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Gene: COQ5 (coenzyme Q5, methyltransferase) Chlorocebus sabaeus

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Symbol:

COQ5

Name:

coenzyme Q5, methyltransferase

RGD ID:

18451031

Description:

ENCODES a protein that exhibits 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (inferred); methyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN ketone biosynthetic process (inferred); methylation (inferred); ubiquinone biosynthetic process (inferred); PARTICIPATES IN ubiquinone biosynthetic pathway; ASSOCIATED WITH COVID-19 (ortholog); intellectual disability (ortholog); primary coenzyme Q10 deficiency 9 (ortholog); FOUND IN extrinsic component of mitochondrial inner membrane (inferred); membrane (inferred); mitochondrial inner membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	115,858,488 - 115,882,184 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	115,856,817 - 115,882,181 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	129,216,939 - 129,241,868 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

intellectual disability (ISO)

primary coenzyme Q10 deficiency 9 (ISO)

short chain acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ketone biosynthetic process (IEA)

methylation (IEA)

ubiquinone biosynthetic process (IEA)

Cellular Component

extrinsic component of mitochondrial inner membrane (IEA)

membrane (IEA)

mitochondrial inner membrane (IEA)

mitochondrial matrix (IEA)

mitochondrion (IEA)

protein-containing complex (IEA)

ubiquinone biosynthesis complex (IEA)

Molecular Function

2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity (IEA)

methyltransferase activity (IEA)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquinone biosynthetic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

COQ5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	115,858,488 - 115,882,184 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	115,856,817 - 115,882,181 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	129,216,939 - 129,241,868 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

COQ5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	120,503,279 - 120,529,158 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	120,503,279 - 120,534,434 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	120,941,082 - 120,966,961 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	119,425,465 - 119,451,347 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	120,575,175 - 120,601,278 (-)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	117,950,872 - 117,976,478 (-)	NCBI		HuRef
CHM1_1	12	120,909,884 - 120,935,770 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	120,492,451 - 120,518,340 (-)	NCBI		T2T-CHM13v2.0

Coq5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	115,417,752 - 115,435,029 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	115,417,725 - 115,435,031 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	115,279,666 - 115,296,974 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	115,279,666 - 115,296,972 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	115,729,711 - 115,746,981 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	115,540,701 - 115,557,971 (+)	NCBI		MGSCv36	mm8
Celera	5	112,377,253 - 112,394,272 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	56.03	NCBI

Coq5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	46,977,632 - 46,994,575 (-)	NCBI		GRCr8
mRatBN7.2	12	41,316,922 - 41,333,855 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	41,316,748 - 41,333,848 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	42,483,601 - 42,500,534 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	43,097,264 - 43,114,198 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	42,157,816 - 42,174,750 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	47,078,753 - 47,095,438 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	47,078,753 - 47,095,438 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	48,872,069 - 48,888,977 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	42,585,095 - 42,602,004 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	42,448,482 - 42,465,470 (-)	NCBI
Celera	12	42,937,655 - 42,953,546 (-)	NCBI		Celera
Cytogenetic Map	12	q16	NCBI

Coq5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	11,124,009 - 11,142,665 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	11,124,009 - 11,142,665 (+)	NCBI	ChiLan1.0	ChiLan1.0

COQ5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	128,572,292 - 128,599,318 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	128,568,669 - 128,600,934 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	118,085,605 - 118,112,591 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	121,459,102 - 121,486,657 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	121,459,102 - 121,486,657 (-)	Ensembl	panpan1.1		panPan2

COQ5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	16,404,370 - 16,421,507 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	16,404,524 - 16,421,477 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	16,407,529 - 16,424,662 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	16,671,520 - 16,688,635 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	16,670,858 - 16,688,621 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	16,631,540 - 16,648,667 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	16,707,838 - 16,724,939 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	16,749,689 - 16,767,013 (-)	NCBI		UU_Cfam_GSD_1.0

Coq5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	145,932,544 - 145,948,006 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936668	431,422 - 448,367 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936668	431,453 - 446,881 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COQ5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	40,460,857 - 40,478,830 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	40,461,610 - 40,480,586 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	42,935,428 - 42,953,304 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Coq5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	13,145,343 - 13,168,246 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	13,145,380 - 13,165,169 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in COQ5
431 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008004947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008004948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000000271 ⟹ ENSCSAP00000015783

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	11	115,856,817 - 115,882,181 (-)	Ensembl

RefSeq Acc Id:

XM_008004947 ⟹ XP_008003138

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	11	115,858,488 - 115,882,184 (-)	NCBI
Vero_WHO_p1.0	NW_023666037	129,216,939 - 129,241,868 (+)	NCBI

Sequence:

show sequence

GGCGTACTCTCTGGCCCTTGTCACTCGACTACCAAGATGGCTGCCCCCAAGAGCTGTGCTCTAT
GGAGCTATTGCGGCCGTGGGTGGTCGCGGGCGATGCGGGGCTGCCAGCTCCTCGGGCTTCGTAG
CTCTTGGCCCGGGGCCCCACTAAGTGCTCGGCTCTTGTCCCAAGAGAAGCAGGCAACGGAAACG
CACTTCGGGTTTGAGACTGTGCCGGAAGAGGAGAAGGGGGGCAAAGTCTATCAGGTGTTTGAAA
GTGTGGCTAAGAAGTATGATGTGATGAATGATATGATGAGTCTTGGTATCCATCGTGTTTGGAA
GGATTTGCTGCTCTGGAAGATGTGCCCGCTTCCTGGGACCCAGCTGCTTGATGTTGCTGGAGGC
ACAGGTGACATTGCATTCCGGTTCCTTAATTATGTTCAGTCCCAGCATCAGAGTAAACAGAAGA
GGCAGTTAAGGGCCCAACAAAATTTATCCTGGGAAGAAATTACCAAAAAGTACCAGAATGAAGA
AGATTCCTTGGGCGGGTCTCGTGTCGTGGTGTGTGACATCAACAAGGAGATGCTAAAGGTTGGA
AAGCAGAAAGCCTTGGCTCAAGGATACAGAGCTGGACTTGCATGGGTATTAGGAGACGCTGAAG
AGCTGCCCTTTGATGATGACAAGTTTGATATTTACACCATTGCCTTTGGGATCCGGAATGTCAC
ACACATTGATCAGGCACTCCAGGAAGCCCATCGGGTGCTGAAACCAGGAGGACGGTTTCTCTGT
CTGGAATTTAGCCAAGTGAACAATCCCCTCATATCCAGGCTTTATGATCTATATAGCTTCCAGG
TCATTCCTGTCCTGGGAGAGGTCATCGCTGGAGACTGGAAGTCCTATCAGTACCTTGTAGAGAG
TATCCGAAGGTTTCCGTCTCAGGAAGAGTTCAAAGAGATGATAGAAGATGCAGGCTTTCACAAG
GTGACCTATGAAAGTCTAACATCAGGCATTGTGGCCATCCATTCTGGCTTCAAACTTTAATTCG
TTTCCTGTCATGGAGCATGAACCAGTCACATCCTGTTGAAAGCCTGGAACTGAAGGATAATCTG
GCAAATGAGACAGCAGGAGAGCATCTCCTCTTAAGGATACGTGCCATGGACTCATGTTTGAATC
GAACAGTCTTAAAGTGGAAGAACAAATTCTTGTCACTTTTTTACAGCTTTCTTTGGAGCTGCTT
CAGTCCGTCTCCCAGAGGCATTTGGTCTGTATTTTTGCTCGACTGCTAATTTCTCTTGGCTGTA
GGGTGTGTGGTTAAGGTACAACCAGCACTAAAGCTCAGTTTTGAAGTGAGTGTATTCATAGCTT
CCCTGCTGGTGCTGCCTTCCAGAGGGATAATAGATCATTTGAACCCAATGACGATTTTTCACCA
GAAAACTTAATTGTACCTGAATCAATCTTTCAGCCTAGGACTAAGTCTAGGCCCAGGTCAGAGT
ACTAATGATCATGAGAATTGTGTGCTGAACCAGTAAACGAGTTTACCTTTTGA

hide sequence

RefSeq Acc Id:

XM_008004948 ⟹ XP_008003139

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	11	115,858,898 - 115,882,178 (-)	NCBI
Vero_WHO_p1.0	NW_023666037	129,216,942 - 129,241,868 (+)	NCBI

Sequence:

show sequence

CTCTCTGGCCCTTGTCACTCGACTACCAAGATGGCTGCCCCCAAGAGCTGTGCTCTATGGAGCT
ATTGCGGCCGTGGGTGGTCGCGGGCGATGCGGGGCTGCCAGCTCCTCGGGCTTCGTAGCTCTTG
GCCCGGGGCCCCACTAAGTGCTCGGCTCTTGTCCCAAGAGAAGCAGGCAACGGAAACGCACTTC
GGGTTTGAGACTGTGCCGGAAGAGGAGAAGGGGGGCAAAGGTGACATTGCATTCCGGTTCCTTA
ATTATGTTCAGTCCCAGCATCAGAGTAAACAGAAGAGGCAGTTAAGGGCCCAACAAAATTTATC
CTGGGAAGAAATTACCAAAAAGTACCAGAATGAAGAAGATTCCTTGGGCGGGTCTCGTGTCGTG
GTGTGTGACATCAACAAGGAGATGCTAAAGGTTGGAAAGCAGAAAGCCTTGGCTCAAGGATACA
GAGCTGGACTTGCATGGGTATTAGGAGACGCTGAAGAGCTGCCCTTTGATGATGACAAGTTTGA
TATTTACACCATTGCCTTTGGGATCCGGAATGTCACACACATTGATCAGGCACTCCAGGAAGCC
CATCGGGTGCTGAAACCAGGAGGACGGTTTCTCTGTCTGGAATTTAGCCAAGTGAACAATCCCC
TCATATCCAGGCTTTATGATCTATATAGCTTCCAGGTCATTCCTGTCCTGGGAGAGGTCATCGC
TGGAGACTGGAAGTCCTATCAGTACCTTGTAGAGAGTATCCGAAGGTTTCCGTCTCAGGAAGAG
TTCAAAGAGATGATAGAAGATGCAGGCTTTCACAAGGTGACCTATGAAAGTCTAACATCAGGCA
TTGTGGCCATCCATTCTGGCTTCAAACTTTAATTCGTTTCCTGTCATGGAGCATGAACCAGTCA
CATCCTGTTGAAAGCCTGGAACTGAAGGATAATCTGGCAAATGAGACAGCAGGAGAGCATCTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_008003138	(Get FASTA)	NCBI Sequence Viewer
	XP_008003139	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000015783
	ENSCSAP00000015783.1

RefSeq Acc Id:	XP_008003138 ⟸ XM_008004947
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9S4J4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_008003139 ⟸ XM_008004948
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSCSAP00000015783 ⟸ ENSCSAT00000000271

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000002254	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000000271	ENTREZGENE
	ENSCSAT00000000271.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
InterPro	SAM-dependent_MTases	UniProtKB/TrEMBL
	UbiE/COQ5_MeTrFase	UniProtKB/TrEMBL
	UbiE/COQ5_MeTrFase_CS	UniProtKB/TrEMBL
KEGG Report	csab:103239257	UniProtKB/TrEMBL
NCBI Gene	COQ5	ENTREZGENE
PANTHER	2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	METHYLTRANSFERASE	UniProtKB/TrEMBL
Pfam	Ubie_methyltran	UniProtKB/TrEMBL
PROSITE	SAM_MT_UBIE	UniProtKB/TrEMBL
	UBIE_1	UniProtKB/TrEMBL
	UBIE_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53335	UniProtKB/TrEMBL
UniProt	A0A0D9S4J4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB