Btnl4 (butyrophilin-like 4) - Rat Genome Database

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Gene: Btnl4 (butyrophilin-like 4) Rattus norvegicus
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Symbol: Btnl4
Name: butyrophilin-like 4
RGD ID: 1624210
Description: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be active in external side of plasma membrane; INTERACTS WITH atrazine; cadmium dichloride; lead diacetate.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: Btnl9; butyrophilin-like 9; LOC686977; RGD1624210; similar to butyrophilin-like 7
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,235,938 - 4,249,413 (+)NCBIGRCr8
mRatBN7.2204,231,350 - 4,244,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,235,141 - 4,244,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,940,923 - 4,950,488 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,302,675 - 4,312,240 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0204,269,526 - 4,283,089 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,240,270 - 4,280,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,348,954 - 6,359,267 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,339,504 - 4,349,053 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15060004  


Genomics

Comparative Map Data
Btnl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,235,938 - 4,249,413 (+)NCBIGRCr8
mRatBN7.2204,231,350 - 4,244,825 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,235,141 - 4,244,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,940,923 - 4,950,488 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,302,675 - 4,312,240 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0204,269,526 - 4,283,089 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,240,270 - 4,280,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,348,954 - 6,359,267 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,339,504 - 4,349,053 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map20p12NCBI
Btnl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,687,320 - 34,696,402 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,685,536 - 34,696,292 (-)EnsemblGRCm39 Ensembl
GRCm381734,468,410 - 34,477,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,466,562 - 34,477,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,605,987 - 34,612,882 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,076,402 - 34,085,423 (-)NCBIMGSCv36mm8
Celera1737,236,071 - 37,242,966 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.06NCBI

Variants

.
Variants in Btnl4
583 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:109
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000072694
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
D20Yum65  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,242,352 - 4,242,458 (-)MAPPERmRatBN7.2
Rnor_6.0204,272,594 - 4,272,699NCBIRnor6.0
Rnor_5.0206,351,950 - 6,352,055UniSTSRnor5.0
RGSC_v3.4204,346,716 - 4,346,821UniSTSRGSC3.4
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 29 38 31 13 18 13 6 66 43 10 1 35 18

Sequence


Ensembl Acc Id: ENSRNOT00000029451   ⟹   ENSRNOP00000034717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,240,270 - 4,279,911 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072694   ⟹   ENSRNOP00000064215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,235,141 - 4,244,690 (+)Ensembl
Rnor_6.0 Ensembl204,269,598 - 4,279,911 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081431   ⟹   ENSRNOP00000071356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,276,470 - 4,280,795 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085980   ⟹   ENSRNOP00000068973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,274,504 - 4,274,530 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086354   ⟹   ENSRNOP00000070288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,269,393 - 4,270,193 (-)Ensembl
RefSeq Acc Id: NM_001166354   ⟹   NP_001159826
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,235,938 - 4,249,413 (+)NCBI
mRatBN7.2204,231,350 - 4,244,825 (+)NCBI
Rnor_6.0204,269,598 - 4,279,911 (-)NCBI
Rnor_5.0206,348,954 - 6,359,267 (-)NCBI
RGSC_v3.4204,339,504 - 4,349,053 (+)ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001159826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE83955 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064215.1
RefSeq Acc Id: NP_001159826   ⟸   NM_001166354
- Peptide Label: precursor
- UniProtKB: M0R4D3 (UniProtKB/TrEMBL),   Q6MG91 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064215   ⟸   ENSRNOT00000072694
Ensembl Acc Id: ENSRNOP00000071356   ⟸   ENSRNOT00000081431
Ensembl Acc Id: ENSRNOP00000034717   ⟸   ENSRNOT00000029451
Ensembl Acc Id: ENSRNOP00000068973   ⟸   ENSRNOT00000085980
Ensembl Acc Id: ENSRNOP00000070288   ⟸   ENSRNOT00000086354
Protein Domains
B30.2/SPRY   Ig-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701340
Promoter ID:EPDNEW_R11859
Type:multiple initiation site
Name:RGD1624210_1
Description:similar to butyrophilin-like 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,280,797 - 4,280,857EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1624210 AgrOrtholog
BioCyc Gene G2FUF-4577 BioCyc
Ensembl Genes ENSRNOG00000046294 Ensembl
  ENSRNOG00000068088 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072694.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  BTN3A2-like_Ig-C UniProtKB/TrEMBL
  Butyrophylin UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  IgSF_BTN/MOG UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
KEGG Report rno:686977 UniProtKB/TrEMBL
NCBI Gene Btnl4 ENTREZGENE
PANTHER BUTYROPHILIN UniProtKB/TrEMBL
  BUTYROPHILIN, SUBFAMILY 3, MEMBER A3-RELATED UniProtKB/TrEMBL
Pfam C2-set_3 UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Btnl4 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046294 RatGTEx
  ENSRNOG00000068088 RatGTEx
SMART IGv UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt M0R4D3 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG91 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG95_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-08 Btnl4  butyrophilin-like 4  RGD1624210  similar to butyrophilin-like 7  Name and Symbol changed 629549 APPROVED
2011-09-08 RGD1624210  butyrophilin-like 9  LOC686977  similar to butyrophilin-like 7  Data merged from RGD:1591244 737654 APPROVED
2006-11-20 LOC686977  similar to butyrophilin-like 7      Symbol and Name status set to provisional 70820 PROVISIONAL