Bak1 (BCL2 antagonist/killer 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Bak1 (BCL2 antagonist/killer 1) Heterocephalus glaber
Analyze
Symbol: Bak1
Name: BCL2 antagonist/killer 1
RGD ID: 18902407
Description: ENCODES a protein that exhibits BH domain binding (ortholog); heat shock protein binding (ortholog); identical protein binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); apoptotic process involved in blood vessel morphogenesis (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); ataxia telangiectasia (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bcl-2 homologous antagonist/killer; Putative Bcl-2-like protein antagonist/killer 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,296,800 - 23,301,223 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475423,297,077 - 23,302,366 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic process  (IEA)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic signaling pathway  (ISO)
B cell apoptotic process  (ISO)
B cell homeostasis  (ISO)
B cell negative selection  (ISO)
blood vessel remodeling  (ISO)
calcium ion transport into cytosol  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to UV  (IEA)
endocrine pancreas development  (ISO)
endoplasmic reticulum calcium ion homeostasis  (IEA)
epithelial cell proliferation  (ISO)
establishment of localization in cell  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
fibroblast apoptotic process  (ISO)
homeostasis of number of cells  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
leukocyte homeostasis  (ISO)
limb morphogenesis  (ISO)
mitochondrial fusion  (ISO)
monoatomic ion transmembrane transport  (IEA)
myeloid cell homeostasis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of proteolysis  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
regulation of apoptotic process  (IEA)
regulation of biological quality  (IEA)
regulation of cell cycle  (ISO)
regulation of mitochondrial membrane permeability  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of transport  (IEA)
release of cytochrome c from mitochondria  (IEA,ISO)
response to ethanol  (ISO)
response to fungus  (ISO)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (ISO)
response to mycotoxin  (ISO)
response to UV-C  (ISO)
response to xenobiotic stimulus  (ISO)
thymocyte apoptotic process  (ISO)
vagina development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,296,800 - 23,301,223 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475423,297,077 - 23,302,366 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
BAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,572,552 - 33,580,276 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,572,547 - 33,580,293 (-)Ensemblhg38GRCh38
GRCh37633,540,329 - 33,548,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,648,301 - 33,656,048 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34633,648,306 - 33,655,959NCBI
Celera635,094,701 - 35,102,448 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,281,784 - 33,289,531 (-)NCBIHuRef
CHM1_1633,542,641 - 33,550,388 (-)NCBICHM1_1
T2T-CHM13v2.0633,393,742 - 33,401,466 (-)NCBIT2T-CHM13v2.0
Bak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,238,786 - 27,247,601 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,238,784 - 27,247,983 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381727,019,812 - 27,028,627 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,019,810 - 27,029,009 (-)Ensemblmm10GRCm38
MGSCv371727,156,757 - 27,165,571 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361726,747,401 - 26,756,216 (-)NCBIMGSCv36mm8
Celera1727,556,267 - 27,565,056 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.65NCBI
Bak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,102,334 - 5,111,615 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl205,102,335 - 5,110,974 (-)EnsemblGRCr8
mRatBN7.2205,100,480 - 5,109,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,100,480 - 5,109,264 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx205,826,258 - 5,834,812 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,188,000 - 5,196,555 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,666,112 - 5,674,701 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,609,620 - 5,618,899 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,609,625 - 5,618,260 (-)Ensemblrn6Rnor6.0
Rnor_5.0207,675,062 - 7,683,731 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4205,255,954 - 5,264,593 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera206,681,267 - 6,689,805 (-)NCBICelera
RGSC_v3.1205,256,180 - 5,264,820 (-)NCBI
Cytogenetic Map20p12NCBI
Bak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,036,415 - 2,041,997 (-)Ensembl
ChiLan1.0NW_0049554372,036,415 - 2,041,997 (-)NCBIChiLan1.0ChiLan1.0
BAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,052,701 - 48,060,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,919,864 - 43,927,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,146,998 - 33,154,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,255,769 - 34,263,211 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,255,769 - 34,263,211 (-)EnsemblpanPan2panpan1.1
BAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,950,359 - 2,957,604 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,948,364 - 2,957,018 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha122,967,686 - 2,970,924 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0123,282,315 - 3,289,076 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,280,333 - 3,289,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,950,651 - 2,953,887 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,031,622 - 3,034,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,129,752 - 3,132,990 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,605,488 - 38,612,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,347,545 - 25,355,789 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,347,608 - 25,354,772 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,808,849 - 29,815,318 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1729,808,849 - 29,815,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,279,191 - 34,286,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,492,776 - 38,502,534 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,492,858 - 38,501,281 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604433,412,290 - 33,419,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000024459   ⟹   ENSHGLP00000024240
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475423,296,800 - 23,301,223 (+)Ensembl
RefSeq Acc Id: XM_004846768   ⟹   XP_004846825
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475423,297,187 - 23,302,366 (+)NCBI
RefSeq Acc Id: XM_021260001   ⟹   XP_021115660
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475423,297,077 - 23,302,366 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004846825 (Get FASTA)   NCBI Sequence Viewer  
  XP_021115660 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB09636 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000024240
GenBank Protein JAN99017 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021115660   ⟸   XM_021260001
- UniProtKB: G5BK25 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004846825   ⟸   XM_004846768
- UniProtKB: G5BK25 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000024240   ⟸   ENSHGLT00000024459


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017276 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000024459 ENTREZGENE
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
InterPro Bcl-2-like_sf UniProtKB/TrEMBL
  Bcl-2_BH1-3 UniProtKB/TrEMBL
  Bcl-2_fam UniProtKB/TrEMBL
  Bcl2-like UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/TrEMBL
KEGG Report hgl:101707336 UniProtKB/TrEMBL
NCBI Gene Bak1 ENTREZGENE
PANTHER PTHR11256 UniProtKB/TrEMBL
  PTHR11256:SF41 UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/TrEMBL
PRINTS BCL2FAMILY UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH2 UniProtKB/TrEMBL
  BH3 UniProtKB/TrEMBL
SMART BCL UniProtKB/TrEMBL
Superfamily-SCOP SSF56854 UniProtKB/TrEMBL
UniProt G5BK25 ENTREZGENE, UniProtKB/TrEMBL