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Gene: IQGAP1 (IQ motif containing GTPase activating protein 1) Chlorocebus sabaeus

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Symbol:

IQGAP1

Name:

IQ motif containing GTPase activating protein 1

RGD ID:

18571043

Description:

ENCODES a protein that exhibits mitogen-activated protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN positive regulation of dendrite development (ortholog); positive regulation of focal adhesion assembly (ortholog); positive regulation of MAP kinase activity (ortholog); PARTICIPATES IN E-cadherin signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); Brain Neoplasms (ortholog); colorectal cancer (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); growth cone (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC103231193; LOC103231194; ras GTPase-activating-like protein IQGAP1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	9,363,273 - 9,485,644 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	9,362,926 - 9,485,526 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	37,209,223 - 37,324,055 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

Brain Neoplasms (ISO)

colorectal cancer (ISO)

D-2-hydroxyglutaric aciduria 2 (ISO)

Experimental Liver Cirrhosis (ISO)

hepatocellular carcinoma (ISO)

Neointima (ISO)

Vascular System Injuries (ISO)

Weight Gain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

caveola assembly (IEA)

cell migration (IEA)

cellular response to calcium ion (IEA)

cellular response to epidermal growth factor stimulus (IEA)

cellular response to fibroblast growth factor stimulus (IEA)

cellular response to platelet-derived growth factor stimulus (IEA)

epidermal growth factor receptor signaling pathway (IEA)

fibroblast growth factor receptor signaling pathway (IEA)

fibroblast migration (IEA)

MAPK cascade (IEA)

mitotic actomyosin contractile ring assembly actin filament organization (IEA)

negative regulation of dephosphorylation (IEA)

neuron projection extension (IEA)

platelet-derived growth factor receptor signaling pathway (IEA)

positive regulation of dendrite development (ISO)

positive regulation of focal adhesion assembly (ISO)

positive regulation of MAP kinase activity (ISO)

positive regulation of MAPK cascade (IEA)

positive regulation of peptidyl-tyrosine autophosphorylation (ISO)

positive regulation of protein kinase activity (ISO)

positive regulation of protein localization (ISO)

positive regulation of vascular associated smooth muscle cell migration (ISO)

regulation of cytokine production (IEA)

regulation of mitotic cell cycle (IEA)

regulation of postsynapse assembly (ISO)

response to angiotensin (ISO)

Cellular Component

actin cytoskeleton (ISO)

apical plasma membrane (IEA)

axon (ISO)

basolateral plasma membrane (IEA)

cell cortex (IEA)

cell leading edge (IEA)

cell-cell junction (IEA)

cortical actin cytoskeleton (IEA)

cytoplasm (IEA)

cytoplasmic ribonucleoprotein granule (IEA)

cytoplasmic side of plasma membrane (IEA)

focal adhesion (IEA)

growth cone (ISO)

lateral plasma membrane (IEA)

microtubule (IEA)

microtubule cytoskeleton (ISO)

midbody (IEA)

neuron projection (IEA)

nucleus (IEA)

plasma membrane (IEA)

plasma membrane bounded cell projection (IEA)

postsynapse (ISO)

protein-containing complex (ISO)

ribonucleoprotein complex (IEA)

ruffle (IEA)

Molecular Function

actin filament binding (IEA)

calcium ion binding (IEA)

calmodulin binding (IEA)

GTPase activator activity (IEA)

MAP-kinase scaffold activity (IEA)

mitogen-activated protein kinase binding (ISO)

molecular adaptor activity (IEA)

phosphatidylinositol-3,4,5-trisphosphate binding (IEA)

protein binding (ISO)

protein domain specific binding (IEA)

protein kinase binding (IEA)

protein phosphatase binding (IEA)

protein serine/threonine kinase activator activity (IEA)

protein-containing complex binding (ISO)

S100 protein binding (IEA)

small GTPase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

E-cadherin signaling pathway (ISO)

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

Rho/Rac/Cdc42 mediated signaling pathway (ISO)

vascular endothelial growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

IQGAP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	9,363,273 - 9,485,644 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	9,362,926 - 9,485,526 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	37,209,223 - 37,324,055 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

