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Gene: NELFB (negative elongation factor complex member B) Chlorocebus sabaeus

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Symbol:

NELFB

Name:

negative elongation factor complex member B

RGD ID:

18568913

Description:

INVOLVED IN cell population proliferation (ortholog); negative regulation of stem cell differentiation (ortholog); negative regulation of transcription elongation by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); developmental and epileptic encephalopathy 14 (ortholog); FOUND IN cytoplasm (ortholog); NELF complex (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

negative elongation factor B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	914,384 - 933,921 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666058	4,373,307 - 4,392,656 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell population proliferation (ISO)

negative regulation of stem cell differentiation (ISO)

negative regulation of transcription elongation by RNA polymerase II (ISO)

stem cell differentiation (ISO)

Cellular Component

cytoplasm (ISO)

NELF complex (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription elongation pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NELFB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	914,384 - 933,921 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666058	4,373,307 - 4,392,656 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

NELFB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	137,255,327 - 137,273,542 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	137,255,327 - 137,273,542 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	140,149,779 - 140,167,994 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	139,269,768 - 139,287,815 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	110,665,618 - 110,683,794 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,609,072 - 109,627,292 (+)	NCBI		HuRef
CHM1_1	9	140,298,493 - 140,316,577 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,492,996 - 149,511,192 (+)	NCBI		T2T-CHM13v2.0

Nelfb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,089,724 - 25,101,501 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,089,724 - 25,101,501 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,199,712 - 25,211,489 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,199,712 - 25,211,489 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,055,232 - 25,067,009 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,021,726 - 25,033,390 (-)	NCBI		MGSCv36	mm8
Celera	2	24,927,483 - 24,939,264 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.06	NCBI

Nelfb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,409,045 - 28,425,564 (-)	NCBI		GRCr8
mRatBN7.2	3	8,010,883 - 8,027,403 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,010,888 - 8,027,403 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,115,610 - 11,132,086 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,701,839 - 19,718,315 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,891,682 - 17,908,158 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,414,448 - 2,431,148 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,414,451 - 2,431,148 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,395,734 - 2,412,431 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,360,222 - 3,376,609 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,360,218 - 3,376,563 (-)	NCBI
Celera	3	2,837,727 - 2,854,117 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

Nelfb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,248,190 - 5,262,044 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	5,248,190 - 5,261,018 (+)	NCBI	ChiLan1.0	ChiLan1.0

NELFB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,126,248 - 2,144,680 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,128,581 - 2,147,028 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	108,314,535 - 108,333,050 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	137,283,264 - 137,301,751 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,278,964 - 137,301,751 (+)	Ensembl	panpan1.1		panPan2

NELFB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,411,725 - 48,425,044 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,408,005 - 48,423,308 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,598,208 - 47,608,900 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,273,065 - 49,283,756 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,206,548 - 49,287,069 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,049,494 - 48,060,162 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,348,232 - 48,358,986 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,395,161 - 48,405,870 (-)	NCBI		UU_Cfam_GSD_1.0

Nelfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,636,347 - 202,648,327 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	726,658 - 738,848 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	726,731 - 738,714 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NELFB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	1	314,117,252 - 314,125,940 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Nelfb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	692,735 - 705,328 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	692,735 - 703,571 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in NELFB
593 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008005483	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008005483 ⟹ XP_008003674

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	914,384 - 933,921 (-)	NCBI
Vero_WHO_p1.0	NW_023666058	4,373,307 - 4,392,656 (+)	NCBI

Sequence:

