TNNT2 (troponin T2, cardiac type) - Rat Genome Database

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Gene: TNNT2 (troponin T2, cardiac type) Chlorocebus sabaeus
Analyze
Symbol: TNNT2
Name: troponin T2, cardiac type
RGD ID: 18435904
Description: ENCODES a protein that exhibits identical protein binding (ortholog); microfilament motor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); atrial cardiac muscle tissue morphogenesis (ortholog); cardiac muscle contraction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); beta thalassemia (ortholog); Cardiomegaly (ortholog); FOUND IN myofibril (ortholog); sarcomere (ortholog); sarcoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: troponin T, cardiac muscle
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,035,563 - 28,054,322 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,040,087 - 28,054,120 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,830,239 - 28,851,566 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,035,563 - 28,054,322 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,040,087 - 28,054,120 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605528,830,239 - 28,851,566 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TNNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,359,014 - 201,377,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,359,008 - 201,377,764 (-)EnsemblGRCh38hg38GRCh38
GRCh371201,328,142 - 201,346,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,594,765 - 199,613,428 (-)NCBINCBI36Build 36hg18NCBI36
Build 341198,059,798 - 198,078,462NCBI
Celera1174,451,992 - 174,470,656 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,494,387 - 172,513,074 (-)NCBIHuRef
CHM1_11202,750,309 - 202,768,995 (-)NCBICHM1_1
T2T-CHM13v2.01200,616,823 - 200,635,489 (-)NCBIT2T-CHM13v2.0
Tnnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,763,933 - 135,780,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,764,092 - 135,779,998 (+)EnsemblGRCm39 Ensembl
GRCm381135,836,315 - 135,852,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,836,354 - 135,852,260 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,732,963 - 137,748,838 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,652,816 - 137,668,671 (+)NCBIMGSCv36mm8
Celera1138,471,192 - 138,487,068 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.32NCBI
Tnnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,819,123 - 49,837,125 (+)NCBIGRCr8
mRatBN7.21347,267,325 - 47,285,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,267,204 - 47,285,388 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,880,350 - 49,893,175 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,168,415 - 51,181,238 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,432,330 - 48,444,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,662,974 - 52,680,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,662,996 - 52,680,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,711,369 - 57,729,182 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,872,972 - 48,885,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,887,014 - 48,899,858 (+)NCBI
Celera1347,589,409 - 47,602,135 (+)NCBICelera
Cytogenetic Map13q13NCBI
Tnnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,487,154 - 37,507,639 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,491,462 - 37,507,360 (-)NCBIChiLan1.0ChiLan1.0
TNNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2148,009,649 - 48,022,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,974,336 - 47,987,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01176,957,298 - 176,976,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,258,314 - 181,277,048 (-)NCBIpanpan1.1PanPan1.1panPan2
TNNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.171,598,306 - 1,620,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl71,598,306 - 1,613,741 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,565,151 - 1,580,081 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.071,523,217 - 1,537,269 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl71,506,647 - 1,543,842 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.171,510,291 - 1,525,219 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,618,096 - 1,633,001 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,642,705 - 1,657,644 (+)NCBIUU_Cfam_GSD_1.0
Tnnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,817,529 - 73,834,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365673,056,845 - 3,068,887 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365673,052,167 - 3,069,077 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,749,335 - 23,763,396 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11023,749,528 - 23,759,696 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,159,010 - 28,173,145 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Tnnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,336,904 - 9,348,396 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248079,332,202 - 9,348,610 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TNNT2
573 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000011995   ⟹   ENSCSAP00000010045
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2528,040,087 - 28,054,120 (+)Ensembl
RefSeq Acc Id: XM_007988972   ⟹   XP_007987163
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,578 - 28,054,322 (+)NCBI
Vero_WHO_p1.0NW_02366605528,832,809 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988973   ⟹   XP_007987164
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,574 - 28,054,316 (+)NCBI
Vero_WHO_p1.0NW_02366605528,830,239 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988974   ⟹   XP_007987165
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,575 - 28,054,316 (+)NCBI
Vero_WHO_p1.0NW_02366605528,830,239 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988975   ⟹   XP_007987166
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,563 - 28,054,316 (+)NCBI
Vero_WHO_p1.0NW_02366605528,830,239 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988976   ⟹   XP_007987167
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,574 - 28,054,322 (+)NCBI
Vero_WHO_p1.0NW_02366605528,832,805 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988979   ⟹   XP_007987170
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,580 - 28,054,322 (+)NCBI
Vero_WHO_p1.0NW_02366605528,832,809 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988981   ⟹   XP_007987172
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,576 - 28,054,322 (+)NCBI
Vero_WHO_p1.0NW_02366605528,832,805 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988982   ⟹   XP_007987173
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,579 - 28,054,316 (+)NCBI
Vero_WHO_p1.0NW_02366605528,832,813 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988983   ⟹   XP_007987174
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12528,035,581 - 28,054,316 (+)NCBI
Vero_WHO_p1.0NW_02366605528,832,811 - 28,851,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037985755   ⟹   XP_037841683
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605528,836,878 - 28,851,566 (+)NCBI
RefSeq Acc Id: XM_037985756   ⟹   XP_037841684
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605528,830,239 - 28,851,566 (+)NCBI
RefSeq Acc Id: XM_037985757   ⟹   XP_037841685
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605528,832,808 - 28,851,566 (+)NCBI
RefSeq Acc Id: XP_007987166   ⟸   XM_007988975
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007987167   ⟸   XM_007988976
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007987164   ⟸   XM_007988973
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007987165   ⟸   XM_007988974
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007987172   ⟸   XM_007988981
- Peptide Label: isoform X9
RefSeq Acc Id: XP_007987163   ⟸   XM_007988972
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RN56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987173   ⟸   XM_007988982
- Peptide Label: isoform X10
RefSeq Acc Id: XP_007987170   ⟸   XM_007988979
- Peptide Label: isoform X6
RefSeq Acc Id: XP_007987174   ⟸   XM_007988983
- Peptide Label: isoform X11
Ensembl Acc Id: ENSCSAP00000010045   ⟸   ENSCSAT00000011995
RefSeq Acc Id: XP_037841684   ⟸   XM_037985756
- Peptide Label: isoform X7
RefSeq Acc Id: XP_037841685   ⟸   XM_037985757
- Peptide Label: isoform X8
RefSeq Acc Id: XP_037841683   ⟸   XM_037985755
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RN56 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011995.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.350 UniProtKB/TrEMBL
InterPro TNNT UniProtKB/TrEMBL
  Troponin UniProtKB/TrEMBL
  Troponin_sf UniProtKB/TrEMBL
KEGG Report csab:103230331 UniProtKB/TrEMBL
NCBI Gene TNNT2 ENTREZGENE
PANTHER PTHR11521 UniProtKB/TrEMBL
  TROPONIN T, CARDIAC MUSCLE UniProtKB/TrEMBL
Pfam Troponin UniProtKB/TrEMBL
Superfamily-SCOP SSF90250 UniProtKB/TrEMBL
UniProt A0A0D9RN56 ENTREZGENE, UniProtKB/TrEMBL