H6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: H6pd (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) Mus musculus
Analyze
Symbol: H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
RGD ID: 1623867
MGI Page MGI
Description: Enables 6-phosphogluconolactonase activity and glucose-6-phosphate dehydrogenase activity. Involved in regulation of cortisol biosynthetic process. Acts upstream of or within pentose-phosphate shunt. Is active in sarcoplasmic reticulum. Is expressed in alimentary system; cerebral cortex; cranium; heart; and liver. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI785303; G6pd; G6pd1; GDH/6PGL endoplasmic bifunctional protein; glucose 1-dehydrogenase; glucose-6-phosphate dehydrogenase 1; Gpd; Gpd-; Gpd-1; Gpd1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,063,931 - 150,093,480 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,063,932 - 150,093,480 (-)EnsemblGRCm39 Ensembl
GRCm384149,979,474 - 150,009,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,979,475 - 150,009,023 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,353,590 - 149,383,132 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364148,823,281 - 148,852,823 (-)NCBIMGSCv36mm8
Celera4152,253,494 - 152,283,077 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map480.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-(-)-perillyl alcohol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
cantharidin  (EXP)
capsaicin  (EXP)
carbon nanotube  (EXP)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
disulfiram  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
fenthion  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
leflunomide  (ISO)
malonaldehyde  (ISO)
MeIQx  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
nickel atom  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perillyl alcohol  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
propiconazole  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trans-caffeic acid  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis. Alcina A, etal., Eur J Hum Genet. 2010 May;18(5):618-20. Epub 2009 Nov 25.
2. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Draper N, etal., Nat Genet. 2003 Aug;34(4):434-9.
3. Effect of diabetes on enzymes involved in rat hepatic corticosterone production. Hyatt T, etal., J Diabetes. 2010 Dec;2(4):275-81. doi: 10.1111/j.1753-0407.2010.00087.x.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:196096   PMID:221612   PMID:751648   PMID:1133851   PMID:1200981   PMID:1477475   PMID:1552159   PMID:1686572   PMID:2044153   PMID:2328987   PMID:2383242   PMID:2400934  
PMID:2883119   PMID:2991555   PMID:3220432   PMID:4348279   PMID:4349512   PMID:4397868   PMID:5358144   PMID:5424503   PMID:5496133   PMID:5527661   PMID:5693479   PMID:6321791  
PMID:6330270   PMID:6618533   PMID:6707444   PMID:6980942   PMID:7247077   PMID:7334202   PMID:7719023   PMID:7774930   PMID:7873877   PMID:8074710   PMID:8094303   PMID:8097440  
PMID:8102917   PMID:8104199   PMID:8183555   PMID:8190122   PMID:8390965   PMID:8415697   PMID:8482578   PMID:8672126   PMID:8875886   PMID:8918916   PMID:9205110   PMID:9390273  
PMID:9680378   PMID:10087289   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11892998   PMID:12466018   PMID:12466851   PMID:12477932   PMID:12831846  
PMID:14610273   PMID:14681479   PMID:15489334   PMID:15782199   PMID:15923630   PMID:16141072   PMID:16141073   PMID:16356929   PMID:17656460   PMID:17823265   PMID:18218694   PMID:18222920  
PMID:18287559   PMID:18779947   PMID:18799693   PMID:20032314   PMID:21052977   PMID:21106871   PMID:21146583   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23415904   PMID:24081658  
PMID:24381005   PMID:24759003   PMID:25993318   PMID:27215380   PMID:28245920   PMID:28749080   PMID:29568102   PMID:30550785   PMID:31127649   PMID:31696216   PMID:38355793  


Genomics

Comparative Map Data
H6pd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,063,931 - 150,093,480 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,063,932 - 150,093,480 (-)EnsemblGRCm39 Ensembl
GRCm384149,979,474 - 150,009,023 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,979,475 - 150,009,023 (-)EnsemblGRCm38mm10GRCm38
MGSCv374149,353,590 - 149,383,132 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364148,823,281 - 148,852,823 (-)NCBIMGSCv36mm8
Celera4152,253,494 - 152,283,077 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map480.65NCBI
H6PD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,234,774 - 9,271,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,234,774 - 9,271,337 (+)EnsemblGRCh38hg38GRCh38
GRCh3719,294,833 - 9,331,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,217,450 - 9,253,983 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419,229,099 - 9,260,797NCBI
Celera18,404,605 - 8,441,131 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef18,445,791 - 8,481,724 (+)NCBIHuRef
CHM1_119,285,083 - 9,321,616 (+)NCBICHM1_1
T2T-CHM13v2.018,769,418 - 8,805,954 (+)NCBIT2T-CHM13v2.0
H6pd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,717,456 - 165,753,158 (-)NCBIGRCr8
mRatBN7.25160,434,499 - 160,470,203 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,438,697 - 160,470,171 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,155,204 - 163,186,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,977,022 - 165,008,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,933,395 - 164,964,767 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05166,994,683 - 167,030,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5166,998,881 - 167,030,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05170,639,363 - 170,671,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,093,827 - 167,125,298 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,106,074 - 167,122,313 (-)NCBI
Celera5158,701,339 - 158,732,691 (-)NCBICelera
Cytogenetic Map5q36NCBI
H6pd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,022,306 - 4,115,077 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,088,354 - 4,115,077 (-)NCBIChiLan1.0ChiLan1.0
H6PD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21218,956,890 - 218,992,571 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,601,960 - 217,637,627 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017,996,315 - 8,031,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119,232,668 - 9,263,094 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19,232,666 - 9,256,631 (+)Ensemblpanpan1.1panPan2
H6PD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,548,136 - 62,577,346 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,548,221 - 62,608,964 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha562,565,183 - 62,594,414 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0562,774,365 - 62,803,560 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,774,303 - 62,803,557 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,772,315 - 62,801,501 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0562,636,227 - 62,665,428 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0563,040,668 - 63,069,873 (+)NCBIUU_Cfam_GSD_1.0
H6pd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,871,094 - 32,893,170 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,351,716 - 3,375,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366233,359,624 - 3,376,598 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
H6PD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,666,601 - 69,700,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1669,666,348 - 69,700,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
H6PD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,502,084 - 122,531,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,503,687 - 122,526,074 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605426,514,853 - 26,546,615 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
H6pd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,025,252 - 3,051,260 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,025,323 - 3,052,486 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2276
Count of miRNA genes:655
Interacting mature miRNAs:825
Transcripts:ENSMUST00000030830, ENSMUST00000084117, ENSMUST00000152907, ENSMUST00000153394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001291004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK032857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW109770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB843483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY149778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU463327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB719080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC892609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC895885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC898808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC903160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC908329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC915265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000030830   ⟹   ENSMUSP00000030830
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,063,932 - 150,093,480 (-)Ensembl
GRCm38.p6 Ensembl4149,979,475 - 150,009,023 (-)Ensembl
Ensembl Acc Id: ENSMUST00000084117   ⟹   ENSMUSP00000081134
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,063,932 - 150,087,587 (-)Ensembl
GRCm38.p6 Ensembl4149,979,475 - 150,003,130 (-)Ensembl
Ensembl Acc Id: ENSMUST00000152907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,084,233 - 150,085,747 (-)Ensembl
GRCm38.p6 Ensembl4149,999,776 - 150,001,290 (-)Ensembl
Ensembl Acc Id: ENSMUST00000153394   ⟹   ENSMUSP00000115647
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4150,080,305 - 150,085,722 (-)Ensembl
GRCm38.p6 Ensembl4149,995,848 - 150,001,265 (-)Ensembl
RefSeq Acc Id: NM_001291004   ⟹   NP_001277933
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,063,931 - 150,087,693 (-)NCBI
GRCm384149,979,474 - 150,003,236 (-)NCBI
Celera4152,253,487 - 152,283,077 (-)NCBI
Sequence:
RefSeq Acc Id: NM_173371   ⟹   NP_775547
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,063,931 - 150,093,480 (-)NCBI
GRCm384149,979,474 - 150,009,023 (-)NCBI
MGSCv374149,353,590 - 149,383,132 (-)RGD
Celera4152,253,487 - 152,283,077 (-)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538458   ⟹   XP_006538521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,063,932 - 150,087,651 (-)NCBI
GRCm384149,979,475 - 150,003,194 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006538459   ⟹   XP_006538522
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,063,932 - 150,085,759 (-)NCBI
GRCm384149,981,094 - 150,001,309 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006538462   ⟹   XP_006538525
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,063,932 - 150,071,768 (-)NCBI
GRCm384149,979,475 - 149,985,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036163545   ⟹   XP_036019438
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394150,063,932 - 150,085,759 (-)NCBI
Sequence:
RefSeq Acc Id: NP_775547   ⟸   NM_173371
- Peptide Label: isoform 1 precursor
- UniProtKB: A2A7A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538521   ⟸   XM_006538458
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006538522   ⟸   XM_006538459
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006538525   ⟸   XM_006538462
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001277933   ⟸   NM_001291004
- Peptide Label: isoform 2 precursor
- UniProtKB: B2KGW7 (UniProtKB/Swiss-Prot),   A2A7A9 (UniProtKB/Swiss-Prot),   Q8BLH1 (UniProtKB/Swiss-Prot),   Q8CFX1 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000115647   ⟸   ENSMUST00000153394
Ensembl Acc Id: ENSMUSP00000030830   ⟸   ENSMUST00000030830
Ensembl Acc Id: ENSMUSP00000081134   ⟸   ENSMUST00000084117
RefSeq Acc Id: XP_036019438   ⟸   XM_036163545
- Peptide Label: isoform X2
- UniProtKB: Q8CFX1 (UniProtKB/Swiss-Prot),   B2KGW7 (UniProtKB/Swiss-Prot),   A2A7A9 (UniProtKB/Swiss-Prot),   Q8BLH1 (UniProtKB/Swiss-Prot)
Protein Domains
Glucosamine/galactosamine-6-phosphate isomerase   Glucose-6-phosphate dehydrogenase C-terminal   Glucose-6-phosphate dehydrogenase NAD-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFX1-F1-model_v2 AlphaFold Q8CFX1 1-789 view protein structure

Promoters
RGD ID:6835448
Promoter ID:MM_KWN:40915
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Kidney,   Lung
Transcripts:OTTMUST00000023910,   OTTMUST00000023911
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364149,375,536 - 149,376,367 (-)MPROMDB
RGD ID:6835451
Promoter ID:MM_KWN:40916
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:UC008VXH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364149,377,206 - 149,377,706 (-)MPROMDB
RGD ID:6835449
Promoter ID:MM_KWN:40917
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000023908
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364149,382,686 - 149,383,352 (-)MPROMDB
RGD ID:6885588
Promoter ID:EPDNEW_M6245
Type:multiple initiation site
Name:H6pd_2
Description:Mus musculus hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase), transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6246  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384150,003,180 - 150,003,240EPDNEW
RGD ID:6885590
Promoter ID:EPDNEW_M6246
Type:initiation region
Name:H6pd_1
Description:Mus musculus hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase), transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M6245  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384150,009,044 - 150,009,104EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2140356 AgrOrtholog
Ensembl Genes ENSMUSG00000028980 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030830 ENTREZGENE
  ENSMUST00000030830.4 UniProtKB/TrEMBL
  ENSMUST00000084117 ENTREZGENE
  ENSMUST00000084117.13 UniProtKB/Swiss-Prot
  ENSMUST00000153394.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1360 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-phosphogluconolactonase_DevB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G6P_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G6P_DH_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G6P_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G6P_DH_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glc/Gal-6P_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGLS UniProtKB/TrEMBL
KEGG Report mmu:100198 UniProtKB/Swiss-Prot
MGD MGI:2140356 ENTREZGENE
NCBI Gene 100198 ENTREZGENE
PANTHER 6-PHOSPHOGLUCONOLACTONASE UniProtKB/TrEMBL
  GDH/6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11054 UniProtKB/TrEMBL
  PTHR23429 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G6PD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G6PD_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glucosamine_iso UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen H6pd PhenoGen
PRINTS G6PDHDRGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G6P_DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100950 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A7A7 ENTREZGENE, UniProtKB/TrEMBL
  A2A7A8_MOUSE UniProtKB/TrEMBL
  A2A7A9 ENTREZGENE
  B2KGW7 ENTREZGENE
  G6PE_MOUSE UniProtKB/Swiss-Prot
  Q3TFM8_MOUSE UniProtKB/TrEMBL
  Q8BLH1 ENTREZGENE
  Q8BMC8_MOUSE UniProtKB/TrEMBL
  Q8CFX1 ENTREZGENE
  Q8QZU3_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2A7A9 UniProtKB/Swiss-Prot
  B2KGW7 UniProtKB/Swiss-Prot
  Q8BLH1 UniProtKB/Swiss-Prot