NELFE (negative elongation factor complex member E) - Rat Genome Database

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Gene: NELFE (negative elongation factor complex member E) Chlorocebus sabaeus
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Symbol: NELFE
Name: negative elongation factor complex member E
RGD ID: 18584419
Description: ENCODES a protein that exhibits chromatin binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); negative regulation of transcription elongation by RNA polymerase II (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH proteasome-associated autoinflammatory syndrome 1 (ortholog); trichohepatoenteric syndrome (ortholog); FOUND IN chromatin (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: negative elongation factor E
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,063,298 - 40,069,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,063,755 - 40,198,451 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,868,805 - 31,875,524 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IEA,ISO)
chromosome  (IEA)
NELF complex  (IEA)
nuclear body  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA,ISO)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NELFE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,063,298 - 40,069,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,063,755 - 40,198,451 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,868,805 - 31,875,524 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NELFE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,952,087 - 31,958,971 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,952,087 - 31,959,038 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,919,864 - 31,926,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,027,843 - 32,034,843 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,027,843 - 32,034,747NCBI
Celera633,519,627 - 33,526,530 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,706,833 - 31,713,834 (-)NCBIHuRef
CHM1_1631,921,945 - 31,928,945 (-)NCBICHM1_1
T2T-CHM13v2.0631,805,292 - 31,812,176 (-)NCBIT2T-CHM13v2.0
Nelfe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,069,367 - 35,075,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,069,367 - 35,075,348 (+)EnsemblGRCm39 Ensembl
GRCm381734,850,391 - 34,856,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,850,391 - 34,856,372 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,987,336 - 34,993,317 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,458,975 - 34,464,214 (+)NCBIMGSCv36mm8
Celera1737,945,699 - 37,951,680 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.4NCBI
Nelfe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,981,259 - 3,987,016 (-)NCBIGRCr8
mRatBN7.2203,976,512 - 3,982,389 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,976,518 - 3,982,355 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,676,633 - 4,682,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,038,381 - 4,044,131 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,575,547 - 4,581,290 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,530,328 - 4,536,085 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,530,342 - 4,536,209 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,610,127 - 6,615,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,077,925 - 4,081,561 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,078,021 - 4,081,787 (-)NCBI
Celera204,048,306 - 4,054,061 (+)NCBICelera
Cytogenetic Map20p12NCBI
Nelfe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437466,690 - 473,084 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437467,018 - 473,084 (-)NCBIChiLan1.0ChiLan1.0
NELFE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,428,781 - 46,435,590 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,390,268 - 42,397,077 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,612,924 - 31,619,732 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,499,538 - 32,506,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,499,540 - 32,506,382 (-)Ensemblpanpan1.1panPan2
NELFE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,406,411 - 1,412,387 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,406,271 - 1,412,324 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,541,468 - 1,547,598 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,548,568 - 1,554,700 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,548,568 - 1,554,605 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,405,843 - 1,411,974 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,474,213 - 1,480,345 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,539,542 - 1,546,943 (-)NCBIUU_Cfam_GSD_1.0
Nelfe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,965,333 - 35,971,346 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,589,942 - 1,598,182 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,589,942 - 1,596,009 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELFE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,040,525 - 24,047,025 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,040,525 - 24,046,932 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,765,281 - 27,771,676 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Nelfe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,300,602 - 24,310,671 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,300,012 - 24,310,777 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NELFE
97 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000007028   ⟹   ENSCSAP00000005214
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1740,063,755 - 40,198,451 (+)Ensembl
RefSeq Acc Id: XM_007973053   ⟹   XP_007971244
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11740,063,298 - 40,069,714 (+)NCBI
Vero_WHO_p1.0NW_02366604431,868,805 - 31,875,524 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007973054   ⟹   XP_007971245
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11740,063,323 - 40,069,714 (+)NCBI
Vero_WHO_p1.0NW_02366604431,868,805 - 31,875,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007973055   ⟹   XP_007971246
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11740,063,298 - 40,069,714 (+)NCBI
Vero_WHO_p1.0NW_02366604431,868,805 - 31,875,478 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007971244 (Get FASTA)   NCBI Sequence Viewer  
  XP_007971245 (Get FASTA)   NCBI Sequence Viewer  
  XP_007971246 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005214.1
RefSeq Acc Id: XP_007971244   ⟸   XM_007973053
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R9C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007971246   ⟸   XM_007973055
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R9C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007971245   ⟸   XM_007973054
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R9C5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000005214   ⟸   ENSCSAT00000007028


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007028.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro NELFE UniProtKB/TrEMBL
  NELFE_RRM UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
NCBI Gene NELFE ENTREZGENE
PANTHER NEGATIVE ELONGATION FACTOR E UniProtKB/TrEMBL
  PTHR17250 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A0D9R9C5 ENTREZGENE, UniProtKB/TrEMBL