Gas1 (growth arrest specific 1) - Rat Genome Database

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Gene: Gas1 (growth arrest specific 1) Mus musculus
Analyze
Symbol: Gas1
Name: growth arrest specific 1
RGD ID: 1623311
MGI Page MGI
Description: Involved in several processes, including negative regulation of cell growth; odontogenesis; and regulation of smoothened signaling pathway. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regulation of smoothened signaling pathway. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human GAS1 (growth arrest specific 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW554192; Gas; Gas-1; growth arrest-specific protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391360,322,219 - 60,325,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1360,322,219 - 60,325,179 (-)EnsemblGRCm39 Ensembl
GRCm381360,174,405 - 60,177,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1360,174,405 - 60,177,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv371360,275,766 - 60,278,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361360,184,028 - 60,186,988 (-)NCBIMGSCv36mm8
Celera1361,235,218 - 61,238,431 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1331.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
diethylstilbestrol  (EXP)
dimercaprol  (EXP)
dioxygen  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flusilazole  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
gemcitabine  (ISO)
gentamycin  (ISO)
hemin  (ISO)
hydroquinone  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lamivudine  (ISO)
lead(II) chloride  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (EXP)
Monobutylphthalate  (EXP)
N-nitrosodiethylamine  (EXP)
nickel dichloride  (EXP)
O-methyleugenol  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium fluoride  (EXP)
sulforaphane  (ISO)
tamoxifen  (EXP,ISO)
tetrachloromethane  (EXP)
tetraphene  (EXP)
thapsigargin  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
troglitazone  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IMP)
axon guidance  (IMP)
camera-type eye development  (IMP)
cell fate commitment  (IGI,IMP)
cell population proliferation  (IMP)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cerebellum morphogenesis  (IMP)
developmental growth  (IMP)
dorsal/ventral neural tube patterning  (IGI,IMP)
dorsal/ventral pattern formation  (IMP)
embryonic cranial skeleton morphogenesis  (IGI,IMP)
embryonic digit morphogenesis  (IGI,IMP)
embryonic morphogenesis  (IGI,IMP)
embryonic skeletal system development  (IGI,IMP)
eye morphogenesis  (IMP)
middle ear morphogenesis  (IMP)
negative regulation of apoptotic process  (IDA,IMP)
negative regulation of cell cycle G1/S phase transition  (NAS)
negative regulation of cell growth  (IDA)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
negative regulation of mitotic cell cycle  (IBA,ISO)
negative regulation of protein processing  (ISO)
negative regulation of smoothened signaling pathway  (IDA)
odontogenesis  (IMP)
outer ear morphogenesis  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of smoothened signaling pathway  (IDA,IMP)
programmed cell death  (IDA)
regulation of cell cycle  (TAS)
regulation of ER to Golgi vesicle-mediated transport  (ISO)
regulation of smoothened signaling pathway  (IMP)
roof of mouth development  (IMP)
smoothened signaling pathway  (IMP)

