Xpo1 (exportin 1) - Rat Genome Database

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Gene: Xpo1 (exportin 1) Heterocephalus glaber
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Symbol: Xpo1
Name: exportin 1
RGD ID: 18900888
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cellular response to salt (ortholog); cellular response to triglyceride (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN CRM1 export pathway; Hedgehog signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH amenorrhea (ortholog); atrial fibrillation (ortholog); colorectal cancer (ortholog); FOUND IN annulate lamellae (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: exportin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624833375,820 - 424,499 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624833375,817 - 424,499 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Xpo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624833375,820 - 424,499 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624833375,817 - 424,499 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
XPO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38261,477,849 - 61,538,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl261,476,032 - 61,538,741 (-)EnsemblGRCh38hg38GRCh38
GRCh37261,704,984 - 61,765,491 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36261,558,573 - 61,618,922 (-)NCBINCBI36Build 36hg18NCBI36
Build 34261,616,719 - 61,677,069NCBI
Celera261,550,297 - 61,610,634 (-)NCBICelera
Cytogenetic Map2p15NCBI
HuRef261,445,666 - 61,506,245 (-)NCBIHuRef
CHM1_1261,635,341 - 61,695,639 (-)NCBICHM1_1
T2T-CHM13v2.0261,483,936 - 61,544,825 (-)NCBIT2T-CHM13v2.0
Xpo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391123,205,768 - 23,248,250 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1123,206,055 - 23,248,249 (+)EnsemblGRCm39 Ensembl
GRCm381123,255,909 - 23,297,597 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1123,256,041 - 23,298,249 (+)EnsemblGRCm38mm10GRCm38
MGSCv371123,156,041 - 23,197,597 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361123,156,041 - 23,197,597 (+)NCBIMGSCv36mm8
Celera1125,383,230 - 25,424,813 (+)NCBICelera
Cytogenetic Map11A3.2NCBI
cM Map1114.28NCBI
Xpo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814101,434,450 - 101,476,705 (+)NCBIGRCr8
mRatBN7.21497,233,282 - 97,275,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1497,233,270 - 97,275,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14101,571,539 - 101,607,053 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.014102,815,887 - 102,851,401 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01499,287,455 - 99,322,969 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014108,007,421 - 108,049,088 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14108,007,724 - 108,049,660 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014108,082,784 - 108,124,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414103,943,249 - 103,978,717 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.114103,962,459 - 103,997,928 (+)NCBI
Celera1496,216,463 - 96,251,770 (+)NCBICelera
Cytogenetic Map14q22NCBI
Xpo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542422,370,006 - 22,420,568 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542422,370,006 - 22,420,568 (+)NCBIChiLan1.0ChiLan1.0
XPO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21264,845,566 - 64,906,271 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A64,849,384 - 64,910,222 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A61,562,372 - 61,622,841 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A62,698,935 - 62,759,059 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A62,698,935 - 62,757,793 (-)Ensemblpanpan1.1panPan2
XPO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11061,541,647 - 61,588,397 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1061,542,211 - 61,585,054 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1061,432,066 - 61,478,799 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01062,551,228 - 62,597,765 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1062,549,829 - 62,598,376 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11062,236,087 - 62,282,603 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01062,538,737 - 62,585,449 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01062,833,751 - 62,880,490 (-)NCBIUU_Cfam_GSD_1.0
Xpo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629221,608,933 - 21,649,530 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364916,921,319 - 6,962,343 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364916,921,753 - 6,962,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XPO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl380,255,146 - 80,300,327 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1380,255,016 - 80,300,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2384,163,542 - 84,182,141 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XPO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11445,428,279 - 45,487,965 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1445,432,619 - 45,488,723 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604566,319,346 - 66,401,611 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004320   ⟹   ENSHGLP00000004260
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624833375,820 - 424,499 (+)Ensembl
RefSeq Acc Id: XM_004867232   ⟹   XP_004867289
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624833375,817 - 424,499 (+)NCBI
RefSeq Acc Id: XM_021246277   ⟹   XP_021101936
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624833386,545 - 424,499 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004867289 (Get FASTA)   NCBI Sequence Viewer  
  XP_021101936 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004260
  ENSHGLP00100038057
GenBank Protein JAO02333 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004867289   ⟸   XM_004867232
- Peptide Label: isoform X1
- UniProtKB: A0A0P6K7E8 (UniProtKB/TrEMBL),   G5C1Y9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021101936   ⟸   XM_021246277
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RXG2 (UniProtKB/TrEMBL),   G5C1Y9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004260   ⟸   ENSHGLT00000004320


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003115 Ensembl, ENTREZGENE
  ENSHGLG00100012227 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004320 ENTREZGENE
  ENSHGLT00100060767 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  CRM1_repeat UniProtKB/TrEMBL
  Exp1_repeat_2 UniProtKB/TrEMBL
  Exportin-1/Importin-b-like UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/TrEMBL
  XPO1/5 UniProtKB/TrEMBL
  XPO1_C_dom UniProtKB/TrEMBL
  XPO1_repeat_3 UniProtKB/TrEMBL
KEGG Report hgl:101725005 UniProtKB/TrEMBL
NCBI Gene Xpo1 ENTREZGENE
PANTHER EXPORTIN-1 UniProtKB/TrEMBL
  PTHR11223 UniProtKB/TrEMBL
Pfam CRM1_C UniProtKB/TrEMBL
  CRM1_repeat UniProtKB/TrEMBL
  CRM1_repeat_2 UniProtKB/TrEMBL
  CRM1_repeat_3 UniProtKB/TrEMBL
  IBN_N UniProtKB/TrEMBL
  Xpo1 UniProtKB/TrEMBL
PROSITE IMPORTIN_B_NT UniProtKB/TrEMBL
SMART CRM1_C UniProtKB/TrEMBL
  IBN_N UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A0P6K7E8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RXG2 ENTREZGENE, UniProtKB/TrEMBL
  G5C1Y9 ENTREZGENE, UniProtKB/TrEMBL