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Gene: IQGAP3 (IQ motif containing GTPase activating protein 3) Chlorocebus sabaeus

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Symbol:

IQGAP3

Name:

IQ motif containing GTPase activating protein 3

RGD ID:

18608757

Description:

ENCODES a protein that exhibits actin filament binding (inferred); calmodulin binding (inferred); GTPase activator activity (inferred); INVOLVED IN positive regulation of protein phosphorylation (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Charcot-Marie-Tooth disease type 2 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cell cortex (inferred); cell-cell junction (inferred); cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ras GTPase-activating-like protein IQGAP3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	7,286,819 - 7,334,352 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	7,286,886 - 7,333,284 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	6,586,464 - 6,633,765 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

gastrointestinal stromal tumor (ISO)

hepatocellular carcinoma (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ERK1 and ERK2 cascade (IEA)

G1/S transition of mitotic cell cycle (IEA)

gene expression (IEA)

mammary gland epithelial cell proliferation (IEA)

mitotic actomyosin contractile ring assembly actin filament organization (IEA)

negative regulation of gene expression (IEA)

positive regulation of gene expression (IEA)

positive regulation of mammary gland epithelial cell proliferation (IEA)

positive regulation of MAPK cascade (IEA)

positive regulation of protein phosphorylation (ISO)

protein phosphorylation (ISO)

Ras protein signal transduction (IEA)

regulation of cell size (IEA)

Cellular Component

cell cortex (IEA)

cell-cell junction (IEA)

cytoplasm (IEA)

lateral plasma membrane (IEA)

plasma membrane bounded cell projection (IEA)

Molecular Function

actin filament binding (IEA)

calmodulin binding (IEA)

GTPase activator activity (IEA)

myosin VI light chain binding (IEA)

protein binding (ISO)

small GTPase binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

IQGAP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	7,286,819 - 7,334,352 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	7,286,886 - 7,333,284 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	6,586,464 - 6,633,765 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

IQGAP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	156,525,405 - 156,572,565 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	156,525,405 - 156,572,604 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	156,495,197 - 156,542,357 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	154,761,821 - 154,809,020 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	153,308,270 - 153,355,469	NCBI
Celera	1	129,568,222 - 129,613,182 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI
HuRef	1	127,855,158 - 127,900,121 (-)	NCBI		HuRef
CHM1_1	1	157,891,665 - 157,938,571 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	155,663,992 - 155,708,965 (-)	NCBI		T2T-CHM13v2.0

Iqgap3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	87,989,309 - 88,028,355 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	87,989,278 - 88,028,355 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	88,082,002 - 88,121,048 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	88,081,971 - 88,121,048 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	87,885,973 - 87,924,970 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	88,167,927 - 88,206,975 (+)	NCBI		MGSCv36	mm8
Celera	3	88,121,650 - 88,160,680 (+)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	38.78	NCBI

Iqgap3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	175,840,001 - 175,881,799 (+)	NCBI		GRCr8
mRatBN7.2	2	173,542,151 - 173,583,956 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	173,542,110 - 173,583,956 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	180,687,034 - 180,729,301 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	178,709,397 - 178,751,662 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	173,309,550 - 173,351,256 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	187,447,477 - 187,489,630 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	187,447,501 - 187,489,630 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	206,850,518 - 206,892,647 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	180,155,679 - 180,198,814 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	180,105,779 - 180,148,920 (+)	NCBI
Celera	2	167,489,087 - 167,530,440 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Iqgap3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	2,628,552 - 2,663,737 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955545	2,627,334 - 2,663,786 (-)	NCBI	ChiLan1.0	ChiLan1.0

IQGAP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	93,271,635 - 93,322,412 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	93,006,109 - 93,051,298 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	131,869,002 - 131,916,554 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	135,695,602 - 135,740,564 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	135,695,602 - 135,740,564 (-)	Ensembl	panpan1.1		panPan2

IQGAP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	41,384,539 - 41,420,529 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	41,382,994 - 41,419,742 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	40,872,320 - 40,909,618 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	41,248,244 - 41,286,318 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	41,248,319 - 41,283,331 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	41,029,802 - 41,067,862 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	41,083,049 - 41,121,112 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	41,366,730 - 41,404,794 (+)	NCBI		UU_Cfam_GSD_1.0

Iqgap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	26,681,729 - 26,721,359 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	5,713,156 - 5,751,721 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	5,712,118 - 5,751,721 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IQGAP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	93,513,187 - 93,559,001 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	93,495,999 - 93,556,915 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	102,133,942 - 102,178,070 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Iqgap3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	1,730,771 - 1,765,180 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624885	1,730,079 - 1,765,250 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in IQGAP3
1162 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007976783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007976784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007976785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037997758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037997759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037997760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000000163 ⟹ ENSCSAP00000015890

