TNNC1 (troponin C1, slow skeletal and cardiac type) - Rat Genome Database

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Gene: TNNC1 (troponin C1, slow skeletal and cardiac type) Chlorocebus sabaeus
Analyze
Symbol: TNNC1
Name: troponin C1, slow skeletal and cardiac type
RGD ID: 18551784
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cardiac muscle contraction (ortholog); diaphragm contraction (ortholog); regulation of ATP-dependent activity (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH cardiomyopathy (ortholog); congenital disorder of glycosylation In (ortholog); dilated cardiomyopathy (ortholog); FOUND IN contractile muscle fiber (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: troponin C, slow skeletal and cardiac muscles
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,816,603 - 13,819,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,816,222 - 13,819,518 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041153,080,316 - 153,083,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNNC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,816,603 - 13,819,572 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,816,222 - 13,819,518 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041153,080,316 - 153,083,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TNNC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,451,100 - 52,454,041 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,451,100 - 52,454,041 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,485,116 - 52,488,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,460,158 - 52,463,098 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,460,157 - 52,463,098NCBI
Celera352,464,352 - 52,467,302 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,547,765 - 52,550,715 (-)NCBIHuRef
CHM1_1352,437,484 - 52,440,434 (-)NCBICHM1_1
T2T-CHM13v2.0352,484,001 - 52,486,942 (-)NCBIT2T-CHM13v2.0
Tnnc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,930,274 - 30,933,671 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,930,269 - 30,933,686 (+)EnsemblGRCm39 Ensembl
GRCm381431,208,312 - 31,211,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,208,312 - 31,211,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv371432,021,498 - 32,024,897 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,037,321 - 30,040,720 (+)NCBIMGSCv36mm8
Celera1427,466,935 - 27,470,320 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Tnnc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,408,607 - 6,412,070 (+)NCBIGRCr8
mRatBN7.2166,400,801 - 6,405,634 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,402,171 - 6,405,634 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,414,415 - 6,417,445 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,559,640 - 7,562,670 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,421,423 - 6,424,453 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,292,207 - 7,295,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,292,096 - 7,295,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,220,777 - 7,223,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,639,357 - 6,642,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,639,312 - 6,642,502 (+)NCBI
Celera168,783,769 - 8,786,737 (-)NCBICelera
Cytogenetic Map16p16NCBI
Tnnc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,434,874 - 2,441,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,438,644 - 2,441,596 (-)NCBIChiLan1.0ChiLan1.0
TNNC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,446,169 - 52,449,158 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,450,941 - 52,453,930 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,393,106 - 52,396,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,621,749 - 53,624,726 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,621,749 - 53,624,726 (-)Ensemblpanpan1.1panPan2
TNNC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,313,983 - 37,317,288 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,311,966 - 37,317,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,295,437 - 37,298,748 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,664,003 - 37,667,314 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,664,083 - 37,667,311 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,027,955 - 37,031,266 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,436,607 - 37,439,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,721,202 - 37,724,515 (+)NCBIUU_Cfam_GSD_1.0
Tnnc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,152,389 - 170,155,387 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,290,913 - 3,294,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,290,961 - 3,293,920 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,591,386 - 34,594,337 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,591,571 - 34,594,320 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,805,313 - 37,808,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Tnnc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,764,742 - 4,770,293 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,763,285 - 4,767,810 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TNNC1
62 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007984497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000011515   ⟹   ENSCSAP00000009582
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2213,816,222 - 13,819,518 (-)Ensembl
RefSeq Acc Id: XM_007984497   ⟹   XP_007982688
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12213,816,603 - 13,819,572 (-)NCBI
Vero_WHO_p1.0NW_023666041153,080,316 - 153,083,290 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007982688 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009582
  ENSCSAP00000009582.1
RefSeq Acc Id: XP_007982688   ⟸   XM_007984497
- UniProtKB: A0A0D9RLU3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000009582   ⟸   ENSCSAT00000011515


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013426 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011515.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro Ca-Reg_Muscle_Contr_Cell_Proc UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
KEGG Report csab:103227734 UniProtKB/TrEMBL
NCBI Gene TNNC1 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN 1, 3 UniProtKB/TrEMBL
  TROPONIN C1, SLOW SKELETAL AND CARDIAC TYPE UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A0D9RLU3 ENTREZGENE, UniProtKB/TrEMBL