LOC103226928 (aldo-keto reductase family 1 member B1)

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Gene: LOC103226928 (aldo-keto reductase family 1 member B1) Chlorocebus sabaeus

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Symbol:

LOC103226928 (Ensembl: AKR1B1)

Name:

aldo-keto reductase family 1 member B1 (Ensembl:aldo-keto reductase family 1 member B)

RGD ID:

18535521

Description:

ENCODES a protein that exhibits cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity (ortholog); L-glucuronate reductase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); cellular response to methylglyoxal (ortholog); cellular response to peptide (ortholog); PARTICIPATES IN D-glycericacidemia pathway; dopa responsive dystonia pathway; familial lipoprotein lipase deficiency pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); Albuminuria (ortholog); allergic disease (ortholog); FOUND IN cytosol (ortholog); extracellular space (ortholog); mast cell granule (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

AKR1B1; aldo-keto reductase family 1 member B; aldose reductase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	103,060,018 - 103,076,844 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	103,059,991 - 103,077,341 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	271,394 - 288,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

Albuminuria (ISO)

allergic disease (ISO)

arteriosclerosis (ISO)

cataract (ISO)

Diabetes Complications (ISO)

Diabetic Nephropathies (ISO)

diabetic neuropathy (ISO)

diabetic retinopathy (ISO)

Endometrial Neoplasms (ISO)

endometriosis (ISO)

Endotoxin-Induced Uveitis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

galactosemia (ISO)

hepatocellular carcinoma (ISO)

Hyperalgesia (ISO)

hyperglycemia (ISO)

hypokalemia (ISO)

Inflammation (ISO)

Myocardial Ischemia (ISO)

nephrogenic diabetes insipidus (ISO)

pleomorphic xanthoastrocytoma (ISO)

stomach cancer (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular hyperosmotic salinity response (IEA)

cellular response to hydrogen peroxide (ISO)

cellular response to methylglyoxal (ISO)

cellular response to peptide (ISO)

daunorubicin metabolic process (IEA)

doxorubicin metabolic process (IEA)

epithelial cell maturation (ISO)

fructose biosynthetic process (ISO)

inner medullary collecting duct development (ISO)

L-ascorbic acid biosynthetic process (ISO)

lipid metabolic process (IEA)

maternal process involved in female pregnancy (ISO)

metanephric collecting duct development (ISO)

monosaccharide metabolic process (ISO)

negative regulation of apoptotic process (ISO)

norepinephrine metabolic process (ISO)

positive regulation of receptor signaling pathway via JAK-STAT (ISO)

positive regulation of smooth muscle cell proliferation (ISO)

regulation of urine volume (ISO)

renal water homeostasis (ISO)

response to thyroid hormone (ISO)

retinoid metabolic process (IEA)

sorbitol biosynthetic process (ISO)

stress-activated protein kinase signaling cascade (ISO)

tissue homeostasis (ISO)

Cellular Component

cytosol (IEA,ISO)

extracellular space (ISO)

mast cell granule (ISO)

mitochondrion (ISO)

nucleoplasm (IEA)

paranodal junction (ISO)

perinuclear region of cytoplasm (ISO)

plasma membrane bounded cell projection cytoplasm (ISO)

Schmidt-Lanterman incisure (ISO)

Schwann cell microvillus (ISO)

Molecular Function

aldose reductase (NADPH) activity (IEA)

cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity (ISO)

glyceraldehyde oxidoreductase activity (IEA)

L-glucuronate reductase activity (ISO)

oxidoreductase activity (IEA)

protein binding (ISO)

retinal dehydrogenase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

LOC103226928
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	103,060,018 - 103,076,844 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	103,059,991 - 103,077,341 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	271,394 - 288,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

AKR1B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	134,442,350 - 134,459,239 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	134,442,356 - 134,459,284 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	134,127,102 - 134,143,991 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	133,777,647 - 133,794,428 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	133,584,361 - 133,601,143	NCBI
Celera	7	128,864,507 - 128,881,287 (-)	NCBI		Celera
Cytogenetic Map	7	q33	NCBI
HuRef	7	128,428,754 - 128,445,534 (-)	NCBI		HuRef
CHM1_1	7	134,061,391 - 134,078,169 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	135,750,388 - 135,767,276 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	133,471,421 - 133,488,201 (-)	NCBI

Akr1b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	34,280,865 - 34,294,424 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	34,279,369 - 34,294,413 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	34,303,930 - 34,317,489 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	34,302,434 - 34,317,478 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	34,253,930 - 34,267,489 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	34,234,092 - 34,247,629 (-)	NCBI		MGSCv36	mm8
Celera	6	34,300,847 - 34,314,402 (-)	NCBI		Celera
Cytogenetic Map	6	B1	NCBI
cM Map	6	14.87	NCBI

Akr1b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	63,899,222 - 63,913,315 (-)	NCBI		GRCr8
mRatBN7.2	4	62,932,033 - 62,946,126 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	62,932,031 - 62,946,157 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	67,882,584 - 67,896,684 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	63,798,307 - 63,812,409 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	62,200,710 - 62,214,808 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	61,706,866 - 61,720,959 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	61,706,864 - 61,720,956 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	61,426,190 - 61,440,279 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	61,645,438 - 61,659,530 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	61,921,567 - 61,935,660 (-)	NCBI
Celera	4	57,984,561 - 57,998,653 (-)	NCBI		Celera
RH 3.4 Map	4	393.32	RGD
Cytogenetic Map	4	q22	NCBI

AKR1B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	171,258,419 - 171,275,280 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	23,268,674 - 23,285,469 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	126,400,861 - 126,417,756 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	138,907,448 - 138,924,317 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	138,912,953 - 138,924,095 (-)	Ensembl	panpan1.1		panPan2

AKR1B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	2,991,888 - 3,006,941 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	2,991,888 - 3,006,940 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	2,649,050 - 2,664,066 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	2,721,426 - 2,736,482 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	2,721,426 - 2,736,481 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	2,926,088 - 2,941,099 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	2,670,903 - 2,685,919 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	2,816,445 - 2,831,531 (+)	NCBI		UU_Cfam_GSD_1.0

Akr1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	21,179,563 - 21,195,800 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936579	1,312,175 - 1,328,397 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AKR1B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	14,684,036 - 14,752,310 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	14,593,516 - 14,752,316 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	15,596,806 - 15,614,673 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007982975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007436 ⟹ ENSCSAP00000005614

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	21	103,059,991 - 103,077,341 (-)	Ensembl

RefSeq Acc Id:

XM_007982975 ⟹ XP_007981166

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	21	103,060,018 - 103,076,844 (-)	NCBI
Vero_WHO_p1.0	NW_023666042	271,394 - 288,078 (+)	NCBI

Sequence:

show sequence

ATGGGATGCCTGTTATTTTCGCTAAAGCATTCGCTTTCACACGAAATACAGCAGCTGAGGAACT
CTTCTCTGCCACGCGGGACGGGGGCTAGCGATGGGGGCGGAAAGAATTCGTTGCCACTAGGACC
TGGCGGAAAAAGCATCCCTGGCGGAAGAAGCATCCCCGCCGACCCCTGGGGTAGGCGGCCGCGG
CACCTCCGACGCAACCAATCAGAAGGGTCCTTCGCGCAGCGGCGCGCCAACCGCAGGCGCCCTT
TCTGCCGGCCTCACGGGCTATTTAAAGATACGGGCCGCGGCCACGACCGCACCGTTTTGGGCGG
GGGTCTGGGGAGCGCAGCAGCCATGGCCAGCCACCTCGTGCTCAACAACGGCGCCAAAATGCCT
ATCCTGGGGCTGGGCACCTGGAAGTCCCCTCCAGGGCAGGTGACTGAGGCCGTGAAGGTGGCCA
TTGACGTCGGGTACCGCCACATCGACTGTGCCCATGTGTACCAGAATGAGAATGAGGTGGGGGT
GGCCATTCAGGAGAAGCTCAGGGAGCAGGTGGTGAAGCGTGAGGAGCTCTTCATCGTCAGCAAG
CTGTGGTGCACGTACCATGAGAAGGGCCTGGTGAAAGGAGCTTGCCAGAAGACGCTCAGCGACC
TGAAGCTGGACTACCTGGACCTCTACCTTATTCACTGGCCAACTGGCTTTAAGCCTGGGAAGGA
ATTTTTCCCATTGGATGAGTCGGGCAATGTGGTTCCCAGTGACACCAACATTCTGGACACATGG
GCGGCCATGGAAGAGCTGGTGGATGAAGGGCTGGTGAAAGCTATTGGCATCTCCAACTTCAACC
ATCTCCAGGGGGAGGCGATCTTAAACAAACCTGGCTTAAAATATAAGCCTGCAGTTAACCAGAT
TGAGTGCCACCCGTACCTCACTCAGGAGAAGTTAATCCAGTACTGCCACTCCAAAGGCATCGTG
GTGACCGCCTACAGCCCCCTCGGCTCTCCTGACAGGCCCTGGGCCAAGCCCGAGGACCCTTCCC
TCCTGGAGGATCCCAGAATCAAGGCGATCGCAGCCAAGCACAATAAAACTACAGCCCAGGTCCT
GATCCGGTTCCCCATGCAGAGGAACTTGGTGGTGATCCCCAAGTCTGTGACACCGGAACGCATT
GCTGAGAACTTTAAGGTCTTTGACTTTGAACTGAGCAACCAGGATATGACCACCTTACTCAGCT
ACAACAGGAACTGGAGGGTCTGTGCCTTGTTGAGCTGTGCCTCCCACAAGGATTACCCCTTCCA
TGAGGAGTTTTGAAGCTGTGGATGCCTGCTCATCCCTAAGTGACCTGTACCTGTGTTTCCTGCC
TCATTTTTTTTTCTTGAAAATGTAGTATGGCCTGTGTCACTCAGCAGCGGGACAGCAACCTGTA
GAGTGGCCAGCGAGGGCGTGTCTAGCTTGATGTTGGATCTGAAGAGCCCTGTCGGTAGAGTAGA
AGTCTCTTCTAGTTTGCTTTGCCCTTCTTTTTGCCCCGCTGGGGAAAGTACAACCTGAATACTC
TTTTCTGACCAAAGAGAAGCAAAATCTACCAGGTCAAAATAGTGCTACTAACAGTTGAGTTTTG
ACTGCTTGGAACTGTAATCCTTTCAGCAAGACTTCTCTTTGCCTCAAATAAAAAGTGCTTTTGT
GAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_007981166	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005614.1

RefSeq Acc Id:

XP_007981166 ⟸ XM_007982975

Ensembl Acc Id:

ENSCSAP00000005614 ⟸ ENSCSAT00000007436

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009365	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007436.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.100	UniProtKB/TrEMBL
InterPro	Aldo/ket_reductase_CS	UniProtKB/TrEMBL
	Aldo/keto_reductase	UniProtKB/TrEMBL
	NADP_OxRdtase_dom	UniProtKB/TrEMBL
	NADP_OxRdtase_dom_sf	UniProtKB/TrEMBL
NCBI Gene	AKR1B1	ENTREZGENE
PANTHER	ALDO-KETO REDUCTASE FAMILY 1 MEMBER B1	UniProtKB/TrEMBL
	ALDO/KETO REDUCTASE	UniProtKB/TrEMBL
Pfam	Aldo_ket_red	UniProtKB/TrEMBL
PRINTS	ALDKETRDTASE	UniProtKB/TrEMBL
PROSITE	ALDOKETO_REDUCTASE_1	UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_2	UniProtKB/TrEMBL
	ALDOKETO_REDUCTASE_3	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51430	UniProtKB/TrEMBL
UniProt	A0A0D9RAH5_CHLSB	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-08	LOC103226928	aldo-keto reductase family 1 member B1	AKR1B1	aldo-keto reductase family 1 member B	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB