NOS3 (nitric oxide synthase 3) - Rat Genome Database

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Gene: NOS3 (nitric oxide synthase 3) Chlorocebus sabaeus
Analyze
Symbol: NOS3
Name: nitric oxide synthase 3
RGD ID: 18387396
Description: ENCODES a protein that exhibits actin binding (ortholog); actin monomer binding (ortholog); arginine binding (ortholog); INVOLVED IN angiogenesis (ortholog); aortic valve morphogenesis (ortholog); blood vessel diameter maintenance (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; eicosanoid signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH acute chest syndrome (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN apical part of cell (ortholog); caveola (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nitric oxide synthase, endothelial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,174,829 - 119,196,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607215,144,615 - 15,167,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute chest syndrome  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
angle-closure glaucoma  (ISO)
anterior ischemic optic neuropathy  (ISO)
aortic valve disease  (ISO)
arteriosclerosis  (ISO)
Arteriovenous Fistula  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
Behcet's disease  (ISO)
bladder neck obstruction  (ISO)
Brain Hypoxia  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (ISO)
central sleep apnea  (ISO)
cerebral infarction  (ISO)
Child Behavior Disorders  (ISO)
cholestasis  (ISO)
Chronic Cerebral Hypoperfusion  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
colitis  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary artery vasospasm  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Gastroparesis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
disease of cellular proliferation  (ISO)
Drug-Induced Enteropathy  (ISO)
end stage renal disease  (ISO)
endometrial carcinoma  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
essential hypertension  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
familial hyperlipidemia  (ISO)
Femur Head Necrosis  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
Graft Occlusion, Vascular  (ISO)
Hemorrhagic Shock  (ISO)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
hepatopulmonary syndrome  (ISO)
high grade glioma  (ISO)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypertension Resistant to Conventional Therapy  (ISO)
Hypertriglyceridemia  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
ileus  (ISO)
impotence  (ISO)
Insulin Resistance  (ISO)
intestinal perforation  (ISO)
Intestinal Reperfusion Injury  (ISO)
Intimal Hyperplasia  (ISO)
intracranial aneurysm  (ISO)
Intracranial Hemorrhages  (ISO)
irritable bowel syndrome  (ISO)
ischemia  (ISO)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyoma  (ISO)
lethal congenital glycogen storage disease of heart  (ISO)
limb ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
long QT syndrome  (ISO)
lung disease  (ISO)
Lung Reperfusion Injury  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
macular retinal edema  (ISO)
male infertility  (ISO)
Metabolic Syndrome  (ISO)
migraine  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
oligospermia  (ISO)
ovarian cancer  (ISO)
overnutrition  (ISO)
Pain  (ISO)
Perennial Allergic Rhinitis  (ISO)
perinatal necrotizing enterocolitis  (ISO)
persistent fetal circulation syndrome  (ISO)
Phyllodes Tumor  (ISO)
placental abruption  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
primary open angle glaucoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary edema  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
Radiation Pneumonitis  (ISO)
renal hypertension  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinopathy of prematurity  (ISO)
Right Ventricular Hypertrophy  (ISO)
Sepsis  (ISO)
sickle cell anemia  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
Sudden Hearing Loss  (ISO)
telangiectasis  (ISO)
Teratozoospermia  (ISO)
Testis Reperfusion Injury  (ISO)
Thromboembolism  (ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
vasculitis  (ISO)
Vaso-occlusive Crisis  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Right  (ISO)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
vestibular disease  (ISO)
vulva cancer  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
aortic valve morphogenesis  (ISO)
blood vessel diameter maintenance  (ISO)
blood vessel remodeling  (ISO)
bone development  (ISO)
calcium ion transport  (ISO)
cellular response to cAMP  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to heat  (ISO)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to magnesium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to rotenone  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
endocardial cushion morphogenesis  (ISO)
endothelial cell migration  (ISO)
establishment of localization in cell  (ISO)
female pregnancy  (ISO)
gene expression  (ISO)
homeostasis of number of cells within a tissue  (ISO)
in utero embryonic development  (ISO)
L-arginine catabolic process  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lung development  (ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of muscle hyperplasia  (ISO)
negative regulation of potassium ion transport  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
nitric oxide biosynthetic process  (ISO)
nitric oxide metabolic process  (ISO)
ovulation from ovarian follicle  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of gene expression  (ISO)
potassium ion transport  (ISO)
protein import into nucleus  (ISO)
pulmonary valve morphogenesis  (ISO)
regulation of nervous system process  (ISO)
regulation of sodium ion transport  (ISO)
regulation of systemic arterial blood pressure by endothelin  (ISO)
regulation of the force of heart contraction by chemical signal  (ISO)
removal of superoxide radicals  (ISO)
response to activity  (ISO)
response to amino acid  (ISO)
response to axon injury  (ISO)
response to carbohydrate  (ISO)
response to corticosterone  (ISO)
response to cytokine  (ISO)
response to erythropoietin  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to fluid shear stress  (ISO)
response to fructose  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to ketone  (ISO)
response to L-arginine  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to magnetism  (ISO)
response to mechanical stimulus  (ISO)
response to mercury ion  (ISO)
response to metal ion  (ISO)
response to nicotine  (ISO)
response to nutrient levels  (ISO)
response to peptide  (ISO)
response to peptide hormone  (ISO)
response to salt  (ISO)
response to ultrasound  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
smooth muscle hyperplasia  (ISO)
vasodilation  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
NOS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,174,829 - 119,196,840 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607215,144,615 - 15,167,202 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NOS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,991,017 - 151,014,588 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,991,017 - 151,014,588 (+)Ensemblhg38GRCh38
GRCh377150,688,105 - 150,711,676 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,319,080 - 150,342,609 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347150,125,794 - 150,149,323NCBI
Celera7145,245,139 - 145,269,020 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,500,690 - 144,524,025 (+)NCBIHuRef
CHM1_17150,696,541 - 150,720,093 (+)NCBICHM1_1
T2T-CHM13v2.07152,163,824 - 152,187,711 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,017,398 - 150,041,276 (+)NCBI
Nos3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,569,772 - 24,589,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,569,808 - 24,589,472 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38524,364,816 - 24,384,474 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,364,810 - 24,384,474 (+)Ensemblmm10GRCm38
MGSCv37523,870,637 - 23,890,292 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36523,874,884 - 23,894,536 (+)NCBIMGSCv36mm8
Celera521,311,457 - 21,334,226 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.32NCBI
Nos3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,686,088 - 11,706,604 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl411,686,268 - 11,706,664 (-)EnsemblGRCr8
mRatBN7.2410,793,834 - 10,814,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,793,834 - 10,814,166 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx415,940,095 - 15,960,412 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,760,284 - 11,780,599 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,112,074 - 10,132,387 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,321,908 - 7,342,404 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,320,668 - 7,342,410 (-)Ensemblrn6Rnor6.0
Rnor_5.047,333,272 - 7,353,767 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.446,158,847 - 6,179,441 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera46,408,408 - 6,428,650 (-)NCBICelera
RGSC_v3.146,158,846 - 6,179,441 (-)NCBI
Cytogenetic Map4q11NCBI
Nos3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,438,010 - 5,460,814 (+)Ensembl
ChiLan1.0NW_0049554915,438,228 - 5,457,308 (+)NCBIChiLan1.0ChiLan1.0
NOS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,411,083 - 187,436,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,421,347 - 39,446,540 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,577,334 - 142,600,702 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,730,009 - 154,755,233 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,730,009 - 154,755,233 (+)EnsemblpanPan2panpan1.1
NOS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,054,196 - 15,072,454 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,011,344 - 15,072,277 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1615,662,484 - 15,680,572 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01616,776,276 - 16,794,533 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11615,148,899 - 15,166,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,730,292 - 15,748,445 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,781,028 - 15,799,144 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nos3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,457,663 - 6,476,277 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,427,093 - 6,446,534 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,427,147 - 6,445,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,209,158 - 6,228,943 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,209,218 - 6,228,912 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,579,253 - 6,602,572 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nos3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,600,212 - 5,619,004 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248005,600,215 - 5,619,020 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in NOS3
371 total Variants

Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_037990968   ⟹   XP_037846896
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607215,144,615 - 15,167,202 (+)NCBI
Protein Sequences
Protein RefSeqs XP_072865596 (Get FASTA)   NCBI Sequence Viewer  
  XP_072865597 (Get FASTA)   NCBI Sequence Viewer  
  XP_072865598 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_037846896   ⟸   XM_037990968


Additional Information

Database Acc Id Source(s)
NCBI Gene NOS3 ENTREZGENE