Mbd5 (methyl-CpG binding domain protein 5) - Rat Genome Database

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Gene: Mbd5 (methyl-CpG binding domain protein 5) Mus musculus
Analyze
Symbol: Mbd5
Name: methyl-CpG binding domain protein 5
RGD ID: 1623858
MGI Page MGI
Description: Predicted to enable chromatin binding activity. Acts upstream of or within glucose homeostasis; positive regulation of growth hormone receptor signaling pathway; and regulation of growth. Predicted to be located in midbody and nucleoplasm. Predicted to be active in chromocenter and nucleus. Is expressed in several structures, including brain; liver; small intestine; spinal cord; and spleen. Used to study autosomal dominant intellectual developmental disorder. Human ortholog(s) of this gene implicated in autism spectrum disorder and autosomal dominant intellectual developmental disorder 1. Orthologous to human MBD5 (methyl-CpG binding domain protein 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9430004D19Rik; AA536666; C030040A15Rik; Gm1630; methyl-CpG-binding domain protein 5; methyl-CpG-binding protein MBD5; predicted gene, OTTMUSG00000012483
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,839,511 - 49,209,702 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,839,520 - 49,215,417 (+)EnsemblGRCm39 Ensembl
GRCm38248,949,499 - 49,319,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,949,508 - 49,325,405 (+)EnsemblGRCm38mm10GRCm38
MGSCv37248,805,028 - 49,172,589 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36249,064,365 - 49,139,005 (+)NCBIMGSCv36mm8
Celera250,621,661 - 50,990,507 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromocenter  (IBA,ISO)
chromosome  (IEA)
midbody  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function
chromatin binding  (IBA,ISO,ISS)
DNA binding  (ISS)
protein binding  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Extended spectrum of MBD5 mutations in neurodevelopmental disorders. Bonnet C, etal., Eur J Hum Genet. 2013 Dec;21(12):1457-61. doi: 10.1038/ejhg.2013.22. Epub 2013 Feb 20.
2. The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1. Cukier HN, etal., Autism Res. 2012 Dec;5(6):385-97. doi: 10.1002/aur.1251. Epub 2012 Oct 10.
3. Reciprocal deletion and duplication at 2q23.1 indicates a role for MBD5 in autism spectrum disorder. Mullegama SV, etal., Eur J Hum Genet. 2014 Jan;22(1):57-63. doi: 10.1038/ejhg.2013.67. Epub 2013 May 1.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. The methyl binding domain containing protein MBD5 is a transcriptional regulator responsible for 2q23.1 deletion syndrome. Walz K and Young JI, Rare Dis. 2014 Nov 3;2(1):e967151. doi: 10.4161/2167549X.2014.967151. eCollection 2014.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466305   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15368895  
PMID:15840001   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23077600   PMID:24750026   PMID:25001218   PMID:26496610  
PMID:32492419   PMID:32503625   PMID:36997128   PMID:38355793  


Genomics

Comparative Map Data
Mbd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,839,511 - 49,209,702 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,839,520 - 49,215,417 (+)EnsemblGRCm39 Ensembl
GRCm38248,949,499 - 49,319,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,949,508 - 49,325,405 (+)EnsemblGRCm38mm10GRCm38
MGSCv37248,805,028 - 49,172,589 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36249,064,365 - 49,139,005 (+)NCBIMGSCv36mm8
Celera250,621,661 - 50,990,507 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.43NCBI
MBD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382148,020,927 - 148,516,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2148,021,011 - 148,516,971 (+)EnsemblGRCh38hg38GRCh38
GRCh372148,778,580 - 149,274,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,932,508 - 148,987,516 (+)NCBINCBI36Build 36hg18NCBI36
Build 342149,049,769 - 149,104,774NCBI
Celera2142,492,728 - 142,985,183 (+)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2140,776,638 - 141,269,422 (+)NCBIHuRef
CHM1_12148,784,226 - 149,276,488 (+)NCBICHM1_1
T2T-CHM13v2.02148,471,381 - 148,967,332 (+)NCBIT2T-CHM13v2.0
Mbd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,742,458 - 54,147,970 (+)NCBIGRCr8
