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Gene: PRTN3 (proteinase 3) Chlorocebus sabaeus

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Symbol:

PRTN3

Name:

proteinase 3

RGD ID:

18602541

Description:

ENCODES a protein that exhibits enzyme binding (ortholog); serine-type endopeptidase activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN cell-cell junction maintenance (ortholog); mature conventional dendritic cell differentiation (ortholog); membrane protein ectodomain proteolysis (ortholog); ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); chronic myeloid leukemia (ortholog); cyclic hematopoiesis (ortholog); FOUND IN azurophil granule lumen (ortholog); cytosol (ortholog); intracellular membrane-bounded organelle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

myeloblastin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	590,193 - 598,829 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	8,318,743 - 8,324,146 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cerebral creatine deficiency syndrome (ISO)

chronic myeloid leukemia (ISO)

cyclic hematopoiesis (ISO)

granulomatosis with polyangiitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell junction maintenance (ISO)

mature conventional dendritic cell differentiation (ISO)

membrane protein ectodomain proteolysis (ISO)

negative regulation of phagocytosis (ISO)

neutrophil extravasation (ISO)

positive regulation of GTPase activity (ISO)

proteolysis (ISO)

Cellular Component

azurophil granule lumen (ISO)

cytosol (ISO)

intracellular membrane-bounded organelle (ISO)

plasma membrane (ISO)

plasma membrane raft (ISO)

Molecular Function

enzyme binding (ISO)

protein binding (ISO)

serine-type endopeptidase activity (ISO)

signaling receptor binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PRTN3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	590,193 - 598,829 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	8,318,743 - 8,324,146 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PRTN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	840,999 - 848,175 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	840,999 - 848,175 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	840,999 - 848,175 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	791,985 - 799,175 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	791,964 - 799,051	NCBI
Celera	19	766,135 - 773,326 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	610,181 - 617,038 (+)	NCBI		HuRef
CHM1_1	19	840,583 - 847,665 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	796,963 - 804,283 (+)	NCBI		T2T-CHM13v2.0

Prtn3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	79,715,499 - 79,719,008 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	79,710,310 - 79,719,008 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	79,879,667 - 79,883,174 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	79,874,476 - 79,883,174 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	79,342,412 - 79,345,919 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,282,796 - 79,286,303 (+)	NCBI		MGSCv36	mm8
Celera	10	80,894,480 - 80,897,987 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Prtn3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,472,750 - 10,482,037 (-)	NCBI		GRCr8
mRatBN7.2	7	9,822,123 - 9,831,300 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	9,822,122 - 9,831,944 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,702,828 - 12,706,274 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,580,909 - 14,584,355 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,440,584 - 12,444,030 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,643,712 - 12,646,951 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,643,516 - 12,646,960 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	12,813,238 - 12,822,399 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,334,722 - 11,338,559 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,334,722 - 11,338,559 (-)	NCBI
Celera	7	7,997,078 - 8,000,317 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

PRTN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	5,171,167 - 5,180,414 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	4,409,659 - 4,418,867 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	283,314 - 291,504 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	810,237 - 817,588 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

PRTN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	77,520,314 - 77,523,563 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	77,520,314 - 77,526,303 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	77,472,358 - 77,477,327 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Variants

Variants in PRTN3
195 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007994532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_007994532 ⟹ XP_007992723

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	590,193 - 598,829 (+)	NCBI
Vero_WHO_p1.0	NW_023666081	8,318,743 - 8,324,146 (-)	NCBI

Sequence:

