Kptn (kaptin) - Rat Genome Database

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Gene: Kptn (kaptin) Mus musculus
Analyze
Symbol: Kptn
Name: kaptin
RGD ID: 1623180
MGI Page MGI
Description: Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Predicted to be located in postsynaptic actin cytoskeleton and stereocilium. Predicted to be part of KICSTOR complex and filamentous actin. Predicted to be active in lamellipodium. Used to study autosomal recessive intellectual developmental disorder 41. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 41. Orthologous to human KPTN (kaptin, actin binding protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310042D10Rik; 2E4; actin-binding protein; C030013F01Rik; KICSTOR complex protein kaptin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39715,853,801 - 15,861,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl715,853,820 - 15,861,441 (+)EnsemblGRCm39 Ensembl
GRCm38716,119,876 - 16,127,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,119,895 - 16,127,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv37716,705,225 - 16,712,865 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,278,430 - 15,286,038 (+)NCBIMGSCv36mm8
Celera713,318,462 - 13,326,094 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12016511   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14755058   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:21677750   PMID:21873635   PMID:23870131   PMID:30973865   PMID:32325033   PMID:37437211   PMID:38355793  


Genomics

Comparative Map Data
Kptn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39715,853,801 - 15,861,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl715,853,820 - 15,861,441 (+)EnsemblGRCm39 Ensembl
GRCm38716,119,876 - 16,127,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,119,895 - 16,127,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv37716,705,225 - 16,712,865 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36715,278,430 - 15,286,038 (+)NCBIMGSCv36mm8
Celera713,318,462 - 13,326,094 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.75NCBI
KPTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,475,150 - 47,485,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1947,475,150 - 47,484,265 (-)EnsemblGRCh38hg38GRCh38
GRCh371947,978,407 - 47,987,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,670,212 - 52,679,333 (-)NCBINCBI36Build 36hg18NCBI36
Build 341952,670,219 - 52,679,263NCBI
Celera1944,784,164 - 44,793,281 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1944,406,561 - 44,415,692 (-)NCBIHuRef
CHM1_11947,980,567 - 47,989,727 (-)NCBICHM1_1
T2T-CHM13v2.01950,306,001 - 50,316,700 (-)NCBIT2T-CHM13v2.0
Kptn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8185,936,922 - 85,937,716 (+)NCBIGRCr8
mRatBN7.2176,808,737 - 76,809,531 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx182,182,588 - 82,183,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0190,746,612 - 90,747,406 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,937,673 - 83,938,467 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,015,714 - 78,016,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,015,722 - 78,023,676 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,282,511 - 79,283,305 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,460,104 - 76,460,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,538,237 - 76,545,894 (+)NCBI
Celera171,298,870 - 71,299,664 (+)NCBICelera
Cytogenetic Map1q21NCBI
Kptn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555741,319,344 - 1,329,395 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555741,321,356 - 1,329,132 (-)NCBIChiLan1.0ChiLan1.0
KPTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22053,626,381 - 53,637,200 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11955,496,371 - 55,505,520 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01944,467,344 - 44,478,150 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11953,122,663 - 53,131,805 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1953,122,663 - 53,131,805 (-)Ensemblpanpan1.1panPan2
KPTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,535,140 - 108,544,405 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,535,681 - 108,543,164 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1108,017,396 - 108,026,135 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01109,061,687 - 109,070,426 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,061,702 - 109,070,426 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,728,663 - 108,737,402 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,373,440 - 108,382,179 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,241,951 - 109,250,690 (+)NCBIUU_Cfam_GSD_1.0
Kptn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,522,173 - 19,537,481 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366641,146,293 - 1,152,968 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366641,146,003 - 1,155,571 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,238,666 - 53,249,163 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,238,650 - 53,246,458 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,771,914 - 48,779,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KPTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,805,756 - 40,815,412 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,804,880 - 40,815,103 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607320,541,040 - 20,550,640 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kptn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,325,107 - 6,331,713 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248326,325,032 - 6,331,915 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kptn
212 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1181
Count of miRNA genes:509
Interacting mature miRNAs:594
Transcripts:ENSMUST00000006178, ENSMUST00000127584, ENSMUST00000129080, ENSMUST00000130170, ENSMUST00000141430, ENSMUST00000149255, ENSMUST00000149388, ENSMUST00000152044
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
25394569Skmw57_mskeletal muscle weight 57, gastroc (mouse)7458046916687861Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse

Markers in Region
AW742723  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38716,127,238 - 16,127,460UniSTSGRCm38
MGSCv37716,712,587 - 16,712,809UniSTSGRCm37
Celera713,325,816 - 13,326,038UniSTS
Cytogenetic Map7A2UniSTS
cM Map715.16UniSTS
Whitehead/MRC_RH7215.45UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000006178   ⟹   ENSMUSP00000006178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,853,820 - 15,861,441 (+)Ensembl
GRCm38.p6 Ensembl716,119,895 - 16,127,516 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,856,797 - 15,857,921 (+)Ensembl
GRCm38.p6 Ensembl716,122,872 - 16,123,996 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129080
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,859,329 - 15,861,289 (+)Ensembl
GRCm38.p6 Ensembl716,125,404 - 16,127,364 (+)Ensembl
Ensembl Acc Id: ENSMUST00000130170
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,853,820 - 15,855,449 (+)Ensembl
GRCm38.p6 Ensembl716,119,895 - 16,121,524 (+)Ensembl
Ensembl Acc Id: ENSMUST00000141430
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,856,730 - 15,857,742 (+)Ensembl
GRCm38.p6 Ensembl716,122,805 - 16,123,817 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149255
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,854,376 - 15,854,888 (+)Ensembl
GRCm38.p6 Ensembl716,120,451 - 16,120,963 (+)Ensembl
Ensembl Acc Id: ENSMUST00000149388
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,854,144 - 15,857,779 (+)Ensembl
GRCm38.p6 Ensembl716,120,219 - 16,123,854 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl715,853,854 - 15,854,897 (+)Ensembl
GRCm38.p6 Ensembl716,119,929 - 16,120,972 (+)Ensembl
RefSeq Acc Id: NM_133727   ⟹   NP_598488
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39715,853,801 - 15,861,441 (+)NCBI
GRCm38716,119,876 - 16,127,516 (+)ENTREZGENE
MGSCv37716,705,225 - 16,712,865 (+)RGD
Celera713,318,462 - 13,326,094 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_598488 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH18316 (Get FASTA)   NCBI Sequence Viewer  
  EDL42110 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000006178
  ENSMUSP00000006178.5
GenBank Protein Q8VCX6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598488   ⟸   NM_133727
- UniProtKB: Q8VCX6 (UniProtKB/Swiss-Prot),   G3X8R1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000006178   ⟸   ENSMUST00000006178

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCX6-F1-model_v2 AlphaFold Q8VCX6 1-430 view protein structure

Promoters
RGD ID:6891900
Promoter ID:EPDNEW_M9401
Type:multiple initiation site
Name:Kptn_1
Description:Mus musculus kaptin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38716,119,885 - 16,119,945EPDNEW
RGD ID:6841404
Promoter ID:MM_KWN:48879
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000042218,   OTTMUST00000042219,   OTTMUST00000042220,   OTTMUST00000042221,   OTTMUST00000042222
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36716,704,496 - 16,705,692 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890380 AgrOrtholog
Ensembl Genes ENSMUSG00000006021 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000006178 ENTREZGENE
  ENSMUST00000006178.5 UniProtKB/TrEMBL
InterPro Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kptn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70394 UniProtKB/TrEMBL
MGD MGI:1890380 ENTREZGENE
NCBI Gene 70394 ENTREZGENE
PANTHER KICSTOR COMPLEX PROTEIN KAPTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15435 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kptn PhenoGen
Superfamily-SCOP SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3X8R1 ENTREZGENE, UniProtKB/TrEMBL
  KPTN_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE