Muc5b (mucin 5, subtype B, tracheobronchial) - Rat Genome Database

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Gene: Muc5b (mucin 5, subtype B, tracheobronchial) Mus musculus
Analyze
Symbol: Muc5b
Name: mucin 5, subtype B, tracheobronchial
RGD ID: 1623927
MGI Page MGI
Description: Acts upstream of or within defense response to bacterium and regulation of macrophage activation. Located in extracellular space. Is expressed in auditory bulla; epithelium; and respiratory system. Human ortholog(s) of this gene implicated in bronchiolitis; idiopathic pulmonary fibrosis; interstitial lung disease 2; and urinary bladder cancer. Orthologous to human MUC5B (mucin 5B, oligomeric mucus/gel-forming).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2300002I04Rik; A130042M24; AV085033; MUC5; MUC9; mucin 5b; mucin-5B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,392,796 - 141,426,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,392,807 - 141,426,821 (+)EnsemblGRCm39 Ensembl
GRCm387141,839,059 - 141,873,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,839,070 - 141,873,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv377149,024,977 - 149,058,990 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,648,460 - 141,682,474 (+)NCBIMGSCv36mm8
Celera7141,593,709 - 141,626,780 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Variants of MUC5B minisatellites and the susceptibility of bladder cancer. Ahn EK, etal., DNA Cell Biol. 2009 Apr;28(4):169-76. doi: 10.1089/dna.2008.0827.
2. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Balague C, etal., Gastroenterology. 1995 Sep;109(3):953-64.
3. In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model. Chen Y, etal., Am J Respir Crit Care Med. 2001 Sep 15;164(6):1059-66.
4. Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion. Elsheikh MN and Mahfouz ME, Laryngoscope. 2006 Mar;116(3):365-9.
5. Mucin deficiency causes functional and structural changes of the ocular surface. Floyd AM, etal., PLoS One. 2012;7(12):e50704. doi: 10.1371/journal.pone.0050704. Epub 2012 Dec 18.
6. MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation. Henke MO, etal., Am J Respir Crit Care Med. 2007 Apr 15;175(8):816-21. Epub 2007 Jan 25.
7. Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis. Kamio K, etal., Am J Respir Crit Care Med. 2005 May 1;171(9):949-57. Epub 2005 Feb 11.
8. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Kirkham S, etal., Am J Respir Crit Care Med. 2008 Nov 15;178(10):1033-9. Epub 2008 Sep 5.
9. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Kirkham S, etal., Biochem J. 2002 Feb 1;361(Pt 3):537-46.
10. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
11. [Toll-like receptor 2 and Toll-like receptor 4 participates in mediation of acute otitis media and mortality in pneumococcal infections in mice]. Li SL, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Dec;46(12):1009-18.
12. Expression of mucins in mucoid otitis media. Lin J, etal., J Assoc Res Otolaryngol. 2003 Sep;4(3):384-93.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Mouse MP Annotation Import Pipeline RGD automated import pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Altered sialyl- and fucosyl-linkage on mucins in cystic fibrosis patients promotes formation of the sialyl-Lewis X determinant on salivary MUC-5B and MUC-7. Shori DK, etal., Pflugers Arch. 2001;443 Suppl 1:S55-61. Epub 2001 Sep 28.
18. HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis. Tang FQ, etal., Cancer Sci. 2008 Dec 4.
19. Otitis media in a new mouse model for CHARGE syndrome with a deletion in the Chd7 gene. Tian C, etal., PLoS One. 2012;7(4):e34944. doi: 10.1371/journal.pone.0034944. Epub 2012 Apr 23.
20. MUC5B secretion is up-regulated in sinusitis compared with controls. Viswanathan H, etal., Am J Rhinol. 2006 Sep-Oct;20(5):554-7.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11208732   PMID:11217851   PMID:11964160   PMID:12466851   PMID:12676567   PMID:14718370   PMID:14984930   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:18091336   PMID:18258655   PMID:18374910   PMID:19110483   PMID:20083776   PMID:21126317   PMID:21267068   PMID:21653907   PMID:21873635   PMID:22005837   PMID:22675208  
PMID:22797898   PMID:24111497   PMID:24317696   PMID:24327612   PMID:25333937   PMID:26968767   PMID:27435107   PMID:28294161   PMID:28355261   PMID:28435155   PMID:28607090   PMID:29565179  
PMID:29579396   PMID:30431351   PMID:30560893   PMID:31030254   PMID:31573335   PMID:31582416   PMID:31699684   PMID:31776260   PMID:32348677   PMID:32372722   PMID:34158522   PMID:34160296  
PMID:35042537   PMID:35294885   PMID:35323039   PMID:35754724   PMID:35776514   PMID:35881171   PMID:36108173   PMID:36111525   PMID:38355793  


Genomics

Comparative Map Data
Muc5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,392,796 - 141,426,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,392,807 - 141,426,821 (+)EnsemblGRCm39 Ensembl
GRCm387141,839,059 - 141,873,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,839,070 - 141,873,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv377149,024,977 - 149,058,990 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,648,460 - 141,682,474 (+)NCBIMGSCv36mm8
Celera7141,593,709 - 141,626,780 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.29NCBI
MUC5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,223,066 - 1,262,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,223,066 - 1,262,172 (+)EnsemblGRCh38hg38GRCh38
GRCh37111,244,296 - 1,283,402 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,200,872 - 1,239,982 (+)NCBINCBI36Build 36hg18NCBI36
Celera111,282,436 - 1,319,815 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,037,643 - 1,074,965 (+)NCBIHuRef
CHM1_1111,243,203 - 1,282,327 (+)NCBICHM1_1
T2T-CHM13v2.0111,294,310 - 1,333,348 (+)NCBIT2T-CHM13v2.0
Muc5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,346,400 - 206,378,367 (+)NCBIGRCr8
mRatBN7.21196,916,861 - 196,948,830 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,916,825 - 196,949,250 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01214,778,459 - 214,811,237 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,778,496 - 214,810,720 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,691,881 - 221,724,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,962,340 - 201,997,147 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1194,545,288 - 194,577,247 (+)NCBICelera
Cytogenetic Map1q41NCBI
Muc5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495547611,021,665 - 11,049,239 (-)NCBIChiLan1.0ChiLan1.0
MUC5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,636,561 - 3,678,118 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,848,247 - 2,890,386 (+)NCBINHGRI_mPanPan1
MUC5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,517,479 - 45,545,765 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,517,474 - 45,545,184 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,126,169 - 44,157,219 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,196,222 - 46,227,346 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11845,644,488 - 45,675,326 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,224,935 - 45,256,112 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01845,962,705 - 45,994,038 (+)NCBIUU_Cfam_GSD_1.0
Muc5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947920,929 - 940,708 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936816174,943 - 209,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12807,685 - 842,096 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MUC5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,040,756 - 1,083,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,042,110 - 1,081,240 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603898,170,452 - 98,213,879 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Muc5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,398,595 - 21,425,755 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Muc5b
1517 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:175
Interacting mature miRNAs:204
Transcripts:ENSMUST00000165147
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11059562Lmr21b_mleishmaniasis resistance 21b (mouse)7110967235144967336Mouse
1302032Alcp12_malcohol preference locus 12 (mouse)Not determined7111166122144995196Mouse
1301590Pbwg3_mpostnatal body weight growth 3 (mouse)Not determined7127311241144995196Mouse
1300566Sluc8_msusceptibility to lung cancer 8 (mouse)Not determined7127398151144995196Mouse
14700684Civq1_mcerebral infarct volume QTL 1 (mouse)7109707335143707335Mouse
1300670Sluc19_msusceptibility to lung cancer 19 (mouse)Not determined7111166122144995196Mouse
14746988Manh63_mmandible shape 63 (mouse)7127735437144995196Mouse
14700687Civq5_mcerebral infarct volume QTL 5 (mouse)7109707335143707335Mouse
14700688Civq6_mcerebral infarct volume QTL 6 (mouse)7109707335143707335Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4142444Femwf5_mfemur work to failure 5 (mouse)Not determined112552248144995196Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1300677Bmd9_mbone mineral density 9 (mouse)Not determined7116634089144995196Mouse
1300747Skts2_mskin tumor susceptibility 2 (mouse)Not determined7112922733144995196Mouse
1301898Alcp14_malcohol preference locus 14 (mouse)Not determined7111166122144995196Mouse
1357711Adbg1_madult body growth 1 (mouse)Not determined7118693381144398314Mouse
10402499Lmr21_mleishmaniasis resistance 21 (mouse)Not determined7110967235144967336Mouse
1301773Stheal7_msoft tissue heal 7 (mouse)Not determined7119132573144995196Mouse

Markers in Region
AV085033  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,872,956 - 141,873,068UniSTSGRCm38
MGSCv377149,058,861 - 149,058,973UniSTSGRCm37
Celera7141,626,651 - 141,626,763UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.01UniSTS
Whitehead/MRC_RH71437.08UniSTS
Muc5b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387141,871,813 - 141,872,679UniSTSGRCm38
MGSCv377149,057,718 - 149,058,584UniSTSGRCm37
Celera7141,625,508 - 141,626,374UniSTS
Cytogenetic Map7F5UniSTS
cM Map769.01UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000165147   ⟹   ENSMUSP00000128276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7141,392,807 - 141,426,821 (+)Ensembl
GRCm38.p6 Ensembl7141,839,070 - 141,873,084 (+)Ensembl
RefSeq Acc Id: NM_028801   ⟹   NP_083077
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,392,809 - 141,426,822 (+)NCBI
GRCm387141,839,072 - 141,873,085 (+)NCBI
MGSCv377149,024,977 - 149,058,990 (+)RGD
Celera7141,593,709 - 141,626,780 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006508653   ⟹   XP_006508716
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397141,392,796 - 141,426,826 (+)NCBI
GRCm387141,839,059 - 141,873,089 (+)NCBI
Sequence:
RefSeq Acc Id: NP_083077   ⟸   NM_028801
- Peptide Label: precursor
- UniProtKB: Q8K1G6 (UniProtKB/TrEMBL),   E9Q5I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508716   ⟸   XM_006508653
- Peptide Label: isoform X1
- UniProtKB: Q8K1G6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000128276   ⟸   ENSMUST00000165147
Protein Domains
CTCK   VWFC   VWFD

Promoters
RGD ID:8666163
Promoter ID:EPDNEW_M11113
Type:multiple initiation site
Name:Muc5b_1
Description:Mus musculus mucin 5, subtype B, tracheobronchial , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387141,839,072 - 141,839,132EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921430 AgrOrtholog
Ensembl Genes ENSMUSG00000066108 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000165147 ENTREZGENE
  ENSMUST00000165147.3 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Cys_knot UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Mucin_vWF_Thrombospondin_sf UniProtKB/TrEMBL
  Ser_inhib-like_sf UniProtKB/TrEMBL
  TIL_dom UniProtKB/TrEMBL
  Unchr_dom_Cys-rich UniProtKB/TrEMBL
  VWF_C UniProtKB/TrEMBL
  VWF_type-D UniProtKB/TrEMBL
  WxxW_domain UniProtKB/TrEMBL
KEGG Report mmu:74180 UniProtKB/TrEMBL
MGD MGI:1921430 ENTREZGENE
NCBI Gene 74180 ENTREZGENE
PANTHER EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED UniProtKB/TrEMBL
  MUCIN-5B UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
  Mucin2_WxxW UniProtKB/TrEMBL
  PF08742 UniProtKB/TrEMBL
  TIL UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
PhenoGen Muc5b PhenoGen
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  VWFC_1 UniProtKB/TrEMBL
  VWFC_2 UniProtKB/TrEMBL
  VWFD UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
  SM00832 UniProtKB/TrEMBL
  VWC UniProtKB/TrEMBL
  VWC_out UniProtKB/TrEMBL
  VWD UniProtKB/TrEMBL
Superfamily-SCOP Cysrich_TIL UniProtKB/TrEMBL
  FnI-like domain UniProtKB/TrEMBL
UniProt E9Q5I3 ENTREZGENE, UniProtKB/TrEMBL
  Q8BYW0_MOUSE UniProtKB/TrEMBL
  Q8K1G6 ENTREZGENE, UniProtKB/TrEMBL
  Q91ZX5_MOUSE UniProtKB/TrEMBL
  Q9CV93_MOUSE UniProtKB/TrEMBL