mRatBN7.2333,588,854 - 33,738,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,333,554 - 33,730,156 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0333,364,812 - 33,504,144 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,440,191 - 33,504,238 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,600,038 - 38,663,451 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera331,856,644 - 31,921,520 (+)NCBICelera
Cytogenetic Map3q12NCBI
Mbd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544014,270,407 - 14,413,597 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544014,267,802 - 14,412,949 (+)NCBIChiLan1.0ChiLan1.0
MBD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,413,395 - 26,910,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,428,361 - 26,924,995 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,347,218 - 11,842,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,380,363 - 152,874,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,754,368 - 152,874,042 (+)Ensemblpanpan1.1panPan2
MBD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,815,388 - 50,250,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1950,186,364 - 50,247,398 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1950,145,330 - 50,371,739 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01951,494,265 - 51,720,677 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,494,282 - 51,728,134 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11950,139,740 - 50,365,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01950,274,378 - 50,500,930 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,671,900 - 51,898,368 (+)NCBIUU_Cfam_GSD_1.0
Mbd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,486,058 - 112,872,593 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646928,744,814 - 28,802,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646928,748,499 - 28,889,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,659,012 - 3,725,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1153,649,859 - 4,096,459 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,337,836 - 3,346,811 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MBD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11033,401,903 - 33,907,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,743,166 - 33,904,508 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040165,632,515 - 166,137,209 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248661,105,616 - 1,162,288 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248661,003,279 - 1,162,545 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mbd5
16289 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3964
Count of miRNA genes:825
Interacting mature miRNAs:1115
Transcripts:ENSMUST00000047413, ENSMUST00000112745, ENSMUST00000112754, ENSMUST00000122841, ENSMUST00000127085, ENSMUST00000132717, ENSMUST00000142250, ENSMUST00000147023, ENSMUST00000147055, ENSMUST00000148796, ENSMUST00000154653
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212953766556453Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22702264256396228Mouse
14746979Manh51_mmandible shape 51 (mouse)22896112962961129Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22459001254890012Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22530805156971811Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22112972555129871Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22896112962961129Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
10449151Hdl8_mhigh density lipoprotein (HDL) level 8 (mouse)23812972567072607Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
10449150Pvldlc1_mplasma VLDL-cholesterol 1 (mouse)23812972567072607Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22368914557689269Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
10449145Lanq1_mlanosterol level QTL 1 (mouse)23812972567072607Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
13464253Ifvrq1_minfluenza virus resistance QTL 1 (mouse)23303449252034492Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2112972555129871Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
1300645Alcp1_malcohol preference locus 1 (mouse)Not determined24522812867838868Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse

Markers in Region
D2Mit374  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38249,115,509 - 49,115,629UniSTSGRCm38