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	7,286,886 - 7,333,284 (+)	Ensembl

RefSeq Acc Id:

XM_007976783 ⟹ XP_007974974

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	7,286,819 - 7,334,352 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	6,586,464 - 6,633,765 (+)	NCBI

Sequence:

show sequence

GGTGTGAACAGGAAGTGTCCTGTCCGGCCGTGGCGACGGTGAGGGGCGGCGGCCCAACGGCGGG
AGATTCAAACCTGGAAAAAGGAGGAACATGGAGAGGAGAGCAGCGGGCCCAGGCCGGGCAGCGT
ATGAACGCCTCACAGCTGAGGAGATGGATGAGCAGAGGCGGCAGAACGTTGCCTATCAGTACCT
GTGCCGGCTGGAGGAGGCCAAGCGCTGGATGGAAGCCTGCCTGAAGGAGGAGCTTCCTTCCCCC
GTGGAGCTGGAGGAGAGCCTTCGCAATGGAGTGCTGCTGGCCAAGCTGGGCCACTGTTTTGCAC
CCTCCGTGGTTCCCTTGAAGAAGATCTATGATGTGGAGCAGCTGCGGTACCAGGCAACTGGCTT
ACATTTCCGTCACACAGACAACATCAACTTTTGGCTGTCTGCAATAGCCCACATTGGTCTGCCT
TCGACCTTTTTCCCAGAGACCACGGACATCTATGACAAAAAGAACATGCCCCGGGTAGTCTACT
GCATCCATGCTCTCAGTCTATTCCTCTTCCGGCTGGGATTGGCCCCTCAGATACATGATCTATA
CGGGAAAGTGAAATTCACAGCTGAGGAACTCAGCAACATGGCATCCGAACTGGCCAAATATGGC
CTCCAGCTGCCTACCTTCAGCAAGATCGGGGGCATCCTGGCCAATGAGCTATCGGTGGATGAGG
CTGCAGTCCATGCAGCTGTTCTTGCCATCAATGAAGCAGTGGAGCGAGGGGTGGTGGAGGACAC
CCTGGCTGCCTTGCAGAATTCCAGTGCTCTTCTGGAGAATCTCCGAGAGCCTCTGGCAGCCATC
TACCAGGAGATGCTGGCCCAGGCCAAGATGGAGAAGGCAGCCAATGCCAGGAACTATTTTTTGC
AGGATGAAAGAGAAAGCCAGGACATCTATGACCACTACCTAACTCAGGCTGAAATCCAGGGCAA
TATCAACCATGTCAACGTCCATGGGGCTCTAGAAGTTGTTGATGACGCCCTGGAAAGACAGAGC
CCTGAAGTCTTGCTCAAGGCCCTTCAAGACCCTGCCCTGGCCCTGCGAGGGGTGAGGAGAGACT
TTGCTGTCTGGTACCTGGAGCAATTGAGCTCAGACAGAGAGCAGAAGGCACAGGAGCTGGGCCT
GGTGGAGCTTCTGGAAAAGGAGGAAGTCCAGGCTGGTGTGGCTGCAGCCAACACAAAGGGTGAC
CAGGAACAAGCCATGCTCCATGCTGTGCAGCGGATCAACAAAGCCATCTGGAGGGGAGTGGCGG
CTGACACTGTGAAGGAGCTGATGTGCCCTGAGGCCCAGCTGCCTCCAGTGTACCCTGTTGCGTC
AGCTGTGTACCAGCAGGAGCTGGCAGTGCTCCAGCGGCAGCAGCAGGGGGAGCTTGGCCAGGAG
GAGCTCTTTGTGGCTGTGGAGATGCTCTCAGCTGTGGTCCTGATTAACCGGGCCCTGGAGGCCC
AGGATGCCAGTGGCTTCTGGAGCAGCCTGGTGAACCCTGCCACAGGCCTGGCAGAGGTGGAAGG
AGAAAATGCCCAGCGTTACTTCGATGCCCTGCTGAAATTGCGACAGGAGCGTGGGATGGGTGAG
GACTTCCTGAGCTGGAATGACCTGCAGGCCACCGTGAGCCAGGTCAATGCACAGGCCCAGGAAG
AGACTGACCGGGTCCTTGCAATCAGCCTCATCAATGAGGCTCTGGACAAAGACAGCCCTGAGAA
GACTCTGTCTGCCCTACTGCTTCCTGCAGCTGGCCTCGATGATATCAGCCTCCCTGTCGCCCCT
