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Gene: SLC25A4 (solute carrier family 25 member 4) Chlorocebus sabaeus

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Symbol:

SLC25A4

Name:

solute carrier family 25 member 4

RGD ID:

18573922

Description:

ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); heart development (ortholog); liver development (ortholog); PARTICIPATES IN electron transport chain pathway; ASSOCIATED WITH alcoholic cardiomyopathy (ortholog); Alzheimer's disease (ortholog); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (ortholog); FOUND IN membrane raft (ortholog); mitochondrial inner membrane (ortholog); mitochondrial outer membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ADP/ATP translocase 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	131,102,077 - 131,106,076 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	111,362,070 - 111,369,325 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcoholic cardiomyopathy (ISO)

Alzheimer's disease (ISO)

autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (ISO)

Cachexia (ISO)

Cardiomegaly (ISO)

chronic progressive external ophthalmoplegia (ISO)

Diabetic Cardiomyopathies (ISO)

dilated cardiomyopathy (ISO)

dilated cardiomyopathy 1H (ISO)

Experimental Liver Cirrhosis (ISO)

facioscapulohumeral muscular dystrophy (ISO)

genetic disease (ISO)

Herpes Simplex Encephalitis 1 (ISO)

hypertrophic cardiomyopathy (ISO)

Left Ventricular Hypertrophy (ISO)

mitochondrial DNA depletion syndrome 12a (ISO)

mitochondrial DNA depletion syndrome 12b (ISO)

mitochondrial metabolism disease (ISO)

mitochondrial myopathy (ISO)

Myocardial Reperfusion Injury (ISO)

myopia (ISO)

restrictive cardiomyopathy (ISO)

sensorineural hearing loss (ISO)

Sudden Cardiac Death (ISO)

Vertigo (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive thermogenesis (IEA)

ADP transport (IEA)

apoptotic mitochondrial changes (IEA,ISO)

heart development (ISO)

liver development (ISO)

mitochondrial ADP transmembrane transport (IEA)

mitochondrial ATP transmembrane transport (IEA)

negative regulation of cardiac muscle cell apoptotic process (ISO)

negative regulation of mitochondrial membrane permeability involved in apoptotic process (ISO)

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (IEA)

negative regulation of necroptotic process (IEA)

positive regulation of cell growth involved in cardiac muscle cell development (ISO)

positive regulation of mitophagy (IEA)

positive regulation of oxidative phosphorylation uncoupler activity (ISO)

proton transmembrane transport (IEA)

regulation of mitochondrial membrane permeability (IEA)

response to interleukin-1 (ISO)

Cellular Component

membrane (IEA)

membrane raft (ISO)

mitochondrial inner membrane (IEA,ISO)

mitochondrial outer membrane (ISO)

mitochondrial permeability transition pore complex (IEA)

mitochondrion (IEA)

Molecular Function

antiporter activity (IEA)

ATP:ADP antiporter activity (IEA)

enzyme binding (ISO)

oxidative phosphorylation uncoupler activity (IEA)

protein binding (ISO)

proton transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

electron transport chain pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SLC25A4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	131,102,077 - 131,106,076 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	111,362,070 - 111,369,325 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

SLC25A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	185,143,266 - 185,150,382 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	185,143,266 - 185,150,382 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	186,064,420 - 186,071,536 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	186,301,392 - 186,305,419 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	186,439,546 - 186,443,573	NCBI
Celera	4	183,391,334 - 183,398,454 (+)	NCBI		Celera
Cytogenetic Map	4	q35.1	NCBI
HuRef	4	181,818,234 - 181,825,547 (+)	NCBI		HuRef
CHM1_1	4	186,040,918 - 186,048,039 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	188,486,951 - 188,494,056 (+)	NCBI		T2T-CHM13v2.0

Slc25a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	46,660,205 - 46,664,099 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	46,659,834 - 46,664,321 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	46,207,168 - 46,211,062 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	46,206,797 - 46,211,284 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	47,292,693 - 47,296,363 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	47,705,502 - 47,710,101 (-)	NCBI		MGSCv36	mm8
MGSCv36	8	45,369,594 - 45,374,194 (-)	NCBI		MGSCv36	mm8
Celera	8	48,888,832 - 48,892,502 (-)	NCBI		Celera
Cytogenetic Map	8	B1.1	NCBI
cM Map	8	26.22	NCBI

Slc25a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	52,805,521 - 52,809,316 (+)	NCBI		GRCr8
mRatBN7.2	16	46,072,935 - 46,076,730 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	46,072,939 - 46,076,733 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	51,474,917 - 51,478,712 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	54,843,795 - 54,847,590 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	50,114,293 - 50,118,088 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	49,266,903 - 49,270,698 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	49,266,903 - 49,270,698 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	48,981,600 - 48,985,395 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	49,353,476 - 49,357,271 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	49,353,550 - 49,357,346 (+)	NCBI
Celera	16	44,072,219 - 44,076,014 (+)	NCBI		Celera
Cytogenetic Map	16	q11	NCBI

Slc25a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	23,878,329 - 23,882,322 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	23,878,329 - 23,882,322 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC25A4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	182,882,901 - 182,886,952 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	183,231,201 - 183,235,234 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	177,310,982 - 177,315,016 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	189,531,914 - 189,534,549 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	189,531,914 - 189,534,549 (+)	Ensembl	panpan1.1		panPan2

SLC25A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	45,454,660 - 45,458,606 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	45,411,810 - 45,542,162 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	45,942,189 - 45,946,135 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	47,671,404 - 47,675,349 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	47,671,405 - 47,675,335 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	45,638,494 - 45,642,440 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	46,251,541 - 46,255,470 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	46,383,474 - 46,387,417 (-)	NCBI		UU_Cfam_GSD_1.0

Slc25a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	33,974,957 - 33,979,529 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936554	4,130,459 - 4,135,044 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936554	4,130,461 - 4,135,046 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC25A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	46,193,746 - 46,200,987 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	46,193,498 - 46,197,989 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	52,922,472 - 52,926,762 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Slc25a4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624769	15,989,547 - 15,997,680 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624769	15,989,527 - 15,993,609 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SLC25A4
64 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008000418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037994268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008000418 ⟹ XP_007998609

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	7	131,102,077 - 131,106,076 (+)	NCBI
Vero_WHO_p1.0	NW_023666037	111,362,070 - 111,366,114 (+)	NCBI

Sequence:

show sequence

GAGGCGGCGGCCCCTTCGCGTCGCGCAGGGTGGGGGACTGCGCGGCGGTGCCAGGCCGGGCGTG
GGCGAGAGCGCGAGCGGGCTGCCTGCGGGCTGAGTGCGTCGAGCTGTCACCATGGGTGATCACG
CTTGGAGCTTCCTAAAGGACTTCCTGGCCGGTGGCGTCGCCGCTGCCGTCTCCAAGACCGCGGT
CGCCCCCATCGAGAGGGTCAAACTGCTGCTGCAGGTCCAGCATGCCAGCAAACAGATCAGTGCT
GAGAAGCAGTACAAAGGGATCATTGATTGTGTGGTGAGAATCCCCAAGGAGCAGGGCTTTCTCT
CCTTCTGGAGGGGTAACCTGGCCAACGTGATCCGTTACTTCCCCACCCAAGCTCTCAACTTCGC
CTTCAAGGACAAGTACAAGCAGCTCTTCTTAGGGGGTGTGGATCGGCATAAGCAGTTCTGGCGC
TACTTTGCTGGTAACCTGGCATCTGGTGGGGCCGCTGGGGCCACCTCCCTTTGCTTTGTCTACC
CGCTGGACTTTGCTAGGACCAGGCTGGCTGCCGACGTGGGCAAGGGTGCTGCCCAGCGTGAGTT
CCATGGTCTGGGCGACTGTATCATCAAGATCTTCAAGTCTGATGGCCTGAGGGGTCTCTACCAA
GGTTTCAACGTCTCTGTCCAAGGCATCATTATCTACAGAGCTGCCTACTTCGGAGTCTATGATA
CTGCCAAGGGGATGCTGCCTGACCCCAAGAACGTGCACATTTTTGTGAGCTGGATGATTGCCCA
GAGTGTGACGGCAGTCGCAGGGCTGGTGTCCTACCCCTTCGACACTGTTCGTCGTAGGATGATG
ATGCAGTCCGGCCGGAAAGGGGCTGATATTATGTACACGGGGACAGTTGACTGCTGGAGGAAGA
TTGCAAAAGATGAAGGAGCCAAGGCCTTCTTCAAAGGTGCCTGGTCCAATGTGTTGAGAGGCAT
GGGCGGCGCTTTTGTATTGGTGTTGTATGATGAGATCAAAAAGTATGTCTAATGTAATTAAAAC
ACAAGTTCACTGATTTACAGTGACCTTGATCCACAAGTTCACAGATCCATTGTGTGGTTTAATA
GACTATTCCTAGGGGAAGTAAAAAGATCTGGGATAAAACCAGACTGAAAGGAATACCTCAGAAA
AGATGCTTCATTGAGTGTTCATTAAACCACAGATGTATTTTGTATTTATTTTACATTTAAATTC
CCACAGCAAATAGAAAATAATTTATCATACTTGTACAATTAACTGAAGTGATAGGAAATAACTG
AATGTGAAACATAAATAAAGACCACTTAATGCA

hide sequence

RefSeq Acc Id:

XM_037994268 ⟹ XP_037850196

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666037	111,362,070 - 111,369,325 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007998609	(Get FASTA)	NCBI Sequence Viewer
	XP_037850196	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015059.1

RefSeq Acc Id:	XP_007998609 ⟸ XM_008000418
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037850196 ⟸ XM_037994268
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9S2H0 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002980	UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000001008.1	UniProtKB/TrEMBL
Gene3D-CATH	Mitochondrial carrier domain	UniProtKB/TrEMBL
InterPro	ADT_euk_type	UniProtKB/TrEMBL
	Mit_carrier	UniProtKB/TrEMBL
	Mitochondrial_sb/sol_carrier	UniProtKB/TrEMBL
	Mt_carrier_dom_sf	UniProtKB/TrEMBL
NCBI Gene	SLC25A4	ENTREZGENE
PANTHER	ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED	UniProtKB/TrEMBL
	ADP/ATP TRANSLOCASE 1	UniProtKB/TrEMBL
Pfam	Mito_carr	UniProtKB/TrEMBL
PRINTS	ADPTRNSLCASE	UniProtKB/TrEMBL
	MITOCARRIER	UniProtKB/TrEMBL
PROSITE	SOLCAR	UniProtKB/TrEMBL
Superfamily-SCOP	Mitochondrial carrier	UniProtKB/TrEMBL
UniProt	A0A0D9S2H0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Annotations - SMPDB