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Gene: CD81 (CD81 molecule) Chlorocebus sabaeus

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Symbol:

CD81

Name:

CD81 molecule

RGD ID:

18586370

Description:

ENCODES a protein that exhibits cholesterol binding (inferred); integrin binding (inferred); lipid binding (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); regulation of growth (ortholog); ASSOCIATED WITH Beckwith-Wiedemann syndrome (ortholog); common variable immunodeficiency (ortholog); common variable immunodeficiency 6 (ortholog); FOUND IN apical plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

CD81 antigen

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CD81 (CD81 molecule)	NCBI	Ortholog
Mus musculus (house mouse):	Cd81 (CD81 antigen)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cd81 (Cd81 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cd81 (CD81 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CD81 (CD81 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CD81 (CD81 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cd81 (CD81 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CD81 (CD81 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cd81 (CD81 molecule)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	2,190,896 - 2,211,838 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	2,190,845 - 2,211,389 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	99,392,792 - 99,413,678 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Beckwith-Wiedemann syndrome (ISO)

common variable immunodeficiency (ISO)

common variable immunodeficiency 6 (ISO)

delta beta-thalassemia (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

hepatitis C (ISO)

long QT syndrome (ISO)

neuronal ceroid lipofuscinosis (ISO)

Segawa Syndrome, Autosomal Recessive (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA)

CD4-positive, alpha-beta T cell costimulation (IEA)

cellular response to low-density lipoprotein particle stimulus (IEA)

humoral immune response mediated by circulating immunoglobulin (IEA)

immune system process (IEA)

immunological synapse formation (IEA)

macrophage fusion (IEA)

myoblast fusion involved in skeletal muscle regeneration (IEA)

osteoclast fusion (IEA)

positive regulation of adaptive immune memory response (IEA)

positive regulation of B cell activation (IEA)

positive regulation of B cell proliferation (IEA)

positive regulation of B cell receptor signaling pathway (IEA)

positive regulation of CD4-positive, alpha-beta T cell proliferation (IEA)

positive regulation of inflammatory response to antigenic stimulus (IEA)

positive regulation of MAPK cascade (IEA)

positive regulation of protein catabolic process in the vacuole (IEA)

positive regulation of protein exit from endoplasmic reticulum (IEA)

positive regulation of receptor clustering (IEA)

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (IEA)

positive regulation of T cell receptor signaling pathway (IEA)

positive regulation of T-helper 2 cell cytokine production (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

protein localization to lysosome (IEA)

protein localization to plasma membrane (IEA)

receptor internalization (IEA)

regulation of cell motility (IEA)

regulation of cell population proliferation (ISO)

regulation of growth (ISO)

regulation of macrophage migration (IEA)

regulation of protein stability (IEA)

symbiont entry into host cell (IEA)

Cellular Component

apical plasma membrane (ISO)

basal plasma membrane (IEA)

basolateral plasma membrane (IEA)

cytosol (IEA)

extracellular exosome (IEA)

immunological synapse (IEA)

membrane (IEA)

plasma membrane (IEA)

tetraspanin-enriched microdomain (IEA)

vesicle (IEA)

Molecular Function

cholesterol binding (IEA)

integrin binding (IEA)

lipid binding (IEA)

MHC class II protein binding (IEA)

protein binding (ISO)

transferrin receptor binding (IEA)

virus receptor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CD81
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	2,190,896 - 2,211,838 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	2,190,845 - 2,211,389 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	99,392,792 - 99,413,678 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CD81
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	2,376,180 - 2,397,397 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	2,376,177 - 2,397,802 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	2,397,410 - 2,418,627 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	2,355,123 - 2,375,225 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	2,355,315 - 2,375,202	NCBI
Celera	11	2,433,431 - 2,453,456 (+)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	2,188,870 - 2,209,001 (+)	NCBI		HuRef
CHM1_1	11	2,397,498 - 2,417,522 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	2,465,548 - 2,486,747 (+)	NCBI		T2T-CHM13v2.0

Cd81
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	142,606,487 - 142,621,667 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	142,606,476 - 142,621,671 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	143,052,750 - 143,067,930 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	143,052,739 - 143,067,934 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	150,238,655 - 150,253,835 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	142,862,185 - 142,877,314 (+)	NCBI		MGSCv36	mm8
Celera	7	142,808,354 - 142,823,535 (+)	NCBI		Celera
Cytogenetic Map	7	F5	NCBI
cM Map	7	88.1	NCBI

Cd81
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	207,665,274 - 207,681,094 (+)	NCBI		GRCr8
mRatBN7.2	1	198,235,861 - 198,251,660 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	198,241,484 - 198,251,660 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	206,614,397 - 206,630,285 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	213,700,545 - 213,716,337 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	206,374,702 - 206,390,494 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	216,237,663 - 216,253,460 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	216,237,697 - 216,253,311 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	223,099,328 - 223,114,942 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	203,327,287 - 203,342,901 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	203,480,739 - 203,496,354 (+)	NCBI
Celera	1	195,804,757 - 195,820,558 (+)	NCBI		Celera
Cytogenetic Map	1	q41-q42	NCBI

Cd81
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	14,155,682 - 14,175,181 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	14,155,682 - 14,175,181 (+)	NCBI	ChiLan1.0	ChiLan1.0

CD81
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	4,780,374 - 4,806,793 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	3,992,792 - 4,018,491 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	2,400,503 - 2,421,132 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	2,442,322 - 2,449,308 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	2,437,991 - 2,449,308 (+)	Ensembl	panpan1.1		panPan2

CD81
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	46,466,484 - 46,474,236 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	46,466,499 - 46,473,868 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	45,067,559 - 45,083,899 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	47,137,460 - 47,153,838 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	46,888,521 - 47,153,823 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	46,585,393 - 46,601,749 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	46,165,925 - 46,182,254 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	46,912,742 - 46,929,121 (+)	NCBI		UU_Cfam_GSD_1.0

Cd81
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	2,718,486 - 2,727,090 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936794	664,115 - 669,800 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936794	664,089 - 670,294 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CD81
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	1,625,736 - 1,641,663 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	1,625,728 - 1,641,662 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Cd81
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	15,192,452 - 15,210,922 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	15,192,446 - 15,210,923 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CD81
454 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008007205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008007267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007814 ⟹ ENSCSAP00000005977

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	1	2,190,845 - 2,211,389 (+)	Ensembl

RefSeq Acc Id:

XM_008007267 ⟹ XP_008005458

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	1	2,190,896 - 2,211,838 (+)	NCBI
Vero_WHO_p1.0	NW_023666038	99,392,792 - 99,413,678 (+)	NCBI

Sequence:

show sequence

AGCGCGCAGCAGCGGAGATAGCGGCGACCCCACCGCGTATCTGGCCAGGCCTCCGGCGCCCCGC
GCCCCTGCGCCCCCGCACCCCCGCGCCCCGTTCTTCGCACCGAGGCCCCGAGGCCAGCCAGGCC
CCCTTGCCGGCTGCCCGCCAGGCCCCGCGCCGGCCCGCCCGCCTCCCAGGACCGGCCCGCGCCC
CGCAGGCCGCCCGCCGCCCGCGTCGCCATGGGAGTGGAGGGGTGTACCAAGTGCATCAAGTACC
TGCTCTTCGTCTTCAATTTCGTCTTCTGGCTGGCTGGAGGCGTGATCCTGGGTGTAGCCTTGTG
GCTCCGCCATGACCCGCAGACTACCAACCTCCTGTATCTGGAGCTGGGAGACAAGCCTGCACCC
AATACCTTCTACGTAGGCATCTACATCCTCATTGCCGTGGGCGCTGTGATGATGTTCGTTGGCT
TCCTGGGCTGCTACGGGGCCATCCAGGAATCCCAGTGCCTGCTGGGGACGTTCTTCACCTGTCT
GGTCATCCTGTTTGCCTGTGAAGTGGCAGCCGGCATCTGGGGCTTTGTCAACAAGGACCAGATT
GCCAAGGATGTGAAGCAGTTCTATGACCAGGCCCTACAGCAGGCTGTGGTGGATGACGACGCCA
ACAATGCCAAGGCCGTGGTGAAGACCTTCCACGAGACGCTTGACTGCTGTGGCTCCAGCACGCT
GGCCGCTCTGACCACCTCAGTGCTCAAGAACAATCTGTGTCCCTCGGGCAGCAACATCATCAGC
AACCTCCTCAAGAAAGACTGCCACCAGAAGATCGATGAGCTCTTCTCCGGGAAGCTGTACCTCA
TCGGCATTGCTGCCATCGTGGTCGCCGTGATCATGATCTTCGAGATGATCCTGAGCATGGTGCT
GTGCTGTGGCATCCGGAACAGCTCCGTGTACTGAGGCCCCGCAGCTCTGGCCGCAAGGACCTCT
GCAGTGCCCCCCTAGTGACCCGGACACTTCTGAGGGGGCCATCACCGCCTGTGTATATAACGTT
TCCGGTATTACTCTGCTACACGTAGCCTTTTTACTTTTGAGGTTTTGTTTTTGTTCTGAACTTT
CCTGTTACCTTTTCAGGGCTGACGTCACATGTAGGTGGCGTGTGTGAGTGGAGACGGGCCTGGG
CCTTGGGGACTGGAGGGCAGGGGTCCTTCTGCCCCTGGGGTCCCAGGGAGTTCTGCCTGCTCAG
CCAGGCCTCTCCTGGGAGCCACTCGCCCAGAGACTCAGCTTGGCCGACCTGGGGGGCTGTGTCC
ACCCAGCCCGCCCGTCCTGTGGGCTGCACAGCTCACCTTGTTCCCTCCTGCCCCGGTTCGAGAG
CCGAGTCTATGGGCACTCTCTGCCTTCATGCACCTGTCCTTTCTAACAGTCACCTCCAACTGTA
ATCACAACATCCTGAATCCGTCATTTAATAAAGAAGGAACGTCAGGCATGCTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008005458	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005977
	ENSCSAP00000005977.1

RefSeq Acc Id:	XP_008005458 ⟸ XM_008007267
- UniProtKB:	A0A0D9RBI8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000005977 ⟸ ENSCSAT00000007814

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009729	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007814.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1450.10	UniProtKB/TrEMBL
InterPro	Tetraspanin	UniProtKB/TrEMBL
	Tetraspanin/Peripherin	UniProtKB/TrEMBL
	Tetraspanin_CS	UniProtKB/TrEMBL
	Tetraspanin_EC2_sf	UniProtKB/TrEMBL
NCBI Gene	CD81	ENTREZGENE
PANTHER	CD81 ANTIGEN	UniProtKB/TrEMBL
	PTHR19282	UniProtKB/TrEMBL
Pfam	Tetraspanin	UniProtKB/TrEMBL
PIRSF	Tetraspanin	UniProtKB/TrEMBL
PRINTS	TMFOUR	UniProtKB/TrEMBL
PROSITE	TM4_1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48652	UniProtKB/TrEMBL
UniProt	A0A0D9RBI8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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