MGSCv37248,971,029 - 48,971,149UniSTSGRCm37
Celera250,789,198 - 50,789,318UniSTS
Cytogenetic Map2C1.1UniSTS
cM Map229.5UniSTS
Whitehead Genetic229.5UniSTS
Whitehead/MRC_RH2819.4UniSTS
D2Mit72  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38249,314,559 - 49,314,700UniSTSGRCm38
MGSCv37249,170,079 - 49,170,220UniSTSGRCm37
Celera250,987,997 - 50,988,138UniSTS
Cytogenetic Map2C1.1UniSTS
cM Map230.0UniSTS
Whitehead Genetic229.5UniSTS
Whitehead_YAC2 UniSTS
RH124450  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38249,259,398 - 49,259,521UniSTSGRCm38
MGSCv37249,114,918 - 49,115,041UniSTSGRCm37
Celera250,932,798 - 50,932,921UniSTS
Cytogenetic Map2C1.1UniSTS
AI426407  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38249,316,602 - 49,316,718UniSTSGRCm38
MGSCv37249,172,122 - 49,172,238UniSTSGRCm37
Celera250,990,040 - 50,990,156UniSTS
Cytogenetic Map2C1.1UniSTS
Whitehead/MRC_RH2828.86UniSTS
G09491  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,949,933 - 48,950,063UniSTSGRCm38
MGSCv37248,805,453 - 48,805,583UniSTSGRCm37
Cytogenetic Map2C1.1UniSTS
MARC_16821-16822:1021560530:2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38248,949,679 - 48,950,139UniSTSGRCm38
MGSCv37248,805,199 - 48,805,659UniSTSGRCm37
Cytogenetic Map2C1.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_029924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006497604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003950018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003950019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK021136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK083019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK173176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV298746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ551845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU610422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX546465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB522230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000047413   ⟹   ENSMUSP00000036847
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl249,135,981 - 49,209,702 (+)Ensembl
GRCm38.p6 Ensembl249,245,969 - 49,319,690 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112745   ⟹   ENSMUSP00000108365
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,839,520 - 49,150,570 (+)Ensembl
GRCm38.p6 Ensembl248,949,508 - 49,260,558 (+)Ensembl
Ensembl Acc Id: ENSMUST00000112754   ⟹   ENSMUSP00000108374
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,839,535 - 49,206,984 (+)Ensembl
GRCm38.p6 Ensembl248,949,523 - 49,316,972 (+)Ensembl
Ensembl Acc Id: ENSMUST00000122841   ⟹   ENSMUSP00000119317
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl249,146,573 - 49,207,010 (+)Ensembl
GRCm38.p6 Ensembl249,256,561 - 49,316,998 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127085
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,840,077 - 49,008,888 (+)Ensembl
GRCm38.p6 Ensembl248,950,065 - 49,118,876 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132717   ⟹   ENSMUSP00000137021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl249,162,196 - 49,215,417 (+)Ensembl
GRCm38.p6 Ensembl249,272,184 - 49,325,405 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142250
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,839,974 - 48,911,452 (+)Ensembl
GRCm38.p6 Ensembl248,949,962 - 49,021,440 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147023
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,840,161 - 48,955,529 (+)Ensembl
GRCm38.p6 Ensembl248,950,149 - 49,065,517 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,840,155 - 49,135,569 (+)Ensembl
GRCm38.p6 Ensembl248,950,143 - 49,245,557 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,839,975 - 48,844,079 (+)Ensembl
GRCm38.p6 Ensembl248,949,963 - 48,954,067 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl248,839,530 - 49,009,024 (+)Ensembl
GRCm38.p6 Ensembl248,949,518 - 49,119,012 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196045   ⟹   ENSMUSP00000143148
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl249,169,486 - 49,206,664 (+)Ensembl
GRCm38.p6 Ensembl249,279,474 - 49,316,652 (+)Ensembl
Ensembl Acc Id: ENSMUST00000196831   ⟹   ENSMUSP00000142821
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl249,169,635 - 49,206,898 (+)Ensembl
GRCm38.p6 Ensembl249,279,623 - 49,316,886 (+)Ensembl
Ensembl Acc Id: ENSMUST00000197712   ⟹   ENSMUSP00000143413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl249,169,487 - 49,206,675 (+)Ensembl
GRCm38.p6 Ensembl249,279,475 - 49,316,663 (+)Ensembl
Ensembl Acc Id: ENSMUST00000199257   ⟹   ENSMUSP00000143060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl249,136,182 - 49,162,091 (+)Ensembl
GRCm38.p6 Ensembl249,246,170 - 49,272,079 (+)Ensembl
RefSeq Acc Id: NM_001290656   ⟹   NP_001277585
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39249,135,912 - 49,207,081 (+)NCBI
GRCm38249,245,900 - 49,317,069 (+)NCBI
Celera250,621,661 - 50,990,507 (+)NCBI
Sequence:
RefSeq Acc Id: NM_029924   ⟹   NP_084200
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,839,520 - 49,207,081 (+)NCBI
GRCm38248,949,508 - 49,317,069 (+)NCBI
MGSCv37248,805,028 - 49,172,589 (+)RGD
Celera250,621,661 - 50,990,507 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006497604   ⟹   XP_006497667
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,319,688 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017314911   ⟹   XP_017170400
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,316,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246624   ⟹   XP_030102484
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,319,688 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246625   ⟹   XP_030102485
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,316,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246628   ⟹   XP_030102488
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,113 - 49,209,700 (+)NCBI
GRCm38248,950,104 - 49,316,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246629   ⟹   XP_030102489
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,316,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246630   ⟹   XP_030102490
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,839,511 - 49,209,700 (+)NCBI
GRCm38248,949,499 - 49,316,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246635   ⟹   XP_030102495
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,839,547 - 49,209,702 (+)NCBI
GRCm38248,950,092 - 49,316,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246638   ⟹   XP_030102498
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,316,998 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157511   ⟹   XP_036013404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157512   ⟹   XP_036013405
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157513   ⟹   XP_036013406
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157515   ⟹   XP_036013408
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,839,511 - 49,209,700 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157516   ⟹   XP_036013409
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157519   ⟹   XP_036013412
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,839,511 - 49,209,700 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036157520   ⟹   XP_036013413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,839,606 - 49,209,702 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003950018
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,319,688 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003950019
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39248,840,104 - 49,209,700 (+)NCBI
GRCm38248,950,092 - 49,319,688 (+)NCBI
Sequence:
RefSeq Acc Id: NP_084200   ⟸   NM_029924
- Peptide Label: isoform a
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497667   ⟸   XM_006497604
- Peptide Label: isoform X2
- UniProtKB: Q69ZJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277585   ⟸   NM_001290656
- Peptide Label: isoform b
- UniProtKB: B1AYB7 (UniProtKB/Swiss-Prot),   B1AYB6 (UniProtKB/Swiss-Prot),   Q69ZJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017170400   ⟸   XM_017314911
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030102490   ⟸   XM_030246630
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030102484   ⟸   XM_030246624
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030102485   ⟸   XM_030246625
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030102498   ⟸   XM_030246638
- Peptide Label: isoform X4
- UniProtKB: F6Q8U1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030102495   ⟸   XM_030246635