show sequence

CCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCAGCCGGTGCTCTCTTCTCTAGGGCG
GCAGCCTGCGACTCACCCTGAGCTCCAGCCTGGAGCGAGATGGGAGGTGGGCTCTGTGGGACAC
CCTCACCCAGCCGTGCCACTTAGGGGCCTGGTCCAGTTGCTGTCCACCTGAGGGTCAGTCGCTT
GCCAAGCCAGGGAACTTGGAAGGCGGTGCCAAATGCCCTGAGCCGCCACCTCCAGGTGGGGTCG
GCCTGGCCAGGCCTCAGGAAGGGCCCAGGGACCCCGCTCACCAGGGCGCAGCCCCACTTCCCCT
AGGCCTTGAGCTGAAGACCCAGCTGGGCTTAGTCACCTGTGCCCTGAAAACTCTGGCCCAGGGC
CCTGCAGACTCCTGTGGCACTGCCAGCAGACTCCCAGGGCCTTCACCTGCCGGGTCCCTGCACT
GCCCCTGCCTGCAGCTTCGCCTGGCTGGGGCTTCCCTTGTTACCACTGGCCTGCCTTCCTACCC
AGGGTTGGGCCCCAAGGCTGCCACCTTGCAGGAGGCTTACCTGCAGTGCCGTCACCTGTACCTC
CCCAAGTCCTTCCCAGACCCAGGACACAGACCAGGCCCAGAGCTCAACCCCTTCAAAAAGGCTC
TGGGCAGCCGCTCCTGTGGCCTCAGCACCATCCCCTTTTGCAGAGAGGAATCCAAGGCCCCAGG
ACTGTGTGTGTGCTGTGCCCCTTGCCCTCCTCTGCCACCGAACCAGCTGGGGGTTGGATGAAGG
CACGGGAACCTTCGCCCTTGGGGTGACCAACTTGGCCAGCAGCAAGAGAGCTGTGCTAGCCCTG
GCCTTGGGAGCTTGGCCCCGCTTGTGGGAACAGGAGCTCTGCTCATGGCTGCACCACCAGGCAC
CCCTGGTGAGACACAAAGCTAGGAGTGGGAGCGGCAGGAAGGATGCAACGATCTCCTCCAGCTG
GGCTGAGGAGGGAGGGCTTCCTGGAGGAGGTGGAGGAAGGAGCCTTTAAGGAAGAGCAAGAGTT
TGTTGGGCAGAGGGAAAAGAAATTTCTAGAGAAAAACTCGGCAGGGAAGACCGAAAAGAGAGAG
GGTGTGTGTGGGGTGCTTGGCGCGGCACTGCCTGCGGGAGGGCGGCGGGCTGGAGAGGCGGGGA
GGCCCGCCTGCGATAAGAAGGGACACTGCGGAACCTGGACTCTCCCTCACGGCTCCGCGGAGCT
CGGTGGGCGCCACAACCTCCCGGTGCCGGGGAGGGCGGCTGTCGCCCGCGCTCCCGCTGCGGGC
CCGGTCTCCGCCAGGCCCCGGCCCCCTGAAGGCGCTCAGACCTCAGTCTTGGCGACAGCGCTGG
GGTGGGCTTCGTGCCCGTTTCACGCGGAGGAAGCCACGCTCAGGAGGGAGGGAGTCTGCGCCCG
TGTCCTGCACCTGCGGAGCGGAGGGGCGGGGAGCTCAACCCCTGGCAAAACGTCCCCGCGGCGC
GTGGCTGCCGCGAGATCAACAAGAGCGTTTTCCATGCTTCTGTACACGAAATTCACTCGGCTGA
CATGACGTCAGTTCAGACCGATCAGCAGATCAGTTCAGCAGATCAGACCGACCCCGCGTCCGCC
CCTCACGCTCCCACCCGCCCTCTTCTGCCAGAAACCCCGGGAGCGGGCGGGAGCGGGCGGGACC
GGGCGGGCGCGACCGGGCGGGCGCATGCGCACTGGGCTGGCTGGGCGGGGTCTCTCGCGCCGGG
AGAGGGAGCTGCTCCCAGGAACCTGCGCGCGGCTCCGGCGGCGTTTCCCGGGGGCCGGTTGGCG
GGCGGACCCGGGCGGTGCGGGGCGGAAGTGGGCGGCTGCGGGACGCGCGCGGAGCCGCGCGGCG
GGCGGGACTTGGCCGAGCTGGAGGGCGTCGGGGAGCGGGGCTCGGGCGGCCCCCGAGGCCCGGC
GGAGCGGGCTTCTGGGGTGTCTGCGGCGGCGCCGGGGGAGCGGGCTGGGGATGGGGCGCCTAGC
CGGGCGGCGGCCGGGGCCTCGGCCATGTTCGCGGGGCTGCAGGACCTGGGCGTGGCCAACGGCG
AGGACCTGAAGGAGACCCTGACCAACTGCACGGAGCCGCTCAAGGCCATCGAGCAGTTCCAGAC
AGAGAATGGCGTGCTGCTGCCCTCTCTTCAGTCGGCTCTCCCCTTCTTGGACCTGCACGGGACG
CCGCGGCTGGAGTTCCACCAGTCGGTGTTCGATGAGCTGCGGGACAAGCTGCTGGAGCGAGTGT
CAGCCATCGCTTCGGAGGGGAAGGCTGAGGAAAGGTACAAGAAGTTGGAAGACCTTCTGGAGAA