IQGAP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	90,388,242 - 90,502,239 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	90,388,242 - 90,502,239 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	90,931,474 - 91,045,471 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	88,732,477 - 88,846,479 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	88,732,476 - 88,846,479	NCBI
Celera	15	67,336,216 - 67,450,214 (+)	NCBI		Celera
Cytogenetic Map	15	q26.1	NCBI
HuRef	15	67,043,721 - 67,156,752 (+)	NCBI		HuRef
CHM1_1	15	90,773,219 - 90,887,196 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	88,144,255 - 88,258,256 (+)	NCBI		T2T-CHM13v2.0

Iqgap1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	80,361,331 - 80,453,288 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	80,361,331 - 80,475,722 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	80,711,583 - 80,815,549 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	80,711,583 - 80,825,974 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	87,856,469 - 87,948,217 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	80,586,294 - 80,676,807 (-)	NCBI		MGSCv36	mm8
Celera	7	78,116,162 - 78,211,858 (-)	NCBI		Celera
Cytogenetic Map	7	D3	NCBI
cM Map	7	45.68	NCBI

Iqgap1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	144,088,788 - 144,178,989 (-)	NCBI		GRCr8
mRatBN7.2	1	134,679,581 - 134,769,776 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	134,679,586 - 134,769,755 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	142,588,968 - 142,679,115 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	149,758,382 - 149,848,532 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	142,676,568 - 142,767,383 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	142,525,041 - 142,615,673 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	142,525,046 - 142,615,673 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	143,476,882 - 143,567,395 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	136,552,358 - 136,642,545 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	136,631,848 - 136,722,691 (-)	NCBI
Celera	1	126,734,261 - 126,824,269 (-)	NCBI		Celera
Cytogenetic Map	1	q31	NCBI

Iqgap1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	14,560,292 - 14,650,036 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	14,558,628 - 14,652,031 (+)	NCBI	ChiLan1.0	ChiLan1.0

IQGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	79,935,362 - 80,049,434 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	83,634,820 - 83,748,904 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	69,076,025 - 69,190,082 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	88,276,762 - 88,390,721 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	88,276,851 - 88,388,594 (+)	Ensembl	panpan1.1		panPan2

IQGAP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	53,683,869 - 53,791,136 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	53,683,791 - 53,792,186 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	56,321,230 - 56,429,279 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	54,099,750 - 54,207,801 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	54,098,495 - 54,207,760 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	53,618,792 - 53,726,768 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	53,830,202 - 53,938,180 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	54,170,507 - 54,278,357 (-)	NCBI		UU_Cfam_GSD_1.0

Iqgap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	129,739,918 - 129,845,387 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	16,489,133 - 16,594,783 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	16,489,127 - 16,594,712 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Iqgap1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	17,702,728 - 17,799,022 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624768	17,703,113 - 17,797,922 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in IQGAP1
2802 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007990469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JBLKOC010000029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000015118 ⟹ ENSCSAP00000013068

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	29	9,362,926 - 9,485,526 (-)	Ensembl

RefSeq Acc Id:

XM_007990469 ⟹ XP_007988660

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	29	9,363,273 - 9,485,644 (-)	NCBI
Vero_WHO_p1.0	NW_023666059	37,209,223 - 37,324,055 (+)	NCBI

Sequence:

show sequence

CATGGGCGGGGCCTCGGGGACCCGGGCAAGCCCGCGCACTTGGCAGGAGCTGCAGCTGCCGCTG
TCCGCGCCTCCAAGGTTTCACGGTTTCTTCAGCTGAGACCTGGGCTCGGCCGCCATGTCCGCCG
CAGACGAGGTTGACGGGCTAGGCGTGGCCCGGCCGCACTATGGCTCTGTCCTGGATAATGAAAG
ACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCAT
TTGGAAGAAGCAAAGAGGTGGATGGAAGCATGCCTAGGGGAAGATCTGCCTCCCACCACAGAAC
TGGAGGAGGGGCTTAGGAATGGGGTCTACCTTGCCAAACTGGGGAACTTCTTCTCTCCCAAAGT
AGTGTCCCTGAAAAAAATCTATGATCGAGAACAGACCAGATACAAGGCGACTGGCCTCCACTTT
AGACACACTGATAATGTGATTCAGTGGTTGAATGCCATGGATGAGATTGGATTGCCTAAGATTT
TTTACCCAGAAACTACGGATATATATGATCGAAAGAACATGCCAAGATGTATCTACTGTATCCA
TGCACTCAGTTTGTACCTGTTCAAGCTAGGCCTGGCCCCTCAGATTCAAGACCTATATGGAAAG
GTTGACTTCACAGAAGAAGAAATCAACAACATGAAGACTGAGTTGGAGAAGTATGGCATCCAAA
TGCCTGCATTTAGCAAGATTGGGGGCATCCTGGCTAATGAACTGTCAGTGGATGAAGCCGCATT
ACATGCTGCTGTTATTGCTATTAATGAAGCTATTGACCATAGAATTCCAGCCGACACATTTGCA
GCTTTGAAAAATCCCAATGCCATGCTTGTAAATCTTGAAGAGCCCTTGGCATCCACTTACCAGG
ATGTACTTTACCAGGCTAAGCAGGACAAAATGACAAATGCTAAAAACAGGACAGAAAACTCAGA
GAGAGAAAGAGATGTTTATGAGGAGCTGCTCACGCAAGCTGAAATTCAAGGCAATGTAAACAAA
GTCAATACATTTTCTGCATTAGCAAACATTGACCTGGCTTTAGAACAAGGAGATGCACTGGCCT
TGTTCAAGGCTCTACAGTCACCAGCCCTGGGTCTTCGAGGACTGCAGCAGCAGAATAGTGACTG
GTACTTGAAGCAGCTCCTGAGTGATAAACAGCAGAAGAGACAGAGTGGTCAGACTGACCCGCTG
CAGAAGGAGGAGCTGCAGTCTGGAGTGGATGCTGCAAACAGTGCTGCCCAGCAATATCAGAGAA
GATTGGCAGCGGTAGCAGTGATTAATGCTGCAATCCAGAAGGGTGTTGCTGAGAAGACTGTTTT
GGAACTGATAAATCCCGAAGCCCAGCTGCCCCAGGTGTATCCATTTGCCGCCGATCTCTATCAG
AAGGAGCTGGCTACCCTGCAGCGACAGAGTCCTGAACATAATCTCACCCACCCAGAGCTCTCTG
TTGCAGTGGAGATGTTGTCATCGGTGGCCCTGATCAACAGGGCATTGGAATCAGGAGATGTGAA
TACAGTGTGGAAGCAGTTGAGCAGTTCAGTTACGGGCCTTACCAATATTGAGGAAGAAAACTGT
CAGAGGTATCTCGATGAGTTGATGAAACTGAAGGCTCAGGCACATGCAGAGAATAATGAATTCA
TTACCTGGAATGATATCCAAGCTTGCGTGGACCATGTGAACCTGGTGGTGCAAGAGGAACATGA
GAGGATTTTAGCCATTGGTTTAATTAATGAAGCCCTGGATGAAGGTGATGCCCAAAAGACTCTG
CAGGCCCTACAGATTCCTGCAGCTAAACTTGAGGGAGTCCTTGCAGAAGTGGCCCAGCATTACC
AAGACACGCTGATTAGAGCGAAGAGAGAGAAAGCCCAGGAAATCCAGGATGAGTCAGCTGTGTT
ATGGTTGGATGAAATTCAAGGTGGAATCTGGCAGTCCAACAAAGACACCCAAGAAGCACAGAAG
TTTGCTTTAGGAATCTTTGCCATTAATGAGGCAGTAGAAAGTGGTGATGTTGGCAAAACACTGA
GTGCCCTTCGTTCCCCTGATGTTGGCTTATATGGAGTCATCCCTGAATGTGGTGAAACTTACCA
GAGTGACCTTGCTGAAGCCAAGAAGAAAAAACTGGCAGTAGGAGATAATAACAGCAAGTGGGTG
AAGCACTGGGTAAAAGGTGGATATTATTATTACCACAATCTGGAGACCCAGGAAGGAGGATGGG
ACGAACCCCCAAATTTTGTGCAAAATTCTATGCAGCTTTCTCGGGAGGAGATCCAGAGTTCTAT
CTCTGGGGTGACTGCTGCATATAACCGAGAACAGCTGTGGCTGGCTAACGAAGGCCTGATCACC
AGGCTGCAGGCTCGGTGCCGTGGATACTTAGTTCGACAGGAATTCCGATCCAGGATGAATTTCC
TAAAGAAGCAAATCCCTGCCATCACCTGCATTCAGTCGCAATGGAGAGGGTACAAGCAGAAGAA
GGCATATCAAGATCGGTTAGCTTACCTGCGTTCCCACAAAGACGAAGTTGTAAAGATTCAGTCC
CTGGCAAGGATGCACCAGGCTAGAAAGCGCTATCGAGATCGCCTGCAGTACTTCCGGGACCATA
TAAATGACATTATCAAAATCCAGGCTTTTATTCGGGCAAACAAAGCTCGGGATGACTACAAGAC
TCTCATCAATGCTGAGGATCCTCCTATGATTGTGGTCCGAAAATTTGTCCACCTGCTGGACCAA
AGTGACCAGGATTTTCAGGAGGAGCTTGACCTTATGAAGATGCGGGAAGAGGTTATCACCCTCA
TTCGTTCTAACCAGCAGCTGGAGAATGACCTCAATCTCATGGATATCAAAATTGGACTGCTAGT
GAAAAATAAGATTACATTGCAGGATGTGGTTTCCCACAGTAAAAAACTTACCAAAAAAAATAAG
GAACAGTTGTCTGATATGATGATGATAAATAAACAAAAGGGAGGTCTCAAGGCTTTGAGCAAGG
AGAAGAGAGAGAAGTTGGAAGCTTACCAGCACCTGTTTTATTTATTGCAAACCAATCCCACCTA
TCTGGCCAAGCTAATTTTTCAGATGCCCCAGAACAAGTCCACCAAGTTCATGGACTCTGTAATC
TTCACACTCTACAACTACGCATCCAACCAGCGAGAAGAGTACCTGCTCCTGCGGCTCTTTAAGA
CAGCGCTTCAAGAGGAAATCAAGTCAAAGGTAGATCAGATTCAAGAGATTGTCACAGGAAATCC
TACGGTTATTAAAATGGTTGTAAGTTTCAACCGTGGTGCCCGTGGCCAGAATGCCCTGAGACAG
ATCTTGGCCCCAGTCGTGAAGGAAATTATGGATGACAAATCTCTCAACATCAAAACTGACCCTG
TGGATATTTACAAATCTTGGGTTAATCAGATGGAGTCTCAGACAGGAGAGGCAAGCAAACTGCC
CTATGATGTGACCCCTGAGCAGGCTCTAGCTCATGAAGAAGTGAAGACACGGCTAGACAGCTCC
ATCAGGAACATGCGGGCTGTGACAGACAAGTTTCTCTCAGCCATTGTCAGCTCTGTGGACAAAA
TCCCTTATGGGATGCGCTTCATTGCCAAAGTGCTGAAGGACTCGTTGCATGAGAAGTTCCCTGA
TGCTGGTGAGGATGAGCTGCTGAAGATTATTGGTAACTTGCTTTATTATCGATACATGAATCCA
GCCATTGTTGCTCCTGATGCCTTTGACATCATTGACCTGTCGGCAGGAGGCCAGCTTACCACAG
ACCAACGCCGAAATCTGGGCTCCATTGCAAAAATGCTTCAGCATGCTGCTTCTAATAAGATGTT
TCTGGGAGATAATGCCCACTTAAGCATCATTAATGAATATCTTTCCCAGTCCTACCAGAAATTC
AGACGGTTTTTCCAAACTGCTTGTGATGTCCCAGAGCTTCAGGATAAATTTAATGTGGATGAAT
ACTCTGATTTAGTAACCCTCACCAAACCAGTAATCTACATTTCCATTGGTGAAATCATCAACAC
CCACACTCTCCTGTTGGATCACCAGGATGCCATTGCTCCGGAGCACAATGATCCAATCCACGAG
CTGCTAGACGACCTCGGCGAGGTGCCCACCATCGAGTCCCTGATAGGGGAAAGCTCTGGCAATT
TAAATGACCCAAATAAGGAGGCACTGGCTAAGACAGAAGTGTCTCTCACCCTGACCAACAAGTT
CGATGTGCCTGGAGATGAGAATGCAGAAATGGATGCTCGAACCATCTTACTGAATACAAAACGT
TTAATTGTGGATGTCATACGGTTCCAGCCAGGAGAGACCTTGACTGAAATCCTGGAAACACCAG
CCACCAGTGAACAGGAAGCAGAGCATCAGAGAGCCATGCAGAGACGTGCTATCCGTGATGCCAA
AACCCCTGACAAGATGAAAAAGTCAAAATCTGTAAAGGAAGACAGCAACCTCACTCTTCAAGAG
AAGAAAGAGAAGATCCAGACAGGTTTAAAGAAGCTAACAGAGCTTGGAACCGTGGACCCAAAGA
ACAAATACCAGGAACTGATCAACGACATTGCCAGGGATATTCGGAATCAGCGGAGGTACCGACA
GAGGAGAAAGGCTGAACTAGTGAAACTGCAACAGACATACGCTGCTCTAAATTCTAAGGCCACC
TTTTATGGGGAGCAGGTGGATTACTATAAAAGCTATATCAAAACCTGCTTGGATAACTTAGCCA
GCAAGGGCAAAGTCTCCAAAAAGCCTAGGGAAATGAAAGGAAAGAAAAGCAAAAAGATTTCTCT
GAAATATACAGCAGCAAGACTACATGAAAAAGGAGTTCTTCTGGAAATTGAGGACCTGCAAGTG
AATCAGTTTAAAAATGTTATCTTTGAAATCAGTCCAACAGAAGAAGTTGGAGACTTTGAAGTGA
AAGCCAAATTCATGGGAGTTCAAATGGAGACTTTTATGTTACATTATCAGGACCTGCTGCAGCT
ACAATATGAAGGAGTTGCAGTCATGAAATTATTTGATAGAGCTAAAGTAAATGTCAACCTCCTG
ATCTTCCTTCTCAACAAAAAGTTCTACGGGAAGTAATTGATCATTTGCTGCCAGCCCAGAAAGA
TAAAGGAAAGAAGCACCTCACAGCTCCTTTCTAGGTCCTTCTTGACTCATTGGAAGCAAAGACC
TAGCCCACAACAGCGCCTCAGTCTGATACACTCCCGATGCCACATTTTTAACTCCTCTCGCTCT
GATGGGACATTTGTTACCCTTTTTTCATAGTGAAATTGTGTTTCAGGCTTAGTCTGACCTTTCT
GGATTCTTCATTTTCTTCCATTACTTAGGAAAGGGTGGAAACTCCACTAAAATTTCTCTGTTGC
TACAGTCTTAGAGGTTGCATTACTATATTGTAAGCTTTGGTGTTTGTTTTAATTACCAATAGGG
ATGGTAGGATTCAAATTTTTGTCATTTAGAAGTGGAAGCCATTAGCACCAGTGACATACATACA
GGATGCACAACTAAAATGTCATGTTATTAACAGTTATTAGGTTGTCATTTAAAAGTAAAGTTCC
TTTATATTTCTGTCCCATCAGGAAGATTGAAGGATATGGGGAATCATTGGTTATCTTCCATTGT
GTTTTTCTTTATGGACAGGAGCTAATGGAAGTGATGGTTGTATGTTCAAAGGAAGCATTTCTAG
AAAAAAGGAGATACTGTTTTTAAATTTCATCATCAAACTTGGGCAGTTCTGTTTGTGTAACTCC
CCGACTAGTGGATGGGAGAGTCCCATTGATAAAATTCAGCTACTTAGATAAATTTGGAATGGGT
TGAGTCATCTGCCTGTTTATGTTGGTGCACAGAGATTGACTTGATTCAAAGAGACAATTCACTC
CATCCCTATGGCAGAGGAATGGGTTAGCCCTAGTGTAGAATGTCATTGTTTTTAAAACTGTTTT
ATATCTTAAGAGTGCCTTATTAAAGTATAGATGTATGTCTTAAAAATGTGGGTGATAGGAATTT
TAAAGATATATATAATGCATCAAAAGCCTCAGAATGAGAAAAGGTTTTTTAAAATGGTTTATCT
GTATATCTGAACTCTTGAAACTTATAGCTAAAACACTAGGATTTATCTGCAGTGTTGCAGAGAT
AATTCTGCCTTAAATTGTCTAAAACATAAAACCAGCCAACCTATGTTACACATGAGATTAAAAC
CAATTTTTCTCCCATTTTTTCTCCTTTTTTCTTTTGCTGCCCACATTGTGCCTTTATTTTATGA
GCCCCAGTTTTCTGGGCTTAGTTTTTTAAAAAAATCAAGTCTAAACATTGAATTTAGGAAGCTT
TTGTTCTTAGATAAAAAGTCATATACTTTTAAAAAAAAAAACAAAAACTTTTTCCAGGAAAATA
TATTGAAATCATGCTGCTGAGCCTCTATTTTCTTTGATGTTTTGGTTCGGTATTCTTTTATAAA
TTTTTAGCATTTAAAATTCAGTGATGTATATTAAGCCAATAAACTGCTTTAATGAATAACAAAC
TATGTGGTGTGTCCCTATTACAAATGCATTTGGAGAAGTATTTTTACGGGACTCTACTCAGGTC
CATGGTTACAGCCCACAGGGAGGCGTGGAGTGCCTGGAAGGATTCGCCACTACCCAGACCTTGT
TTTTTGTTGTATTTTGGAAGACAGGTTTTTTAAATAAACATTTTCCTCAGATTAAAAGATAATG
CTGTTAACAACTAGCATTGCCTCAAAAACTGGGGCCAGCCAAAGTGTGTCAGCCCTATTTCCTT
AAAAGAGGCTGTCAATCCCAAAGGCCACATCCAAGACAGGCAGTCATGAGCAGAGTTTAGAGCG
CCTATAATAAAATGCGGCAGTTACTTTTAAGGACTATAGCTCCCTCAACATGACTGCTAATGCA
GAATAGTGTAAAATGCACTTCAAGAATGTTGATGATGATGATGATACAGAATTGTGGCTTTAGT
AGCATAGAAGATGCCCCAACAAACTCATGGTGTTGAAACCACGCGGTTCTCATTACTGTTACTT
ATTAGCTGTAGCATTCTCTGTCTCCTCTCTCTCCTCCTTTGACCTTCTCCTCAACCAGCCATCA
TGACATTTACCATGAATTTACTTCCTCCCAAGAGTTTGGACTGCCCATCAGATTGTTGCTGCAC
ACAGTTGCCTTTGTATCTCTGTATGAAATTAAAGGTCATTTGTTCA

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Protein Sequences


Protein RefSeqs	XP_007988660	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013068.1

RefSeq Acc Id:	XP_007988660 ⟸ XM_007990469
- UniProtKB:	A0A0D9RWS9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000013068 ⟸ ENSCSAT00000015118

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017030	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015118.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/TrEMBL
	1.20.5.190	UniProtKB/TrEMBL
	2.20.70.10	UniProtKB/TrEMBL
	GTPase Activation - p120gap, domain 1	UniProtKB/TrEMBL
	Myosin, subunit A	UniProtKB/TrEMBL
InterPro	CH-domain	UniProtKB/TrEMBL
	CH_dom_sf	UniProtKB/TrEMBL
	IQ_motif_EF-hand-BS	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RasGAP_C	UniProtKB/TrEMBL
	RasGAP_CS	UniProtKB/TrEMBL
	RasGAP_dom	UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/TrEMBL
	WW_dom	UniProtKB/TrEMBL
KEGG Report	csab:103231194	UniProtKB/TrEMBL
NCBI Gene	LOC103231194	ENTREZGENE
PANTHER	RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF	UniProtKB/TrEMBL
	RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1	UniProtKB/TrEMBL
Pfam	PF00307	UniProtKB/TrEMBL
	PF00612	UniProtKB/TrEMBL
	RasGAP	UniProtKB/TrEMBL
	RasGAP_C	UniProtKB/TrEMBL
PROSITE	PS50021	UniProtKB/TrEMBL
	PS50096	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_1	UniProtKB/TrEMBL
	RAS_GTPASE_ACTIV_2	UniProtKB/TrEMBL
	WW_DOMAIN_1	UniProtKB/TrEMBL
	WW_DOMAIN_2	UniProtKB/TrEMBL
SMART	RasGAP	UniProtKB/TrEMBL
	SM00015	UniProtKB/TrEMBL
	SM00033	UniProtKB/TrEMBL
	SM00456	UniProtKB/TrEMBL
Superfamily-SCOP	RGC domain-like	UniProtKB/TrEMBL
	SSF47576	UniProtKB/TrEMBL
	SSF48350	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0D9RWS9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	IQGAP1	IQ motif containing GTPase activating protein 1	LOC103231194	ras GTPase-activating-like protein IQGAP1	Symbol and/or name change	5135510	APPROVED
2020-12-03	LOC103231194	ras GTPase-activating-like protein IQGAP1	LOC103231193	ras GTPase-activating-like protein IQGAP1	Data merged from RGD:18569334	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)