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Gene: HEATR3 (HEAT repeat containing 3) Chlorocebus sabaeus

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Symbol:

HEATR3

Name:

HEAT repeat containing 3

RGD ID:

18363161

Description:

ENCODES a protein that exhibits unfolded protein binding (inferred); INVOLVED IN erythrocyte maturation (inferred); protein import into nucleus (inferred); ribosomal large subunit biogenesis (inferred); ASSOCIATED WITH Diamond-Blackfan anemia (ortholog); Diamond-Blackfan anemia 1 (ortholog); Diamond-Blackfan Anemia 21 (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

HEAT repeat-containing protein 3; LOC103232632; uncharacterized LOC103232632

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	35,865,090 - 35,906,611 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	35,865,134 - 35,908,271 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	40,588,241 - 40,643,761 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Diamond-Blackfan anemia (ISO)

Diamond-Blackfan anemia 1 (ISO)

Diamond-Blackfan Anemia 21 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

erythrocyte maturation (IEA)

protein import into nucleus (IEA)

ribosomal large subunit biogenesis (IEA)

Molecular Function

unfolded protein binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

HEATR3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	35,865,090 - 35,906,611 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	35,865,134 - 35,908,271 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	40,588,241 - 40,643,761 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HEATR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	50,065,970 - 50,107,272 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	50,065,964 - 50,107,272 (+)	Ensembl			hg38	GRCh38
GRCh37	16	50,099,881 - 50,141,183 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	48,657,382 - 48,696,893 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	16	34,613,203 - 34,679,975 (+)	NCBI		Celera
Cytogenetic Map	16	q12.1	NCBI
HuRef	16	35,988,200 - 36,053,654 (+)	NCBI		HuRef
CHM1_1	16	51,507,140 - 51,546,658 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	55,863,712 - 55,905,022 (+)	NCBI		T2T-CHM13v2.0

Heatr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	88,864,453 - 88,901,656 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	88,864,483 - 88,898,655 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	88,137,885 - 88,171,952 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	88,137,855 - 88,172,027 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	90,661,784 - 90,695,851 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	91,027,990 - 91,062,057 (+)	NCBI		MGSCv36	mm8
Celera	8	92,409,477 - 92,444,792 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	43.06	NCBI

Heatr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	35,065,915 - 35,103,779 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	35,067,060 - 35,103,978 (-)	Ensembl				GRCr8
mRatBN7.2	19	18,892,477 - 18,930,502 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	18,893,144 - 18,930,509 (-)	Ensembl				mRatBN7.2
Rnor_6.0	19	19,858,419 - 19,896,782 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	19,858,416 - 19,896,421 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	30,883,214 - 30,921,221 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	20,204,999 - 20,242,364 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	18,777,148 - 18,815,511 (-)	NCBI		Celera
RGSC_v3.1	19	20,210,399 - 20,247,067 (-)	NCBI
Cytogenetic Map	19	p11	NCBI

Heatr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	8,183,395 - 8,224,117 (+)	Ensembl
ChiLan1.0	NW_004955433	8,183,701 - 8,224,117 (+)	NCBI	ChiLan1.0	ChiLan1.0

HEATR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	59,523,229 - 59,563,729 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	65,428,284 - 65,469,664 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	30,329,163 - 30,369,658 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	49,212,645 - 49,251,043 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	49,212,645 - 49,251,043 (+)	Ensembl			panPan2	panpan1.1

HEATR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	65,178,268 - 65,218,129 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	65,151,717 - 65,218,109 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	61,751,008 - 61,790,828 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	65,723,708 - 65,763,860 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	65,694,868 - 65,764,431 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	62,546,824 - 62,586,651 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	63,566,436 - 63,606,242 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	64,455,290 - 64,495,117 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Heatr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	56,367,114 - 56,400,056 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	3,188,820 - 3,222,354 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	3,189,008 - 3,222,242 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HEATR3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	34,708,080 - 34,759,158 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	34,706,561 - 34,759,172 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Heatr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624757	6,558,342 - 6,597,552 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624757	6,522,808 - 6,597,460 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in HEATR3
1020 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007992827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038008510	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038008511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_073015357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JBLKOC010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000003430 ⟹ ENSCSAP00000001708

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	5	35,865,134 - 35,908,271 (+)	Ensembl

RefSeq Acc Id:

XM_007992827 ⟹ XP_007991018

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	35,865,090 - 35,906,611 (+)	NCBI
Vero_WHO_p1.0	NW_023666047	40,599,721 - 40,643,761 (-)	NCBI

Sequence:

show sequence

CCCCGCCCCGACCCCGACCCAGCAGACGACGCGCCGCGCGCCTGCGCACGGTTTCCCCATGTGT
TCTCCAGCCGTCAGCAGGCCCAGCTGAGCAGCAGCCACGGACGTTGCTTGTCACCGGCGCGGCA
GCCTCCCCCGCCTGCTGTTGCCCTCCTCCCTCGGTGGTCTGTCAGCACAGCGCACGTCGCCATG
GGTAAGAGCCGGACGAAGCGCTTCAAGCGACCTCAGTTCTCCCCTACGGGCGACTGTCAGGCCG
AGGCGGCTGCGGCGGCGAATGGGACCGGAGGCGAGGAGGACGACGGGCCAGCGGCGGAGCTGCT
GGAAAAGCTGCAGCACCCGAGCGCCGAGGTCCGCGAGTGCGCCTGCGCGGGGCTGGCCCGGCTG
GTGCAGCAGCGGCCGGCACTCCCGGGCCTGGCGCGCCGAGACGCCGTGCGCCGCCTCGGGCCGC
TGCTTCTGGACCCTAGCCTGGCCGTCAGGGAGACTGCAGCCGGCGCGCTGAGAAATCTCAGTGC
TTGTGGAGGTTTTGAAGTTTGTGATGACATGGTGACTAAGGATATCATGACCCCTCTGGTTGTG
CTGCTAAAAGAGTGTAGTGCTGGACTGGATTCAAATGAGATGTCCCTGCAGGAGAAAAAAGATC
AGAACAGAAATTCTGTTGAGAACATAGCCAATGAGGCTGTGAACGTGCTGTGGAATATATGTGA
ATGCAGTAGTAGAGCAGTGTCTATATTCAACAAAGAAGGGTGTTTGGAGATTGTGTTAAAGTAT
TTAAGTAGGTTTCCTACCAATGTTGACCTGGCTATTTCAGTAGCATATTGTTTGCAGACAGTGA
CCGAGGATAACCCAGAGCTGCTGAAGTCTTTCAGTGCTACAGCACTGAACGTGCTGGAATCAGC
ACTGCTTTCTCCTGTTAGTTCCATGGAATCCCTTCTATTGAAGACATTGGTAGCAGGCACAATT
TGGAATCTAAAGGACATTATTCCATGCAAGAGTCAAGCAGAAATCATAAATGCCTTACTAAAGA
TCTTATCTGAAGTTTTGGGAATGGATGCTGGTGAAACAGTTATTCAAATGAAAGAGACTGAAAC
GCAAAGGTTAAAAACTGCTGCAGAGGCTGAGGAAATACTAGAGAACACTAATGGGGATGATTTG
ATTGAAGATGATGAAATGGAAGGAATTTCTCATAAGAGAAAAGTCAGAAGGAAAACTTTCGTTT
CAGATTTACTTCCGCCCACTGACAAGGAGCTGAGAGAGACTATAGCATTGCTGACAGCTCAACA
GACTGCTCTGGAAATTATCGTCAACATGTGCTGCAATGAAGATCCCTCTGATGACGAATGGGAA
GAACTTTCTAGCAGTGATGAAAGTGATACATTTATGGAGAATTCCTTCAGTGAGTGCGGGGGTC
AGCTGTTCACTCCCCTCTGCCTCTCCCATGAGGTTCACACTGCTCTCACCAACTACCTCATCCC
AAAGAAGATTTTTGAGAAAACTGCCTTTCCAAACAGCATTGCAGTTGACCTATGTTCTAGGAAC
CCTACTTGGAAACCTTTGATTAGAAAAATGAACACTATTCAGTGCAGAGCCCTCTTCTGTCTCC
AGAGTCTTGTGTCCCTCCTGGATGTGGAGCACCTGGGAGGAGCCGCAGCCCTTCAGACGCTTGC
ACAGCATCTGTCACAGCTGCTTTTTTCTCAGCCAGATTTTGCTAAACATGCTGACTTTCTAGAA
GCCATAAGTAGTGCTTTGAGGGCCCTTTTGCAAACAATGGCCTCCAAGAACATTTCCCAGTGCA
TGACTCCTGATCAGCTGATGACATTATGCAAAGCAGGCATTCATAGTAGTAATGTCGGGGTTAG
AGTGAATGTCGTTAGCATTTTAGGAATCACTGGCAGCGTCCTTGCCAAAGAAGATGGTACACTT
GAAACTCTTAAGAATATTGGGTGCTTTCTGCTTGAGGTTACCACCAAAGATCCTTCCCTTGTGG
TAGCAGGAGAAGCTTTGGATGCCCTCTTTGATGTTTTTGCAGATGGTAAAGAAGCCGAAAGAGC
CTCGATTGAAATTAAATTATTATCTGCTCTGAAAGAATTCCAGCCGGTCTTTAAAATGAAGATA
CGTAAAGAAGGGAGAGGTAACTGTAGCACAGATCAGCTGTGTGTTCTTGACAATGTGAAAATGA
ATTTGAGAAGATTTATTGCTTATCAAGAAACTGTTGAGAAAAGACTGACTTCTTAATCCCAAAA
AGAAACAGTTCTTCCCCCAAAGTAGTCAATGCTCAGAATACTAAAAGGTTTTCTTTGAATGTAT
ATGTTTCTGAAAGTCCTCTGTTAATGCTTACATTCTGTACATTCTGTAAAAACTTCAAAACCTG
GCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCCGGGTGGGTGGATCACT
TGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAGCTCCATGCATGAGCATGGTGGC
AAATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGGAGGAGAATCGGTTGAACCTGGGAGGCG
GAGGTTGCAGTGAGCTGAGATCACACTACTGCACACAGCCTGGGTGACAGAGGGAGACTCTGTC
TCCAAAA

hide sequence

RefSeq Acc Id:

XM_038008510 ⟹ XP_037864438

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666047	40,588,241 - 40,643,761 (-)	NCBI

RefSeq Acc Id:

XM_038008511 ⟹ XP_037864439

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666047	40,588,241 - 40,643,151 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007991018	(Get FASTA)	NCBI Sequence Viewer
	XP_072871458	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000001708
	ENSCSAP00000001708.1

RefSeq Acc Id:	XP_007991018 ⟸ XM_007992827
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSCSAP00000001708 ⟸ ENSCSAT00000003430

RefSeq Acc Id:	XP_037864438 ⟸ XM_038008510
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_037864439 ⟸ XM_038008511
- Peptide Label:	isoform X3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005398	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003430.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Nuclear_Import_Ribosome_Adapt	UniProtKB/TrEMBL
NCBI Gene	HEATR3	ENTREZGENE
PANTHER	HEAT REPEAT-CONTAINING PROTEIN 3	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	TPR_SYO1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
UniProt	A0A0D9QZB9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-12-03	HEATR3	HEAT repeat containing 3	LOC103232632	uncharacterized LOC103232632	Data merged from RGD:18764174	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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