show sequence

CAGGTGTCCCCAGACCTCGCCCAGGGTCCCCTTGGGGCAGAATCACCCCTTGATTGAGAATCGT
GGCCTTAAAGGGGGAACAAAACCCCCAGACAAAAGCTGGCAGGAGGATGTCCGCTGGGGCTTCA
GGCACTGAGGGCACTCGTGGGGCCCCGCCCTCCCCAGCTCCACATCCTGTCCCCTGCACCTGTC
GGTTTCCAGCTCACCCACCCATGGGACACGGCTGTCACGGCCCGCTTTGTGGGGGCCACAGGGA
CCTCGTCAGGGAGGCATCTCCTTGTGGGTGGCACGTGGGTGTGTGTTGCGCTGAGGGCTGTGGC
CATGTTGCCCACCTGGCCAGGGACCCCCGACTTGGGTGGGTGAGAGCCAGCCTCCCCGCCCCCA
CGAAGTTCAGGACCTTGAGTCCAAAGCGCCCGCATCCTCCCTGGAGTCCATTCTGACTCCCGGG
CTCCCAAGGCAAAAGGAGGAAGTGGGGACCCAGCCTGGGCATTGGGCAACCCAACGGCCTCTGC
CATTGGGCTATAAGAGGAGCTTGACTGGGGGTGCACCCTGGACCCCACCATGGCTCCCAGCCAC
CGGCCCCCCAGCCCTGCCCTGGCGTCCGTGCTGCTGGTCTTGCTGCTGAGTGGTGCTGCCTGGG
CTGCGGAGATCGTGGGCGGACGCGAGGCGCAGCCACACTCCAGGCCCTACATGGCCTCGCTGCA
GGTGCAGAGCGACCTGGGCAGCCACTTCTGCGGGGGCACCTTGATCCACCCCAGCTTCGTGCTG
ACGGCCGCGCACTGCCTGCAGGACATCCCCCACCGCCTGGTGAACGTGGTGCTCGGAGCCCACA
ACGTGCACACGCAGGAGCCCGGCCAGCAGCACTTCTCAGTGGCGCAGGTGTTTCAGAACAACTA
CGACGCTGAGAACAAACTGAACGACGTTCTCCTCATCCAGCTAAACCGTCCGGCCAACCTCAGT
GCCTCCGTCGCCACAGTCCAGCTGCCACAGCAGGACCAGCCAGTGCCCCACGGCACCCAGTGCC
TGGCCATGGGCTGGGGACGCGTGGGCACCCACGACCCCCCAGCCCGGGTCCTGCAGGAGCTCAA
TGTCACCGTGGTCACCTTCCTGTGCCGGCCACACAACGTGTGCACTTTCGTCCCTCGCCGTAGT
GCCGGCATCTGCTTTGGAGACTCAGGTGGCCCCCTGATCTGTGACGGCGTCATCCAGGGAGTAG
ACTCCTTTGTGATCCGGGGATGTGCCACCCGCCAGTTTCCCGACTTCTTCGCACGGGTAGCCCT
CTACGTGGACTGGATCCGTTCCACGCTGCGCCGCGTGGGGGCCGAGGGCCACCCCTGAGCCGCC
CCCACCGCACTGGCCGGGACCCGAGCCCGGCTCCAAACCCTCGAGGGGGATCTTTGGACAGAAG
CAGCTCTTCTCCGAACACTGCCTCCTCCACCCGGGTCCGGGACAGCCCCACCCGTCGCCCCACA
CTGCCTCCCTCGGGTCTCCGGGAGACAGGCCGGCCCTGCACCTCTCCCCGCCGTGACCTCAATA
AACGTTGAAACTCCCCCCCGGCTCCTGTCTGTCCTTCCCACATAGGGAGCGGAGGGAGAACTGC
CCAGAGGTCCCCAGGTTTCAAGTCCCTGAGTCCCAAACTCAGGATGGGGAGAGTCGGAGCGGGG
ATGGGGGCCCAGGTCGCAGGGGGTCTCTCTCCTGGATGCTCGTGGCTGTGGGTTCTAATCCGGC
CCCATCAGAGTGGCCCTGGGCAGGTTGTTATTCATCTCCATGCCTCGGTTTCCTCATCTGGGAA
ATGGAGTCACCCCAGGCGTTTCCTAGAACTGGCGAGGAGCCCATGTGGGCCCTCAGGGCTCCAG
CTGTGTCCCTGCCGGCTCAGGGGCTCCTTGAGGAGGGGGATGGGGATGGGGGAGCACCCTGGAG
GGCTTCCTGGAGGAGGTGGCAGTGCCAGAGCTGCATACCAAGGTGTGAACAGAAACATCCTAAG
GGCCACCAGGCAGGGGGCACGGTCTGGGCAGAGGCCTGAGGATGAGAGGCCAGGGAACGGGGAG
GAGGGCAGGCAGGGGAGGGGTGTCGGTGCAGGGGAGGGGTGACGGGGTTGGAGCGCTATTTCTC
CTAGGAGGGGTAGGCAGGGGAGGAGTCCCCTGGTGGAAGCATGAGGAATGAACTGGGGGAGAGG
CCAGAGGGGCGGTCTGAGGCGGGGAAGAGGTGGGACTCACAGTCCCGCTCAGACAGATAAGTGG
CCACGAGAAGGAGGCATTAACCACGGAGAGGGGACGACCTGCTCCAGGACACACATAGCTCCTT
GCTGTCCTTTTTCTTTTTTTTCCTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACGCAGGC
TGGAGAGCAGTGGC

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Protein Sequences


Protein RefSeqs	XP_007992723	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_007992723 ⟸ XM_007994532

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	PRTN3	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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