Lrp5 (LDL receptor related protein 5) - Rat Genome Database

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Gene: Lrp5 (LDL receptor related protein 5) Heterocephalus glaber
Analyze
Symbol: Lrp5
Name: LDL receptor related protein 5
RGD ID: 18899907
Description: ENCODES a protein that exhibits coreceptor activity (ortholog); toxin transmembrane transporter activity (ortholog); INVOLVED IN adipose tissue development (ortholog); amino acid transport (ortholog); anatomical structure regression (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Aicardi-Goutieres Syndrome 3 (ortholog); autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); FOUND IN receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: low-density lipoprotein receptor-related protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,438,274 - 18,551,338 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
amino acid transport  (ISO)
anatomical structure regression  (ISO)
anterior/posterior pattern specification  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
blood vessel morphogenesis  (ISO)
bone development  (IEA)
bone marrow development  (ISO)
bone morphogenesis  (ISO)
bone remodeling  (IEA,ISO)
branching involved in mammary gland duct morphogenesis  (IEA,ISO)
canonical Wnt signaling pathway  (IEA)
cell migration involved in gastrulation  (IEA,ISO)
cell-cell adhesion  (ISO)
cell-cell signaling involved in mammary gland development  (ISO)
cholesterol homeostasis  (ISO)
cholesterol metabolic process  (ISO)
embryonic digit morphogenesis  (IEA,ISO)
endocytosis  (IEA)
establishment of blood-brain barrier  (IEA,ISO)
establishment of blood-retinal barrier  (IEA,ISO)
extracellular matrix-cell signaling  (ISO)
gastrulation with mouth forming second  (IEA,ISO)
gene expression  (ISO)
glucose catabolic process  (ISO)
limb morphogenesis  (ISO)
mammary gland development  (ISO)
mammary gland duct morphogenesis  (ISO)
mesodermal cell migration  (IEA,ISO)
negative regulation of osteoblast differentiation  (ISO)
nervous system development  (IEA)
Norrin signaling pathway  (IEA)
osteoblast development  (ISO)
osteoblast proliferation  (ISO)
positive regulation of cell differentiation  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of apoptotic process  (ISO)
regulation of biological quality  (IEA)
regulation of blood pressure  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
regulation of osteoblast differentiation  (IEA)
response to peptide hormone  (ISO)
retina morphogenesis in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (IEA)
small molecule metabolic process  (IEA)
somatic stem cell population maintenance  (ISO)
vasculature development  (ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Lrp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476718,438,274 - 18,551,338 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381168,298,412 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1168,312,591 - 68,449,275 (+)Ensemblhg38GRCh38
GRCh371168,080,059 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,570 - 68,100,925 (+)NCBICHM1_1
T2T-CHM13v2.01168,302,748 - 68,454,184 (+)NCBIT2T-CHM13v2.0
Lrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,634,828 - 3,736,564 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)Ensemblmm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBIMGSCv36mm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.33NCBI
Lrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,243,499 - 210,346,886 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1210,243,502 - 210,346,822 (-)EnsemblGRCr8
mRatBN7.21200,814,247 - 200,917,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1200,814,250 - 200,917,581 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1209,187,284 - 209,290,934 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,276,237 - 216,379,561 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01208,950,420 - 209,053,745 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)Ensemblrn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1198,369,819 - 198,473,093 (-)NCBICelera
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Cytogenetic Map1q42-q43NCBI
Lrp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)Ensembl
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
LRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2969,265,553 - 69,403,200 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11170,308,771 - 70,446,940 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,794,645 - 66,840,019 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)EnsemblpanPan2panpan1.1
LRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1848,048,981 - 48,156,123 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01850,355,437 - 50,463,484 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,355,578 - 50,464,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11849,575,315 - 49,682,550 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,149,276 - 49,256,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01849,942,316 - 50,049,714 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,303,946 - 5,374,226 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365991,746,406 - 1,814,321 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,614 - 4,653,944 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,090,048 - 6,224,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038103,373,623 - 103,436,978 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000017456   ⟹   ENSHGLP00000017283
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476718,438,274 - 18,551,338 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000017457   ⟹   ENSHGLP00000017284
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476718,438,373 - 18,518,597 (-)Ensembl
RefSeq Acc Id: XM_004852629   ⟹   XP_004852686
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,438,165 - 18,551,360 (-)NCBI
RefSeq Acc Id: XM_021264481   ⟹   XP_021120140
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,438,165 - 18,551,360 (-)NCBI
RefSeq Acc Id: XR_002397359
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476718,438,545 - 18,551,362 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004852686 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120140 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017283
RefSeq Acc Id: XP_021120140   ⟸   XM_021264481
- Peptide Label: isoform X2
- UniProtKB: A0AAX6TGK6 (UniProtKB/TrEMBL),   G5BTV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852686   ⟸   XM_004852629
- Peptide Label: isoform X1
- UniProtKB: A0AAX6PIS3 (UniProtKB/TrEMBL),   G5BTV2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000017284   ⟸   ENSHGLT00000017457
Ensembl Acc Id: ENSHGLP00000017283   ⟸   ENSHGLT00000017456


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012372 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000017456 ENTREZGENE
Gene3D-CATH Laminin UniProtKB/TrEMBL
  Low-density Lipoprotein Receptor UniProtKB/TrEMBL
  TolB, C-terminal domain UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  Cueball_EGF_LRP_Nidogen UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  LRP5/6 UniProtKB/TrEMBL
KEGG Report hgl:101711921 UniProtKB/TrEMBL
NCBI Gene Lrp5 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5 UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 6 UniProtKB/TrEMBL
  VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED UniProtKB/TrEMBL
Pfam FXa_inhibition UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PIRSF LDL_recpt-rel_p5/6 UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  LDL receptor-like module UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0AAX6PIS3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6TGK6 ENTREZGENE, UniProtKB/TrEMBL
  G5BTV2 ENTREZGENE, UniProtKB/TrEMBL