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Gene: RDH5 (retinol dehydrogenase 5) Chlorocebus sabaeus

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Symbol:

RDH5

Name:

retinol dehydrogenase 5

RGD ID:

18650620

Description:

ENCODES a protein that exhibits all-trans-retinol dehydrogenase (NAD+) activity (inferred); androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity (inferred); androsterone dehydrogenase [NAD(P)+] activity (inferred); INVOLVED IN retinoid metabolic process (inferred); steroid metabolic process (inferred); PARTICIPATES IN retinoid cycle metabolic pathway; ASSOCIATED WITH Congenital Abnormalities (ortholog); congenital stationary night blindness (ortholog); fundus albipunctatus (ortholog); FOUND IN cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

11-cis retinol dehydrogenase

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RDH5 (retinol dehydrogenase 5)	NCBI	Ortholog
Mus musculus (house mouse):	Rdh5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Rdh5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rdh5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RDH5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RDH5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rdh5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RDH5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rdh5 (retinol dehydrogenase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,667,461 - 51,672,386 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	51,668,803 - 51,672,192 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	194,322,273 - 194,327,136 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Congenital Abnormalities (ISO)

congenital stationary night blindness (ISO)

fundus albipunctatus (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

myopia (ISO)

night blindness (ISO)

optic atrophy (ISO)

retinitis pigmentosa (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

retinoid metabolic process (IEA)

steroid metabolic process (IEA)

Cellular Component

cell body (ISO)

endoplasmic reticulum lumen (IEA)

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (IEA)

Molecular Function

all-trans-retinol dehydrogenase (NAD+) activity (IEA)

androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity (IEA)

androsterone dehydrogenase [NAD(P)+] activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein homodimerization activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

retinoid cycle metabolic pathway (ISO)

References

Genomics

Comparative Map Data

RDH5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,667,461 - 51,672,386 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	51,668,803 - 51,672,192 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	194,322,273 - 194,327,136 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

RDH5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	55,720,393 - 55,724,705 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	55,720,367 - 55,724,705 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,114,177 - 56,118,489 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,400,488 - 54,404,756 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	54,400,487 - 54,404,754	NCBI
Celera	12	55,766,620 - 55,770,996 (+)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,152,966 - 53,157,341 (+)	NCBI		HuRef
CHM1_1	12	56,080,940 - 56,085,314 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	55,687,027 - 55,691,339 (+)	NCBI		T2T-CHM13v2.0

Rdh5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,749,457 - 128,755,906 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,749,462 - 128,758,757 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,913,588 - 128,920,037 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,913,593 - 128,922,888 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	128,350,646 - 128,356,353 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	128,316,537 - 128,322,222 (-)	NCBI		MGSCv36	mm8
Celera	10	131,306,272 - 131,311,979 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.19	NCBI

Rdh5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,912,120 - 1,931,836 (-)	NCBI		GRCr8
mRatBN7.2	7	1,341,172 - 1,346,863 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	1,340,934 - 1,351,558 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	4,105,451 - 4,111,129 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,981,111 - 5,986,789 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	6,282,399 - 6,288,308 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	3,335,681 - 3,342,573 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	3,335,742 - 3,342,491 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	3,305,900 - 3,311,463 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	2,212,121 - 2,217,394 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	2,215,941 - 2,216,641 (-)	NCBI
Celera	7	1,211,351 - 1,216,834 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Rdh5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,352,012 - 3,365,080 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,356,324 - 3,361,701 (+)	NCBI	ChiLan1.0	ChiLan1.0

RDH5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	38,603,587 - 38,608,452 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	38,600,356 - 38,605,222 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	33,186,871 - 33,191,539 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,911,309 - 33,916,301 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,911,309 - 33,920,506 (-)	Ensembl	panpan1.1		panPan2

RDH5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	120,386 - 125,195 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	120,057 - 125,197 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	182,788 - 187,948 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	127,659 - 132,829 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	124,738 - 132,464 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	105,355 - 110,512 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	348,472 - 353,628 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	472,362 - 477,524 (+)	NCBI		UU_Cfam_GSD_1.0

Rdh5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,674,990 - 58,678,776 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	191,128 - 199,777 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	191,136 - 195,279 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RDH5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,166,510 - 21,170,897 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,166,869 - 21,170,913 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	22,646,730 - 22,650,759 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Rdh5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	12,290,688 - 12,304,712 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	12,293,578 - 12,299,981 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in RDH5
73 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008003565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008003566	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000003347 ⟹ ENSCSAP00000001629

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	11	51,668,803 - 51,672,192 (+)	Ensembl

RefSeq Acc Id:

XM_008003565 ⟹ XP_008001756

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	11	51,668,358 - 51,672,386 (+)	NCBI
Vero_WHO_p1.0	NW_023666037	194,322,273 - 194,327,136 (-)	NCBI

Sequence:

show sequence

TTGAGACAGTCAGTGAGATGCTCAGCATCACACAGCAAATCTGAGGCCACCAGGACTAAATGCG
GGGTTCTTGGCCCTATACATCATTCCAAACACAAGACACAGGTTGCATATAGAAGGTTCAATGT
CCCTGGTTTAGTAGGAGAGAAAGTGTGAGGCAAGCAAGAAGATGCCTCTGCTCCATACGCAGGT
CTGTACACAGGACCTGGCTCATGTGGCTTTAGTTAAATTAGCCACAAATACAGGGTCTGCCCAC
ATCTTTGCTTTGCACAGATGAGCCATAGTTGGCCAATTATCTGCCAACCAGATAATTTCTCAAT
ATGCTCACACCAGATGCTTCCAGCTAGGGAAGGTATTAGGGGAAAGGGCTTGAGGGCCGCAGTA
AACTGGACAAGTTTTTCTGCCCAGCCTAGGCTGCCACCTGTAGGTCACTTGGGCTCCAGCTATG
TGGCTGCCTCTGCTGCTGGGTGCCTTACTCTGGGCAGTGCTGTGGTTGCTCAGGGACCGGCAGA
GCCTGCCCGCCAGCGATGCCTTTGTCTTCATCACCGGCTGTGACTCAGGCTTTGGGCGCCTTCT
GGCACTGCAGCTGGACCAGAGAGGCTTCCGAGTCCTGGCCAGCTGCCTGACTCCCTCTGGGGCC
GAGGACCTGCAGCGGGTGGCCTCCTCCCGCCTCCACACTACCCTGCTGGATATCACTGATCCCC
AGAGCGTCCAGCAGGCAGCCAAGTGGGTGGAGACGCACGTTAAGGAAGCAGGGCTTTTTGGTCT
GGTGAATAATGCTGGTGTGGCTGGTATCATCGGACCCACACCATGGCTGACCCGGGATGATTTC
CAGCGGGTGCTGAATGTGAACACAATGGGTCCCATCGGGGTCACCCTTGCCCTGCTACCTCTGC
TGCAGCAAGCCCGGGGCCGGGTGATCAACATCACCAGCGTCCTGGGTCGCCTGGCAGCCAATGG
TGGGGGCTACTGTGTCTCCAAATTTGGCCTGGAGGCCTTCTCTGACAGTCTGAGGCGGGATGTG
GCTCATTTTGGGATACGAGTCTCCATCGTGGAGCCTGGCTTCTTCCGAACCCCTGTGACCAACC
TGGAGAGTCTGGAGAAAACCCTGCAGGCCTGTTGGGCACGGCTACCTCCTGCCACACAGGCCCA
CTATGGGGGGGCCTTCCTCACCAAGTACCTGAAAATGCAACAGCGCATCATGAACCTCATCTGT
GACCCGGACCTAACCAAGGTGAGCAAATGCCTGGAGCATGCCCTGACTGCTCGACACCCCCGAA
CCCGCTACAGCCCAGGCTGGGATGCCAAGCTGCTCTGGCTGCCTGCCTCCTACCTGCCAGCCAG
CCTGGTGGATGCTGTGCTCACCTGGATCCTTCCCAAGCCTGCCCAAGCAGTCTGTTGAATCCAG
CCTTCCAGCAAGAGATTGTTTTTCAAGGGCAAGGACTTTATTTCTGCCCCCACCCTGGTACTGC
CTGGTGCCTGCCACAAAATAAGCACTAACAAAAGTGTATTGTTTAAAAAATAAAAAGAAGGTGG
GCAGAAATGAATGTGCCCAGTGGAAGGCTGACCCCATTTAAGTGCCAACTACTCCAAACC

hide sequence

Protein Sequences


Protein RefSeqs	XP_008001756	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000001629
	ENSCSAP00000001629.1

RefSeq Acc Id:	XP_008001756 ⟸ XM_008003565
- UniProtKB:	A0A0D9QZ40 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000001629 ⟸ ENSCSAT00000003347

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005320	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003347.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
KEGG Report	csab:103238482	UniProtKB/TrEMBL
NCBI Gene	RDH5	ENTREZGENE
PANTHER	RETINOL DEHYDROGENASE 5	UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A0D9QZ40	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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