Faslg (Fas ligand) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Faslg (Fas ligand) Heterocephalus glaber
Analyze
Symbol: Faslg
Name: Fas ligand
RGD ID: 18899826
Description: ENCODES a protein that exhibits death receptor binding (ortholog); tumor necrosis factor receptor binding (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to type II interferon (ortholog); endosomal lumen acidification (ortholog); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); abdominal aortic aneurysm (ortholog); Acute Experimental Pancreatitis (ortholog); FOUND IN caveola (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor necrosis factor ligand superfamily member 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247719,032,016 - 9,038,825 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247719,031,978 - 9,038,760 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
1q24 Deletion Syndrome  (ISO)
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
Acute Hepatitis  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
atherosclerosis  (ISO)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type IB  (ISO)
biliary tract benign neoplasm  (ISO)
brain glioma  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery disease  (ISO)
cervix uteri carcinoma in situ  (ISO)
cholangiocarcinoma  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clonorchiasis  (ISO)
congestive heart failure  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial combined hyperlipidemia  (ISO)
Fetal Growth Retardation  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (ISO)
graft-versus-host disease  (ISO)
HELLP syndrome  (ISO)
hepatitis  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
Hypothermia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Immunodeficiency 98 with Autoinflammation, X-Linked  (ISO)
infectious mononucleosis  (ISO)
Intestinal Reperfusion Injury  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive lobular carcinoma  (ISO)
Kidney Reperfusion Injury  (ISO)
leiomyoma  (ISO)
limited scleroderma  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
pre-eclampsia  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
rheumatoid arthritis  (ISO)
seminoma  (ISO)
Sepsis  (ISO)
Spinal Cord Compression  (ISO)
substance-related disorder  (ISO)
testicular disease  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Faslg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247719,032,016 - 9,038,825 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247719,031,978 - 9,038,760 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
FASLG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,659,103 - 172,666,876 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,659,103 - 172,666,876 (+)EnsemblGRCh38hg38GRCh38
GRCh371172,628,243 - 172,636,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,894,808 - 170,902,636 (+)NCBINCBI36Build 36hg18NCBI36
Celera1145,737,693 - 145,745,520 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1143,852,795 - 143,860,622 (+)NCBIHuRef
CHM1_11174,050,496 - 174,058,323 (+)NCBICHM1_1
T2T-CHM13v2.01172,016,214 - 172,023,987 (+)NCBIT2T-CHM13v2.0
Fasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,608,260 - 161,616,064 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,608,258 - 161,616,064 (-)EnsemblGRCm39 Ensembl
GRCm381161,780,691 - 161,788,495 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,780,689 - 161,788,495 (-)EnsemblGRCm38mm10GRCm38
MGSCv371163,710,820 - 163,718,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361163,617,366 - 163,625,172 (-)NCBIMGSCv36mm8
Celera1164,235,655 - 164,243,458 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.95NCBI
Faslg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81376,680,885 - 76,706,042 (-)NCBIGRCr8
mRatBN7.21374,151,519 - 74,172,760 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1374,154,954 - 74,162,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1376,724,620 - 76,731,883 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01378,031,667 - 78,038,929 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01375,291,523 - 75,298,787 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01379,696,811 - 79,717,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1379,698,445 - 79,705,705 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01384,590,119 - 84,605,900 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41377,472,950 - 77,480,210 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11377,487,137 - 77,494,398 (-)NCBI
Celera1373,908,438 - 73,915,703 (-)NCBICelera
Cytogenetic Map13q22NCBI
Faslg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540613,098,662 - 13,107,389 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540613,098,479 - 13,107,045 (+)NCBIChiLan1.0ChiLan1.0
FASLG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2177,076,483 - 77,084,478 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1176,756,472 - 76,764,434 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01148,159,826 - 148,167,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11151,868,430 - 151,876,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1151,868,430 - 151,876,281 (+)Ensemblpanpan1.1panPan2
FASLG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1726,335,837 - 26,344,224 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,335,846 - 26,344,224 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha725,866,683 - 25,875,068 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0726,086,377 - 26,094,750 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl726,086,386 - 26,094,750 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,997,538 - 26,005,908 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0726,067,461 - 26,075,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0726,217,995 - 26,226,386 (-)NCBIUU_Cfam_GSD_1.0
Faslg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,942,494 - 96,949,833 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648114,789,547 - 14,795,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASLG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9115,068,090 - 115,076,464 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19115,068,314 - 115,075,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29126,641,066 - 126,647,827 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASLG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12556,488,572 - 56,496,469 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2556,489,417 - 56,496,251 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605558,094,483 - 58,102,557 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004853423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01050430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000016308   ⟹   ENSHGLP00000016139
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247719,032,016 - 9,038,825 (-)Ensembl
RefSeq Acc Id: XM_004853423   ⟹   XP_004853480
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247719,031,978 - 9,038,760 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004853480 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004853480   ⟸   XM_004853423
- UniProtKB: A0AAX6PJS0 (UniProtKB/TrEMBL),   G5ART7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016139   ⟸   ENSHGLT00000016308


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011544 Ensembl
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro FASL UniProtKB/TrEMBL
  TNF_CS UniProtKB/TrEMBL
  TNF_dom UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
NCBI Gene Faslg ENTREZGENE
PANTHER TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6 UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PRINTS FASLIGAND UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
  TNF-like UniProtKB/TrEMBL
UniProt A0AAX6PJS0 ENTREZGENE, UniProtKB/TrEMBL
  G5ART7 ENTREZGENE, UniProtKB/TrEMBL