Cartpt (CART prepropeptide) - Rat Genome Database

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Gene: Cartpt (CART prepropeptide) Heterocephalus glaber
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Symbol: Cartpt
Name: CART prepropeptide
RGD ID: 18901803
Description: ENCODES a protein that exhibits neuropeptide hormone activity (inferred); INVOLVED IN behavioral response to cocaine (ortholog); cAMP biosynthetic process (ortholog); cellular response to estradiol stimulus (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alcohol-Related Disorders (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Cocaine- and amphetamine-regulated transcript protein; cocaine- and amphetamine-regulated transcript protein preproprotein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905751,223 - 752,845 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905751,032 - 753,012 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult feeding behavior  (IEA)
behavioral response to cocaine  (ISO)
cAMP biosynthetic process  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to starvation  (IEA)
chemical synaptic transmission  (IEA)
circadian regulation of gene expression  (ISO)
circadian rhythm  (ISO)
conditioned place preference  (ISO)
detection of chemical stimulus involved in sensory perception of pain  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
drinking behavior  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
glucose metabolic process  (ISO)
intracellular calcium ion homeostasis  (ISO)
intracellular glucose homeostasis  (IEA)
negative regulation of appetite  (IEA,ISO)
negative regulation of bone resorption  (IEA)
negative regulation of cytosolic calcium ion concentration  (ISO)
negative regulation of D-glucose import  (ISO)
negative regulation of eating behavior  (ISO)
negative regulation of glucagon secretion  (ISO)
negative regulation of locomotion  (ISO)
negative regulation of relaxation of smooth muscle  (ISO)
negative regulation of type B pancreatic cell apoptotic process  (ISO)
neuropeptide signaling pathway  (IEA)
operant conditioning  (ISO)
positive regulation of blood pressure  (IEA)
positive regulation of epinephrine secretion  (IEA)
positive regulation of exocytosis  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of transmission of nerve impulse  (IEA)
positive regulation of type B pancreatic cell proliferation  (ISO)
regulation of bone remodeling  (IEA)
regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
regulation of circadian sleep/wake cycle, REM sleep  (ISO)
regulation of circadian sleep/wake cycle, wakefulness  (ISO)
regulation of exocytosis  (ISO)
regulation of heart rate by chemical signal  (ISO)
regulation of insulin secretion  (ISO)
regulation of lipid biosynthetic process  (ISO)
regulation of lipid catabolic process  (ISO)
regulation of locomotion involved in locomotory behavior  (ISO)
regulation of systemic arterial blood pressure by neurotransmitter  (ISO)
response to corticosterone  (ISO)
response to corticotropin-releasing hormone  (ISO)
response to ethanol  (ISO)
response to food  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to insulin  (ISO)
response to morphine  (ISO)
response to starvation  (ISO)
somatostatin secretion  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cartpt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905751,223 - 752,845 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905751,032 - 753,012 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CARTPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38571,719,275 - 71,721,045 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl571,719,275 - 71,721,048 (+)EnsemblGRCh38hg38GRCh38
GRCh37571,015,102 - 71,016,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36571,050,750 - 71,052,628 (+)NCBINCBI36Build 36hg18NCBI36
Celera566,910,678 - 66,912,563 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,220,931 - 66,222,816 (+)NCBIHuRef
CHM1_1570,447,686 - 70,449,571 (+)NCBICHM1_1
T2T-CHM13v2.0572,200,597 - 72,202,367 (+)NCBIT2T-CHM13v2.0
Cartpt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,034,991 - 100,037,191 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,034,997 - 100,037,599 (-)EnsemblGRCm39 Ensembl
GRCm381399,898,483 - 99,910,179 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,898,489 - 99,901,091 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,668,439 - 100,670,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613100,998,914 - 101,000,892 (-)NCBIMGSCv36mm8
Celera13103,550,272 - 103,552,922 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.9NCBI
Cartpt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8232,989,215 - 32,991,794 (-)NCBIGRCr8
mRatBN7.2231,255,098 - 31,257,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,255,098 - 31,290,713 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,333,324 - 38,335,346 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,427,667 - 36,429,691 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,220,463 - 31,222,481 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,125,249 - 30,127,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,125,249 - 30,127,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,285,118 - 49,287,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,889,817 - 30,891,837 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,810,185 - 30,812,206 (-)NCBI
Celera227,276,402 - 27,278,422 (-)NCBICelera
Cytogenetic Map2q12NCBI
Cartpt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955575551,991 - 555,149 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955575551,991 - 555,118 (+)NCBIChiLan1.0ChiLan1.0
CARTPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2443,593,184 - 43,595,366 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1541,746,812 - 41,748,989 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0543,591,683 - 43,593,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1544,236,114 - 44,238,229 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl544,236,114 - 44,238,229 (-)Ensemblpanpan1.1panPan2
CARTPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,865,043 - 54,867,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,865,298 - 54,867,158 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,831,747 - 51,833,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,380,658 - 55,382,812 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,380,662 - 55,382,560 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,441,398 - 52,443,555 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,208,304 - 53,210,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,099,675 - 54,101,833 (+)NCBIUU_Cfam_GSD_1.0
Cartpt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213186,139,406 - 186,141,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365494,717,771 - 4,719,395 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365494,717,337 - 4,719,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CARTPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1648,043,492 - 48,045,592 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11648,043,558 - 48,045,592 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,989,808 - 51,991,843 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CARTPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1466,058,755 - 66,060,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl466,058,769 - 66,061,112 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,805,312 - 14,807,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000000697   ⟹   ENSHGLP00000000657
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624905751,223 - 752,845 (+)Ensembl
RefSeq Acc Id: XM_004872854   ⟹   XP_004872911
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624905751,032 - 753,012 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004872911 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB15035 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000657
GenBank Protein JAO03552 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004872911   ⟸   XM_004872854
- UniProtKB: G5C0H4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000657   ⟸   ENSHGLT00000000697


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000571 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000697 ENTREZGENE
Gene3D-CATH 4.10.40.30 UniProtKB/TrEMBL
InterPro CART UniProtKB/TrEMBL
  CART_C_sf UniProtKB/TrEMBL
KEGG Report hgl:101710231 UniProtKB/TrEMBL
NCBI Gene Cartpt ENTREZGENE
PANTHER COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PROTEIN UniProtKB/TrEMBL
  PTHR16655 UniProtKB/TrEMBL
Pfam CART UniProtKB/TrEMBL
Superfamily-SCOP SSF64546 UniProtKB/TrEMBL
UniProt G5C0H4 ENTREZGENE, UniProtKB/TrEMBL