Gjc2 (gap junction protein, gamma 2) - Rat Genome Database

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Gene: Gjc2 (gap junction protein, gamma 2) Mus musculus
Analyze
Symbol: Gjc2
Name: gap junction protein, gamma 2
RGD ID: 1623025
MGI Page MGI
Description: Enables gap junction channel activity. Acts upstream of or within cell-cell signaling and response to toxic substance. Located in gap junction and myelin sheath. Is expressed in brain; ovary; and spinal cord. Used to study hypomyelinating leukodystrophy 2. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B230382L12Rik; connexin 47 type A; connexin 47 type C; connexin 47 type D; connexin o; connexin-47; Cx47; Cxno; gap junction alpha-12 protein; gap junction gamma-2 protein; gap junction membrane channel protein alpha 12; gap junction protein, chi 2; Gja1; Gja12; MGC130506
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,066,390 - 59,074,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,066,394 - 59,074,039 (-)EnsemblGRCm39 Ensembl
GRCm381159,175,564 - 59,183,213 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,175,568 - 59,183,213 (-)EnsemblGRCm38mm10GRCm38
MGSCv371158,989,066 - 58,996,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,991,761 - 58,999,408 (-)NCBIMGSCv36mm8
Celera1163,940,632 - 63,948,320 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GJA12 mutations in children with recessive hypomyelinating leukoencephalopathy. Bugiani M, etal., Neurology. 2006 Jul 25;67(2):273-9. Epub 2006 May 17.
2. Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model. Cui Y, etal., J Neuroinflammation. 2014 Mar 6;11:42. doi: 10.1186/1742-2094-11-42.
3. GJC2 missense mutations cause human lymphedema. Ferrell RE, etal., Am J Hum Genet. 2010 Jun 11;86(6):943-8. doi: 10.1016/j.ajhg.2010.04.010. Epub 2010 May 27.
4. GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease. Henneke M, etal., Neurology. 2008 Mar 4;70(10):748-54. Epub 2007 Dec 19.
5. Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis. Markoullis K, etal., Glia. 2012 Jul;60(7):1053-66. doi: 10.1002/glia.22334. Epub 2012 Mar 27.
6. Promoter mutation is a common variant in GJC2-associated Pelizaeus-Merzbacher-like disease. Meyer E, etal., Mol Genet Metab. 2011 Dec;104(4):637-43. doi: 10.1016/j.ymgme.2011.08.032. Epub 2011 Sep 8.
7. Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat. Mukhamedshina YO, etal., Spinal Cord. 2016 May;54(5):347-59. doi: 10.1038/sc.2015.161. Epub 2015 Sep 29.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Hereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutations. Orthmann-Murphy JL, etal., Brain. 2009 Feb;132(Pt 2):426-38. doi: 10.1093/brain/awn328. Epub 2008 Dec 4.
10. Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype. Ostergaard P, etal., J Med Genet. 2011 Apr;48(4):251-5. doi: 10.1136/jmg.2010.085563. Epub 2011 Jan 25.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations. Singh AK, etal., Toxicol Sci. 2011 Aug;122(2):526-38. doi: 10.1093/toxsci/kfr115. Epub 2011 May 10.
15. Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. Tress O, etal., PLoS Genet. 2011 Jul;7(7):e1002146. doi: 10.1371/journal.pgen.1002146. Epub 2011 Jul 7.
16. Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease. Uhlenberg B, etal., Am J Hum Genet. 2004 Aug;75(2):251-60. Epub 2004 Jun 10.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11160382   PMID:11217851   PMID:11501764   PMID:12466851   PMID:12477932   PMID:12805295   PMID:12843301   PMID:14681012  
PMID:15081111   PMID:15183511   PMID:15293232   PMID:15466892   PMID:15676282   PMID:16141072   PMID:16141073   PMID:16203097   PMID:16452087   PMID:17065440   PMID:18973575   PMID:20211698  
PMID:20468052   PMID:20578039   PMID:21396451   PMID:21515254   PMID:21677750   PMID:21873635   PMID:22513384   PMID:22649229   PMID:23591958   PMID:25037920   PMID:25524707   PMID:25914045  
PMID:26051537   PMID:26953188   PMID:27568567   PMID:27899284   PMID:28732089   PMID:29023979   PMID:29490274   PMID:30325069   PMID:30355030   PMID:31932428   PMID:32266943   PMID:33472059  
PMID:36446400   PMID:37142655  


Genomics

Comparative Map Data
Gjc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,066,390 - 59,074,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,066,394 - 59,074,039 (-)EnsemblGRCm39 Ensembl
GRCm381159,175,564 - 59,183,213 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,175,568 - 59,183,213 (-)EnsemblGRCm38mm10GRCm38
MGSCv371158,989,066 - 58,996,715 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,991,761 - 58,999,408 (-)NCBIMGSCv36mm8
Celera1163,940,632 - 63,948,320 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1137.05NCBI
GJC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381228,149,930 - 228,159,826 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1228,149,930 - 228,159,826 (+)EnsemblGRCh38hg38GRCh38
GRCh371228,337,631 - 228,347,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,404,176 - 226,414,150 (+)NCBINCBI36Build 36hg18NCBI36
Build 341224,644,287 - 224,654,260NCBI
Celera1201,527,795 - 201,537,768 (+)NCBICelera
Cytogenetic Map1q42.13NCBI
HuRef1198,852,444 - 198,862,502 (+)NCBIHuRef
CHM1_11229,609,739 - 229,619,848 (+)NCBICHM1_1
T2T-CHM13v2.01227,338,927 - 227,348,822 (+)NCBIT2T-CHM13v2.0
Gjc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81044,462,203 - 44,470,924 (-)NCBIGRCr8
mRatBN7.21043,962,642 - 43,971,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1043,962,642 - 43,970,467 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1048,656,460 - 48,664,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,146,818 - 48,154,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01043,650,415 - 43,658,227 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01045,526,740 - 45,535,520 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1045,526,745 - 45,534,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01045,282,830 - 45,291,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41045,480,937 - 45,488,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1043,225,920 - 43,233,731 (-)NCBICelera
Cytogenetic Map10q22NCBI
Gjc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955581291,537 - 294,752 (-)NCBIChiLan1.0ChiLan1.0
GJC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2121,446,828 - 21,456,976 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1121,385,126 - 21,395,272 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01203,551,556 - 203,561,702 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11208,762,974 - 208,772,229 (+)NCBIpanpan1.1PanPan1.1panPan2
GJC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.114810,388 - 819,248 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl14810,386 - 820,420 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha14332,072 - 340,760 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.014531,302 - 539,994 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.114722,120 - 730,807 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.014502,958 - 511,636 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.014488,819 - 497,515 (-)NCBIUU_Cfam_GSD_1.0
Gjc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721387,727,408 - 87,735,276 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493686469,445 - 70,752 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493686467,608 - 71,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl251,258,207 - 51,267,962 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1251,257,623 - 51,267,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2253,844,201 - 53,854,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,568,664 - 1,579,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl251,569,427 - 1,570,752 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660551,449,049 - 1,451,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gjc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624937898,876 - 905,247 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gjc2
266 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:828
Count of miRNA genes:277
Interacting mature miRNAs:344
Transcripts:ENSMUST00000108790, ENSMUST00000108793
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
13513917Heal54_mwound healing/ regeneration 54 (mouse)115787291759879610Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
AV026611  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,184,103 - 59,184,485UniSTSGRCm38
MGSCv371158,997,605 - 58,997,987UniSTSGRCm37
Celera1163,949,210 - 63,949,586UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11777.45UniSTS
RH124198  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,183,918 - 59,184,027UniSTSGRCm38
MGSCv371158,997,420 - 58,997,529UniSTSGRCm37
Celera1163,949,025 - 63,949,134UniSTS
Cytogenetic Map11B1.3UniSTS
RH125874  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,183,883 - 59,184,132UniSTSGRCm38
MGSCv371158,997,385 - 58,997,634UniSTSGRCm37
Celera1163,948,990 - 63,949,239UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11778.12UniSTS
RH143586  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,176,881 - 59,177,020UniSTSGRCm38
MGSCv371158,990,383 - 58,990,522UniSTSGRCm37
Celera1163,941,948 - 63,942,087UniSTS
Cytogenetic Map11B1.3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000108790   ⟹   ENSMUSP00000104418
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,066,394 - 59,074,039 (-)Ensembl
GRCm38.p6 Ensembl1159,175,568 - 59,183,213 (-)Ensembl
Ensembl Acc Id: ENSMUST00000108793   ⟹   ENSMUSP00000104421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,066,394 - 59,073,652 (-)Ensembl
GRCm38.p6 Ensembl1159,175,568 - 59,182,826 (-)Ensembl
RefSeq Acc Id: NM_080454   ⟹   NP_536702
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,066,390 - 59,074,039 (-)NCBI
GRCm381159,175,564 - 59,183,213 (-)ENTREZGENE
MGSCv371158,989,066 - 58,996,715 (-)RGD
Celera1163,940,632 - 63,948,320 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_175452   ⟹   NP_780661
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,066,390 - 59,073,652 (-)NCBI
GRCm381159,175,564 - 59,182,826 (-)NCBI
MGSCv371158,989,066 - 58,996,715 (-)RGD
Celera1163,940,632 - 63,948,320 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156249   ⟹   XP_036012142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,066,390 - 59,073,565 (-)NCBI
Sequence:
RefSeq Acc Id: NP_536702   ⟸   NM_080454
- UniProtKB: Q8BQS2 (UniProtKB/Swiss-Prot),   Q6TLV2 (UniProtKB/Swiss-Prot),   Q9EPM1 (UniProtKB/Swiss-Prot),   Q8BQU6 (UniProtKB/Swiss-Prot),   A0A654IDS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_780661   ⟸   NM_175452
- UniProtKB: Q8BQS2 (UniProtKB/Swiss-Prot),   Q6TLV2 (UniProtKB/Swiss-Prot),   Q9EPM1 (UniProtKB/Swiss-Prot),   Q8BQU6 (UniProtKB/Swiss-Prot),   A0A654IDS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000104418   ⟸   ENSMUST00000108790
Ensembl Acc Id: ENSMUSP00000104421   ⟸   ENSMUST00000108793
RefSeq Acc Id: XP_036012142   ⟸   XM_036156249
- Peptide Label: isoform X1
- UniProtKB: Q8BQU6 (UniProtKB/Swiss-Prot),   Q8BQS2 (UniProtKB/Swiss-Prot),   Q6TLV2 (UniProtKB/Swiss-Prot),   Q9EPM1 (UniProtKB/Swiss-Prot),   A0A654IDS7 (UniProtKB/TrEMBL)
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BQU6-F1-model_v2 AlphaFold Q8BQU6 1-440 view protein structure

Promoters
RGD ID:6820948
Promoter ID:MM_KWN:7622
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:NM_080454,   NM_175452
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361158,996,331 - 58,997,382 (-)MPROMDB
RGD ID:8674790
Promoter ID:EPDNEW_M15426
Type:multiple initiation site
Name:Gjc2_1
Description:Mus musculus gap junction protein, gamma 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15427  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,182,826 - 59,182,886EPDNEW
RGD ID:8674792
Promoter ID:EPDNEW_M15427
Type:multiple initiation site
Name:Gjc2_2
Description:Mus musculus gap junction protein, gamma 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15426  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,183,203 - 59,183,263EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2153060 AgrOrtholog
Ensembl Genes ENSMUSG00000043448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000108790 ENTREZGENE
  ENSMUST00000108790.2 UniProtKB/Swiss-Prot
  ENSMUST00000108793 ENTREZGENE
  ENSMUST00000108793.9 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:118454 UniProtKB/Swiss-Prot
MGD MGI:2153060 ENTREZGENE
NCBI Gene 118454 ENTREZGENE
PANTHER GAP JUNCTION GAMMA-2 PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gjc2 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A654IDS7 ENTREZGENE, UniProtKB/TrEMBL
  CXG2_MOUSE UniProtKB/Swiss-Prot
  Q2HJ05_MOUSE UniProtKB/TrEMBL
  Q6TLV2 ENTREZGENE
  Q8BQS2 ENTREZGENE
  Q8BQU6 ENTREZGENE
  Q9EPM1 ENTREZGENE
UniProt Secondary Q6TLV2 UniProtKB/Swiss-Prot
  Q8BQS2 UniProtKB/Swiss-Prot
  Q9EPM1 UniProtKB/Swiss-Prot