GAGCTTTTCTCTGGTCAAGATGCCGTCCCTGCAGCCCGTGGTGATGTGCGTCATGAAGCACCTG
CCCAAGGTTCCTGAGAAAAAGCTGAAGCTAGTAATGGCTGACAAGGAGCTGTATCGAGCCTGCG
CCGTGGAGGTGAAGCGGCAGATCTGGCAAGACAACCAGGCTCTCTTTGGGGATGAGGTTTCCCC
GTTGCTGAAGCAGTACATCCTGGAGAAGGAGAGCGCGCTCTTCAGCACAGAGCTCTCTGTTCTG
CACAACTTCTTCAGCCCTTCCCCCAAGACCAGGCGCCAGGGCGAGGTGGTGCAGCGGCTGACGC
AGATGGTGGGGAAGAACGTGAAGCTGTACGACATGGTGCTGCAGTTTCTGCGTACGCTCTTCCT
GCGCACGCGGAATGTGCACTACTGCACGCTGCGGGCTGAGCTGCTCATGTCCCTGCATGACCTG
GACGTGGGTGAGATCTGCACCGTGGACCCGTGCCACAAGTTCACCTGGTGCCTGGACGCCTGCA
TCCGAGAGCGGTTCGTGGACAGCAAGAGGGCGCGGGAGCTGCAGGGGTTTCTCGATGGAGTCAA
GAAGGGCCAGGAGCAGGTGCTGGGGGACCTGTCCATGATCCTGTGTGACCCCTTCGCCATCAAC
ACCCTGGCCCTGAGCACAGTCAGGCACCTGCAGGAGCTGGTCGGCCAGGAGACACTGCCCAGGG
ACAGCCCCGACCTGCTGCTGCTGCTCCGGCTGCTGGCACTGGGCCAGGGAGCCTGGGACATGAT
TGACAGCCAGGTCTTCAAGGAGCCCAAGATGGAGGTAGAGCTCATCACCAGGTTCCTCCCGATG
CTCATGTCCTTCCTCGTGGATGACTACACTTTCAATGTGGATCAGAAACTTCCGGCCGAGGAGA
AAGCCCCAGTCTCATATCCAAACACACTTCCCGAAAGCTTCACTAAGTTTTTGCAGGAGCAGCG
CATGGCCTGCGAGGTGGGGCTGTACTACGTCCTGCATATCACCAAGCAGAGGAACAAGAATGCG
CTCCTCCGCCTGCTGCCGGGGCTGGTGGAGACCTTTGGCGACTTGGCCTTTGGTGACATCTTCC
TCCACCTGCTCACGGGCAGCCTTGCGCTGCTGGCCGACGAATTTGCCCTTGAGGACTTCTGCAG
CAGCCTCTTCGACGGCTTCTTCCTCACTGCCTCTCCGAGGAAGGAGAACGTGCACCGGCACGCG
CTGCGGCTTCTCATTCACCTGCACCCCAGGGTGGCCCCATCTAAGCTGGAGGCCTTGCAGAAGG
CCCTGGAGCCCACAGGCCAGAGTGGAGAGGCAGTGAAGGAGCTTTACTCCCAGCTCGGCGAGAA
GCTGGAACAACTGGACCACCGGAAGCCCAGCCCAGCGCAGGCTGTGGAGACGCCGGCCCTGGAG
CTGCCCCTCCCCAGCGTGCCCGCCCCTGCCCCACTCTGAGGGTCCTCCAGGCCTGCTCGGGTTC
CGGGGCCCTGCTGAGTCGCGGCCCTGCTCAGCCAGAAGGGGCTCCCGGACCTGGGTATACAGGG
CAGTCCCTCCTCCCGGGGCTGTGGCTGGGCCTGTCCTGGGGTCATGGCCCCCTGCTTCCTGCTC
CTTGGAGCAGGCTCCCGGACCTTGTCCGCCATCCACGCAGTGGCTCCGAGGGCACAGCCTCTCC
TTGTACTTTCACAGCCACAGAAAGTGTGCTCATTTTCCGTTTTCCTGGGTTAGGAAAACACTAC
CTGTTTTCCAAGGGGAGAGGGTGGGGCCTCTTCATTGGCTCAGCCTGGCAAAAGTGAGGCACAC
TGCTATTGTCTTGGGGTTGTGGAGATGGACCCGTGACCCCGTGGAGGCCGTGTGGGGGCAGCAG
CCTGGCCTCTGCCATGGTGGGTGTCCTGGGGCCTGTGTGGAGGGAGCCACCTCATCCTGCAGCC
CAAGTCACAGGTGTGGCCAGAACAAGCCCAGGTGCACCTGTGGCCTTGTTTCACCCTTGGAACC
AGCACTCCTCGCCCAGCAGCGCCGCCTTCAGCGGCCGTGACGAGGCCAGCTGGACACATGGTGA
GATTTTCTCGTATGTAAATAAAAGGCGTTTTGGTAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008003674	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_008003674 ⟸ XM_008005483

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	NELFB	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations