Gldc (glycine decarboxylase) - Rat Genome Database

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Gene: Gldc (glycine decarboxylase) Mus musculus
Analyze
Symbol: Gldc
Name: glycine decarboxylase
RGD ID: 1623050
MGI Page MGI
Description: Predicted to enable several functions, including glycine binding activity; glycine dehydrogenase (decarboxylating) activity; and vitamin B6 binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in mitochondrion. Is expressed in several structures, including central nervous system; integumental system; limb; sensory organ; and urinary system. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in glycine encephalopathy and glycine encephalopathy 1. Orthologous to human GLDC (glycine decarboxylase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: b2b2679C; b2b2679Clo; D030049L12Rik; D19Wsu57; D19Wsu57e; glycine cleavage system P protein; glycine dehydrogenase (aminomethyl-transferring); glycine dehydrogenase (decarboxylating), mitochondrial; glycine dehydrogenase [decarboxylating], mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,075,847 - 30,152,829 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,075,847 - 30,152,829 (-)EnsemblGRCm39 Ensembl
GRCm381930,098,441 - 30,175,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,098,447 - 30,175,429 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,172,937 - 30,249,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,164,444 - 30,241,415 (-)NCBIMGSCv36mm8
Celera1930,873,665 - 30,951,190 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1924.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
3-chloropropane-1,2-diol  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antimycin A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
Brodifacoum  (ISO)
buspirone  (ISO)
butan-1-ol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
diclofenac  (ISO)
diquat  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenpyroximate  (ISO)
fentin chloride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glycidyl methacrylate  (ISO)
GW 4064  (EXP)
HC toxin  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
menadione  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (EXP)
nefazodone  (ISO)
nimesulide  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (EXP)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
rotenone  (ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tacedinaline  (ISO)
tacrolimus hydrate  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
glycine cleavage complex  (IBA,IEA,ISO)
mitochondrion  (HDA,IBA,ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mild glycine encephalopathy (NKH) in a large kindred due to a silent exonic GLDC splice mutation. Flusser H, etal., Neurology. 2005 Apr 26;64(8):1426-30.
2. Genomic deletion within GLDC is a major cause of non-ketotic hyperglycinaemia. Kanno J, etal., J Med Genet. 2007 Mar;44(3):e69.
3. Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC (Glycine Dehydrogenase) in Gastric Carcinoma. Min HL, etal., Anticancer Res. 2016 Jan;36(1):179-87.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Pai YJ, etal., Nat Commun. 2015 Mar 4;6:6388. doi: 10.1038/ncomms7388.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
Additional References at PubMed
PMID:8889548   PMID:9811942   PMID:10072599   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12904583  
PMID:14681479   PMID:15226823   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17510459   PMID:18614015   PMID:20439489   PMID:21677750   PMID:21873635   PMID:23070814  
PMID:24154525   PMID:24457600   PMID:25807483   PMID:26599272   PMID:28056489   PMID:28130547   PMID:29141214   PMID:30973865   PMID:31794432   PMID:32098917   PMID:32325033   PMID:32743799  
PMID:33524012   PMID:33569080   PMID:34321999   PMID:35012549   PMID:35727412   PMID:38171330   PMID:38355793   PMID:38822427   PMID:39210012  


Genomics

Comparative Map Data
Gldc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,075,847 - 30,152,829 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,075,847 - 30,152,829 (-)EnsemblGRCm39 Ensembl
GRCm381930,098,441 - 30,175,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,098,447 - 30,175,429 (-)EnsemblGRCm38mm10GRCm38
MGSCv371930,172,937 - 30,249,908 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361930,164,444 - 30,241,415 (-)NCBIMGSCv36mm8
Celera1930,873,665 - 30,951,190 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1924.87NCBI
GLDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3896,532,467 - 6,645,729 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl96,532,467 - 6,645,729 (-)EnsemblGRCh38hg38GRCh38
GRCh3796,532,467 - 6,645,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3696,522,464 - 6,635,692 (-)NCBINCBI36Build 36hg18NCBI36
Build 3496,522,468 - 6,635,650NCBI
Celera96,469,938 - 6,583,174 (-)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef96,487,440 - 6,600,082 (-)NCBIHuRef
CHM1_196,533,234 - 6,646,419 (-)NCBICHM1_1
T2T-CHM13v2.096,537,521 - 6,650,780 (-)NCBIT2T-CHM13v2.0
Gldc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,296,753 - 237,375,620 (-)NCBIGRCr8
mRatBN7.21227,883,249 - 227,962,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,883,249 - 227,962,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,285,270 - 236,364,242 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,214,954 - 243,293,934 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,037,217 - 236,116,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,295,140 - 248,377,122 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,297,331 - 248,377,093 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01255,544,863 - 255,624,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,846,690 - 233,925,736 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,011,236 - 234,089,583 (-)NCBI
Celera1225,029,994 - 225,108,807 (-)NCBICelera
Cytogenetic Map1q52NCBI
Gldc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543410,431,983 - 10,533,002 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543410,431,434 - 10,533,118 (-)NCBIChiLan1.0ChiLan1.0
GLDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211117,935,713 - 118,045,297 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19117,941,661 - 118,051,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v096,347,381 - 6,456,042 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.196,527,242 - 6,635,778 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl96,527,242 - 6,635,779 (-)Ensemblpanpan1.1panPan2
GLDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11127,491,639 - 27,584,450 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1127,414,834 - 27,584,450 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1126,274,927 - 26,367,677 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01128,350,544 - 28,443,332 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1128,265,114 - 28,443,675 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11127,074,254 - 27,167,008 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01126,893,508 - 26,986,195 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01127,562,632 - 27,654,945 (-)NCBIUU_Cfam_GSD_1.0
Gldc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947142,555,653 - 142,642,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365391,007,820 - 1,095,054 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365391,008,340 - 1,095,044 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,608,849 - 215,715,059 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,608,854 - 215,715,062 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11272,876,992 - 72,990,671 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1272,877,017 - 72,990,668 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603861,215,190 - 61,329,981 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gldc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473611,022,691 - 11,134,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473611,022,691 - 11,133,950 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gldc
3252 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:148
Interacting mature miRNAs:154
Transcripts:ENSMUST00000025778
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
1357596Tgct3_mtesticular germ cell tumor 3 (mouse)Not determined192198409132912719Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
1357568Tgct4_mtesticular germ cell tumor 4 (mouse)Not determined192777198535295381Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse

Markers in Region
AI194796  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,098,717 - 30,098,823UniSTSGRCm38
MGSCv371930,173,207 - 30,173,313UniSTSGRCm37
Celera1930,873,935 - 30,874,041UniSTS
Cytogenetic Map19CUniSTS
cM Map1925.0UniSTS
Whitehead/MRC_RH19303.7UniSTS
D9Mit34.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7F1UniSTS
Cytogenetic Map13D1UniSTS
Cytogenetic Map1C3UniSTS
Cytogenetic Map2C1.3UniSTS
Cytogenetic Map19D1UniSTS
Cytogenetic Map9F1UniSTS
Cytogenetic Map1FUniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map3F2UniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map11E1UniSTS
Cytogenetic Map2H4UniSTS
Cytogenetic Map8B3.3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map4E2UniSTS
Cytogenetic Map2E5UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map5G3UniSTS
Cytogenetic MapXA5UniSTS
Cytogenetic Map10C1UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map6F2UniSTS
Cytogenetic Map1C1.3UniSTS
Cytogenetic Map16B1UniSTS
Cytogenetic Map12C1UniSTS
Cytogenetic Map7E2UniSTS
Cytogenetic Map9F2UniSTS
Cytogenetic Map5FUniSTS
Cytogenetic Map2H1UniSTS
Cytogenetic Map2E2UniSTS
Cytogenetic Map15F1UniSTS
Cytogenetic Map15E1UniSTS
Cytogenetic Map3G2UniSTS
Cytogenetic Map6F3UniSTS
Cytogenetic Map13B3UniSTS
Cytogenetic Map12F1UniSTS
Cytogenetic Map1E4UniSTS
Cytogenetic Map1E3UniSTS
Cytogenetic Map5E1UniSTS
Cytogenetic Map7F3UniSTS
Cytogenetic Map16B3UniSTS
Cytogenetic Map14D2UniSTS
Cytogenetic Map19C2UniSTS
Cytogenetic Map19D3UniSTS
Cytogenetic Map1H5UniSTS
Cytogenetic Map1DUniSTS
Cytogenetic Map14BUniSTS
Cytogenetic Map11CUniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map6G3UniSTS
Cytogenetic Map7A1UniSTS
Cytogenetic Map7A3UniSTS
Cytogenetic Map8E1UniSTS
Cytogenetic Map8A2UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2BUniSTS
Cytogenetic Map5A3UniSTS
Cytogenetic Map9DUniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map19C3UniSTS
Cytogenetic Map13A2-A3UniSTS
Cytogenetic Map4C6UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17B1UniSTS
Cytogenetic Map17A3.3UniSTS
Cytogenetic Map13A1UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map15D3UniSTS
Cytogenetic Map8D2UniSTS
Cytogenetic Map12A3UniSTS
Cytogenetic Map1H2.1UniSTS
Cytogenetic Map7F5UniSTS
Cytogenetic Map7CUniSTS
Cytogenetic Map2E1UniSTS
Cytogenetic Map11B2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map16A1UniSTS
Cytogenetic Map5G1UniSTS
Cytogenetic Map6A2UniSTS
Cytogenetic Map7B1UniSTS
Cytogenetic Map3F2.2UniSTS
Cytogenetic Map5C3.1UniSTS
Cytogenetic Map2C3UniSTS
Cytogenetic Map17A3.2-A3.3UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map11B1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map2C2UniSTS
Cytogenetic Map19CUniSTS
Cytogenetic Map17E1.3UniSTS
Cytogenetic Map5A1UniSTS
Cytogenetic Map11B5UniSTS
Cytogenetic Map9A5.2UniSTS
Cytogenetic Map1A1UniSTS
Cytogenetic Map13A5UniSTS
Cytogenetic MapXA1.1UniSTS
Cytogenetic Map4D2.3UniSTS
Cytogenetic Map4B3UniSTS
Cytogenetic Map3A3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map8CUniSTS
Cytogenetic Map12EUniSTS
Cytogenetic Map10C2UniSTS
Cytogenetic Map5G2UniSTS
Cytogenetic Map5B1UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map2H3UniSTS
Cytogenetic Map2A1UniSTS
Cytogenetic Map1H1UniSTS
Cytogenetic Map15F3UniSTS
Cytogenetic Map9E1UniSTS
Cytogenetic Map9CUniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map12C3UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map5B2UniSTS
Cytogenetic Map3DUniSTS
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map6B1UniSTS
Cytogenetic MapXC-DUniSTS
Cytogenetic Map5G1.3UniSTS
Cytogenetic Map7D1-E2UniSTS
Cytogenetic Map11A1UniSTS
Cytogenetic Map13B1UniSTS
Cytogenetic Map1H2.2UniSTS
Cytogenetic Map8C3UniSTS
Cytogenetic Map11DUniSTS
Cytogenetic MapXA7.3UniSTS
Cytogenetic Map16C1.1UniSTS
Cytogenetic Map15F2UniSTS
Cytogenetic Map9A2UniSTS
Cytogenetic Map1H4-H6UniSTS
Cytogenetic Map12D2UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map5E5UniSTS
Cytogenetic Map1H3UniSTS
Cytogenetic Map19BUniSTS
cM Map950.0UniSTS
Whitehead Genetic943.7UniSTS
RH125989  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,111,322 - 30,111,526UniSTSGRCm38
MGSCv371930,185,812 - 30,186,016UniSTSGRCm37
Celera1930,886,534 - 30,886,738UniSTS
Cytogenetic Map19CUniSTS
cM Map1925.0UniSTS
Whitehead/MRC_RH19305.0UniSTS
RH125877  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381930,098,449 - 30,098,668UniSTSGRCm38
MGSCv371930,172,939 - 30,173,158UniSTSGRCm37
Celera1930,873,667 - 30,873,886UniSTS
Cytogenetic Map19CUniSTS
cM Map1925.0UniSTS
Gldc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19CUniSTS
cM Map19 UniSTS
Gldc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19CUniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000025778   ⟹   ENSMUSP00000025778
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,075,847 - 30,152,829 (-)Ensembl
GRCm38.p6 Ensembl1930,098,447 - 30,175,429 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,092,221 - 30,152,829 (-)Ensembl
GRCm38.p6 Ensembl1930,114,821 - 30,175,429 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1930,118,803 - 30,122,631 (-)Ensembl
GRCm38.p6 Ensembl1930,141,403 - 30,145,231 (-)Ensembl
RefSeq Acc Id: NM_138595   ⟹   NP_613061
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391930,075,847 - 30,152,829 (-)NCBI
GRCm381930,098,441 - 30,175,441 (-)NCBI
MGSCv371930,172,937 - 30,249,908 (-)RGD
Celera1930,873,659 - 30,951,213 (-)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_613061   ⟸   NM_138595
- Peptide Label: precursor
- UniProtKB: Q91W43 (UniProtKB/Swiss-Prot),   Q8BJQ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000025778   ⟸   ENSMUST00000025778
Protein Domains
Aromatic amino acid beta-eliminating lyase/threonine   Glycine cleavage system P-protein N-terminal   Glycine dehydrogenase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91W43-F1-model_v2 AlphaFold Q91W43 1-1025 view protein structure

Promoters
RGD ID:13679244
Promoter ID:EPDNEW_M23771
Type:initiation region
Name:Gldc_1
Description:Mus musculus glycine decarboxylase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381930,175,426 - 30,175,486EPDNEW
RGD ID:6830053
Promoter ID:MM_KWN:26821
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver
Transcripts:ENSMUST00000070303,   NM_138595,   UC008HEK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361930,249,639 - 30,250,139 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1341155 AgrOrtholog
Ensembl Genes ENSMUSG00000024827 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025778 ENTREZGENE
  ENSMUST00000025778.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
InterPro ArAA_b-elim_lyase/Thr_aldolase UniProtKB/Swiss-Prot
  GcvP UniProtKB/Swiss-Prot
  GDC-P_C UniProtKB/Swiss-Prot
  GDC-P_N UniProtKB/Swiss-Prot
  GDC_P UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report mmu:104174 UniProtKB/Swiss-Prot
MGD MGI:1341155 ENTREZGENE
NCBI Gene Gldc ENTREZGENE
PANTHER GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11773 UniProtKB/Swiss-Prot
Pfam Beta_elim_lyase UniProtKB/Swiss-Prot
  GcvP2_C UniProtKB/Swiss-Prot
  GDC-P UniProtKB/Swiss-Prot
PhenoGen Gldc PhenoGen
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt GCSP_MOUSE UniProtKB/Swiss-Prot
  Q8BJQ7 ENTREZGENE, UniProtKB/TrEMBL
  Q91W43 ENTREZGENE
  Q9CRJ4_MOUSE UniProtKB/TrEMBL