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Gene: PENK (proenkephalin) Chlorocebus sabaeus

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Symbol:

PENK

Name:

proenkephalin

RGD ID:

18367864

Description:

ENCODES a protein that exhibits opioid peptide activity (inferred); opioid receptor binding (inferred); receptor ligand activity (inferred); INVOLVED IN aggressive behavior (ortholog); behavioral fear response (ortholog); cellular response to cAMP (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); amyotrophic lateral sclerosis type 1 (ortholog); Anhedonia (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell body fiber (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

proenkephalin-A

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PENK (proenkephalin)	NCBI	Ortholog
Mus musculus (house mouse):	Penk (preproenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Penk (proenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Penk (proenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PENK (proenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PENK (proenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Penk (proenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PENK (proenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Penk (proenkephalin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	52,458,113 - 52,463,933 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	52,457,904 - 52,463,859 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	89,329,730 - 89,335,563 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

amyotrophic lateral sclerosis type 1 (ISO)

Anhedonia (ISO)

Catalepsy (ISO)

Drug-Induced Dyskinesia (ISO)

dystonia (ISO)

epilepsy (ISO)

heroin dependence (ISO)

Hyperalgesia (ISO)

Hyperphagia (ISO)

Knee Osteoarthritis (ISO)

Myocardial Ischemia (ISO)

narcolepsy (ISO)

nervous system disease (ISO)

opiate dependence (ISO)

overactive bladder syndrome (ISO)

Pain (ISO)

Parkinson's disease (ISO)

Prostatic Neoplasms (ISO)

spinal disease (ISO)

Visceral Pain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aggressive behavior (IEA,ISO)

behavioral fear response (IEA,ISO)

cellular response to cAMP (ISO)

cellular response to oxidative stress (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

cellular response to virus (ISO)

cellular response to vitamin D (ISO)

chemical synaptic transmission (IEA)

G protein-coupled opioid receptor signaling pathway (IEA)

general adaptation syndrome, behavioral process (ISO)

glial cell proliferation (ISO)

locomotory behavior (IEA,ISO)

locomotory exploration behavior (ISO)

neuropeptide signaling pathway (IEA)

osteoblast differentiation (ISO)

positive regulation of behavioral fear response (ISO)

regulation of long-term synaptic depression (ISO)

response to bacterium (IEA,ISO)

response to calcium ion (ISO)

response to epinephrine (ISO)

response to estradiol (ISO)

response to ethanol (ISO)

response to hypoxia (ISO)

response to immobilization stress (ISO)

response to lipopolysaccharide (ISO)

response to nicotine (ISO)

response to toxic substance (ISO)

sensory perception (IEA)

sensory perception of pain (IEA,ISO)

startle response (IEA,ISO)

synaptic signaling via neuropeptide (ISO)

transmission of nerve impulse (IEA)

Cellular Component

axon (ISO)

axon terminus (IEA,ISO)

cell body fiber (ISO)

chromaffin granule lumen (IEA)

dendrite (IEA,ISO)

extracellular region (IEA)

neuronal cell body (IEA,ISO)

neuronal dense core vesicle lumen (ISO)

perikaryon (ISO)

plasma membrane (IEA)

symmetric synapse (ISO)

synaptic vesicle lumen (ISO)

Molecular Function

opioid peptide activity (IEA)

opioid receptor binding (IEA)

protein binding (ISO)

receptor ligand activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PENK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	52,458,113 - 52,463,933 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	52,457,904 - 52,463,859 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	89,329,730 - 89,335,563 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PENK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	56,440,957 - 56,446,641 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	56,436,674 - 56,446,671 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	57,353,516 - 57,359,200 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	57,516,070 - 57,521,143 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	57,516,069 - 57,521,143	NCBI
Celera	8	53,344,310 - 53,350,077 (-)	NCBI		Celera
Cytogenetic Map	8	q12.1	NCBI
HuRef	8	52,820,608 - 52,826,373 (-)	NCBI		HuRef
CHM1_1	8	57,405,395 - 57,411,158 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	56,818,203 - 56,823,883 (-)	NCBI		T2T-CHM13v2.0

Penk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	4,133,536 - 4,138,815 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	4,133,531 - 4,138,819 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	4,133,536 - 4,138,815 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	4,133,531 - 4,138,819 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	4,060,683 - 4,065,592 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	4,060,683 - 4,065,592 (-)	NCBI		MGSCv36	mm8
Celera	4	4,092,742 - 4,097,651 (-)	NCBI		Celera
Cytogenetic Map	4	A1	NCBI
cM Map	4	2.31	NCBI

Penk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	21,981,381 - 21,987,074 (-)	NCBI		GRCr8
mRatBN7.2	5	17,183,799 - 17,189,160 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	17,183,806 - 17,189,129 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	19,402,516 - 19,407,452 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	21,001,023 - 21,005,959 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	20,754,402 - 20,759,344 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	17,056,412 - 17,061,762 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	17,056,419 - 17,061,837 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	21,834,409 - 21,839,759 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	17,509,323 - 17,514,265 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	17,516,079 - 17,517,452 (-)	NCBI
Celera	5	16,529,164 - 16,534,106 (-)	NCBI		Celera
Cytogenetic Map	5	q12	NCBI

Penk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	15,426,017 - 15,426,685 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	15,425,712 - 15,426,685 (-)	NCBI	ChiLan1.0	ChiLan1.0

PENK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	72,075,726 - 72,081,540 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	47,800,250 - 47,806,064 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	52,864,388 - 52,870,144 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	50,234,170 - 50,239,949 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	50,234,170 - 50,239,949 (-)	Ensembl	panpan1.1		panPan2

PENK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	7,757,543 - 7,763,137 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	7,757,857 - 7,762,398 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	8,069,914 - 8,075,462 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	7,832,106 - 7,837,657 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	29	7,844,842 - 7,850,120 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	7,975,639 - 7,980,923 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	8,254,882 - 8,260,429 (-)	NCBI		UU_Cfam_GSD_1.0

Penk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	71,763,745 - 71,769,230 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936496	3,016,218 - 3,021,738 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936496	3,016,247 - 3,021,726 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PENK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	75,525,555 - 75,530,876 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	75,525,497 - 75,530,403 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	82,444,889 - 82,449,745 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Penk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624886	3,595,450 - 3,613,593 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624886	3,595,485 - 3,613,117 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in PENK
171 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	18	34	34	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008000696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038000479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000012644 ⟹ ENSCSAP00000010674

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	8	52,457,904 - 52,463,859 (-)	Ensembl

RefSeq Acc Id:

XM_008000696 ⟹ XP_007998887

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	8	52,458,113 - 52,463,933 (-)	NCBI
Vero_WHO_p1.0	NW_023666039	89,329,730 - 89,335,563 (+)	NCBI

Sequence:

show sequence

CCGCCGGCGATTGGGGAGCGCGCGCCTCCTTCGGTTTGGGGCTAATTATAAAGTGGCTCCAGCC
GCCGTTAAGCCCCGGGACGGCGAGGCAGGCGCTCAGAGCCCCGCGGCGACGCTGAGGACCGCGA
CGAGTTGTGTCTGGAACCCGGCTTTTCCAATTGGCCTGCTGCATCCGAACAGCGTCAACTCCAT
GGCGTGGTTCCTGAGACTCTGCCCTTGGCTGCTGTTGCTCGGCCCCGGGCTTCTGGCGACAGTG
CGGGCAGAATGCAGCCAGGATTGCGCGACGTGCAGCTACCGCCTGGTGCGCCCCGCCGACATCA
ACTTCCTGGCTTGCGTAATGGAATGTGAAGGAAAACTGCCTTCTCTGAAAATTTGGGAAACCTG
CAAGGAGCTCCTGCAGCTGTCCAAACCAGAGCTTCCTCAAGATGGCACCGGCACCCTCAGAGAA
AACAGCAAACCAGAAGAGAGCCATTTGCTAGCCAAAAGGTATGGGGGCTTCATGAAAAGGTATG
GAGGCTTCATGAAGAAAATGGATGAGCTTTATCCCATGGAGCCAGAAGAAGAGGCCAATGGAAG
TGAGATCCTCGCCAAGCGGTATGGGGGCTTCATGAAGAAGGATGCAGAGGAGGACGACTTGCTG
GCCAATTCCTCAGACCTGCTGAAAGAGCTTCTGGAAACAGGGGACAACCGAGAGCATAGCCACC
ACCAGGATGGCAGTGATAATGAGGAAGAAGTGAGCAAGAGATATGGGGGCTTCATGAGAGGCTT
AAAGAGAAGCCCCCAACTGGAAGATGAAGCCAAAGAGCTGCAGAAGCGATATGGGGGCTTCATG
AGAAGAGTGGGTCGCCCAGAGTGGTGGATGGACTACCAGAAACGGTATGGAGGCTTCCTGAAGC
GCTTTGCTGAGGCTCTGCCCTCCAACGAAGAAGGGGAAAGTTACTCCAAAGAAGTTCCTGAAAT
GGAAAAAAGATACGGAGGATTTATGAGATTTTAATACCCTTTCCCACTAATGGCCCCAGGCCCC
AGCAAGCCTCCCTCCATCCTCCAGTGAGAAACTGCTGATGGTGTTTTATTGTCATGTGTTTGTT
GCTTGCCTTGTATAGTTGACTTCATTGTCTGGATAACTATACAACCTGAAAACTGTCATTTCAG
GTTCTGTGCTCTTTTTGGAGTCTTTAAGCTCAGTGTTCGTCTGTTGCAGCTATCTCTTTTTCAT
GCTAAAATAGTTTTTGTTATCTTGTCTCTTATTTTTGACAAACATCAATAAATGCTTACTTGTA
TATAGAGATAATAAACCTATTACCCCAAGTGCATAA

hide sequence

RefSeq Acc Id:

XM_038000479 ⟹ XP_037856407

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666039	89,329,744 - 89,335,563 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007998887	(Get FASTA)	NCBI Sequence Viewer
	XP_037856407	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000010674.1

RefSeq Acc Id:	XP_007998887 ⟸ XM_008000696
- UniProtKB:	A0A0D9RPY5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000010674 ⟸ ENSCSAT00000012644

RefSeq Acc Id:	XP_037856407 ⟸ XM_038000479
- UniProtKB:	A0A0D9RPY5 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000014552	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000012644.1	UniProtKB/TrEMBL
InterPro	Opioid_neupept	UniProtKB/TrEMBL
	Proenkphlin_A	UniProtKB/TrEMBL
KEGG Report	csab:103236834	UniProtKB/TrEMBL
NCBI Gene	PENK	ENTREZGENE
PANTHER	PTHR11438	UniProtKB/TrEMBL
	PTHR11438:SF3	UniProtKB/TrEMBL
Pfam	Opiods_neuropep	UniProtKB/TrEMBL
PRINTS	OPIOIDPRCRSR	UniProtKB/TrEMBL
	PENKAPRCRSR	UniProtKB/TrEMBL
PROSITE	OPIOIDS_PRECURSOR	UniProtKB/TrEMBL
UniProt	A0A0D9RPY5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD