze
Symbol: Dab2
Name: DAB adaptor protein 2
RGD ID: 18903747
Description: ENCODES a protein that exhibits AP-2 adaptor complex binding (ortholog); clathrin binding (ortholog); integrin binding (ortholog); INVOLVED IN cell morphogenesis (ortholog); cellular response to epidermal growth factor stimulus (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH Brain Injuries (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); metabolic acidosis (ortholog); FOUND IN apical plasma membrane (ortholog); clathrin coat of coated pit (ortholog); clathrin-coated vesicle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DAB2, clathrin adaptor protein; disabled homolog 2; Disabled-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475915,459,288 - 15,520,924 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475915,459,436 - 15,520,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cell morphogenesis  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
clathrin coat assembly  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
hematopoietic stem cell proliferation  (ISO)
in utero embryonic development  (ISO)
integrin-mediated signaling pathway  (ISO)
leading edge cell differentiation  (IEA)
myeloid cell differentiation  (ISO)
negative regulation of androgen receptor signaling pathway  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cell growth  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of protein localization to plasma membrane  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of aldosterone biosynthetic process  (ISO)
positive regulation of aldosterone secretion  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of clathrin-dependent endocytosis  (IEA)
positive regulation of early endosome to late endosome transport  (IEA)
positive regulation of endocytosis  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of integrin-mediated signaling pathway  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of transcription elongation by RNA polymerase II  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IEA)
receptor-mediated endocytosis  (IEA,ISO)
regulation of Rho-dependent protein serine/threonine kinase activity  (ISO)
renal protein absorption  (ISO)
response to salt  (ISO)
response to steroid hormone  (ISO)
transforming growth factor beta receptor signaling pathway  (IEA)

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Dab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475915,459,288 - 15,520,924 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475915,459,436 - 15,520,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38539,371,677 - 39,424,980 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl539,371,675 - 39,462,300 (-)EnsemblGRCh38hg38GRCh38
GRCh37539,371,779 - 39,425,082 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map5p13.1NCBI
HuRef539,323,383 - 39,377,010 (-)NCBIHuRef
CHM1_1539,373,679 - 39,427,330 (-)NCBICHM1_1
T2T-CHM13v2.0539,621,190 - 39,674,588 (-)NCBIT2T-CHM13v2.0
Dab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39156,329,269 - 6,470,196 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl156,329,269 - 6,470,193 (+)EnsemblGRCm39 Ensembl
GRCm38156,299,788 - 6,440,715 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl156,299,788 - 6,440,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv37156,249,789 - 6,390,712 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36156,247,064 - 6,387,927 (+)NCBIMGSCv36mm8
Celera156,148,799 - 6,289,867 (+)NCBICelera
Cytogenetic Map15A1NCBI
cM Map152.15NCBI
Dab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8257,241,947 - 57,294,893 (+)NCBIGRCr8
mRatBN7.2255,514,692 - 55,567,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl255,514,700 - 55,567,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx262,644,828 - 62,666,312 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0260,718,369 - 60,739,859 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0255,720,837 - 55,742,323 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0255,747,353 - 55,768,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl255,747,318 - 55,768,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0275,489,435 - 75,510,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4255,714,874 - 55,736,370 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1255,643,109 - 55,664,600 (+)NCBI
Celera251,166,390 - 51,187,877 (+)NCBICelera
Cytogenetic Map2q16NCBI
Dab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542623,852,752 - 23,883,030 (-)NCBIChiLan1.0ChiLan1.0
DAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2470,912,082 - 70,967,698 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1569,067,621 - 69,121,333 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0570,951,198 - 71,004,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1575,954,815 - 76,044,789 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl576,022,143 - 76,041,443 (+)Ensemblpanpan1.1panPan2
DAB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1469,625,874 - 69,648,349 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl469,625,527 - 69,648,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha469,274,405 - 69,324,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0470,113,533 - 70,163,994 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl470,113,545 - 70,163,987 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1469,862,358 - 69,913,299 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0469,975,198 - 70,025,729 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0470,513,789 - 70,564,779 (+)NCBIUU_Cfam_GSD_1.0
Dab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213228,434,139 - 228,472,266 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365182,915,764 - 2,937,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365182,915,819 - 2,936,474 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1624,590,645 - 24,646,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11624,590,638 - 24,776,937 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21625,732,883 - 25,757,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1438,171,320 - 38,224,275 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl438,173,026 - 38,224,231 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607128,550,756 - 28,603,647 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004517   ⟹   ENSHGLP00000004455
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475915,459,288 - 15,520,924 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004518   ⟹   ENSHGLP00000004456
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475915,459,288 - 15,520,924 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004519   ⟹   ENSHGLP00000004457
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475915,459,288 - 15,520,924 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004520   ⟹   ENSHGLP00000004458
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475915,459,288 - 15,520,924 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004521   ⟹   ENSHGLP00000004459
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475915,496,934 - 15,517,224 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004522   ⟹   ENSHGLP00000004460
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475915,496,934 - 15,507,838 (+)Ensembl
RefSeq Acc Id: XM_004848584   ⟹   XP_004848641
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475915,459,567 - 15,520,225 (+)NCBI
RefSeq Acc Id: XM_021261468   ⟹   XP_021117127
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475915,459,788 - 15,520,225 (+)NCBI
RefSeq Acc Id: XM_021261469   ⟹   XP_021117128
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475915,459,788 - 15,520,225 (+)NCBI
RefSeq Acc Id: XM_021261470   ⟹   XP_021117129
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475915,459,788 - 15,520,225 (+)NCBI
RefSeq Acc Id: XM_021261471   ⟹   XP_021117130
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475915,459,436 - 15,520,225 (+)NCBI
RefSeq Acc Id: XM_021261472   ⟹   XP_021117131
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475915,459,791 - 15,520,225 (+)NCBI
RefSeq Acc Id: XP_021117130   ⟸   XM_021261471
- Peptide Label: isoform X3
- UniProtKB: G5AND9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004848641   ⟸   XM_004848584
- Peptide Label: isoform X3
- UniProtKB: G5AND9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021117127   ⟸   XM_021261468
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021117128   ⟸   XM_021261469
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021117129   ⟸   XM_021261470
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021117131   ⟸   XM_021261472
- Peptide Label: isoform X4
Ensembl Acc Id: ENSHGLP00000004459   ⟸   ENSHGLT00000004521
Ensembl Acc Id: ENSHGLP00000004456   ⟸   ENSHGLT00000004518
Ensembl Acc Id: ENSHGLP00000004457   ⟸   ENSHGLT00000004519
Ensembl Acc Id: ENSHGLP00000004460   ⟸   ENSHGLT00000004522
Ensembl Acc Id: ENSHGLP00000004455   ⟸   ENSHGLT00000004517
Ensembl Acc Id: ENSHGLP00000004458   ⟸   ENSHGLT00000004520


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003257 Ensembl, ENTREZGENE
  ENSHGLG00100003288 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004518 ENTREZGENE
  ENSHGLT00000004520 ENTREZGENE
  ENSHGLT00100004402 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro DAB1/2_SBM UniProtKB/TrEMBL
  Dab_PTB UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
KEGG Report hgl:101725399 UniProtKB/TrEMBL
NCBI Gene Dab2 ENTREZGENE
PANTHER DISABLED HOMOLOG 2 UniProtKB/TrEMBL
  PID DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam DAB2_SBM UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PROSITE PID UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0AAX6T6G8_HETGA UniProtKB/TrEMBL
  A0AAX6T784_HETGA UniProtKB/TrEMBL
  A0AAX6TB31_HETGA UniProtKB/TrEMBL
  G5AND9 ENTREZGENE, UniProtKB/TrEMBL