FBXW7 (F-box and WD repeat domain containing 7) - Rat Genome Database

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Pathways
Gene: FBXW7 (F-box and WD repeat domain containing 7) Chlorocebus sabaeus
Analyze
Symbol: FBXW7
Name: F-box and WD repeat domain containing 7
RGD ID: 18615410
Description: ENCODES a protein that exhibits cyclin binding (inferred); identical protein binding (inferred); phosphothreonine residue binding (inferred); INVOLVED IN cellular response to UV (ortholog); DNA damage response (ortholog); G1/S transition of mitotic cell cycle (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); basal cell carcinoma (ortholog); Breast Neoplasms (ortholog); FOUND IN endoplasmic reticulum (ortholog); Golgi apparatus (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box/WD repeat-containing protein 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1798,894,261 - 99,105,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl798,892,504 - 99,106,084 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603778,541,091 - 78,756,369 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to UV  (ISO)
DNA damage response  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
lung development  (ISO)
negative regulation of gene expression  (IEA)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of osteoclast development  (IEA)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of ubiquitin-dependent protein catabolic process  (ISO)
Notch signaling pathway  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA)
positive regulation of proteasomal protein catabolic process  (IEA)
positive regulation of protein targeting to mitochondrion  (IEA)
positive regulation of protein ubiquitination  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of ubiquitin-dependent protein catabolic process  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA,ISO)
protein destabilization  (ISO)
protein stabilization  (ISO)
protein ubiquitination  (IEA,ISO)
regulation of cell migration involved in sprouting angiogenesis  (ISO)
regulation of circadian rhythm  (IEA)
regulation of mitophagy  (IEA)
regulation of mitotic cell cycle  (ISO)
regulation of protein stability  (IEA)
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  (IEA)
sister chromatid cohesion  (IEA)
ubiquitin recycling  (IEA)
vasculature development  (IEA)
vasculogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
FBXW7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1798,894,261 - 99,105,955 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl798,892,504 - 99,106,084 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603778,541,091 - 78,756,369 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FBXW7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384152,320,544 - 152,536,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4152,320,544 - 152,536,092 (-)Ensemblhg38GRCh38
GRCh374153,241,696 - 153,457,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364153,461,860 - 153,675,622 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344153,601,099 - 153,690,635NCBI
Celera4150,566,189 - 150,779,958 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4148,968,491 - 149,182,492 (-)NCBIHuRef
CHM1_14153,220,162 - 153,434,185 (-)NCBICHM1_1
T2T-CHM13v2.04155,643,699 - 155,859,255 (-)NCBIT2T-CHM13v2.0
Fbxw7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39384,721,901 - 84,886,505 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl384,722,575 - 84,886,505 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38384,814,990 - 84,979,198 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl384,815,268 - 84,979,198 (+)Ensemblmm10GRCm38
MGSCv37384,619,499 - 84,783,120 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36385,038,138 - 85,063,561 (+)NCBIMGSCv36mm8
Celera384,827,347 - 84,997,996 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map337.7NCBI
Fbxw7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82172,447,738 - 172,609,591 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2172,447,738 - 172,609,591 (+)EnsemblGRCr8
mRatBN7.22170,149,706 - 170,311,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2170,149,694 - 170,309,941 (+)EnsemblmRatBN7.2
Rnor_6.02184,230,191 - 184,309,805 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2184,231,260 - 184,309,664 (-)Ensemblrn6Rnor6.0
Rnor_5.02203,633,724 - 203,708,120 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42176,675,226 - 176,750,737 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2164,144,641 - 164,303,043 (+)NCBICelera
Cytogenetic Map2q34NCBI
Fbxw7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554716,848,101 - 6,955,881 (-)Ensembl
ChiLan1.0NW_0049554716,852,459 - 7,026,590 (-)NCBIChiLan1.0ChiLan1.0
FBXW7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23150,206,219 - 150,420,227 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14150,563,293 - 150,777,771 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04144,660,676 - 144,874,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14156,312,274 - 156,527,649 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4156,312,274 - 156,402,351 (-)EnsemblpanPan2panpan1.1
FBXW7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11550,187,579 - 50,417,188 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1550,189,240 - 50,417,195 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1550,529,850 - 50,761,421 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01550,869,433 - 51,101,086 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1550,870,969 - 50,964,288 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11550,130,239 - 50,363,954 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01550,231,872 - 50,463,188 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01550,542,860 - 50,774,097 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbxw7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530140,081,138 - 40,271,734 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366892,259,477 - 2,344,764 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366892,261,163 - 2,449,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl876,482,844 - 76,699,348 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1876,482,027 - 76,699,354 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Fbxw7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248583,775,795 - 3,873,336 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248583,778,842 - 3,974,351 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in FBXW7
2800 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000001342   ⟹   ENSCSAP00000014736
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl798,892,504 - 99,106,084 (-)Ensembl
RefSeq Acc Id: XM_007999999   ⟹   XP_007998190
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1798,894,261 - 98,985,875 (-)NCBI
Vero_WHO_p1.0NW_02366603778,541,535 - 78,756,368 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008000000   ⟹   XP_007998191
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1798,894,261 - 99,105,955 (-)NCBI
Vero_WHO_p1.0NW_02366603778,541,535 - 78,756,369 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008000001   ⟹   XP_007998192
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1798,894,261 - 98,984,987 (-)NCBI
Vero_WHO_p1.0NW_02366603778,541,091 - 78,602,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008000002   ⟹   XP_007998193
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1798,894,261 - 98,926,450 (-)NCBI
Vero_WHO_p1.0NW_02366603778,541,091 - 78,572,637 (-)NCBI
Sequence:
RefSeq Acc Id: XP_007998191   ⟸   XM_008000000
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S1J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007998190   ⟸   XM_007999999
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S1J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007998192   ⟸   XM_008000001
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007998193   ⟸   XM_008000002
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCSAP00000014736   ⟸   ENSCSAT00000001342


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003313 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001342.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103236395 UniProtKB/TrEMBL
NCBI Gene FBXW7 ENTREZGENE
PANTHER F-BOX/WD REPEAT-CONTAINING PROTEIN 7 UniProtKB/TrEMBL
  PHOSPHOLIPASE A-2-ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE FBOX UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
  SSF81383 UniProtKB/TrEMBL
UniProt A0A0D9S1J7 ENTREZGENE, UniProtKB/TrEMBL