- Peptide Label: isoform X3
- UniProtKB: B1AYB7 (UniProtKB/Swiss-Prot),   B1AYB6 (UniProtKB/Swiss-Prot),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030102489   ⟸   XM_030246629
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030102488   ⟸   XM_030246628
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000143413   ⟸   ENSMUST00000197712
Ensembl Acc Id: ENSMUSP00000137021   ⟸   ENSMUST00000132717
Ensembl Acc Id: ENSMUSP00000108365   ⟸   ENSMUST00000112745
Ensembl Acc Id: ENSMUSP00000108374   ⟸   ENSMUST00000112754
Ensembl Acc Id: ENSMUSP00000036847   ⟸   ENSMUST00000047413
Ensembl Acc Id: ENSMUSP00000143060   ⟸   ENSMUST00000199257
Ensembl Acc Id: ENSMUSP00000143148   ⟸   ENSMUST00000196045
Ensembl Acc Id: ENSMUSP00000142821   ⟸   ENSMUST00000196831
Ensembl Acc Id: ENSMUSP00000119317   ⟸   ENSMUST00000122841
RefSeq Acc Id: XP_036013408   ⟸   XM_036157515
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013412   ⟸   XM_036157519
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013413   ⟸   XM_036157520
- Peptide Label: isoform X3
- UniProtKB: B1AYB7 (UniProtKB/Swiss-Prot),   B1AYB6 (UniProtKB/Swiss-Prot),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013404   ⟸   XM_036157511
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013405   ⟸   XM_036157512
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013409   ⟸   XM_036157516
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036013406   ⟸   XM_036157513
- Peptide Label: isoform X1
- UniProtKB: B1AYB5 (UniProtKB/TrEMBL),   Q69ZJ2 (UniProtKB/TrEMBL)
Protein Domains
MBD   PWWP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1AYB6-F1-model_v2 AlphaFold B1AYB6 1-1498 view protein structure

Promoters
RGD ID:6831806
Promoter ID:MM_KWN:29137
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000112745,   NM_029924,   OTTMUST00000029500,   OTTMUST00000029618,   OTTMUST00000029619,   OTTMUST00000029632,   OTTMUST00000029633,   OTTMUST00000029644,   OTTMUST00000029645,   OTTMUST00000029646,   OTTMUST00000029647,   UC008JPQ.1,   UC008JPR.1,   UC008JPS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36248,804,606 - 48,805,107 (+)MPROMDB
RGD ID:6877266
Promoter ID:EPDNEW_M2084
Type:initiation region
Name:Mbd5_1
Description:Mus musculus methyl-CpG binding domain protein 5 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2085  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38248,949,598 - 48,949,658EPDNEW
RGD ID:6877268
Promoter ID:EPDNEW_M2085
Type:single initiation site
Name:Mbd5_2
Description:Mus musculus methyl-CpG binding domain protein 5 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M2084  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38248,981,487 - 48,981,547EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2138934 AgrOrtholog
Ensembl Genes ENSMUSG00000036792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047413 ENTREZGENE
  ENSMUST00000112745.8 UniProtKB/Swiss-Prot
  ENSMUST00000112754 ENTREZGENE
  ENSMUST00000112754.8 UniProtKB/Swiss-Prot
  ENSMUST00000122841 ENTREZGENE
Gene3D-CATH 2.30.30.140 UniProtKB/Swiss-Prot
InterPro Methyl_CpG_DNA-bd UniProtKB/Swiss-Prot
KEGG Report mmu:109241 UniProtKB/Swiss-Prot
MGD MGI:2138934 ENTREZGENE
NCBI Gene Mbd5 ENTREZGENE
PANTHER METHYL-CPG-BINDING DOMAIN PROTEIN 5 UniProtKB/Swiss-Prot
  PTHR16112 UniProtKB/Swiss-Prot
PhenoGen Mbd5 PhenoGen
PROSITE MBD UniProtKB/Swiss-Prot
SMART MBD UniProtKB/Swiss-Prot
Superfamily-SCOP Tudor/PWWP/MBT UniProtKB/Swiss-Prot
UniProt A0A0G2JEL9_MOUSE UniProtKB/TrEMBL
  A0A0G2JF81_MOUSE UniProtKB/TrEMBL
  A0A0G2JFF3_MOUSE UniProtKB/TrEMBL
  A0A0G2JG39_MOUSE UniProtKB/TrEMBL
  B1AYB5 ENTREZGENE, UniProtKB/TrEMBL
  B1AYB6 ENTREZGENE
  B1AYB7 ENTREZGENE
  F6Q8U1 ENTREZGENE, UniProtKB/TrEMBL
  MBD5_MOUSE UniProtKB/Swiss-Prot
  Q3TTF1_MOUSE UniProtKB/TrEMBL
  Q69ZJ2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B1AYB7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Mbd5  methyl-CpG binding domain protein 5  AI426407  expressed sequence AI426407  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 AI426407  expressed sequence AI426407  Mbd5  methyl-CpG binding domain protein 5  Symbol and/or name change 5135510 APPROVED
2016-04-05 Mbd5  methyl-CpG binding domain protein 5  OTTMUSG00000012483  predicted gene, OTTMUSG00000012483  Data merged from RGD:2294260 737654 PROVISIONAL