CGGTACCATCTCCTCCTTGTGGCAGCCAAAAGGCAGAAGGCCCAGGTGACAGGGGATCCTGGAG
CTGTGCTGTGGCTTGAGGAGATCCGCCAGGGAGTGGTCAGAGCCAACCAGGACACTAATACAGC
TCAGAGAATGGCTCTTGGTGTGGCCGCCATCAATCAAGCCATCAAGGAGGGCAAGGCAGCCCAG
ACTGAGCGGGTGTTGAGGAACCCCGCAGTAGCCCTTCGAGGGGTAGTTCCCAACTGTGCCAACG
GCTACCAGCGAGCCCTGGAAGGTGCCATGGCAAAGAAACAGCGTCCAGCAGACTCAGCTTTCTG
GGTTCAACATGACATGAACGATGGCACTGCCTACTACTTCCATCTGCAGACCTTCCAGGGGACC
TGGGAGCAACCCTCTGGCTGCCGCCTCCACACCTCTCACCTGACCCGGGAGGAGATCCAGTCAG
CTGTCACCAAGGTCACTGCTGCCTATGACCGCCAACAGCTCTGGAAAGCCAACACTGGCTTTGT
CGTCCAGCTCCAGGCCCGCCTCCGTGGCTTCCTAGTTCGACAGAAGTTTGCTGAGCATTCCCAC
TTTCTGAGGACCTGGCTCCCAGCAGTCATCCAGATCCAGGCTCATTGGCGGGGTTATAGGCAGC
GGAAGATTTACCTGGAGCGGTTGCGGTATTTTAAGGCAAACCTGGATGCCATAATCAAGATCCA
GGCCTGGGCCCGGATGTGGGCAACTCGGAGGCAATACCTGAGGCGTCTGCACTACTTCCAGAAG
AACGTTAAGTCCATTGTAAAGATCCAGGCATTTTTCCGAGCCAGGAAAGCCCAGGATGACTACA
GGATATTAGTGCATGCACCCCACCCTCCTCTCAGTGTGGTCCGCAGATTTGCCCATCTCTTGAA
TCAAAGCCAGCAGGACTTCTTGGCTGAGGCAGAGCTGCTGAAGCTCCAGGAAGAGGTAGTTAGG
AAGATCCGATCCAATCAGCAGCTGGAGCAGGACCTCAACATCATGGACATCAAGATTGGCCTGC
TGGTGAAGAACCGGATCACTCTGCAGGAAGTGGTCTCCCACTGCAAGAAGCTGACCAAGAGGAA
TAAGGAACAGCTGTCGGATATGATGGTTCTGGACAAGCAGAAGGGATTAAAGTCACTGAGCAAA
GAGAAACGGCAGAAACTAGAAGCATACCAACACCTCTTCTACCTGCTCCAGACTCAGCCCATCT
ACCTGGCCAAGCTGATCTTTCAGATGCCACAGAACAAAACCACCAAGTTCATGGAGGCAGTGAT
TTTCAGCCTGTACAACTATGCCTCCAGCCGCCGAGAGGCCTATCTCCTGCTCCAGCTGTTCAAG
ACAGCACTCCAGGAGGAAATCAAGTCAAAGGTGGAGCAGCCCCAGGACGTGGTGACAGGCAACC
CAACAGTGGTGAGGCTGGTGGTGAGATTCTACCGCAATGGGCGGGGACAGAGTGCCCTGCAGGA
GATTCTGGGCAAGGTTATCCAGGATGTGCTAGAGGACAAAGTGCTCAGCGTCCACACAGACCCT
GTCCACCTCTATAAGAATTGGATCAACCAGACTGAGGCCCAGACAGGGCAGCACAGCCATCTCC
CGTATGATGTCACCCCGGAGCAGGCCTTGAGCCACCCCGAGGTCCAGAGACAATTGGATATCGC
CCTACGCAACCTCCTCGCCATGACTGATAAGTTCCTTGCAGCCATTACTTCATCTGTGGACCAA
ATTCCGTACGGGATGCGATATGTGGCCAAAGTCCTGAAGGCAACTCTGGCAGAGAAATTCCCTG
ACGCCACAGACGGCGAGGTCTATAAGGTGGTCGGGAACCTCCTGTACTACCGCTTCCTGAACCC
AGCTGTGGTGGCTCCTGATGCCTTCGACATTGTGGCCATGGCAGCTGGTGGCACCCTGGCTGCC
CCCCAGCGCCATGCCCTGGGGGCTGTGGCTCAGCTCCTACAGCACGCTGCGGCTGGCAAGGCCT
TCTCTGGGCAGAGCCAGCACCTGCGGGTCCTGAATGACTATCTGGAGGAAACACACCTCAAGTT
CAGGAAGTTCATCCACAGAGCCTGCCAGGTGCCAGAGCCAGAGGAGCGTTTTGCAGTGGACGAG
TACTCAGACATGGTGGCTGTGGCCAAACCTGTGGTGTACATTACCGTGGGGGAGCTGGTCAACA
CGCACAGGCTGTTGCTGGAGCACCAGGACTGCATTGCCTCTGATCACCAAGACCCCCTGCATGA
GCTCTTGGAGGACCTTGGGGAGCTGCCCACCATCCCTGACCTTATTGGGGAGAGCATTGCTGCA
GATGGGCACACGGACCTGAGCAAGCTAGAAGTGTCCCTGACACTGACCAACAAGTTTGAAGGAC
TGGAGGCAGACACTGATGACTCCAACACCCGTAGCCTGCTTCTGAGCACCAAGCAGCTGTTGGC
CGATATCATACAGTTCCATCCCGGGGACACCCTCAAGGAGATCCTGTCCCTCTCGGCTTCCAGA
GAGCAGGAAGCAGCCCACAAGCAGCTGATGAGCCGACGCCAGGCCTGTGCAGCCCAGACACCGG
AGCCACTGCGACAACACCGCTCACTGACAGCTCACTCCCTCCTGCCACTGGCAGAGAAGCAGCG
GCGTGTCCTGCGGAACCTGCGCCAACTTGAAGCCCTGGGGTTGGTCAGCGCCAGAAATGGCTAC
CAGGGGCTAGTGGACGAGCTGGCCAAGGACATCCGCAACCAGCACAGACACAGGCACAGGCGGA
AGGCGGAGCTGGTGAAGCTGCAGGCCACATTACAGGGCCTGAGCACTAAGACCACCTTCTATGA
GGAGCAGGGTGACTACTACAGCCAGTACATCCGGGCCTGCCTGGACCACCTGGCCCCCGACTCC
AAGAGTTCTGGGAAGGGGAAGAAGCAGCCTTCTCTTCATTACACTGCTGCTCAGCTTCTGGAAA
AGGGTGTCTTGGTGGAAATTGAAGATCTTCCCGCCTCTCACTTCAGAAACGTCATCTTTGACAT
CACCCCGGGAGATGAGGCAGGAAAGTTTGAAGTAAATGCCAAGTTCCTGGGTGTGGACATGGAG
CGATTTCAGCTTCACTATCAGGACCTCCTGCAGCTCCAGTATGAGGGTGTGGCTGTCATGAAAC
TCTTCAACAAGGCCAAAGTCAATGTCAACCTTCTCATCTTCCTCCTCAACAAGAAGTTTTTGCG
GAAGTGACAGAAGCAAAGGGTGCTACCCAAGCCCCTCTTACCTTGCTGGATGCTTTCTTCACCA
CTGCGCTTCCCTGCAGACACCCAGACCTCAGGACTGGGCAAGGCCCAGGGATTCTCACCTCTTC
CCCAGCTGGGAGGAGCTTGTTTGCCTGGCCACAGACAGTGTATCTTCTAATTGGCTAAAGTGGG
CCTTGCCCAGAGTCCAGCTGTGTGGCTTTTATCATGTATGATAAACCCCTGGCTTTCCTGCCAG
ATGGTAGAACATGGACCTTGGCCTGGGAAGGCCATTATTCTTGTGTCTGCTACTGCCCTCCCAT
GGTCACCCCAATATTACAAGCACTGCCCCAGCGACTTGATTTCACCTCTGTGTTCCTTCTCTTT
GCACTCGCACAAAGCCAGGGCCAGGCTCCCCATCCCTACCTCCCACTGCATCAGCAGTGGGTGT
TCCTGCCCTGCCTGAGTCTAGGCAGCTCTGCTGCTGTGATCTGCACACCCTTCAACCCCGGGCA
GGGACTGGGGGGATACAGTGTGTGTTAGTGCCCACGTGGCATTGTGGCACTGTTGCCCCCCGTG
GCAGCATGGGCAAGTTGACCTTCCATTAGCCTCAAGTCTTGTTCTCTTGTTTGTGGTCTGTTTA
ATATGTGGGTCACTAGGGTATTTATTCTCTCTCCCATCCTTACACACCGGATCATTGTGCAGCC
TTAATCAGGGTTTTAATGCTTTCTTTTTTTTTTTTTTTTTTTTTAGCTCAAAGAGAGTTCTCAT
TTTTGCCTATTCAAACTAATATCCATGCCATGTTTTATACCTTGGATTTAAAGTCACCTTAGGT
TGGGGCAAAAGAGTCCTCACTCATGTTTAAGATCTTGTTATTTCAGCTTCATAAGATCCAAGAG
GAGTCTTTCCCTTTTCTCTTTTACCCTCAGGATTCTCATGCCTTACAGCTGACTCTTCCAGGCA
ATTTCCATAGATCTTCTGTCCTGCCTCTGCCACAGTCTCTGTTGTCCCCACATCTACCCAACTT
CCTGTACTGTTGCCCTTCTGATGTTAATAAAAGCAGCTGTTACTCCCA

hide sequence

RefSeq Acc Id:

XM_007976785 ⟹ XP_007974976

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	7,286,819 - 7,334,352 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	6,586,464 - 6,633,765 (+)	NCBI

Sequence:

show sequence

GGTGTGAACAGGAAGTGTCCTGTCCGGCCGTGGCGACGGTGAGGGGCGGCGGCCCAACGGCGGG
AGATTCAAACCTGGAAAAAGGAGGAACATGGAGAGGAGAGCAGCGGGCCCAGGCCGGGCAGCGT
ATGAACGCCTCACAGCTGAGGAGATGGATGAGCAGAGGCGGCAGAACGTTGCCTATCAGTACCT
GTGCCGGCTGGAGGAGGCCAAGCGCTGGATGGAAGCCTGCCTGAAGGAGGAGCTTCCTTCCCCC
GTGGAGCTGGAGGAGAGCCTTCGCAATGGAGTGCTGCTGGCCAAGCTGGGCCACTGTTTTGCAC
CCTCCGTGGTTCCCTTGAAGAAGATCTATGATGTGGAGCAGCTGCGGTACCAGGCAACTGGCTT
ACATTTCCGTCACACAGACAACATCAACTTTTGGCTGTCTGCAATAGCCCACATTGGTCTGCCT
TCGACCTTTTTCCCAGAGACCACGGACATCTATGACAAAAAGAACATGCCCCGGGTAGTCTACT
GCATCCATGCTCTCAGTCTATTCCTCTTCCGGCTGGGATTGGCCCCTCAGATACATGATCTATA
CGGGAAAGTGAAATTCACAGCTGAGGAACTCAGCAACATGGCATCCGAACTGGCCAAATATGGC
CTCCAGCTGCCTACCTTCAGCAAGATCGGGGGCATCCTGGCCAATGAGCTATCGGTGGATGAGG
CTGCAGTCCATGCAGCTGTTCTTGCCATCAATGAAGCAGTGGAGCGAGGGGTGGTGGAGGACAC
CCTGGCTGCCTTGCAGAATTCCAGTGCTCTTCTGGAGAATCTCCGAGAGCCTCTGGCAGCCATC
TACCAGGAGATGCTGGCCCAGGCCAAGATGGAGAAGGCAGCCAATGCCAGGAACTATGATGAAA
GAGAAAGCCAGGACATCTATGACCACTACCTAACTCAGGCTGAAATCCAGGGCAATATCAACCA
TGTCAACGTCCATGGGGCTCTAGAAGTTGTTGATGACGCCCTGGAAAGACAGAGCCCTGAAGTC
TTGCTCAAGGCCCTTCAAGACCCTGCCCTGGCCCTGCGAGGGGTGAGGAGAGACTTTGCTGTCT
GGTACCTGGAGCAATTGAGCTCAGACAGAGAGCAGAAGGCACAGGAGCTGGGCCTGGTGGAGCT
TCTGGAAAAGGAGGAAGTCCAGGCTGGTGTGGCTGCAGCCAACACAAAGGGTGACCAGGAACAA
GCCATGCTCCATGCTGTGCAGCGGATCAACAAAGCCATCTGGAGGGGAGTGGCGGCTGACACTG
TGAAGGAGCTGATGTGCCCTGAGGCCCAGCTGCCTCCAGTGTACCCTGTTGCGTCAGCTGTGTA
CCAGCAGGAGCTGGCAGTGCTCCAGCGGCAGCAGCAGGGGGAGCTTGGCCAGGAGGAGCTCTTT
GTGGCTGTGGAGATGCTCTCAGCTGTGGTCCTGATTAACCGGGCCCTGGAGGCCCAGGATGCCA
GTGGCTTCTGGAGCAGCCTGGTGAACCCTGCCACAGGCCTGGCAGAGGTGGAAGGAGAAAATGC
CCAGCGTTACTTCGATGCCCTGCTGAAATTGCGACAGGAGCGTGGGATGGGTGAGGACTTCCTG
AGCTGGAATGACCTGCAGGCCACCGTGAGCCAGGTCAATGCACAGGCCCAGGAAGAGACTGACC
GGGTCCTTGCAATCAGCCTCATCAATGAGGCTCTGGACAAAGACAGCCCTGAGAAGACTCTGTC
TGCCCTACTGCTTCCTGCAGCTGGCCTCGATGATATCAGCCTCCCTGTCGCCCCTCGGTACCAT
CTCCTCCTTGTGGCAGCCAAAAGGCAGAAGGCCCAGGTGACAGGGGATCCTGGAGCTGTGCTGT
