Nlrp1a (NLR family, pyrin domain containing 1A) - Rat Genome Database

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Gene: Nlrp1a (NLR family, pyrin domain containing 1A) Mus musculus
Analyze
Symbol: Nlrp1a
Name: NLR family, pyrin domain containing 1A
RGD ID: 1623841
MGI Page MGI
Description: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and nucleic acid binding activity. Involved in positive regulation of interleukin-1 beta production and response to muramyl dipeptide. Acts upstream of or within defense response to bacterium and programmed necrotic cell death. Predicted to be located in nucleoplasm. Predicted to be part of NLRP1 inflammasome complex and NLRP3 inflammasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CARD7; caspase recruitment domain protein; caspase recruitment domain-containing protein 7; death effector filament-forming Ced-4-like apoptosis protein; DEFCAP; Gm14; Gm15; N; NAC; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT/LRR/pyrin domain-containing protein 1; Nalp1; Nalp1a; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A, CAST/EiJ strain specific; NLR family, pyrin domain containing 1A, PWK/PhJ strain specific; NLR family, pyrin domain containing 1A, WSB/EiJ strain specific; Nlrp1; nucleotide-binding domain and caspase recruitment domain; PP1044
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Nlrp1c-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,982,023 - 71,035,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,983,062 - 71,035,530 (-)EnsemblGRCm39 Ensembl
GRCm381171,091,197 - 71,144,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,092,236 - 71,144,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,904,699 - 70,958,206 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,908,431 - 70,958,561 (-)NCBIMGSCv36mm8
Celera1178,634,796 - 78,688,328 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal eye morphology  (IEA)
abnormal heart morphology  (IEA)
abnormal inflammatory response  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal leukopoiesis  (IAGP)
brain inflammation  (IAGP)
decreased B cell number  (IEA)
decreased B-1 B cell number  (IEA)
decreased B-1b cell number  (IEA)
decreased B-2 B cell number  (IEA)
decreased body weight  (IEA)
decreased CD8-positive, alpha-beta T cell number  (IEA)
decreased central memory CD8 positive, alpha-beta T cell number  (IEA)
decreased eosinophil cell number  (IAGP)
decreased interleukin-1 beta secretion  (IEA)
decreased lymphocyte cell number  (IAGP)
decreased macrophage cell number  (IAGP)
decreased monocyte cell number  (IAGP)
decreased NK cell number  (IEA)
decreased single-positive T cell number  (IEA)
decreased T cell number  (IEA)
enlarged heart  (IEA)
enlarged spleen  (IAGP)
hypoglycemia  (IEA)
increased circulating interleukin-18 level  (IAGP)
increased dendritic cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased IgE level  (IEA)
increased inflammatory response  (IAGP)
increased macrophage apoptosis  (IEA)
increased macrophage cytokine production  (IAGP)
increased neutrophil cell number  (IAGP)
increased susceptibility to infection induced morbidity/mortality  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased tumor necrosis factor secretion  (IEA)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
meningitis  (IAGP)
microphthalmia  (IEA)
myocarditis  (IAGP)
pancreas inflammation  (IAGP)
premature death  (IAGP)
skin inflammation  (IAGP)
thrombocytopenia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12775719   PMID:15967716   PMID:16141072   PMID:16141073   PMID:16429160   PMID:18495787   PMID:18511561  
PMID:19494813   PMID:19924255   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22753929   PMID:23219391   PMID:23506131   PMID:24008734   PMID:24218483   PMID:24337744   PMID:24549849  
PMID:24606891   PMID:24606892   PMID:24699513   PMID:25024200   PMID:25681332   PMID:25725098   PMID:25879281   PMID:26434621   PMID:26603191   PMID:27199506   PMID:27381056   PMID:28733143  
PMID:30001530   PMID:30214011   PMID:30342528   PMID:32421904   PMID:35777263   PMID:37245530   PMID:37625833   PMID:38178196   PMID:38355793  


Genomics

Comparative Map Data
Nlrp1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,982,023 - 71,035,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,983,062 - 71,035,530 (-)EnsemblGRCm39 Ensembl
GRCm381171,091,197 - 71,144,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,092,236 - 71,144,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,904,699 - 70,958,206 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,908,431 - 70,958,561 (-)NCBIMGSCv36mm8
Celera1178,634,796 - 78,688,328 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
NLRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,501,396 - 5,584,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,499,415 - 5,619,424 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,404,716 - 5,487,829 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,345,443 - 5,428,556 (-)NCBINCBI36Build 36hg18NCBI36
Celera175,421,095 - 5,503,841 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef175,294,862 - 5,377,604 (-)NCBIHuRef
CHM1_1175,414,362 - 5,497,490 (-)NCBICHM1_1
T2T-CHM13v2.0175,395,133 - 5,478,273 (-)NCBIT2T-CHM13v2.0
Nlrp1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,277,134 - 56,332,229 (-)NCBIGRCr8
mRatBN7.21055,778,560 - 55,833,639 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,778,560 - 55,825,180 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,458,304 - 60,504,924 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,946,824 - 59,993,447 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,445,908 - 55,492,512 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,692,474 - 57,747,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,692,474 - 57,822,498 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,437,815 - 57,492,207 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,963,708 - 58,007,925 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,960,835 - 58,122,088 (-)NCBI
Celera1054,924,259 - 54,970,955 (-)NCBICelera
Cytogenetic Map10q24NCBI
NLRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,096,919 - 13,194,847 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,079,526 - 15,162,296 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,562,129 - 5,667,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,541,559 - 5,623,659 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,542,007 - 5,623,091 (-)Ensemblpanpan1.1panPan2
NLRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,264,554 - 31,299,538 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,266,621 - 31,299,304 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,399,983 - 31,440,503 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,369,269 - 31,407,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,370,391 - 31,404,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,334,819 - 31,372,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,293,857 - 31,331,580 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,467,813 - 31,507,973 (+)NCBIUU_Cfam_GSD_1.0
Nlrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,611,186 - 53,653,113 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,248,903 - 2,289,151 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,248,153 - 2,290,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NLRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11251,479,968 - 51,495,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NLRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,930,643 - 4,983,378 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605916,600,759 - 16,674,092 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Nlrp1a
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:144
Interacting mature miRNAs:150
Transcripts:ENSMUST00000048514, ENSMUST00000108518
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
D11Die19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,124,128 - 71,124,277UniSTSGRCm38
MGSCv371170,937,630 - 70,937,779UniSTSGRCm37
Celera1178,667,735 - 78,667,884UniSTS
Cytogenetic Map11B4UniSTS
cM Map11 UniSTS
Rara  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C3UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map11D-E1UniSTS
Cytogenetic MapXA7.2UniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map1H2.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map17B2UniSTS
cM Map1157.8UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017314354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK157034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY355339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR936847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU424436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ117601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC539856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC539857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC539858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC539859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC539860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC539861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT629147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT629150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LT629153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000048514   ⟹   ENSMUSP00000038186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,983,062 - 71,033,192 (-)Ensembl
GRCm38.p6 Ensembl1171,092,236 - 71,142,366 (-)Ensembl
Ensembl Acc Id: ENSMUST00000108518   ⟹   ENSMUSP00000104158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,983,062 - 71,035,530 (-)Ensembl
GRCm38.p6 Ensembl1171,092,236 - 71,144,704 (-)Ensembl
RefSeq Acc Id: NM_001004142   ⟹   NP_001004142
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,982,023 - 71,035,530 (-)NCBI
GRCm381171,091,197 - 71,144,704 (-)NCBI
MGSCv371170,904,699 - 70,958,206 (-)RGD
Celera1178,634,796 - 78,688,328 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017314354   ⟹   XP_017169843
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,982,157 - 71,035,780 (-)NCBI
GRCm381171,091,332 - 71,144,969 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156458   ⟹   XP_036012351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,982,157 - 71,035,780 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036156459   ⟹   XP_036012352
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,982,157 - 71,035,780 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001004142   ⟸   NM_001004142
- UniProtKB: Q67EY4 (UniProtKB/Swiss-Prot),   Q3U0B5 (UniProtKB/Swiss-Prot),   Q2LKU9 (UniProtKB/Swiss-Prot),   M4TJP5 (UniProtKB/Swiss-Prot),   M4T632 (UniProtKB/Swiss-Prot),   M4T4C8 (UniProtKB/Swiss-Prot),   M4T3K8 (UniProtKB/Swiss-Prot),   A0A1G5SJ32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169843   ⟸   XM_017314354
- Peptide Label: isoform X1
- UniProtKB: Q67EY4 (UniProtKB/Swiss-Prot),   Q3U0B5 (UniProtKB/Swiss-Prot),   Q2LKU9 (UniProtKB/Swiss-Prot),   M4TJP5 (UniProtKB/Swiss-Prot),   M4T632 (UniProtKB/Swiss-Prot),   M4T4C8 (UniProtKB/Swiss-Prot),   M4T3K8 (UniProtKB/Swiss-Prot),   A0A1G5SJ32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000104158   ⟸   ENSMUST00000108518
Ensembl Acc Id: ENSMUSP00000038186   ⟸   ENSMUST00000048514
RefSeq Acc Id: XP_036012352   ⟸   XM_036156459
- Peptide Label: isoform X1
- UniProtKB: Q67EY4 (UniProtKB/Swiss-Prot),   Q3U0B5 (UniProtKB/Swiss-Prot),   Q2LKU9 (UniProtKB/Swiss-Prot),   M4TJP5 (UniProtKB/Swiss-Prot),   M4T632 (UniProtKB/Swiss-Prot),   M4T4C8 (UniProtKB/Swiss-Prot),   M4T3K8 (UniProtKB/Swiss-Prot),   A0A1G5SJ32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036012351   ⟸   XM_036156458
- Peptide Label: isoform X1
- UniProtKB: Q67EY4 (UniProtKB/Swiss-Prot),   Q3U0B5 (UniProtKB/Swiss-Prot),   Q2LKU9 (UniProtKB/Swiss-Prot),   M4TJP5 (UniProtKB/Swiss-Prot),   M4T632 (UniProtKB/Swiss-Prot),   M4T4C8 (UniProtKB/Swiss-Prot),   M4T3K8 (UniProtKB/Swiss-Prot),   A0A1G5SJ32 (UniProtKB/TrEMBL)
Protein Domains
CARD   FIIND   NACHT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2LKU9-F1-model_v2 AlphaFold Q2LKU9 1-1182 view protein structure

Promoters
RGD ID:6821433
Promoter ID:MM_KWN:8277
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000108519,   NM_001004142,   UC007JXR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361170,957,906 - 70,958,406 (-)MPROMDB
RGD ID:8675400
Promoter ID:EPDNEW_M15730
Type:multiple initiation site
Name:Nlrp1a_1
Description:Mus musculus NLR family, pyrin domain containing 1A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381171,144,788 - 71,144,848EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684861 AgrOrtholog
Ensembl Genes ENSMUSG00000069830 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048514.11 UniProtKB/Swiss-Prot
  ENSMUST00000108518 ENTREZGENE
  ENSMUST00000108518.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
  Death Domain, Fas UniProtKB/TrEMBL
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
  Ribonuclease Inhibitor UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARD8/ASC/NALP1_CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIIND_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRP_Inflammasome UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:195046 UniProtKB/Swiss-Prot
MGD MGI:2684861 ENTREZGENE
NCBI Gene Nlrp1a ENTREZGENE
PANTHER NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIIND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NLRC4_HD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD2_WH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nlrp1a PhenoGen
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FIIND UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_RI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP DEATH domain UniProtKB/TrEMBL
  P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
  RNI-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47986 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
UniProt A0A1G5SJ32 ENTREZGENE, UniProtKB/TrEMBL
  M4T3K8 ENTREZGENE
  M4T4C8 ENTREZGENE
  M4T632 ENTREZGENE
  M4TJP5 ENTREZGENE
  NLR1A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3U0B5 ENTREZGENE
  Q67EY4 ENTREZGENE
UniProt Secondary M4T3K8 UniProtKB/Swiss-Prot
  M4T4C8 UniProtKB/Swiss-Prot
  M4T632 UniProtKB/Swiss-Prot
  M4TJP5 UniProtKB/Swiss-Prot
  Q3U0B5 UniProtKB/Swiss-Prot
  Q67EY4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Nlrp1a  NLR family, pyrin domain containing 1A  Nalp1  NACHT, leucine rich repeat and PYD containing 1  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Nalp1  NACHT, leucine rich repeat and PYD containing 1  Nlrp1a  NLR family, pyrin domain containing 1A  Symbol and/or name change 5135510 APPROVED