LOC103225480 (aflatoxin B1 aldehyde reductase member 2)

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Gene: LOC103225480 (aflatoxin B1 aldehyde reductase member 2) Chlorocebus sabaeus

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Symbol:

LOC103225480

Name:

aflatoxin B1 aldehyde reductase member 2

RGD ID:

18752045

Description:

ENCODES a protein that exhibits aldose reductase (NADPH) activity (ortholog); phenanthrene-9,10-epoxide hydrolase activity (ortholog); INVOLVED IN daunorubicin metabolic process (ortholog); doxorubicin metabolic process (ortholog); ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); Alzheimer's disease (ortholog); autism spectrum disorder (ortholog); FOUND IN cytosol (ortholog); Golgi apparatus (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

AKR7A2; aldo-keto reductase family 7 member A2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	113,234,257 - 113,242,445 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	2,916,852 - 2,925,038 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ISO)

Alzheimer's disease (ISO)

autism spectrum disorder (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital disorder of glycosylation Ir (ISO)

hyperprolinemia type 2 (ISO)

pancreatic ductal adenocarcinoma (ISO)

Parkinson's disease 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

daunorubicin metabolic process (ISO)

doxorubicin metabolic process (ISO)

Cellular Component

cytosol (ISO)

Golgi apparatus (ISO)

mitochondrion (ISO)

nuclear envelope (ISO)

Molecular Function

aldose reductase (NADPH) activity (ISO)

phenanthrene-9,10-epoxide hydrolase activity (ISO)

protein binding (ISO)

References

Genomics

Comparative Map Data

LOC103225480
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	113,234,257 - 113,242,445 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	2,916,852 - 2,925,038 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

AKR7A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	19,302,708 - 19,312,146 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	19,301,991 - 19,312,144 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	19,629,202 - 19,638,640 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	19,503,046 - 19,511,227 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	19,375,768 - 19,383,946	NCBI
Celera	1	17,957,442 - 17,965,624 (-)	NCBI		Celera
Cytogenetic Map	1	p36.13	NCBI
HuRef	1	17,875,577 - 17,884,829 (-)	NCBI		HuRef
CHM1_1	1	19,738,505 - 19,747,943 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,126,242 - 19,135,681 (-)	NCBI		T2T-CHM13v2.0

Akr7a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	139,038,005 - 139,046,097 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	139,038,055 - 139,045,737 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	139,310,720 - 139,318,786 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	139,310,744 - 139,318,426 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	138,866,659 - 138,874,701 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	138,582,820 - 138,590,501 (+)	NCBI		MGSCv36	mm8
Celera	4	141,097,258 - 141,105,993 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.64	NCBI

Akr7a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,835,589 - 156,844,127 (+)	NCBI		GRCr8
mRatBN7.2	5	151,552,375 - 151,560,914 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,552,343 - 151,560,909 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	154,250,866 - 154,259,404 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	156,025,214 - 156,033,752 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	156,006,202 - 156,014,739 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,759,448 - 157,768,473 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,759,416 - 157,768,471 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	161,499,603 - 161,508,628 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	158,097,679 - 158,106,217 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	158,107,717 - 158,116,254 (+)	NCBI
Celera	5	149,932,592 - 149,941,127 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Akr7a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955452	6,844 - 13,868 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100981962
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	207,802,957 - 207,822,054 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	206,919,935 - 206,938,840 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	18,262,631 - 18,270,783 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	19,309,211 - 19,317,836 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	19,309,471 - 19,317,227 (-)	Ensembl	panpan1.1		panPan2

AKR7A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	79,334,179 - 79,343,880 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	79,334,205 - 79,343,007 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	75,849,105 - 75,858,155 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	79,956,898 - 79,965,951 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	79,956,898 - 79,968,886 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	76,717,803 - 76,726,853 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	77,727,438 - 77,736,710 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	78,798,535 - 78,808,663 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101974041
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	39,740,406 - 39,748,246 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936474	5,565,715 - 5,573,048 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKR7A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	77,754,174 - 77,761,667 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	77,754,172 - 77,761,609 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	71,816,268 - 71,823,705 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007980267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007980269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007980267 ⟹ XP_007978458

