Bin2 (bridging integrator 2) - Rat Genome Database

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Gene: Bin2 (bridging integrator 2) Mus musculus
Analyze
Symbol: Bin2
Name: bridging integrator 2
RGD ID: 1623351
MGI Page MGI
Description: Predicted to enable phospholipid binding activity. Predicted to be involved in several processes, including phagocytosis, engulfment; plasma membrane tubulation; and podosome assembly. Predicted to be active in plasma membrane and podosome. Predicted to colocalize with phagocytic cup. Is expressed in liver and thymus primordium. Orthologous to human BIN2 (bridging integrator 2).
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,538,963 - 100,567,384 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,538,958 - 100,567,434 (-)EnsemblGRCm39 Ensembl
GRCm3815100,641,082 - 100,669,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,641,077 - 100,669,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715100,470,388 - 100,499,933 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,464,266 - 100,497,536 (-)NCBIMGSCv36mm8
Celera15102,795,111 - 102,822,575 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
phagocytic cup  (IBA,ISO)
plasma membrane  (IBA,ISO)
podosome  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11544199   PMID:12466851   PMID:12477932   PMID:14691545   PMID:17015433   PMID:21267068   PMID:21873635   PMID:32325033   PMID:32554809   PMID:32750041   PMID:37118338  


Genomics

Comparative Map Data
Bin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,538,963 - 100,567,384 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,538,958 - 100,567,434 (-)EnsemblGRCm39 Ensembl
GRCm3815100,641,082 - 100,669,503 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,641,077 - 100,669,553 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715100,470,388 - 100,499,933 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,464,266 - 100,497,536 (-)NCBIMGSCv36mm8
Celera15102,795,111 - 102,822,575 (-)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.37NCBI
BIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,281,038 - 51,324,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,281,038 - 51,324,668 (-)EnsemblGRCh38hg38GRCh38
GRCh371251,674,822 - 51,718,452 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,961,089 - 50,004,205 (-)NCBINCBI36Build 36hg18NCBI36
Build 341249,961,089 - 50,004,205NCBI
Celera1250,476,304 - 50,519,423 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1248,707,566 - 48,750,862 (-)NCBIHuRef
CHM1_11251,641,019 - 51,684,174 (-)NCBICHM1_1
T2T-CHM13v2.01251,243,929 - 51,287,483 (-)NCBIT2T-CHM13v2.0
Bin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,620,782 - 133,647,019 (-)NCBIGRCr8
mRatBN7.27131,742,001 - 131,768,208 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,742,002 - 131,786,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,544,073 - 133,570,314 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,769,655 - 135,795,899 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,683,292 - 135,709,465 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,273,832 - 142,304,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,273,833 - 142,300,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,078,978 - 140,105,528 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,408,145 - 139,434,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,484,581 - 139,510,787 (-)NCBI
Celera7128,218,252 - 128,244,472 (-)NCBICelera
Cytogenetic Map7q36NCBI
Bin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555471,774,330 - 1,798,031 (-)NCBIChiLan1.0ChiLan1.0
BIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,862,523 - 42,905,717 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,859,285 - 42,902,479 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,430,061 - 37,473,182 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,314,443 - 38,357,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,314,126 - 38,357,264 (+)Ensemblpanpan1.1panPan2
BIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,563,431 - 3,597,363 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,563,475 - 3,596,817 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,660,984 - 42,694,586 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,608,352 - 3,641,907 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,557,543 - 3,641,427 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,575,875 - 3,609,440 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,562,423 - 3,595,991 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,058,238 - 43,091,854 (-)NCBIUU_Cfam_GSD_1.0
Bin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,263,598 - 64,295,980 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365128,869,131 - 8,901,171 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2517,315,117 - 17,331,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,480,322 - 47,521,970 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037198,573,888 - 198,616,360 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bin2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624816941,199 - 992,157 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bin2
619 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:988
Count of miRNA genes:406
Interacting mature miRNAs:462
Transcripts:ENSMUST00000182068, ENSMUST00000182494, ENSMUST00000182574, ENSMUST00000182775, ENSMUST00000182814, ENSMUST00000183193, ENSMUST00000183211
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined79908940104073951Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580313634104073951Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580884933104073951Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580884933104073951Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82615474104073951Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585896437104073951Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585896437104073951Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585896437104073951Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585901546104073951Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92788640103425899Mouse
14700689Carg5_mCandida albicans resistance gene 5 (mouse)1597697881103008427Mouse
11528547Sluc34_msusceptibility to lung cancer 34 (mouse)1597884933102896555Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000182068   ⟹   ENSMUSP00000138316
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,543,186 - 100,567,386 (-)Ensembl
GRCm38.p6 Ensembl15100,645,305 - 100,669,505 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182494
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,543,324 - 100,549,541 (-)Ensembl
GRCm38.p6 Ensembl15100,645,443 - 100,651,660 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182574   ⟹   ENSMUSP00000138102
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,543,282 - 100,567,406 (-)Ensembl
GRCm38.p6 Ensembl15100,645,401 - 100,669,525 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182775   ⟹   ENSMUSP00000138673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,538,964 - 100,567,408 (-)Ensembl
GRCm38.p6 Ensembl15100,641,083 - 100,669,527 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182814   ⟹   ENSMUSP00000138158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,538,964 - 100,567,386 (-)Ensembl
GRCm38.p6 Ensembl15100,641,083 - 100,669,505 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183193
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,547,018 - 100,548,600 (-)Ensembl
GRCm38.p6 Ensembl15100,649,137 - 100,650,719 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183211   ⟹   ENSMUSP00000138523
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,538,958 - 100,567,434 (-)Ensembl
GRCm38.p6 Ensembl15100,641,077 - 100,669,553 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238935   ⟹   ENSMUSP00000159169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl15100,542,520 - 100,567,386 (-)Ensembl
GRCm38.p6 Ensembl15100,644,639 - 100,669,505 (-)Ensembl
RefSeq Acc Id: NM_001270537   ⟹   NP_001257466
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,538,963 - 100,567,384 (-)NCBI
GRCm3815100,641,082 - 100,669,503 (-)NCBI
Celera15102,795,111 - 102,822,575 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368666   ⟹   NP_001355595
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,538,963 - 100,567,384 (-)NCBI
GRCm3815100,641,082 - 100,669,503 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521281   ⟹   XP_006521344
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915100,538,963 - 100,549,833 (-)NCBI
GRCm3815100,641,082 - 100,651,952 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001257466   ⟸   NM_001270537
- Peptide Label: isoform 1
- UniProtKB: S4R270 (UniProtKB/TrEMBL),   S4R1B8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521344   ⟸   XM_006521281
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001355595   ⟸   NM_001368666
- Peptide Label: isoform 2
- UniProtKB: S4R1B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000138523   ⟸   ENSMUST00000183211
RefSeq Acc Id: ENSMUSP00000138673   ⟸   ENSMUST00000182775
RefSeq Acc Id: ENSMUSP00000138158   ⟸   ENSMUST00000182814
RefSeq Acc Id: ENSMUSP00000159169   ⟸   ENSMUST00000238935
RefSeq Acc Id: ENSMUSP00000138102   ⟸   ENSMUST00000182574
RefSeq Acc Id: ENSMUSP00000138316   ⟸   ENSMUST00000182068
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z6Q9-F1-model_v2 AlphaFold D3Z6Q9 1-489 view protein structure

Promoters
RGD ID:6826194
Promoter ID:MM_KWN:19753
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000100198,   LINCRNA_401,   XM_001000082_BIN2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615100,499,584 - 100,500,084 (-)MPROMDB
RGD ID:8685074
Promoter ID:EPDNEW_M20567
Type:initiation region
Name:Bin2_1
Description:Mus musculus bridging integrator 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815100,669,503 - 100,669,563EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3611448 AgrOrtholog
Ensembl Genes ENSMUSG00000098112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000182068.8 UniProtKB/TrEMBL
  ENSMUST00000182574.2 UniProtKB/TrEMBL
  ENSMUST00000182775.8 UniProtKB/TrEMBL
  ENSMUST00000182814.8 UniProtKB/TrEMBL
  ENSMUST00000183211 ENTREZGENE
  ENSMUST00000183211.8 UniProtKB/TrEMBL
  ENSMUST00000238935 ENTREZGENE
  ENSMUST00000238935.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amphiphysin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bin2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:668218 UniProtKB/TrEMBL
MGD MGI:3611448 ENTREZGENE
NCBI Gene 668218 ENTREZGENE
PANTHER AMPHIPHYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46514:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bin2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bin2 PhenoGen
PRINTS AMPHIPHYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F8MQ05_MOUSE UniProtKB/TrEMBL
  BIN2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  S4R171_MOUSE UniProtKB/TrEMBL
  S4R1B8 ENTREZGENE, UniProtKB/TrEMBL
  S4R1Q1_MOUSE UniProtKB/TrEMBL
  S4R270 ENTREZGENE, UniProtKB/TrEMBL
  S4R2J8_MOUSE UniProtKB/TrEMBL