LILRB4 (leukocyte immunoglobulin like receptor B4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: LILRB4 (leukocyte immunoglobulin like receptor B4) Chlorocebus sabaeus
Analyze
Symbol: LILRB4
Name: leukocyte immunoglobulin like receptor B4
RGD ID: 18389855
Description: ENCODES a protein that exhibits apolipoprotein binding (ortholog); fibronectin binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN Fc receptor mediated inhibitory signaling pathway (ortholog); interleukin-10-mediated signaling pathway (ortholog); mast cell activation (ortholog); FOUND IN cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor subfamily B member 4; LOC103235563
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,299,764 - 47,333,711 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607327,574,619 - 27,579,928 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway  (IEA)
cytokine-mediated signaling pathway  (IEA)
Fc receptor mediated inhibitory signaling pathway  (ISO)
immune response-regulating signaling pathway  (IEA)
interleukin-10-mediated signaling pathway  (ISO)
mast cell activation  (ISO)
negative regulation of activated T cell proliferation  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of cytotoxic T cell differentiation  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of interleukin-5 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of intracellular signal transduction  (ISO)
negative regulation of IP-10 production  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of monocyte activation  (ISO)
negative regulation of osteoclast differentiation  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of T cell costimulation  (ISO)
negative regulation of T cell cytokine production  (ISO)
negative regulation of T cell proliferation  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of type II interferon production  (ISO)
positive regulation of CD8-positive, alpha-beta T cell differentiation  (ISO)
positive regulation of regulatory T cell differentiation  (ISO)
positive regulation of T cell anergy  (ISO)
receptor internalization  (ISO)
tolerance induction  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LILRB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,299,764 - 47,333,711 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607327,574,619 - 27,579,928 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LILRB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,662,985 - 54,668,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,643,889 - 54,670,359 (+)EnsemblGRCh38hg38GRCh38
GRCh371955,174,437 - 55,180,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,865,936 - 59,871,660 (+)NCBINCBI36Build 36hg18NCBI36
Build 341959,866,263 - 59,873,621NCBI
Celera1952,214,265 - 52,220,001 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,497,246 - 51,504,797 (+)NCBIHuRef
CHM1_11955,167,838 - 55,175,378 (+)NCBICHM1_1
T2T-CHM13v2.01957,737,351 - 57,762,244 (+)NCBIT2T-CHM13v2.0
Lilrb4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391051,356,757 - 51,362,417 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1051,356,728 - 51,362,799 (+)EnsemblGRCm39 Ensembl
GRCm381051,480,612 - 51,486,329 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1051,480,632 - 51,486,703 (+)EnsemblGRCm38mm10GRCm38
MGSCv371051,200,485 - 51,206,025 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361051,169,094 - 51,174,634 (+)NCBIMGSCv36mm8
Celera1052,324,193 - 52,329,733 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1025.5NCBI
Lilrb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,847,685 - 78,853,294 (-)NCBIGRCr8
mRatBN7.2169,805,020 - 69,810,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,805,250 - 69,810,660 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx175,164,131 - 75,169,435 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,728,450 - 83,733,754 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,872,043 - 76,877,344 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,393,854 - 73,399,448 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,393,850 - 73,399,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,149,247 - 75,154,729 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,165,498 - 69,170,800 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,243,608 - 69,248,911 (-)NCBI
Celera167,336,070 - 67,340,685 (+)NCBICelera
Cytogenetic Map1q12NCBI
LILRB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22060,682,282 - 60,688,657 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,605,700 - 62,612,079 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,606,681 - 51,612,751 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,392,690 - 60,453,555 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC484306
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,779,562 - 102,786,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,843,014 - 102,849,207 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,426,664 - 103,432,846 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11103,068,755 - 103,074,937 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,827,945 - 102,834,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,541,899 - 103,548,063 (-)NCBIUU_Cfam_GSD_1.0
LOC100517285
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1658,996,449 - 59,001,088 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,920,421 - 53,925,036 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in LILRB4
1424 total Variants

Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_037992047   ⟹   XP_037847975
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607327,574,619 - 27,579,928 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037847975 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016207.1
RefSeq Acc Id: XP_037847975   ⟸   XM_037992047
- UniProtKB: A0A0D9S5R8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001828 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016706.1 UniProtKB/TrEMBL
Gene3D-CATH Immunoglobulins UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig-like_Receptors_ImmuneReg UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
NCBI Gene LOC103235563 ENTREZGENE
PANTHER LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 4 UniProtKB/TrEMBL
  MHC CLASS I NK CELL RECEPTOR UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL
UniProt A0A0D9S5R8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-12-08 LILRB4  leukocyte immunoglobulin like receptor B4  LOC103235563  leukocyte immunoglobulin-like receptor subfamily B member 2  Symbol and/or name change 5135510 APPROVED