Cellular Component
membrane  (IDA)
plasma membrane  (IBA,IDA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior eye segment morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal basisphenoid bone morphology  (IAGP)
abnormal cerebellar foliation  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellar Purkinje cell layer  (IAGP)
abnormal cerebellum development  (IAGP)
abnormal cerebellum external granule cell layer morphology  (IAGP)
abnormal ciliary body morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal digit development  (IAGP)
abnormal digit morphology  (IAGP)
abnormal embryo turning  (IAGP)
abnormal external auditory canal morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal eye morphology  (IAGP)
abnormal face development  (IAGP)
abnormal floor plate morphology  (IAGP)
abnormal gait  (IAGP)
abnormal heart tube morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal intervertebral disk morphology  (IAGP)
abnormal iris morphology  (IAGP)
abnormal limb bone morphology  (IAGP)
abnormal limb bud morphology  (IAGP)
abnormal limb mesenchyme morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal lower incisor morphology  (IAGP)
abnormal malleus manubrium morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal malleus neck morphology  (IAGP)
abnormal malleus processus brevis morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal medial nasal prominence morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal molar morphology  (IAGP)
abnormal nasal capsule morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal nose morphology  (IAGP)
abnormal otic capsule morphology  (IAGP)
abnormal palatal mesenchymal cell proliferation  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal premaxilla morphology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal retina ganglion layer morphology  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal rostral-caudal body axis extension  (IAGP)
abnormal secondary palate development  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal styloid process morphology  (IAGP)
abnormal synchondrosis  (IAGP)
abnormal tegmen tympani morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal temporal bone squamous part morphology  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral body morphology  (IAGP)
abnormal vitreous body morphology  (IAGP)
abnormal vomeronasal organ morphology  (IAGP)
absent gonial bone  (IAGP)
absent hypoglossal canal  (IAGP)
absent incus  (IAGP)
absent malleus  (IAGP)
absent mandible  (IAGP)
absent mandibular symphysis  (IAGP)
absent maxilla  (IAGP)
absent tympanic ring  (IAGP)
absent upper incisors  (IAGP)
absent vomeronasal organ  (IAGP)
alisphenoid bone hypoplasia  (IAGP)
bifid tongue  (IAGP)
brachydactyly  (IAGP)
brachyphalangia  (IAGP)
cardiac edema  (IAGP)
cervical vertebral fusion  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
coloboma  (IAGP)
decreased embryo size  (IAGP)
decreased eye pigmentation  (IAGP)
decreased fetal size  (IAGP)
decreased neuronal precursor cell number  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged pericardium  (IAGP)
failure of palatal shelf elevation  (IAGP)
gonial bone hypoplasia  (IAGP)
holoprosencephaly  (IAGP)
impaired balance  (IAGP)
increased neuronal precursor cell number  (IAGP)
microphthalmia  (IAGP)
midface hypoplasia  (IAGP)
narrow eye opening  (IAGP)
oligodactyly  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
polydactyly  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature coronal suture closure  (IAGP)
premaxilla hypoplasia  (IAGP)
short limbs  (IAGP)
short mandible  (IAGP)
short maxilla  (IAGP)
short Meckel's cartilage  (IAGP)
short metacarpal bones  (IAGP)
short metatarsal bones  (IAGP)
single external naris  (IAGP)
small alisphenoid bone  (IAGP)
small cerebellum  (IAGP)
small cranium  (IAGP)
small lens  (IAGP)
small parietal bone  (IAGP)
styloid process hypoplasia  (IAGP)
syndactyly  (IAGP)
synostosis  (IAGP)
thin apical ectodermal ridge  (IAGP)
thin cerebellar granule layer  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Interactions between Hedgehog proteins and their binding partners come into view. Beachy PA, etal., Genes Dev. 2010 Sep 15;24(18):2001-12.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1347472   PMID:1427878   PMID:1505026   PMID:2569712   PMID:3409319   PMID:8127893   PMID:8226788   PMID:8307588   PMID:8666395   PMID:8889548   PMID:9188486   PMID:9189272  
PMID:9671732   PMID:9932288   PMID:10349636   PMID:10922068   PMID:10996315   PMID:10996316   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11231094   PMID:11356029   PMID:11456441  
PMID:11456442   PMID:11572986   PMID:11906213   PMID:11955608   PMID:12399319   PMID:12466851   PMID:12477932   PMID:14681479   PMID:15070677   PMID:15151988   PMID:15459106   PMID:15489334  
PMID:15760903   PMID:16141072   PMID:16141073   PMID:16168717   PMID:16551639   PMID:16602821   PMID:17504940   PMID:17504941   PMID:17525797   PMID:18038450   PMID:18539269   PMID:18554416  
PMID:18981472   PMID:19211681   PMID:19449303   PMID:19478089   PMID:21150899   PMID:21440680   PMID:21664576   PMID:21664577   PMID:21802063   PMID:21820049   PMID:21858068   PMID:21873635  
PMID:22898775   PMID:23429478   PMID:23813868   PMID:24529556   PMID:24813615   PMID:24952961   PMID:25063195   PMID:25453830   PMID:25458012   PMID:25535338   PMID:25804736   PMID:26161998  
PMID:26186931   PMID:26439398   PMID:26740594   PMID:26930384   PMID:27391369   PMID:27657450   PMID:27811357   PMID:28052872   PMID:28315934   PMID:28442042   PMID:28771384   PMID:28799057  
PMID:28874785   PMID:29030970   PMID:29031500   PMID:29110208   PMID:29139542   PMID:29395133   PMID:30635555   PMID:31373354   PMID:31719045   PMID:32021964   PMID:32332736   PMID:33028094  
PMID:33060130   PMID:34140513   PMID:34309509   PMID:34698766   PMID:34767969   PMID:34796774   PMID:35942939   PMID:36265686   PMID:36459481   PMID:36971701  


Genomics

Comparative Map Data
Gas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391360,322,219 - 60,325,179 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1360,322,219 - 60,325,179 (-)EnsemblGRCm39 Ensembl
GRCm381360,174,405 - 60,177,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1360,174,405 - 60,177,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv371360,275,766 - 60,278,896 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361360,184,028 - 60,186,988 (-)NCBIMGSCv36mm8
Celera1361,235,218 - 61,238,431 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1331.92NCBI
GAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38986,944,362 - 86,947,506 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl986,944,362 - 86,947,506 (-)EnsemblGRCh38hg38GRCh38
GRCh37989,559,277 - 89,562,421 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36988,749,098 - 88,751,924 (-)NCBINCBI36Build 36hg18NCBI36
Build 34986,788,831 - 86,791,658NCBI
Celera960,128,056 - 60,130,876 (-)NCBICelera
Cytogenetic Map9q21.33NCBI
HuRef959,383,451 - 59,386,172 (-)NCBIHuRef
CHM1_1989,705,737 - 89,708,564 (-)NCBICHM1_1
T2T-CHM13v2.0999,095,595 - 99,098,739 (-)NCBIT2T-CHM13v2.0
Gas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2174,482,014 - 4,485,155 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx174,501,253 - 4,504,238 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0176,042,584 - 6,045,570 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0174,497,694 - 4,500,679 (+)NCBIRnor_WKY
Rnor_6.0174,846,116 - 4,849,350 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,846,789 - 4,847,940 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0177,072,776 - 7,075,999 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera174,606,730 - 4,609,964 (+)NCBICelera
Cytogenetic Map17p14NCBI
Gas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955432727,784 - 729,096 (+)NCBIChiLan1.0ChiLan1.0
GAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1952,471,996 - 52,473,168 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0958,079,700 - 58,082,849 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1986,137,630 - 86,140,170 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl986,139,009 - 86,140,045 (-)Ensemblpanpan1.1panPan2
GAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1172,927,346 - 72,930,119 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl172,927,670 - 72,928,827 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha173,689,084 - 73,690,386 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0173,232,667 - 73,233,972 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1173,042,847 - 73,044,149 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0172,809,335 - 72,810,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0173,514,553 - 73,515,855 (+)NCBIUU_Cfam_GSD_1.0
GAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1028,509,261 - 28,510,301 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11028,509,168 - 28,511,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21032,610,336 - 32,613,309 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11297,590,381 - 97,593,209 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1297,591,762 - 97,592,805 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603885,913,252 - 85,916,646 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480910,415,592 - 10,416,596 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480910,414,935 - 10,417,838 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gas1
118 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:362
Count of miRNA genes:285
Interacting mature miRNAs:306
Transcripts:ENSMUST00000065086
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse

Markers in Region
AW554192  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381360,174,928 - 60,175,057UniSTSGRCm38
MGSCv371360,276,289 - 60,276,418UniSTSGRCm37
Celera1361,235,741 - 61,235,871UniSTS
Cytogenetic Map13B3-C2UniSTS
Whitehead/MRC_RH13632.6UniSTS
Gas1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381360,175,029 - 60,176,042UniSTSGRCm38
MGSCv371360,276,390 - 60,277,403UniSTSGRCm37
Celera1361,235,843 - 61,236,856UniSTS
Cytogenetic Map13B3-C2UniSTS
cM Map1337.0UniSTS
Gas1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381360,174,525 - 60,174,688UniSTSGRCm38
MGSCv371360,275,886 - 60,276,049UniSTSGRCm37
Celera1361,235,338 - 61,235,501UniSTS
Cytogenetic Map13B3-C2UniSTS
cM Map1337.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065086   ⟹   ENSMUSP00000064555
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1360,322,219 - 60,325,179 (-)Ensembl
GRCm38.p6 Ensembl1360,174,405 - 60,177,365 (-)Ensembl
RefSeq Acc Id: ENSMUST00000223933   ⟹   ENSMUSP00000153311
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1360,323,601 - 60,324,755 (-)Ensembl
GRCm38.p6 Ensembl1360,175,787 - 60,176,941 (-)Ensembl
RefSeq Acc Id: NM_008086   ⟹   NP_032112
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391360,322,219 - 60,325,179 (-)NCBI
GRCm381360,174,405 - 60,177,535 (-)ENTREZGENE
MGSCv371360,275,766 - 60,278,896 (-)RGD
Celera1361,235,218 - 61,238,431 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032112 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH55747 (Get FASTA)   NCBI Sequence Viewer  
  AAH58628 (Get FASTA)   NCBI Sequence Viewer  
  CAA46256 (Get FASTA)   NCBI Sequence Viewer  
  Q01721 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_032112   ⟸   NM_008086
- UniProtKB: Q01721 (UniProtKB/Swiss-Prot),   A0A286YD87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000153311   ⟸   ENSMUST00000223933
RefSeq Acc Id: ENSMUSP00000064555   ⟸   ENSMUST00000065086
Protein Domains
GDNF/GAS1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01721-F1-model_v2 AlphaFold Q01721 1-343 view protein structure

Promoters
RGD ID:8680570
Promoter ID:EPDNEW_M18316
Type:multiple initiation site
Name:Gas1_1
Description:Mus musculus growth arrest specific 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381360,177,365 - 60,177,425EPDNEW
RGD ID:6823916
Promoter ID:MM_KWN:14360
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000109819,   NM_008086,   NM_008086_GAS1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361360,275,861 - 60,279,887 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95655 AgrOrtholog
Ensembl Genes ENSMUSG00000052957 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000064555 ENTREZGENE
  ENSMUSP00000064555.6 UniProtKB/Swiss-Prot
  ENSMUSP00000153311.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065086 ENTREZGENE
  ENSMUST00000065086.6 UniProtKB/Swiss-Prot
  ENSMUST00000223933.2 UniProtKB/TrEMBL
InterPro GAS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDNF/GAS1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14451 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95655 ENTREZGENE
NCBI Gene 14451 ENTREZGENE
PANTHER GROWTH ARREST-SPECIFIC PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GDNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gas1 PhenoGen
SMART GDNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286YD87 ENTREZGENE, UniProtKB/TrEMBL
  GAS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TNT6_MOUSE UniProtKB/TrEMBL