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Gene: RHCG (Rh family C glycoprotein) Chlorocebus sabaeus

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Symbol:

RHCG

Name:

Rh family C glycoprotein

RGD ID:

18414368

Description:

ENCODES a protein that exhibits ammonium channel activity (inferred); ankyrin binding (inferred); carbon dioxide transmembrane transporter activity (inferred); INVOLVED IN ammonium homeostasis (inferred); ammonium transmembrane transport (inferred); carbon dioxide transmembrane transport (inferred); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); D-2-hydroxyglutaric aciduria 2 (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ammonium transporter Rh type C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	8,015,391 - 8,040,811 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	8,015,620 - 8,040,486 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	38,774,862 - 38,799,656 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

D-2-hydroxyglutaric aciduria 2 (ISO)

Hypoaldosteronism (ISO)

hypokalemia (ISO)

kidney failure (ISO)

metabolic acidosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ammonium homeostasis (IEA)

ammonium transmembrane transport (IEA)

carbon dioxide transmembrane transport (IEA)

intracellular monoatomic ion homeostasis (IEA)

regulation of pH (IEA)

transepithelial ammonium transport (IEA)

Cellular Component

apical plasma membrane (IEA,ISO)

basal plasma membrane (ISO)

basolateral plasma membrane (IEA,ISO)

cytoplasmic vesicle (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

ammonium channel activity (IEA)

ankyrin binding (IEA)

carbon dioxide transmembrane transporter activity (IEA)

identical protein binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RHCG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	8,015,391 - 8,040,811 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	8,015,620 - 8,040,486 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	38,774,862 - 38,799,656 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

RHCG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	89,471,407 - 89,496,583 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	89,471,398 - 89,496,589 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	90,014,638 - 90,039,814 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	87,815,642 - 87,840,803 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	87,815,645 - 87,840,803	NCBI
Celera	15	66,417,127 - 66,442,288 (-)	NCBI		Celera
Cytogenetic Map	15	q26.1	NCBI
HuRef	15	66,127,581 - 66,152,746 (-)	NCBI		HuRef
CHM1_1	15	89,855,641 - 89,880,764 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	87,227,437 - 87,252,613 (-)	NCBI		T2T-CHM13v2.0

Rhcg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	79,243,111 - 79,267,405 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	79,243,111 - 79,267,405 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	79,593,363 - 79,617,657 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	79,593,363 - 79,617,657 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	86,738,249 - 86,762,543 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	79,466,882 - 79,491,161 (-)	NCBI		MGSCv36	mm8
Celera	7	76,996,917 - 77,021,608 (-)	NCBI		Celera
Cytogenetic Map	7	D2	NCBI
cM Map	7	45.09	NCBI

Rhcg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	142,941,046 - 142,965,242 (-)	NCBI		GRCr8
mRatBN7.2	1	133,531,704 - 133,555,902 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	133,531,716 - 133,555,876 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	141,441,386 - 141,465,168 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	148,610,769 - 148,634,552 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	141,528,475 - 141,552,260 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	141,325,854 - 141,349,881 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	141,325,856 - 141,349,881 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	142,286,922 - 142,310,949 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	135,361,418 - 135,386,461 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	135,439,824 - 135,464,867 (-)	NCBI
Celera	1	125,594,825 - 125,618,934 (-)	NCBI		Celera
Cytogenetic Map	1	q31	NCBI

Rhcg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	15,639,551 - 15,654,293 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	15,639,425 - 15,657,708 (+)	NCBI	ChiLan1.0	ChiLan1.0

RHCG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	79,021,969 - 79,050,885 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	82,726,346 - 82,755,232 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	68,165,708 - 68,190,964 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	87,372,238 - 87,397,011 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	87,372,238 - 87,397,011 (-)	Ensembl	panpan1.1		panPan2

RHCG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	52,503,172 - 52,526,362 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	52,503,176 - 52,526,719 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	55,136,730 - 55,159,917 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	52,919,695 - 52,942,920 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	52,918,628 - 52,943,290 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	52,441,812 - 52,464,994 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	52,652,116 - 52,675,289 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	52,992,155 - 53,015,328 (-)	NCBI		UU_Cfam_GSD_1.0

Rhcg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	130,981,170 - 131,005,380 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	15,328,364 - 15,353,404 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	15,329,147 - 15,353,301 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RHCG
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	55,046,245 - 55,071,475 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	55,046,244 - 55,071,504 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	60,022,002 - 60,039,452 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Rhcg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	16,623,599 - 16,644,189 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624768	16,623,667 - 16,644,149 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in RHCG
687 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
58	18	17	19	19	56	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007990351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007990352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000015254 ⟹ ENSCSAP00000013199

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	29	8,015,620 - 8,040,486 (-)	Ensembl

RefSeq Acc Id:

XM_007990352 ⟹ XP_007988543

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	29	8,015,923 - 8,040,811 (-)	NCBI
Vero_WHO_p1.0	NW_023666059	38,774,862 - 38,799,656 (+)	NCBI

Sequence:

show sequence

CCCCGTTTCCCTGTTCAGCAGAACAAAAGGAGAAAGGCCCCAGTATCAACCGGAGACACAGAAG
TTGGGGCACCCTGATCCTCCTGCCCACTGCCTTATCGGCCTCTGCTCCTGCCGCTGTCCCCCAG
CCCAACGCGGGGAATCTTTTGGGACCCTTGGCTTGGGTTGGGCTCCTGCCAGTTGGGCGAGCGC
GCGGGCGGTGCCCGAGTCAGCTGCTCCGTGCCCCACGTGGCCGCCCCGCCCCCTTGCCCGGGTC
TCAAAAGCCCCGCCGGCCTCCGAGCGTCCGAACTGCCCGCTGCCCGCCCGGCCAGGCAGCCCTG
CAACATGGCCTGGAACACCAACCTCCGCTGGCGGCTGCCGCTCACCTGCCTGCTCCTGCAGGTA
GCTATGGTGATTCTCTTCGGGGTGTTTGTGCGCTACGACTTCGATGCGGACGCCCACTGGTGGA
CAGAGAGGAAGCACAAGAACTTGAGCGAGGTGGAGAACGAATTCTACTATCGCTACCCGAGCTT
CCAGGACGTGCACGTGATGGTCTTCGTGGGCTTCGGCTTCCTCATGACCTTCCTGCAGCGCTAC
GGCTTCAGCGCCGTCGGCTTCAACTTCCTGCTGGCGGCATTCGGCATCCAGTGGGCGCTGCTCA
TGCAGGGCTGGTTCCACTTCTTAGAAGACCGCTACATCGTCGTGGGAGTGGAGAATCTCATCAA
CGCTGACTTCTGCGTGGCCTCTGTCTGCGTGGCCTTTGGGGCAGTTCTGGGTAAAGTCAGCCCC
ATTCAGCTGCTCATCATGACTTTCTTCCAAGTGACCCTCTTCGCTGTGAATGAGTTCATTCTCC
TTAACCTGCTAAAGGTGAAGGATGCAGGGGGCTCCATGACCATCCACACATTTGGCGCCTACTT
TGGGCTCACAGTGACCCGGATCCTCTACCGACGCAACCTAGAGCAGAGCAAGGAGAGACAGAGT
TCTGCGTACCAGTCGGACCTCTTTGCCATGATTGGCACACTCTTCCTTTGGATGTACTGGCCCA
GCTTCAACTCAGCCATATCCTACCATGGGGACAGCCAGCACCGAGCCGCCATCAACACCTACTG
CTCCTTGGCAGCCTGTGTGCTTACCTCGGTGGCAGTATCCAGTGCCCTGCACAAGAAGGGCAAG
CTGGACATGGTGCACATCCAGAATGCCACGCTCGCAGGAGGGGTGGCCGTGGGTACCGCTGCTG
AGATGATGCTCATGCCTTATGGCGCCCTCATCATTGGCTTCATCTGTGGCATCATCTCGACCCT
GGGTTTTGTATACCTGACCCCATTCCTGGAGTCCCGGCTGCACATCCAGGACACATGTGGCATT
AACAATCTGCATGGCATTCCTGGCATCATAGGCGGCATCGTGGGTGCTGTGACAGCGGCCTCCG
CCAGCCTTGAAGTCTATGGAAAAGAAGGGCTTGTCCATGCCTTTGACTTTCAAGATTTCAAGAG
GGACTGGACTGCAAGAACACAGGGAAAGTTCCAGATTTATGGTCTCTTGGTGACCCTGGCCATG
GCCCTGATGGGTGGCATCATTGTGGGGCTTATTTTGAGATTACCATTCTGGGGACAACCTTCAG
ATGAGAACTGCTTTGAGGATGCAGTCTACTGGGAGATGCCTGAAGGGAACAGCACTGTCTACAT
CCCTGAAGATCCCACCTTCAAGCCCTCAGGACCCTCAGTACCCTCAGTACCCATGGTGTCCCCA
CTACCCATGGCTTCCTCAGTACCCTTGGTACCCTAGGCTCCCAGGGCAGGTGAGGAGCAGGCTC
CACAGACTGTCCTGGGGCTCCAGAGGAGCTGGTGCTGACCTAACTAGGGACACAAGAGCGAGCA
AGCAGCACCCCCACCTGCTGGCTTGGCCTCAAGGTGCCTCCATCCCTTCCCTCCCCTTCATCCC
AGGGGGTCTGCCTGAGAATGGAGAAGGAGAAACTACAAACAAAGTGGGCATCCAAGCCAGGTTC
TGGCTGCAGAAGTTCTGCCTCTGCCTGGGGTCTTAGCCACACTGGAGAAAAACAGGCTCAGAGT
GGGGCTAGAGCCTGGGGGTGAACCTGAGCACTCCTAGGAGACAACTTAGCTGCCAGTCACCACC
TATGAGGCTCTTCTACCCACTGCCTGCACATCAGCCAGCATCTCCTATGCTCCCTGGGTCCCCT
AGACTTCTCTGTGTTGTGTAGGTGGCAGCCTCCGGGAATAAACATTCTTGATGTCCTTTGTAAA
A

hide sequence

Protein Sequences


Protein RefSeqs	XP_007988543	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000013199
	ENSCSAP00000013199.1

RefSeq Acc Id:	XP_007988543 ⟸ XM_007990352
- UniProtKB:	A0A0D9RX60 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000013199 ⟸ ENSCSAT00000015254

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000017160	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000015254.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.3430.10	UniProtKB/TrEMBL
InterPro	Ammonium/urea_transptr	UniProtKB/TrEMBL
	NH4_transpt_AmtB-like_dom	UniProtKB/TrEMBL
	RhesusRHD	UniProtKB/TrEMBL
NCBI Gene	RHCG	ENTREZGENE
PANTHER	AMMONIUM TRANSPORTER	UniProtKB/TrEMBL
	AMMONIUM TRANSPORTER RH TYPE C	UniProtKB/TrEMBL
Pfam	Ammonium_transp	UniProtKB/TrEMBL
PRINTS	RHESUSRHD	UniProtKB/TrEMBL
Superfamily-SCOP	Ammonium transporter	UniProtKB/TrEMBL
UniProt	A0A0D9RX60	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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