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	113,234,258 - 113,242,445 (+)	NCBI
Vero_WHO_p1.0	NW_023666033	2,916,852 - 2,925,038 (-)	NCBI

Sequence:

show sequence

AACGCGCAGGCGCTGCTGCTATGCTGAGCGCCGCGTCTCGCGTAGTCTCCCGCGCCGCCGTACC
TTGCGCGCTTCGCTCCCCGCAGCCCGAGGCCCGCGCGCTAGCCATGTCCCGGCCACCGCCACCG
CGGGTCGCCACGGTGCTGGGCACCATGGAGATGGGGCGCCGCATGGACGCGCCCGCCAGCGCCG
CGGCCGTGCGCGCCTTTCTGGAGCGCGGCCACACCGAACTGGACACGGCCTTCATGTACAGCGA
CGGCCAGTCCGAGACCATCCTGGGCGGTCTGGGGCTCGGGCTGGGCGGCAGTGACTGCAGAGTG
AAAATTGCCACCAAGGCCAACCCTTGGGATGGAAAATCACTAAAGCCTGACAGTCTCCGGTCCC
AGCTGGAGACATCACTGAAGCGGCTGCAGTGTCCCCGAGTGGACCTCTTCTACCTACATGCACC
TGACCACAGCACTCCAGTGGAAGAGACACTGCGCGCCTGCCACCAGCTGCACCAGGAGGGCAAG
TTCGTGGAGCTTGGCCTCTCCAACTATGCTGCCTGGGAAGTGGCCGAGATCTGTACCCTCTGCA
AGAGCAACGGTTGGATCCTGCCCACTGTGTACCAGGGCATGTACAACGCCACCACCCGGCAGGT
GGAAACGGAGCTCCTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTG
GCTGGGGGCCTGCTGACTGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCCGTGGGCC
GCTTCTTTGGGAATAGCTGGGCTGAGACCTACAGGAATCGCTTCTGGAAGGAGCACCACTTCCA
GGCCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCACATATGGCGCCAGCGCCCCCAGCATGACC
TCGGCTGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGGGTGCCCACGGGGACACGGTCA
TCCTGGGCATGTCCAGCCTGGAGCAGCTGGAGCAGAACTTGGCAGCAACGGAGGAAGGGCCCCT
GGAGCCGGCTGTCGTGGACGCCTTTAATCAAGCCTGGCATTTGGTTGCTCACGAATGTCCCAAC
TACTTCCGCTAGGCCCATCGTGGCTCAGGCTGCCCAAGGCTCTTCTGTCACCTCTTTTGTTCTC
TCACACTGACCAGTCTTGGCCTTAAGCTGCCTCAGCAGAATCTTTCTGGATTGTCTAGATCCAT
GCATTATTTTTCTAGCTTCCTGCCTCGCTCCCTGTTTACTTTACACTGTGAAAGGCGGGGGTGA
GTCCCACTTGAGCACTCCCTGTTGAATAAAGCAGGCATTTGACCTGGCTGTCGCCCAGGTCTTG
AGTGAACCCCAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007978458	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017129.1

RefSeq Acc Id:	XP_007978458 ⟸ XM_007980267
- UniProtKB:	A0A0D9S8E0 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000878	UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017655.1	UniProtKB/TrEMBL
Gene3D-CATH	NADP-dependent oxidoreductase domain	UniProtKB/TrEMBL
InterPro	AKR_Detox_Biosynth	UniProtKB/TrEMBL
	NADP_OxRdtase_dom	UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/TrEMBL
NCBI Gene	AKR7A2	ENTREZGENE
PANTHER	NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN	UniProtKB/TrEMBL
	NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED	UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/TrEMBL
Superfamily-SCOP	NAD(P)-linked oxidoreductase	UniProtKB/TrEMBL
UniProt	A0A0D9S8E0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	LOC103225480	aflatoxin B1 aldehyde reductase member 2	AKR7A2	aldo-keto reductase family 7 member A2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD