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Gene: HCRT (hypocretin neuropeptide precursor) Chlorocebus sabaeus

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Symbol:

HCRT

Name:

hypocretin neuropeptide precursor

RGD ID:

18340833

Description:

ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); type 1 orexin receptor binding (ortholog); type 2 orexin receptor binding (ortholog); INVOLVED IN eating behavior (ortholog); excitatory postsynaptic potential (ortholog); negative regulation of DNA replication (ortholog); PARTICIPATES IN orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH cannabis dependence (ortholog); cocaine abuse (ortholog); Cocaine-Related Disorders (ortholog); FOUND IN neuronal dense core vesicle lumen (ortholog); secretory granule (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

orexin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	64,083,199 - 64,085,393 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	64,084,070 - 64,085,292 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	34,898,734 - 34,900,062 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cannabis dependence (ISO)

cocaine abuse (ISO)

Cocaine-Related Disorders (ISO)

Guillain-Barre syndrome (ISO)

heroin dependence (ISO)

hyperglycemia (ISO)

Hyperphagia (ISO)

Hypothermia (ISO)

narcolepsy (ISO)

Narcolepsy 1 (ISO)

neurodegenerative disease (ISO)

nicotine dependence (ISO)

obesity (ISO)

obstructive sleep apnea (ISO)

Pain (ISO)

Prader-Willi syndrome (ISO)

Recurrence (ISO)

sleeping sickness (ISO)

Weight Gain (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

eating behavior (IEA,ISO)

excitatory postsynaptic potential (ISO)

feeding behavior (IEA)

negative regulation of DNA replication (ISO)

negative regulation of potassium ion transport (ISO)

negative regulation of transmission of nerve impulse (ISO)

neuropeptide signaling pathway (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of calcium ion transport (ISO)

positive regulation of cold-induced thermogenesis (IEA)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of transmission of nerve impulse (IEA,ISO)

regulation of neurotransmitter secretion (IEA,ISO)

release of sequestered calcium ion into cytosol (ISO)

response to alcohol (ISO)

response to starvation (IEA)

sleep (IEA)

temperature homeostasis (IEA,ISO)

Cellular Component

cytoplasmic vesicle (IEA)

endoplasmic reticulum (IEA)

neuronal dense core vesicle lumen (ISO)

perinuclear region of cytoplasm (IEA)

rough endoplasmic reticulum (IEA)

secretory granule (ISO)

synapse (IEA)

Molecular Function

neuropeptide hormone activity (IEA,ISO)

type 1 orexin receptor binding (IEA,ISO)

type 2 orexin receptor binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

orexin/hypocretin signaling pathway (ISO)

orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1 (ISO)

orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2 (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HCRT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	64,083,199 - 64,085,393 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	64,084,070 - 64,085,292 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	34,898,734 - 34,900,062 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

HCRT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	42,184,060 - 42,185,452 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	42,184,060 - 42,185,452 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	40,336,078 - 40,337,470 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	37,589,604 - 37,590,996 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	37,589,603 - 37,590,996	NCBI
Celera	17	36,990,305 - 36,991,697 (-)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	36,101,194 - 36,102,586 (-)	NCBI		HuRef
CHM1_1	17	40,571,806 - 40,573,198 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	43,040,552 - 43,041,944 (-)	NCBI		T2T-CHM13v2.0

Hcrt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	100,652,519 - 100,653,757 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	100,651,895 - 100,653,757 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	100,761,693 - 100,762,931 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	100,761,069 - 100,762,931 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	100,623,007 - 100,624,245 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	100,577,783 - 100,579,021 (-)	NCBI		MGSCv36	mm8
Celera	11	111,378,254 - 111,379,492 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	63.6	NCBI

Hcrt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	86,190,289 - 86,191,524 (-)	NCBI		GRCr8
mRatBN7.2	10	85,689,979 - 85,691,214 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	85,689,465 - 85,691,210 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	90,726,483 - 90,727,718 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,205,335 - 90,206,570 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	85,598,213 - 85,599,448 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	88,669,216 - 88,670,430 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	88,669,214 - 88,670,430 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	88,463,386 - 88,464,600 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	89,699,633 - 89,700,847 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	89,714,002 - 89,715,214 (-)	NCBI
Celera	10	84,405,435 - 84,406,649 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Hcrt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	16,235,819 - 16,237,457 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	16,235,819 - 16,237,457 (-)	NCBI	ChiLan1.0	ChiLan1.0

HCRT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	22,798,659 - 22,800,095 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	24,688,821 - 24,691,491 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	15,130,581 - 15,132,024 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	15,353,203 - 15,354,594 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	15,353,203 - 15,354,594 (+)	Ensembl	panpan1.1		panPan2

HCRT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,729,616 - 20,732,074 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	20,730,779 - 20,732,028 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	20,191,816 - 20,193,065 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	21,448,985 - 21,450,877 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	21,449,587 - 21,450,836 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	20,234,894 - 20,236,143 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	20,501,999 - 20,503,248 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,605,051 - 20,606,300 (+)	NCBI		UU_Cfam_GSD_1.0

Hcrt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	20,066,733 - 20,068,144 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	17,006,997 - 17,008,369 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	17,007,001 - 17,008,363 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HCRT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	20,588,027 - 20,589,988 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	20,588,597 - 20,589,991 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	20,877,771 - 20,880,147 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Hcrt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	1,744,648 - 1,746,633 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	1,744,782 - 1,747,360 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HCRT
42 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
64	35	18	34	34	48	19

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008012653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008012654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_501093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000001154 ⟹ ENSCSAP00000014916

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	64,084,070 - 64,085,292 (+)	Ensembl

RefSeq Acc Id:

XM_008012654 ⟹ XP_008010845

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	64,083,199 - 64,085,393 (+)	NCBI
Vero_WHO_p1.0	NW_023666077	34,898,734 - 34,900,062 (+)	NCBI

Sequence:

show sequence

AGAATCACTTGAACCCAAGGCAGGGGTTGCAGTGAGCCAAGATGATCATACCACTGCACTCCAG
CCTGAGCGACAAGACCAAAATTTAGTCACACACACACACACACACACACACACACACACACACA
CACACAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAAGAAAGAGAAATTGGGCTTG
GTTTTAGCTTCTTACCTCCTACTGCCTAGGCTGGGTTTTCAAGGTTTTCCATATCAGAGGCTAG
TGGAAGGGGCAGAAGGGGAGAAGAAAGCTAGGGGGAGGGGGGCAGCTAAGGAACCTTTCCATGA
AGGAAGAAGGTCCTGGAGCCTAACAGTCCCCAGGGGCAGTGACAAGAAGCAGGGGAGGGAGAGG
ACTGCTGCTGGCTGCTCCACCCCCTACACACAGAATGTGGGGTCTTGCGCATCTGCCTCTCTCC
TGCCCCTAATTAGTAGCTGCCTCCCTCCATATTGTCCCAGGCCAGCGCCTCTTTTGTGCTCCCA
GATGCCTGGGTGCAAGGTGGCCTCATTAGTGCCCGGAGACCGCCCCATCTCCAGGGAGCAGGCG
GACAGACAAGGGGGTGATTAGGGGCACAGTGATCCAACCCTGGCCTCTGAACGCAGCAGCGGCC
ATTCCTTGGGCCCAGCCTGGAGACGGCCCCCCTGCAGGAGGCTAATCTTAGACTTGCCTTTGTC
TGGCCCGGGTGTGGACGTAAGTGCCTGTCAATTCCCTGCCACCTCAGAGCACTATAAACCCCAG
ACCCCTGGGAGAGGGTCACAATCAACAGCCTCAAGGTTCCTGGCTTTTTGAACCACCGCAGACA
TCTCCTTTCCCGGCTGCCCCACCCTGAGCACCAGATACCATGAACCTTCCTTCCACAAAGGTCT
GCTGGGCCGCCGTGACGCTACTGCTGCTGCTGCTGCTGCTGCCGCCCGCGCTGCTGTCGCCCGG
GGCGGCTGCACAGCCCCTGCCCGACTGCTGTCGTCAAAAGACGTGCTCCTGCCGCCTCTACGAG
CTGCTGCATGGTGCGGGCAATCACGCGGCCGGCATCCTCACGCTGGGCAAGCGGCGATCCGGGC
CCCCTGGCCTCCAGGGTCGGTTGCAGCGCCTCCTGCAGGCCAGCGGCAACCACGCCGCGGGCAT
CCTGACCATGGGCCGCCGCGCAGGCGCAGAGCCAGCGCCTCGCCCCTGCCTCGGGCGCCACTGT
CCCGCTGCGGCCGCCACATCCGTAGCGCCCGGGGGACAGTCCGGGATCTGAGTCTTTCTTCGGG
CCCTGTCCTGGCCCAGGCCTCTGCCCTCTGCCCACCCAGCGTCAGCCCCCAGAAAAACGGCAAT
AAAGACGAGTCTCCATTCGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_008010845	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000014916
	ENSCSAP00000014916.1

RefSeq Acc Id:	XP_008010845 ⟸ XM_008012654
- UniProtKB:	A0A0D9S227 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000014916 ⟸ ENSCSAT00000001154

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000003125	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000001154.1	UniProtKB/TrEMBL
InterPro	Orexin	UniProtKB/TrEMBL
NCBI Gene	HCRT	ENTREZGENE
PANTHER	OREXIN	UniProtKB/TrEMBL
	PTHR15173	UniProtKB/TrEMBL
Pfam	Orexin	UniProtKB/TrEMBL
PIRSF	Orexin	UniProtKB/TrEMBL
PRINTS	OREXINPP	UniProtKB/TrEMBL
UniProt	A0A0D9S227	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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