ITPR1 (inositol 1,4,5-trisphosphate receptor type 1) - Rat Genome Database

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Gene: ITPR1 (inositol 1,4,5-trisphosphate receptor type 1) Chlorocebus sabaeus
Analyze
Symbol: ITPR1
Name: inositol 1,4,5-trisphosphate receptor type 1
RGD ID: 18455527
Description: ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); inositol 1,4,5-trisphosphate-gated calcium channel activity (ortholog); INVOLVED IN calcium import into the mitochondrion (ortholog); calcium ion transport (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); anterior segment dysgenesis (ortholog); asthma (ortholog); FOUND IN dendrite (ortholog); endoplasmic reticulum membrane (ortholog); GABA-ergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12240,574,569 - 40,925,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2240,574,374 - 40,926,842 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium import into the mitochondrion  (ISO)
calcium ion transmembrane transport  (IEA)
calcium ion transport  (IEA,ISO)
calcium-mediated signaling  (IEA)
cell morphogenesis  (IEA)
cellular response to cAMP  (ISO)
cellular response to hypoxia  (ISO)
dendrite development  (ISO)
endoplasmic reticulum calcium ion homeostasis  (IEA,ISO)
epithelial fluid transport  (IEA)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA)
ion channel modulating, G protein-coupled receptor signaling pathway  (IEA)
ligand-gated ion channel signaling pathway  (IEA)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcium-mediated signaling  (IEA)
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway  (IEA)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of insulin secretion  (IEA)
positive regulation of neuron projection development  (ISO)
post-embryonic development  (IEA,ISO)
protein homotetramerization  (IEA)
regulation of cytosolic calcium ion concentration  (IEA)
regulation of postsynaptic cytosolic calcium ion concentration  (IEA)
release of sequestered calcium ion into cytosol  (IEA)
release of sequestered calcium ion into cytosol by endoplasmic reticulum  (IEA)
response to hypoxia  (IEA)
single fertilization  (IEA)
voluntary musculoskeletal movement  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ITPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12240,574,569 - 40,925,857 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2240,574,374 - 40,926,842 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ITPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3834,493,348 - 4,847,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl34,493,345 - 4,847,506 (+)EnsemblGRCh38hg38GRCh38
GRCh3734,535,032 - 4,889,190 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3634,510,034 - 4,864,286 (+)NCBINCBI36Build 36hg18NCBI36
Build 3434,510,135 - 4,864,079NCBI
Celera34,473,120 - 4,827,522 (+)NCBICelera
Cytogenetic Map3p26.1NCBI
HuRef34,468,779 - 4,822,934 (+)NCBIHuRef
CHM1_134,485,103 - 4,839,760 (+)NCBICHM1_1
T2T-CHM13v2.034,487,354 - 4,841,309 (+)NCBIT2T-CHM13v2.0
Itpr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,190,044 - 108,528,077 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6108,190,057 - 108,528,070 (+)EnsemblGRCm39 Ensembl
GRCm386108,213,083 - 108,551,116 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,213,096 - 108,551,109 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,163,090 - 108,501,108 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366108,178,895 - 108,516,886 (+)NCBIMGSCv36mm8
Celera6110,018,018 - 110,348,287 (+)NCBICelera
Cytogenetic Map6E1- E2NCBI
cM Map649.74NCBI
Itpr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84142,743,401 - 143,066,505 (+)NCBIGRCr8
mRatBN7.24141,187,377 - 141,554,240 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4141,187,418 - 141,510,491 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4146,609,417 - 146,932,882 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04142,390,143 - 142,713,600 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04141,034,101 - 141,357,581 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04140,247,297 - 140,580,749 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,247,313 - 140,580,748 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04204,714,729 - 205,047,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44143,705,360 - 144,030,051NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4129,839,611 - 130,162,657 (+)NCBICelera
RH 3.4 Map4 RGD
Cytogenetic Map4q41NCBI
ITPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v224,506,900 - 4,861,017 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan134,511,663 - 4,865,777 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v034,448,574 - 4,802,545 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.134,549,775 - 4,904,811 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl34,572,921 - 4,904,811 (+)Ensemblpanpan1.1panPan2
ITPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,746,171 - 13,065,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,747,315 - 13,064,198 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2012,719,920 - 13,038,750 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02012,789,247 - 13,108,309 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2012,789,627 - 13,108,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12012,494,231 - 12,813,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02012,835,196 - 13,153,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02012,821,769 - 13,140,816 (-)NCBIUU_Cfam_GSD_1.0
Itpr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494210,941,137 - 11,243,016 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365773,896,390 - 4,198,411 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365773,896,455 - 4,198,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,068,126 - 61,398,912 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11361,068,131 - 61,398,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21367,499,295 - 67,702,956 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Itpr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477314,856,804 - 15,193,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477314,856,803 - 15,193,173 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ITPR1
8140 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000009024   ⟹   ENSCSAP00000007155
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2240,574,374 - 40,926,842 (+)Ensembl
RefSeq Acc Id: XM_007985062   ⟹   XP_007983253
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985065   ⟹   XP_007983256
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,882 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985066   ⟹   XP_007983257
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,882 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985067   ⟹   XP_007983258
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,882 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985068   ⟹   XP_007983259
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,882 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985069   ⟹   XP_007983260
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,882 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985070   ⟹   XP_007983261
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985071   ⟹   XP_007983262
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985072   ⟹   XP_007983263
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985073   ⟹   XP_007983264
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007985074   ⟹   XP_007983265
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12240,574,569 - 40,925,857 (+)NCBI
Vero_WHO_p1.0NW_023666041125,743,247 - 126,095,217 (-)NCBI
Sequence:
RefSeq Acc Id: XP_007983253   ⟸   XM_007985062
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007983256   ⟸   XM_007985065
- Peptide Label: isoform X2
- UniProtKB: A0A0D9REW6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007983260   ⟸   XM_007985069
- Peptide Label: isoform X6
RefSeq Acc Id: XP_007983257   ⟸   XM_007985066
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007983261   ⟸   XM_007985070
- Peptide Label: isoform X7
RefSeq Acc Id: XP_007983264   ⟸   XM_007985073
- Peptide Label: isoform X10
RefSeq Acc Id: XP_007983258   ⟸   XM_007985067
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007983262   ⟸   XM_007985071
- Peptide Label: isoform X8
RefSeq Acc Id: XP_007983259   ⟸   XM_007985068
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007983263   ⟸   XM_007985072
- Peptide Label: isoform X9
RefSeq Acc Id: XP_007983265   ⟸   XM_007985074
- Peptide Label: isoform X11
Ensembl Acc Id: ENSCSAP00000007155   ⟸   ENSCSAT00000009024


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010951 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009024.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/TrEMBL
  IP3 receptor type 1 binding core, RIH domain UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/TrEMBL
  InsP3_rcpt UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/TrEMBL
  MIR_motif UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/TrEMBL
  RIH_dom UniProtKB/TrEMBL
  Ryanodine_IP3_receptor UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/TrEMBL
NCBI Gene ITPR1 ENTREZGENE
PANTHER INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR, TYPE 1A UniProtKB/TrEMBL
  MIR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Ins145_P3_rec UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  MIR UniProtKB/TrEMBL
  RIH_assoc UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/TrEMBL
PRINTS INSP3RECEPTR UniProtKB/TrEMBL
PROSITE MIR UniProtKB/TrEMBL
SMART MIR UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF82109 UniProtKB/TrEMBL
UniProt A0A0D9REW6 ENTREZGENE, UniProtKB/TrEMBL