GGCTTGAGGAGATCCGCCAGGGAGTGGTCAGAGCCAACCAGGACACTAATACAGCTCAGAGAAT
GGCTCTTGGTGTGGCCGCCATCAATCAAGCCATCAAGGAGGGCAAGGCAGCCCAGACTGAGCGG
GTGTTGAGGAACCCCGCAGTAGCCCTTCGAGGGGTAGTTCCCAACTGTGCCAACGGCTACCAGC
GAGCCCTGGAAGGTGCCATGGCAAAGAAACAGCGTCCAGCAGACTCAGCTTTCTGGGTTCAACA
TGACATGAACGATGGCACTGCCTACTACTTCCATCTGCAGACCTTCCAGGGGACCTGGGAGCAA
CCCTCTGGCTGCCGCCTCCACACCTCTCACCTGACCCGGGAGGAGATCCAGTCAGCTGTCACCA
AGGTCACTGCTGCCTATGACCGCCAACAGCTCTGGAAAGCCAACACTGGCTTTGTCGTCCAGCT
CCAGGCCCGCCTCCGTGGCTTCCTAGTTCGACAGAAGTTTGCTGAGCATTCCCACTTTCTGAGG
ACCTGGCTCCCAGCAGTCATCCAGATCCAGGCTCATTGGCGGGGTTATAGGCAGCGGAAGATTT
ACCTGGAGCGGTTGCGGTATTTTAAGGCAAACCTGGATGCCATAATCAAGATCCAGGCCTGGGC
CCGGATGTGGGCAACTCGGAGGCAATACCTGAGGCGTCTGCACTACTTCCAGAAGAACGTTAAG
TCCATTGTAAAGATCCAGGCATTTTTCCGAGCCAGGAAAGCCCAGGATGACTACAGGATATTAG
TGCATGCACCCCACCCTCCTCTCAGTGTGGTCCGCAGATTTGCCCATCTCTTGAATCAAAGCCA
GCAGGACTTCTTGGCTGAGGCAGAGCTGCTGAAGCTCCAGGAAGAGGTAGTTAGGAAGATCCGA
TCCAATCAGCAGCTGGAGCAGGACCTCAACATCATGGACATCAAGATTGGCCTGCTGGTGAAGA
ACCGGATCACTCTGCAGGAAGTGGTCTCCCACTGCAAGAAGCTGACCAAGAGGAATAAGGAACA
GCTGTCGGATATGATGGTTCTGGACAAGCAGAAGGGATTAAAGTCACTGAGCAAAGAGAAACGG
CAGAAACTAGAAGCATACCAACACCTCTTCTACCTGCTCCAGACTCAGCCCATCTACCTGGCCA
AGCTGATCTTTCAGATGCCACAGAACAAAACCACCAAGTTCATGGAGGCAGTGATTTTCAGCCT
GTACAACTATGCCTCCAGCCGCCGAGAGGCCTATCTCCTGCTCCAGCTGTTCAAGACAGCACTC
CAGGAGGAAATCAAGTCAAAGGTGGAGCAGCCCCAGGACGTGGTGACAGGCAACCCAACAGTGG
TGAGGCTGGTGGTGAGATTCTACCGCAATGGGCGGGGACAGAGTGCCCTGCAGGAGATTCTGGG
CAAGGTTATCCAGGATGTGCTAGAGGACAAAGTGCTCAGCGTCCACACAGACCCTGTCCACCTC
TATAAGAATTGGATCAACCAGACTGAGGCCCAGACAGGGCAGCACAGCCATCTCCCGTATGATG
TCACCCCGGAGCAGGCCTTGAGCCACCCCGAGGTCCAGAGACAATTGGATATCGCCCTACGCAA
CCTCCTCGCCATGACTGATAAGTTCCTTGCAGCCATTACTTCATCTGTGGACCAAATTCCGTAC
GGGATGCGATATGTGGCCAAAGTCCTGAAGGCAACTCTGGCAGAGAAATTCCCTGACGCCACAG
ACGGCGAGGTCTATAAGGTGGTCGGGAACCTCCTGTACTACCGCTTCCTGAACCCAGCTGTGGT
GGCTCCTGATGCCTTCGACATTGTGGCCATGGCAGCTGGTGGCACCCTGGCTGCCCCCCAGCGC
CATGCCCTGGGGGCTGTGGCTCAGCTCCTACAGCACGCTGCGGCTGGCAAGGCCTTCTCTGGGC
AGAGCCAGCACCTGCGGGTCCTGAATGACTATCTGGAGGAAACACACCTCAAGTTCAGGAAGTT
CATCCACAGAGCCTGCCAGGTGCCAGAGCCAGAGGAGCGTTTTGCAGTGGACGAGTACTCAGAC
ATGGTGGCTGTGGCCAAACCTGTGGTGTACATTACCGTGGGGGAGCTGGTCAACACGCACAGGC
TGTTGCTGGAGCACCAGGACTGCATTGCCTCTGATCACCAAGACCCCCTGCATGAGCTCTTGGA
GGACCTTGGGGAGCTGCCCACCATCCCTGACCTTATTGGGGAGAGCATTGCTGCAGATGGGCAC
ACGGACCTGAGCAAGCTAGAAGTGTCCCTGACACTGACCAACAAGTTTGAAGGACTGGAGGCAG
ACACTGATGACTCCAACACCCGTAGCCTGCTTCTGAGCACCAAGCAGCTGTTGGCCGATATCAT
ACAGTTCCATCCCGGGGACACCCTCAAGGAGATCCTGTCCCTCTCGGCTTCCAGAGAGCAGGAA
GCAGCCCACAAGCAGCTGATGAGCCGACGCCAGGCCTGTGCAGCCCAGACACCGGAGCCACTGC
GACAACACCGCTCACTGACAGCTCACTCCCTCCTGCCACTGGCAGAGAAGCAGCGGCGTGTCCT
GCGGAACCTGCGCCAACTTGAAGCCCTGGGGTTGGTCAGCGCCAGAAATGGCTACCAGGGGCTA
GTGGACGAGCTGGCCAAGGACATCCGCAACCAGCACAGACACAGGCACAGGCGGAAGGCGGAGC
TGGTGAAGCTGCAGGCCACATTACAGGGCCTGAGCACTAAGACCACCTTCTATGAGGAGCAGGG
TGACTACTACAGCCAGTACATCCGGGCCTGCCTGGACCACCTGGCCCCCGACTCCAAGAGTTCT
GGGAAGGGGAAGAAGCAGCCTTCTCTTCATTACACTGCTGCTCAGCTTCTGGAAAAGGGTGTCT
TGGTGGAAATTGAAGATCTTCCCGCCTCTCACTTCAGAAACGTCATCTTTGACATCACCCCGGG
AGATGAGGCAGGAAAGTTTGAAGTAAATGCCAAGTTCCTGGGTGTGGACATGGAGCGATTTCAG
CTTCACTATCAGGACCTCCTGCAGCTCCAGTATGAGGGTGTGGCTGTCATGAAACTCTTCAACA
AGGCCAAAGTCAATGTCAACCTTCTCATCTTCCTCCTCAACAAGAAGTTTTTGCGGAAGTGACA
GAAGCAAAGGGTGCTACCCAAGCCCCTCTTACCTTGCTGGATGCTTTCTTCACCACTGCGCTTC
CCTGCAGACACCCAGACCTCAGGACTGGGCAAGGCCCAGGGATTCTCACCTCTTCCCCAGCTGG
GAGGAGCTTGTTTGCCTGGCCACAGACAGTGTATCTTCTAATTGGCTAAAGTGGGCCTTGCCCA
GAGTCCAGCTGTGTGGCTTTTATCATGTATGATAAACCCCTGGCTTTCCTGCCAGATGGTAGAA
CATGGACCTTGGCCTGGGAAGGCCATTATTCTTGTGTCTGCTACTGCCCTCCCATGGTCACCCC
AATATTACAAGCACTGCCCCAGCGACTTGATTTCACCTCTGTGTTCCTTCTCTTTGCACTCGCA
CAAAGCCAGGGCCAGGCTCCCCATCCCTACCTCCCACTGCATCAGCAGTGGGTGTTCCTGCCCT
GCCTGAGTCTAGGCAGCTCTGCTGCTGTGATCTGCACACCCTTCAACCCCGGGCAGGGACTGGG
GGGATACAGTGTGTGTTAGTGCCCACGTGGCATTGTGGCACTGTTGCCCCCCGTGGCAGCATGG
GCAAGTTGACCTTCCATTAGCCTCAAGTCTTGTTCTCTTGTTTGTGGTCTGTTTAATATGTGGG
TCACTAGGGTATTTATTCTCTCTCCCATCCTTACACACCGGATCATTGTGCAGCCTTAATCAGG
GTTTTAATGCTTTCTTTTTTTTTTTTTTTTTTTTTAGCTCAAAGAGAGTTCTCATTTTTGCCTA
TTCAAACTAATATCCATGCCATGTTTTATACCTTGGATTTAAAGTCACCTTAGGTTGGGGCAAA
AGAGTCCTCACTCATGTTTAAGATCTTGTTATTTCAGCTTCATAAGATCCAAGAGGAGTCTTTC
CCTTTTCTCTTTTACCCTCAGGATTCTCATGCCTTACAGCTGACTCTTCCAGGCAATTTCCATA
GATCTTCTGTCCTGCCTCTGCCACAGTCTCTGTTGTCCCCACATCTACCCAACTTCCTGTACTG
TTGCCCTTCTGATGTTAATAAAAGCAGCTGTTACTCCCA

hide sequence

RefSeq Acc Id:

XM_037997758 ⟹ XP_037853686

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666038	6,586,464 - 6,633,765 (+)	NCBI

RefSeq Acc Id:

XM_037997759 ⟹ XP_037853687

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666038	6,586,464 - 6,633,765 (+)	NCBI

RefSeq Acc Id:

XM_037997760 ⟹ XP_037853688

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666038	6,586,464 - 6,633,765 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007974974	(Get FASTA)	NCBI Sequence Viewer
	XP_007974976	(Get FASTA)	NCBI Sequence Viewer
	XP_037853686	(Get FASTA)	NCBI Sequence Viewer
	XP_037853687	(Get FASTA)	NCBI Sequence Viewer
	XP_037853688	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015890.1

RefSeq Acc Id:	XP_007974974 ⟸ XM_007976783
- Peptide Label:	isoform X4
- UniProtKB:	A0A0D9S4V1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_007974976 ⟸ XM_007976785
- Peptide Label:	isoform X5
- UniProtKB:	A0A0D9S4V1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000015890 ⟸ ENSCSAT00000000163

RefSeq Acc Id:	XP_037853686 ⟸ XM_037997758
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9S4V1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037853687 ⟸ XM_037997759
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9S4V1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_037853688 ⟸ XM_037997760
- Peptide Label:	isoform X3
- UniProtKB:	A0A0D9S4V1 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002151	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000000163.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/TrEMBL
	1.20.5.190	UniProtKB/TrEMBL
	GTPase Activation - p120gap, domain 1	UniProtKB/TrEMBL
InterPro	CH-domain	UniProtKB/TrEMBL
	CH_dom_sf	UniProtKB/TrEMBL
	IQ_motif_EF-hand-BS	UniProtKB/TrEMBL
	RasGAP_C	UniProtKB/TrEMBL
	RasGAP_CS	UniProtKB/TrEMBL
	RasGAP_dom	UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/TrEMBL
	WW_dom	UniProtKB/TrEMBL
NCBI Gene	IQGAP3	ENTREZGENE
PANTHER	RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF	UniProtKB/TrEMBL
	RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP3	UniProtKB/TrEMBL
Pfam	PF00307	UniProtKB/TrEMBL
	PF00612	UniProtKB/TrEMBL
	RasGAP	UniProtKB/TrEMBL
	RasGAP_C	UniProtKB/TrEMBL
PROSITE	PS50021	UniProtKB/TrEMBL
	PS50096	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_1	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_2	UniProtKB/TrEMBL
	WW_DOMAIN_1	UniProtKB/TrEMBL
	WW_DOMAIN_2	UniProtKB/TrEMBL
SMART	RasGAP	UniProtKB/TrEMBL
	SM00015	UniProtKB/TrEMBL
	SM00033	UniProtKB/TrEMBL
Superfamily-SCOP	RGC domain-like	UniProtKB/TrEMBL
	SSF47576	UniProtKB/TrEMBL
	SSF48350	UniProtKB/TrEMBL
UniProt	A0A0D9S4V1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD