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Gene: CCK (cholecystokinin) Chlorocebus sabaeus

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Symbol:

CCK

Name:

cholecystokinin

RGD ID:

18398116

Description:

ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); axonogenesis (ortholog); cholecystokinin signaling pathway (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); alcohol dependence (ortholog); Alcohol Withdrawal Delirium (ortholog); FOUND IN axon hillock (ortholog); axon initial segment (ortholog); dendrite (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CCK (cholecystokinin)	NCBI	Ortholog
Mus musculus (house mouse):	Cck (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cck (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cck (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CCK (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CCK (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cck (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CCK (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cck (cholecystokinin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	3,698,192 - 3,705,443 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	3,698,173 - 3,704,956 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	163,500,609 - 163,507,518 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute pancreatitis (ISO)

alcohol dependence (ISO)

Alcohol Withdrawal Delirium (ISO)

alcoholic pancreatitis (ISO)

Anorexia (ISO)

Bulimia (ISO)

Catalepsy (ISO)

cataract (ISO)

congenital muscular dystrophy-dystroglycanopathy type A8 (ISO)

Drug-Induced Dyskinesia (ISO)

Experimental Diabetes Mellitus (ISO)

Fever (ISO)

Gallstones (ISO)

gastric ulcer (ISO)

gastrointestinal system disease (ISO)

Hallucinations (ISO)

Hyperalgesia (ISO)

Hyperkinesis (ISO)

Inflammation (ISO)

liver disease (ISO)

Metabolic Syndrome (ISO)

morbid obesity (ISO)

Neurobehavioral Manifestations (ISO)

nicotine dependence (ISO)

Pain (ISO)

pancreatitis (ISO)

Parkinson's disease (ISO)

toxic encephalopathy (ISO)

Unconsciousness (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic DNA fragmentation (ISO)

axonogenesis (ISO)

cholecystokinin signaling pathway (ISO)

digestion (IEA)

eating behavior (ISO)

memory (ISO)

mitochondrial depolarization (ISO)

negative regulation of appetite (ISO)

negative regulation of behavioral fear response (ISO)

negative regulation of eating behavior (ISO)

neuron migration (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of behavioral fear response (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of glutamate secretion (ISO)

positive regulation of pancreatic amylase secretion by cholecystokinin signaling pathway (ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

positive regulation of protein-containing complex assembly (ISO)

release of cytochrome c from mitochondria (ISO)

signal transduction (IEA)

synaptic signaling via neuropeptide (ISO)

visual learning (ISO)

Cellular Component

axon (IEA)

axon hillock (ISO)

axon initial segment (ISO)

dendrite (ISO)

extracellular region (IEA)

extracellular space (IEA,ISO)

GABA-ergic synapse (ISO)

neuronal cell body (ISO)

neuronal dense core vesicle lumen (ISO)

perikaryon (ISO)

terminal bouton (ISO)

Molecular Function

hormone activity (ISO)

neuropeptide hormone activity (IEA,ISO)

peptide hormone receptor binding (IEA)

protein binding (ISO)

receptor ligand activity (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CCK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	3,698,192 - 3,705,443 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	3,698,173 - 3,704,956 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	163,500,609 - 163,507,518 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

CCK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	42,257,826 - 42,266,185 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	42,257,825 - 42,266,185 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	42,299,318 - 42,307,677 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	42,274,322 - 42,281,399 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	42,274,321 - 42,281,399	NCBI
Celera	3	42,238,692 - 42,247,029 (-)	NCBI		Celera
Cytogenetic Map	3	p22.1	NCBI
HuRef	3	42,342,652 - 42,351,001 (-)	NCBI		HuRef
CHM1_1	3	42,250,425 - 42,258,774 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	42,275,821 - 42,284,183 (-)	NCBI		T2T-CHM13v2.0

Cck
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	121,318,890 - 121,324,728 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	121,318,890 - 121,324,760 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	121,489,824 - 121,495,694 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	121,489,824 - 121,495,694 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	121,398,942 - 121,404,807 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	121,338,523 - 121,344,360 (-)	NCBI		MGSCv36	mm8
Celera	9	121,960,523 - 121,966,357 (-)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	72.43	NCBI

Cck
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	130,031,012 - 130,037,702 (-)	NCBI		GRCr8
mRatBN7.2	8	121,153,499 - 121,160,194 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	121,153,500 - 121,160,084 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	126,751,677 - 126,758,281 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	124,950,740 - 124,957,344 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	122,780,342 - 122,786,944 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	130,120,525 - 130,127,515 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	130,120,523 - 130,127,392 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	129,312,785 - 129,319,582 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	126,492,636 - 126,499,220 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	126,512,372 - 126,518,954 (-)	NCBI
Celera	8	120,288,523 - 120,295,093 (-)	NCBI		Celera
RH 3.4 Map	8	1254.7	RGD
RH 3.4 Map	8	1282.1	RGD
Cytogenetic Map	8	q32	NCBI

Cck
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	28,438,806 - 28,443,458 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	28,438,806 - 28,443,458 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	42,225,061 - 42,233,431 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	42,229,822 - 42,238,192 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	42,168,012 - 42,176,358 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	42,431,021 - 42,439,396 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	42,431,022 - 42,439,396 (-)	Ensembl	panpan1.1		panPan2

CCK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	11,414,254 - 11,419,990 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	11,414,249 - 11,454,198 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	11,451,726 - 11,457,488 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	11,701,990 - 11,707,749 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	11,701,991 - 11,707,673 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	11,504,111 - 11,509,872 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	11,646,349 - 11,652,103 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	11,650,493 - 11,656,260 (-)	NCBI		UU_Cfam_GSD_1.0

Cck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	200,424,409 - 200,429,945 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936695	2,776,831 - 2,782,061 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936695	2,776,705 - 2,782,280 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	25,937,645 - 25,945,793 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	25,940,674 - 25,945,879 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	28,610,211 - 28,615,371 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Cck
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	77,309,633 - 77,314,384 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	77,310,080 - 77,314,258 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CCK
210 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
62	22	18	20	20	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007983784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000014892 ⟹ ENSCSAP00000012851

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	22	3,698,173 - 3,704,956 (-)	Ensembl

RefSeq Acc Id:

XM_007983784 ⟹ XP_007981975

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	22	3,698,192 - 3,705,443 (-)	NCBI
Vero_WHO_p1.0	NW_023666041	163,500,609 - 163,507,518 (+)	NCBI

Sequence:

show sequence

GCTCCGGGGTAGGGGGGCCCACGCCCCATCCCTCTCAGAATCGCGCCTTACTGACGCTCAGTCC
CGCCCAGTGTCCACCCCTCACCCCACCCCAGTTTCCTTTCTGGACCCTCCGGTCCCCAAAGCGA
ACTAAGCTAGCGGCAGCTTCTCCATCCCGGGGAAGACTCCAAACTCCTGGGTTTCCCACCTTGG
AGAGCACTGCTCTGGAATGCGCAGGGGAGCGGCAGCTGGAAAGGGTTGGAAGGAAGCTTCTCGG
ACCCAGAGGGACGCGGACACCCGGCCCAGCCTGGGAGGGGTTAAATCCGCCCCACTGGACCACC
TCCCCCTTTCCCCCAGGAGCCACTTCAACCGGTTGTCGTCCCAGTGGCCACCCTCTGAGCACGT
GTTGCTGCCAGTCTGCGTCAGCGCTGGGTAAATACATGACTGGGCGACGCCGCCGGGCGGGGCT
ATTTAAGAGGCAGCCGCCCTCTGGTCCTCCCTGAACTTGGCTCAGCTGCCGGGCTGCTCCGGTT
GGAAACGCCAAGCCAGCTGCGTTCTAATCCAAAAGCCATGAACAGCGGCGTGCGCCTGTGCGTA
CTGATGGCGGTACTGGCGGCTGGCGCCCTGGCGCAGCCGGTGCCTCCCGCAGAGCCCGCGGGCT
CCGGGCTGCAGCGGCCAGAGGCGCCCCGTAGGCAGCTGAGGGCAGTGCAGAGAACGGACGGGGA
GTCCCGAGCGCACCTGGGCGCGCTGCTGGCGAGATACATCCAGCAGGCCAGGAAAGCTCCTTCT
GGGCGAATGTCCATCATTAAGAACCTGCAGAACCTGGACCCCAGCCACAGGATAAGTGACCGGG
ACTACATGGGCTGGATGGATTTTGGCCGTCGCAGTGCCGAGGAGTATGAGTACCCCTCCTAGAG
GACCAGCCTCCATTGGCCCAACGAGAAGCAACCTCCCAACCCAGAGGAGGCAGAATAAGAAAAC
AATCACACCATATCTCATTGTCTGTGGAGTTTGACATTGTATGTATCTATTTATTAAGTTCTCA
ATGTGAAAAATGTGTCTGTAAAAATTGTCCAGTGCAACCACACACCTCACCAGAACTATACAAA
GGGAAGACAAAATGTTTTCCTCATCTGTGACTCCTGGTCTGAAAATGTTGTTATGCGATTAAAG
TGATTTCATTCTGCCCTGTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007981975	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000012851
	ENSCSAP00000012851.1

RefSeq Acc Id:	XP_007981975 ⟸ XM_007983784
- UniProtKB:	A0A0D9RW62 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000012851 ⟸ ENSCSAT00000014892

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000016797	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000014892.1	UniProtKB/TrEMBL
InterPro	CCK-like	UniProtKB/TrEMBL
	Gastrin/CCK	UniProtKB/TrEMBL
	Gastrin/cholecystokinin_CS	UniProtKB/TrEMBL
KEGG Report	csab:103227453	UniProtKB/TrEMBL
NCBI Gene	CCK	ENTREZGENE
PANTHER	CHOLECYSTOKININ	UniProtKB/TrEMBL
	PTHR10786	UniProtKB/TrEMBL
Pfam	Gastrin	UniProtKB/TrEMBL
PROSITE	GASTRIN	UniProtKB/TrEMBL
SMART	GASTRIN	UniProtKB/TrEMBL
UniProt	A0A0D9RW62	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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